Association of Bone Mineral Density, Bone Turnover Markers, and Vertebral Fractures with All-Cause Mortality in Type 2 Diabetes Mellitus (original) (raw)

References

1. Matheus AS, Tannus LR, Cobas RA, Palma CC, Negrato CA, Gomes MB (2013) Impact of diabetes on cardiovascular disease: an update. Int J Hypertens 2013:653789
   Article PubMed PubMed Central Google Scholar
2. Fisher-Hoch SP, Mathews CE, McCormick JB (2013) Obesity, diabetes and pneumonia: the menacing interface of non-communicable and infectious diseases. Trop Med Int Health 18:1510–1519
   Article PubMed Google Scholar
3. Gallagher EJ, LeRoith D (2015) Obesity and diabetes: the increased risk of cancer and cancer-related mortality. Physiol Rev 95:727–748
   Article CAS PubMed PubMed Central Google Scholar
4. Almdal T, Scharling H, Jensen JS, Vestergaad H (2004) The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up. Arch Intern Med 164:1422–1426
   Article PubMed Google Scholar
5. Barret-Connor E, Holbrook TL (1992) Sex differences in osteoporosis in older adults with non-insulin-dependent diabetes mellitus. JAMA 268:3333–3337
   Article Google Scholar
6. Vestergaard P (2007) Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis. Osteoporos Int 18:427–444
   Article CAS PubMed Google Scholar
7. Yamamoto M, Yamaguchi T, Yamauchi M, Kaji H, Sugimoto T (2009) Diabetic patients have an increased risk of vertebral fractures independent of bone mineral density or diabetic complications. J Bone Miner Res 24:702–709
   Article CAS PubMed Google Scholar
8. Haentjens P, Magaziner J, Colon-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152:380–390
   Article PubMed PubMed Central Google Scholar
9. Ensrund KE, Thompson DE, Cauley JA, Nevitt MC, Kado DM, Hochberg MC, Santora AC 2nd, Black DM (2009) Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. J Am Geriatr Soc 48:241–249
   Article Google Scholar
10. Sambrook PN, Chen CJ, March L, Cameron ID, Cumming RG, Lord SR, Simpson JM, Seibel MJ (2006) High bone turnover is an independent predictor of mortality in the frail elderly. J Bone Miner Res 21:549–555
    Article PubMed Google Scholar
11. Lerchbaum E, Schwetx V, Pilz S, Grammer TB, Look M, Boehm BO, Obermayer-Pietsch B, März W (2012) Association of bone turnover markers with mortality in men referred to coronary angiography. Osteoporos Int 24:1321–1332
    Article PubMed Google Scholar
12. Lerchbaum E, Schwetz V, Pilz S, Boehm BO, März W (2014) Association of bone turnover markers with mortality in women referred to coronary angiography: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Osteoporos Int 25:455–465
    Article CAS PubMed Google Scholar
13. Gulin T, Kruljac I, Kirigin L, Merc M, Pavic M, Trcin MT, Bokulic A, Megla ZB, Kastelan D (2016) Advanced age, high & #x03B2;-CTX levels, and impaired renal function are independent risk factors for all-cause one-year mortality in hip fracture patients. Calcif Tissue Int 98:67–75
    Article CAS PubMed Google Scholar
14. Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Hankey GJ, Beilby JP, Norman PE (2012) Associations of total osteocalcin with all-cause and cardiovascular mortality in older men: the Health In Men Study. Osteoporos Int 23:599–606
    Article CAS PubMed Google Scholar
15. Saito M, Fujii K, Mori Y, Marumo K (2006) Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats. Osteoporos Int 17:1514–1523
    Article CAS PubMed Google Scholar
16. Liu C, Wo J, Zhao Q, Wang Y, Wang B, Zhao W (2015) Association between serum total osteocalcin level and type 2 diabetes mellitus: a systematic review and meta-analysis. Horm Metab Res 47:813–819
    Article CAS PubMed Google Scholar
17. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130:456–469
    Article CAS PubMed PubMed Central Google Scholar
18. Pi M, Quarles LD (2012) Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks. Endocrinology 153:2062–2069
    Article CAS PubMed PubMed Central Google Scholar
19. Jung CH, Lee WJ, Hwang JY, Lee MJ, Seol SM, Kim YM, Lee YL, Park JY (2013) The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway. Metabolism 62:1250–1257
    Article CAS PubMed Google Scholar
20. Zhou B, Li H, Liu J, Xu L, Zang W, Wu S, Sun H (2013) Intermittent injections of osteocalcin reverse autophagic dysfunction and endoplasmic reticulum stress resulting from diet-induced obesity in the vascular tissue via the NFκB-p65-dependent mechanism. Cell Cycle 12:1901–1903
