Plasma levels of macrophage migration inhibitory factor are elevated in patients with severe sepsis (original) (raw)
Abstract.
Objective: To investigate the role of macrophage migration inhibitory factor (MIF) as a marker of severity of systemic inflammation in patients with severe sepsis and critically ill postsurgical patients. Design: Prospective observational study in consecutive patients with severe sepsis, critically ill nonseptic postsurgical patients, and healthy blood donors. Setting: A surgical intensive care unit of a university hospital. Patients and participants: 19 patients with severe sepsis, 18 critically ill nonseptic postsurgical patients, and 10 healthy blood donors. Measurements and results: MIF plasma levels of patients and participants were measured. Interleukin 6 plasma levels were monitored as a control marker of inflammation. The median MIF plasma level was four to five times higher in patients with severe sepsis (2.70 ng/ml, range 0.31–19.59) and in critically ill nonseptic postsurgical patients (2.43 ng/ml, range 0.49–4.31) than in healthy blood donors (0.56 ng/ml, range 0.16–1.68). MIF plasma levels did not differ between the patient groups. Conclusions: MIF serves as a general marker for systemic inflammation in septic and nonseptic acute critical illness, but MIF does not discriminate for severity or differentiate between infectious and noninfectious origins of an acute critical illness.
Access this article
Subscribe and save
- Get 10 units per month
- Download Article/Chapter or eBook
- 1 Unit = 1 Article or 1 Chapter
- Cancel anytime Subscribe now
Buy Now
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Instant access to the full article PDF.
Author information
Authors and Affiliations
- Klinik und Poliklinik für Anästhesiologie und Spezielle Intensivmedizin, Rheinischen Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
Lutz Lehmann, Uwe Novender, Stefan Schroeder, Tilman von Spiegel, Christian Putensen, Andreas Hoeft & Frank Stüber - Institut für Neuropathologie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
Torsten Pietsch
Authors
- Lutz Lehmann
You can also search for this author inPubMed Google Scholar - Uwe Novender
You can also search for this author inPubMed Google Scholar - Stefan Schroeder
You can also search for this author inPubMed Google Scholar - Torsten Pietsch
You can also search for this author inPubMed Google Scholar - Tilman von Spiegel
You can also search for this author inPubMed Google Scholar - Christian Putensen
You can also search for this author inPubMed Google Scholar - Andreas Hoeft
You can also search for this author inPubMed Google Scholar - Frank Stüber
You can also search for this author inPubMed Google Scholar
Additional information
Final revision received: 18 May 2001
Electronic Publication
Rights and permissions
About this article
Cite this article
Lehmann, L., Novender, U., Schroeder, S. et al. Plasma levels of macrophage migration inhibitory factor are elevated in patients with severe sepsis.Intensive Care Med 27, 1412–1415 (2001). https://doi.org/10.1007/s001340101022
- Received: 30 November 2000
- Accepted: 01 June 2001
- Published: 10 July 2001
- Issue Date: August 2001
- DOI: https://doi.org/10.1007/s001340101022