Cortical regions contributing to the anterior commissure in man (original) (raw)

Abstract

The human anterior commissure is believed, by extrapolation from data obtained in macaque monkeys, to convey axons from the temporal and orbitofrontal cortex. Reports of interhemispheric transfer and sexual dimorphism related to the anterior commissure, however, make more precise data on the human anterior commissure desirable. We investigated the connectivity of the human anterior commissure in six adults (male and female) that had circumscribed hemispheric lesions in temporal, frontal, parietal or occipital cortices or in infrapallidal white matter using the Nauta for anterogradely degenerating axons. Axons originating in the inferior part of temporal or occipital lobes, occipital convexity and possibly central fissure and prefrontal convexity were found to cross the midsagittal plane in the anterior commissure. The largest contigent of commissural axons originated in the inferior part of the temporal lobe; it displayed a roughly topographic organization, preferentially running through the inferior part of the commissure. The inferior temporal contigent seemed to reach homotopic and heterotopic targets in the opposite hemisphere. Among the latter were the amygdala and possibly the orbitofrontal cortex. The present data suggest that the human anterior commissure conveys axons from much larger territories than expected from work on non-human primates. Similarly to the human and non-human primate corpus callosum, the anterior commissure is roughly topographically organized and participates in heterotopic connectivity.

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Authors and Affiliations

1. Institut de Physiologie, Université de Lausanne, Lausanne, Switzerland, , , , , , CH
   Gabrielle Di Virgilio
2. Institut de Physiologie, Université de Lausanne and Division de Neuropsychologie, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 7, CH-1005 Lausanne, Switzerland e-mail: sclarke@iphysiol.unil.ch Tel.: +41-21-692-55-29, Fax: +41-21-692-55-05, , , , , , CH
   S. Clarke
3. Division de Neuropathologie, Centre Médical Universitaire, Geneva, Switzerland, , , , , , CH
   Gianpaolo Pizzolato
4. Pathologisches Institut, Universitätsspital, Bern, Switzerland, , , , , , CH
   Thomas Schaffner

Authors

1. Gabrielle Di Virgilio
2. S. Clarke
3. Gianpaolo Pizzolato
4. Thomas Schaffner

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Received: 16 March 1998 / Accepted: 15 July 1998

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Di Virgilio, G., Clarke, S., Pizzolato, G. et al. Cortical regions contributing to the anterior commissure in man.Exp Brain Res 124, 1–7 (1999). https://doi.org/10.1007/s002210050593

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• Issue date: January 1999
• DOI: https://doi.org/10.1007/s002210050593