A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells (original) (raw)
References
Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dube MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP (2004) Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 36:77–82 ArticlePubMedCAS Google Scholar
Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, Loukopoulos D, Camaschella C (2003) Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 33:21–22 ArticlePubMedCAS Google Scholar
Lanzara C, Roetto A, Daraio F, Rivard S, Ficarella R, Simard H, Cox TM, Cazzola M, Piperno A, Gimenez-Roqueplo AP, Grammatico P, Volinia S, Gasparini P, Camaschella C (2004) Spectrum of hemojuvelin gene mutations in 1q-linked juvenile hemochromatosis. Blood 103:4317–4321 ArticlePubMedCAS Google Scholar
Huang FW, Pinkus JL, Pinkus GS, Fleming MD, Andrews NC (2005) A mouse model of juvenile hemochromatosis. J Clin Invest 115:2187–2191 ArticlePubMed Google Scholar
Lin L, Goldberg YP, Ganz T (2005) Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 106:2884–2889 ArticlePubMed Google Scholar
Niederkofler V, Salie R, Arber S (2005) Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 115:2180–2186 ArticlePubMed Google Scholar
Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090–2093 ArticlePubMedCAS Google Scholar
Ganz T, Nemeth E (2006) Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 290:G199–203 ArticlePubMed Google Scholar
Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117:285–297 ArticlePubMedCAS Google Scholar
Muckenthaler M, Roy CN, Custodio AO, Minana B, deGraaf J, Montross LK, Andrews NC, Hentze MW (2003) Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 34:102–107 ArticlePubMedCAS Google Scholar
Nicolas G, Viatte L, Lou DQ, Bennoun M, Beaumont C, Kahn A, Andrews NC, Vaulont S (2003) Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat Genet 34:97–101 ArticlePubMedCAS Google Scholar
Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crawford DH, Subramaniam VN, Powell LW, Anderson GJ, Ramm GA (2003) Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 361:669–673 ArticlePubMedCAS Google Scholar
Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C (2005) Hepcidin is decreased in TFR2-Hemochromatosis. Blood 105:1803–1806 ArticlePubMedCAS Google Scholar
Wallace DF, Summerville L, Lusby PE, Subramaniam VN (2005) First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut 54:980–986 ArticlePubMedCAS Google Scholar
Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38:531–539 ArticlePubMed Google Scholar
Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY (2007) Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest 117:1933–1939 ArticlePubMedCAS Google Scholar
Miyazono K, Maeda S, Imamura T (2005) BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev 16:251–263 ArticlePubMed Google Scholar
Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, Cooperman S, Eckhaus M, Rouault T, Mishra L, Deng CX (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2:399–409 ArticlePubMed Google Scholar
Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU (2006) STAT-3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 109:353–358 ArticlePubMed Google Scholar
Wrighting DMAN (2006) Interleukin-6 induces hepcidin expression through STAT3. Blood 108:3204–3209 ArticlePubMed Google Scholar
Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM (1998) Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17:3091–3100 ArticlePubMedCAS Google Scholar
Yang YC, Piek E, Zavadil J, Liang D, Xie D, Heyer J, Pavlidis P, Kucherlapati R, Roberts AB, Bottinger EP (2003) Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A 100:10269–10274 ArticlePubMedCAS Google Scholar
Mostert V, Wolff S, Dreher I, Kohrle J, Abel J (2001) Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-beta. Eur J Biochem 268:6176–6181 ArticlePubMedCAS Google Scholar
Korchynskyi O, ten Dijke P (2002) Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem 277:4883–4891 ArticlePubMedCAS Google Scholar
Kusanagi K, Inoue H, Ishidou Y, Mishima HK, Kawabata M, Miyazono K (2000) Characterization of a bone morphogenetic protein-responsive Smad-binding element. Mol Biol Cell 11:555–565 PubMedCAS Google Scholar
Truksa J, Peng H, Lee P, Beutler E (2006) Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci U S A 103:10289–10293 ArticlePubMed Google Scholar
Massague J, Seoane J, Wotton D (2005) Smad transcription factors. Genes Dev 19:2783–2810 ArticlePubMed Google Scholar
Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL, Hill CS (2006) Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J 25:4490–4502 ArticlePubMed Google Scholar
Truksa J, Lee P, Beutler E (2007) The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters. Blood Cells Mol Dis 39:255–262 ArticlePubMedCAS Google Scholar
Truksa J, Lee P, Peng H, Flanagan J, Beutler E (2007) The distal location of the iron responsive region of the hepcidin promoter. Blood 110:3436–3437 ArticlePubMedCAS Google Scholar
Lee P, Peng H, Gelbart T, Beutler E (2004) The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Proc Natl Acad Sci U S A 101:9263–9265 ArticlePubMedCAS Google Scholar
Constante M, Jiang W, Wang D, Raymond VA, Bilodeau M, Santos MM (2006) Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation. Am J Physiol Gastrointest Liver Physiol 291:G229–237 ArticlePubMed Google Scholar
Frazer DM, Wilkins SJ, Millard KN, McKie AT, Vulpe CD, Anderson GJ (2004) Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE. Br J Haematol 126:434–436 ArticlePubMed Google Scholar
Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, Sanchez M, Gaudino A, Hentze MW, Andrews NC, Muckenthaler MU (2004) An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet 36:481–485 ArticlePubMedCAS Google Scholar