    Article CAS PubMed PubMed Central Google Scholar
21. Kanazawa I, Yamaguchi T, Tada Y, Yamauchi M, Yano S, Sugimoto T (2011) Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes. Bone 48:720–725
    Article CAS PubMed Google Scholar
22. Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T (2009) Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab 94:45–49
    Article CAS PubMed Google Scholar
23. Ogawa-Furuya N, Yamaguchi T, Yamamoto M, Kanazawa I, Sugimoto T (2013) Serum osteocalcin levels are inversely associated with abdominal aortic calcification in men with type 2 diabetes mellitus. Osteoporos Int 24:2223–2230
    Article CAS PubMed Google Scholar
24. Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S, Sugimoto T (2011) Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int 22:187–194
    Article CAS PubMed Google Scholar
25. Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T (2009) Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus. J Clin Endocrinol Metab 94:3031–3037
    Article CAS PubMed Google Scholar
26. Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T (2009) Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and vertebral fractures in type 2 diabetes mellitus. Eur J Endocrinol 160:265–273
    Article CAS PubMed Google Scholar
27. Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137–1148
    Article CAS PubMed Google Scholar
28. Report of a WHO Study Group (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organ Tech Rep Ser 843:1–129
    Google Scholar
29. Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, Hermo L, Suarez S, Roth BL, Ducy P, Karsenty G (2011) Endocrine regulation of male fertility by the skeleton. Cell 144:796–809
    Article CAS PubMed PubMed Central Google Scholar
30. Karsenty G, Oury F (2014) Regulation of male fertility by the bone-derived hormone osteocalcin. Mol Cell Endocrinol 382:521–526
    Article CAS PubMed Google Scholar
31. Richards JB, Valdes AM, Burling K, Perks UC, Spector TD (2007) Serum adiponectin and bone mineral density in women. J Clin Endocrinol Metab 92:1517–1523
    Article CAS PubMed Google Scholar
32. Oh KW, Lee WY, Rhee EJ, Baek KH, Yoon KH, Kang MI, Yun EJ, Park CY, Ihm SH, Choi MG, Yoo HJ, Park SW (2005) The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men. Clin Endocrinol 63:131–138
    Article CAS Google Scholar
33. Kadowaki T, Yamauchi T (2005) Adiponectin and adiponectin receptors. Endocr Rev 26:439–451
    Article CAS PubMed Google Scholar
34. Yamauchi T, Hara K, Kubota N, Terauchi Y, Tobe K, Froguel P, Nagai R, Kadowaki T (2003) Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. Curr Drug Targets Immune Endocr Metabol Disord 3:243–254
    Article CAS PubMed Google Scholar
35. Dalamaga M, Diakopoulos KN, Mantzoros CS (2012) The role of adiponectin in cancer: a review of current evidence. Endocr Rev 33:547–594
    Article CAS PubMed PubMed Central Google Scholar
36. Kanazawa I, Tanaka K, Ogawa N, Yamauchi M, Yamaguchi T, Sugimoto T (2013) Undercarboxylated osteocalcin is positively associated with free testosterone in male patients with type 2 diabetes mellitus. Osteoporos Int 24:1115–1119
    Article CAS PubMed Google Scholar
37. De Almeida Pereira Coutinho M, Bandeira E, de Almeida JM, Godoi ET, Vasconcelos G, Bandeira F (2013) Low bone mass is associated with increased carotid intima media thickness in men with type 2 diabetes mellitus. Clin Med Insights Endocrinol Diabetes 6:1–6
    PubMed PubMed Central Google Scholar
38. Kanis JA, McCloskey EV, Johansson H, Strom O, Borqstrom F, Oden A, National Osteoporosis Guideline Group (2008) Case finding for the management of osteoporosis with FRAX–assessment and intervention thresholds for the UK. Osteoporos Int 19:1395–1408
    Article CAS PubMed Google Scholar
39. Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA (1999) Mortality after all major types of osteoporotic fracture in men and women an observational study. Lancet 353:878–882
    Article CAS PubMed Google Scholar
40. Klop C, van Staa TP, Cooper C, Harvey NC, de Vries F (2017) The epidemiology of mortality after fracture in England: variation by age, sex, time, geographic location, and ethnicity. Osteoporos Int 28:161–168
    Article CAS PubMed Google Scholar

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