Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1) (original) (raw)
References
Ahn KJ, Jeong HK, Choi HS, Ryoo SR, Kim YJ, Goo JS, Choi SY, Han JS, Ha I, Song WJ (2006) DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects. Neurobiol Dis 22:463–472 ArticlePubMedCAS Google Scholar
Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S (2004) Chromosome 21 and Down syndrome: from genomics to pathophysiology. Nat Rev 5:725–738 ArticleCAS Google Scholar
Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S (2009) Down’s syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 459:1126–1130 ArticlePubMedCAS Google Scholar
Branchi I, Bichler Z, Minghetti L, Delabar JM, Malchiodi-Albedi F, Gonzalez MC, Chettouh Z, Nicolini A, Chabert C, Smith DJ, Rubin EM, Migliore-Samour D, Alleva E (2004) Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. J Neuropathol Exp Neurol 63:429–440 PubMedCAS Google Scholar
Chabert C, Jamon M, Cherfouh A, Duquenne V, Smith DJ, Rubin E, Roubertoux PL (2004) Functional analysis of genes implicated in Down syndrome: 1. Cognitive abilities in mice transpolygenic for Down syndrome chromosomal region-1 (DCR-1). Behav Genet 34:559–569 ArticlePubMed Google Scholar
Chan B, Greenan G, McKeon F, Ellenberger T (2005) Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc Natl Acad Sci USA 102:13075–13080 ArticlePubMedCAS Google Scholar
Chang KT, Shi YJ, Min KT (2003) The drosophila homolog of Down’s syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci USA 100:15794–15799 ArticlePubMedCAS Google Scholar
Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436:725–730 ArticlePubMedCAS Google Scholar
Chrast R, Scott HS, Madani R, Huber L, Wolfer DP, Prinz M, Aguzzi A, Lipp HP, Antonarakis SE (2000) Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Hum Mol Genet 9:1853–1864 ArticlePubMedCAS Google Scholar
Cook CN, Hejna MJ, Magnuson DJ, Lee JM (2005) Expression of calcipressin1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer’s disease. J Alzheimers Dis 8:63–73 PubMedCAS Google Scholar
Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Perez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X (2007) Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J 21:3023–3028 ArticlePubMedCAS Google Scholar
Dunbier AK, Anderson H, Ghazoui Z, Lopez-Knowles E, Pancholi S, Ribas R, Drury S, Sidhu K, Leary A, Martin LA, Dowsett M (2011) ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1. PLoS Genet 7:e1001382 ArticlePubMedCAS Google Scholar
Ermak G, Morgan TE, Davies KJ (2001) Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer’s disease. J Biol Chem 276:38787–38794 ArticlePubMedCAS Google Scholar
Fuentes JJ, Pritchard MA, Estivill X (1997) Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Genomics 44:358–361 ArticlePubMedCAS Google Scholar
Fuentes JJ, Genesca L, Kingsbury TJ, Cunningham KW, Perez-Riba M, Estivill X, de la Luna S (2000) DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet 9:1681–1690 ArticlePubMedCAS Google Scholar
Genesca L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Perez-Riba M (2003) Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. Biochem J 374:567–575 ArticlePubMedCAS Google Scholar
Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG (1999) A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell 3:97–108 ArticlePubMedCAS Google Scholar
Hasle H (2001) Pattern of malignant disorders in individuals with Down’s syndrome. Lancet Oncol 2:429–436 ArticlePubMedCAS Google Scholar
Herault Y, Duchon A, Velot E, Marechal D, Brault V (2012) The in vivo Down syndrome genomic library in mouse. Prog Brain Res 197:169–197 ArticlePubMedCAS Google Scholar
Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, Ferrara N, Gerber HP (2004) Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood 104:149–158 ArticlePubMedCAS Google Scholar
Hilioti Z, Gallagher DA, Low-Nam ST, Ramaswamy P, Gajer P, Kingsbury TJ, Birchwood CJ, Levchenko A, Cunningham KW (2004) GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes Dev 18:35–47 ArticlePubMedCAS Google Scholar
Hogan PG, Chen L, Nardone J, Rao A (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17:2205–2232 ArticlePubMedCAS Google Scholar
Iizuka M, Abe M, Shiiba K, Sasaki I, Sato Y (2004) Down syndrome candidate region 1, a downstream target of VEGF, participates in endothelial cell migration and angiogenesis. J Vasc Res 41:334–344 ArticlePubMedCAS Google Scholar
Kingsbury TJ, Cunningham KW (2000) A conserved family of calcineurin regulators. Genes Dev 14:1595–1604 PubMedCAS Google Scholar
Kulnane LS, Lamb BT (2001) Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice. Neurobiol Dis 8:982–992 ArticlePubMedCAS Google Scholar
Kwak HI, Gustafson T, Metz RP, Laffin B, Schedin P, Porter WW (2007) Inhibition of breast cancer growth and invasion by single-minded 2s. Carcinogenesis 28:259–266 ArticlePubMedCAS Google Scholar
Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD (1993) Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nat Genet 5:22–30 ArticlePubMedCAS Google Scholar
Lange AW, Molkentin JD, Yutzey KE (2004) DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Dev Biol 266:346–360 ArticlePubMedCAS Google Scholar
Lange AW, Rothermel BA, Yutzey KE (2005) Restoration of DSCR1 to disomy in the trisomy 16 mouse model of Down syndrome does not correct cardiac or craniofacial development anomalies. Dev Dyn 233:954–963 ArticlePubMedCAS Google Scholar
Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, Court DL, Jenkins NA, Copeland NG (2001) A highly efficient _Escherichia coli_-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73:56–65 ArticlePubMedCAS Google Scholar
Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT (2003) Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. Hum Mol Genet 12:2949–2956 ArticlePubMedCAS Google Scholar
Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE (2011a) Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci 33:404–413 ArticlePubMedCAS Google Scholar
Liu C, Morishima M, Yu T, Matsui S, Zhang L, Fu D, Pao A, Costa AC, Gardiner KJ, Cowell JK, Nowak NJ, Parmacek MS, Liang P, Baldini A, Yu YE (2011b) Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet 130:623–632 ArticlePubMedCAS Google Scholar
Ludwig T, Fisher P, Murty V, Efstratiadis A (2001) Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice. Oncogene 20:3937–3948 ArticlePubMedCAS Google Scholar
Ma H, Xiong H, Liu T, Zhang L, Godzik A, Zhang Z (2004) Aggregate formation and synaptic abnormality induced by DSCR1. J Neurochem 88:1485–1496 ArticlePubMedCAS Google Scholar
Macian F (2005) NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 5:472–484 ArticlePubMedCAS Google Scholar
Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC (2004) Vascular endothelial growth factor-and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. J Biol Chem 279:50537–50554 ArticlePubMedCAS Google Scholar
Nikolaev AY, Li M, Puskas N, Qin J, Gu W (2003) Parc: a cytoplasmic anchor for p53. Cell 112:29–40 ArticlePubMedCAS Google Scholar
Osoegawa K, Mammoser AG, Wu C, Frengen E, Zeng C, Catanese JJ, de Jong PJ (2001) A bacterial artificial chromosome library for sequencing the complete human genome. Genome Res 11:483–496 ArticlePubMedCAS Google Scholar
Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A, Arancio O (2008) Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 28:14537–14545 ArticlePubMedCAS Google Scholar
Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H (2006) Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway. Mol Cancer Res 4:811–820 ArticlePubMedCAS Google Scholar
Reynolds LE, Watson AR, Baker M, Jones TA, D’Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM (2010) Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome. Nature 465:813–817 ArticlePubMedCAS Google Scholar
Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, Williams RS (2000) A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem 275:8719–8725 ArticlePubMedCAS Google Scholar
Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F (2008) Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth. Cancer Cell 13:420–431 ArticlePubMedCAS Google Scholar
Sanna B, Brandt EB, Kaiser RA, Pfluger P, Witt SA, Kimball TR, van Rooij E, De Windt LJ, Rothenberg ME, Tschop MH, Benoit SC, Molkentin JD (2006) Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci USA 103:7327–7332 ArticlePubMedCAS Google Scholar
Smith DJ, Rubin EM (1997) Functional screening and complex traits: human 21q22.2 sequences affecting learning in mice. Hum Mol Genet 6:1729–1733 ArticlePubMedCAS Google Scholar
Smith DJ, Stevens ME, Sudanagunta SP, Bronson RT, Makhinson M, Watabe AM, O’Dell TJ, Fung J, Weier HU, Cheng JF, Rubin EM (1997) Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. Nat Genet 16:28–36 ArticlePubMedCAS Google Scholar
Stewart MP, McDowall A, Hogg N (1998) LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2 + -dependent protease, calpain. J Cell Biol 140:699–707 ArticlePubMedCAS Google Scholar
Sussan TE, Yang A, Li F, Ostrowski MC, Reeves RH (2008) Trisomy represses Apc(Min)-mediated tumours in mouse models of Down’s syndrome. Nature 451:73–75 ArticlePubMedCAS Google Scholar
Vega RB, Rothermel BA, Weinheimer CJ, Kovacs A, Naseem RH, Bassel-Duby R, Williams RS, Olson EN (2003) Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proc Natl Acad Sci USA 100:669–674 ArticlePubMedCAS Google Scholar
Voronov SV, Frere SG, Giovedi S, Pollina EA, Borel C, Zhang H, Schmidt C, Akeson EC, Wenk MR, Cimasoni L, Arancio O, Davisson MT, Antonarakis SE, Gardiner K, De Camilli P, Di Paolo G (2008) Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down’s syndrome. Proc Natl Acad Sci USA 105:9415–9420 ArticlePubMedCAS Google Scholar
Winder DG, Sweatt JD (2001) Roles of serine/threonine phosphatases in hippocampal synaptic plasticity. Nat Rev Neurosci 2:461–474 ArticlePubMedCAS Google Scholar
Wiseman FK, Alford KA, Tybulewicz VL, Fisher EM (2009) Down syndrome––recent progress and future prospects. Hum Mol Genet 18:R75–R83 ArticlePubMedCAS Google Scholar
Wolvetang EJ, Wilson TJ, Sanij E, Busciglio J, Hatzistavrou T, Seth A, Hertzog PJ, Kola I (2003) ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Hum Mol Genet 12:247–255 ArticlePubMedCAS Google Scholar
Xing L, Salas M, Lin CS, Zigman W, Silverman W, Subramaniyam S, Murty VV, Tycko B (2007) Faithful tissue-specific expression of the human chromosome 21-linked COL6A1 gene in BAC-transgenic mice. Mamm Genome 18:113–122 ArticlePubMedCAS Google Scholar
Yang A, Reeves RH (2011) Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome. Cancer Res 71:3573–3581 ArticlePubMedCAS Google Scholar
Yang J, Rothermel B, Vega RB, Frey N, McKinsey TA, Olson EN, Bassel-Duby R, Williams RS (2000) Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ Res 87:E61–E68 ArticlePubMedCAS Google Scholar
Zeng H, Chattarji S, Barbarosie M, Rondi-Reig L, Philpot BD, Miyakawa T, Bear MF, Tonegawa S (2001) Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory. Cell 107:617–629 ArticlePubMedCAS Google Scholar