Prognostic Factors and Outcome of 438 Chinese Patients with Hepatocellular Carcinoma Underwent Partial Hepatectomy in a Single Center (original) (raw)

Abstract

Objective

This study was designed to evaluate the prognostic factors and outcome of 438 Chinese patients with hepatocellular carcinoma who underwent partial hepatectomy in a single center.

Methods

Clinicopathological data of 438 patients with hepatocellular carcinoma who underwent partial hepatectomy at the author’s hospital between 1991 and 2004 were reviewed retrospectively. The Kaplan–Meier method was adopted for evaluating survival. Prognostic factors were assessed by Cox proportional hazard model and logistic regression model.

Results

The perioperative (30 days) mortality and morbidity were 7.5% (33/438) and 21.7% (95/438), respectively. The operative mortality decreased significantly from 10.6% (23/218) in 1991–2001 to 4.5% (10/220) in 2002–2004 (P = 0.019). Postoperative overall survival rates at 1 year, 3 years, and 5 years were 72.2%, 53.5%, and 43.3%, respectively. Cox multivariate analysis indicated that Child-Pugh score, tumor size, capsular invasion, tumor stage, vascular invasion, and resection margin were independent prognostic factors for overall survival (P < 0.05). Also, 254 cases had tumor recurrence after operation and 87 cases of them were reoperated. Logistic multivariate analysis showed that tumor size, capsular invasion, vascular invasion, lymph node metastasis, extrahepatic metastasis, and resection margin were independent risk factors of tumor recurrence (P < 0.05).

Conclusions

Tumor size, capsular invasion, vascular invasion, and resection margin were the main factors that may impact the overall survival and tumor recurrence. Because resection margin was the only factor that relates to the surgery, enough resection margin (>2 cm) should be obtained whenever possible.

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Acknowledgement

The Special Research Foundation of the National Nature Science Foundation of China (30872487).

Conflicts of interest

The authors certify that this is an original, unpublished work that is not under consideration elsewhere. We had no conflicts of interest to disclose.

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Authors and Affiliations

  1. Department of Hepato-Pancreato-Biliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, Guangdong Province, China
    Jie Wang, Lei-bo Xu, Chao Liu, Ya-jin Chen & Qing-jia Ou
  2. Department of Emergency, Huangpu Branch of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China
    Hao-wei Pang

Authors

  1. Jie Wang
  2. Lei-bo Xu
  3. Chao Liu
  4. Hao-wei Pang
  5. Ya-jin Chen
  6. Qing-jia Ou

Corresponding author

Correspondence toChao Liu.

Additional information

Jie Wang and Lei-bo Xu contribute equally to this work.

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Wang, J., Xu, Lb., Liu, C. et al. Prognostic Factors and Outcome of 438 Chinese Patients with Hepatocellular Carcinoma Underwent Partial Hepatectomy in a Single Center.World J Surg 34, 2434–2441 (2010). https://doi.org/10.1007/s00268-010-0664-4

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