A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice (original) (raw)

Abstract.

C57Bl/6 mice reproducibly prefer to ingest more 10% ethanol in a two-bottle choice paradigm than do DBA/2J mice. In this paper we report the identification of two new sex-specific alcohol preference (Alcp) loci. Melo and associates (1996) identified two loci: Alcp1, a male-specific locus on Chromosome (Chr) 2, and Alcp2, a female- and cross-specific locus on Chr 11. We have additionally identified Alcp3, a male-specific locus on Chr 3, and Alcp4, a female-specific locus on Chr 1. We have also performed a statistical analysis to exclude the possibility of undiscovered major alcohol preference loci that are not sex-specific in our backcross paradigm. Our results indicate that alcohol preference in C57BL/6 mice, as measured in our backcross, is largely controlled in a sex-specific manner.

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Authors and Affiliations

  1. Princeton University, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA, , , , , , US
    Jeremy L. Peirce, Rachel Derr, Jay Shendure, Therese Kolata & Lee M. Silver

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  1. Jeremy L. Peirce
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  2. Rachel Derr
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  3. Jay Shendure
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  4. Therese Kolata
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  5. Lee M. Silver
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Received: 15 September 1998 / Accepted: 8 October 1998

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Peirce, J., Derr, R., Shendure, J. et al. A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice. 9, 942–948 (1998). https://doi.org/10.1007/s003359900904

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