Change in Lean Body Mass Is a Major Determinant of Change in Areal Bone Mineral Density of the Proximal Femur: A 12-Year Observational Study (original) (raw)

Abstract

Our objective was to assess the contribution of lean body mass (LBM) and fat body mass (FBM) to areal bone mineral density (aBMD) in women during the years surrounding menopause. We used a 12-year observational design. Participants included 75 Caucasian women who were premenopausal, 53 of whom were available for follow-up. There were two measurement periods: baseline and 12-year follow-up. At both measurement periods, bone mineral content and aBMD of the proximal femur, posterior-anterior lumbar spine, and total body was assessed using dual-energy X-ray absorptiometry (DXA). LBM and FBM were derived from the total-body scans. General health, including current menopausal status, hormone replace therapy use, medication use, and physical activity, was assessed by questionnaires. At the end of the study, 44% of the women were postmenopausal. After controlling for baseline aBMD, current menopausal status, and current hormone replacement therapy, we found that change in LBM was independently associated with change in aBMD of the proximal femur (P = 0.001). The cross-sectional analyses also indicated that LBM was a significant determinant of aBMD of all three DXA-scanned sites at both baseline and follow-up. These novel longitudinal data highlight the important contribution of LBM to the maintenance of proximal femur bone mass at a key time in women’s life span, the years surrounding menopause.

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Acknowledgment

The Canadian Institutes of Health Research funded this study. Drs. McKay and Liu-Ambrose are Michael Smith Foundation for Health Research Career Scholars. Dr. Khan is a Canadian Institutes of Health Research (Institute of Musculoskeletal Health and Arthritis) New Investigator. Ms. Sherar is a Community and Population Health Research Strategic Training Fellow and Mr. Mundt is a Canadian Institutes of Health Research Regional Partnership Program Doctoral Research Scholar.

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Authors and Affiliations

  1. UBC Bone Health Research Group: Centre for Hip Health, BC Women’s Hospital and Health Centre Osteoporosis Program, and Faculty of Medicine, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada, V5Z 1L8
    T. Liu-Ambrose, L. Kravetsky, K. M. Khan & H. A. McKay
  2. Department of Orthopaedics, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada, V5Z 1L8
    T. Liu-Ambrose & H. A. McKay
  3. School of Rehabilitation Sciences, University of British Columbia, T325-2211 Westbrook Mall, Vancouver, BC, Canada, V6T 2B5
    T. Liu-Ambrose
  4. Department of Experimental Medicine, University of British Columbia, 5125 Koerner Pavilion, 2211 Westbrook Mall, Vancouver, BC, Canada, V6T 1Z3
    L. Kravetsky
  5. College of Kinesiology, University of Saskatchewan, 87 Campus Drive, Saskatoon, SK, Canada, S7N 5B3
    D. Bailey, L. Sherar, C. Mundt & A. Baxter-Jones
  6. School of Human Movement Studies, University of Queensland, Level 5, Building 26, St. Lucia, QLD, Australia, 4072
    D. Bailey
  7. Department of Family Practice, University of British Columbia, 5950 University Blvd., Vancouver, BC, Canada
    K. M. Khan & H. A. McKay
  8. School of Human Kinetics, University of British Columbia, 210-6081 University Blvd., Vancouver, BC, Canada, V6T 1Z1
    K. M. Khan

Authors

  1. T. Liu-Ambrose
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  2. L. Kravetsky
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  3. D. Bailey
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  4. L. Sherar
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  5. C. Mundt
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  6. A. Baxter-Jones
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  7. K. M. Khan
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  8. H. A. McKay
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Correspondence toH. A. McKay.

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Liu-Ambrose, T., Kravetsky, L., Bailey, D. et al. Change in Lean Body Mass Is a Major Determinant of Change in Areal Bone Mineral Density of the Proximal Femur: A 12-Year Observational Study.Calcif Tissue Int 79, 145–151 (2006). https://doi.org/10.1007/s00223-006-0098-z

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