Translocator protein (18 kDa) (TSPO) as a therapeutic target for anxiety and neurologic disorders (original) (raw)
References
Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapere JJ, Lindemann P, Norenberg MD, Nutt D, Weizman A, Zhang MR, Gavish M (2006) Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 27:402–409 ArticleCASPubMed Google Scholar
Anholt RR, Pedersen PL, De Souza EB, Snyder SH (1986) The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J Biol Chem 261:576–583 CASPubMed Google Scholar
Joseph-Liauzun E, Delmas P, Shire D, Ferrara P (1998) Topological analysis of the peripheral benzodiazepine receptor in yeast mitochondrial membranes supports a five-transmembrane structure. J Biol Chem 273:2146–2152 ArticleCASPubMed Google Scholar
McEnery MW, Snowman AM, Trifiletti RR, Snyder SH (1992) Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 89:3170–3174 ArticleCASPubMedPubMed Central Google Scholar
Garnier M, Dimchev AB, Boujrad N, Price JM, Musto NA, Papadopoulos V (1994) In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. Mol Pharmacol 45:201–211 CASPubMed Google Scholar
Veenman L, Shandalov Y, Gavish M (2008) VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis. J Bioenerg Biomembr 40:199–205 ArticleCASPubMed Google Scholar
Lacapere JJ, Papadopoulos V (2003) Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids 68:569–585 ArticleCASPubMed Google Scholar
Casellas P, Galiegue S, Basile AS (2002) Peripheral benzodiazepine receptors and mitochondrial function. Neurochem Int 40:475–486 ArticleCASPubMed Google Scholar
Gavish M, Bachman I, Shoukrun R, Katz Y, Veenman L, Weisinger G, Weizman A (1999) Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev 51:629–650 CASPubMed Google Scholar
Kuhlmann AC, Guilarte TR (2000) Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity. J Neurochem 74:1694–1704 ArticleCASPubMed Google Scholar
Maeda J, Higuchi M, Inaji M, Ji B, Haneda E, Okauchi T, Zhang MR, Suzuki K, Suhara T (2007) Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor. Brain Res 1157:100–111 ArticleCASPubMed Google Scholar
Hirsch JD, Beyer CF, Malkowitz L, Beer B, Blume AJ (1989) Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control. Mol Pharmacol 35:157–163 CASPubMed Google Scholar
Corsi L, Geminiani E, Baraldi M (2008) Peripheral benzodiazepine receptor (PBR) new insight in cell proliferation and cell differentiation review. Curr Clin Pharmacol 3:38–45 ArticleCASPubMed Google Scholar
Veenman L, Papadopoulos V, Gavish M (2007) Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des 13:2385–2405 ArticleCASPubMed Google Scholar
Besman MJ, Yanagibashi K, Lee TD, Kawamura M, Hall PF, Shively JE (1989) Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor. Proc Natl Acad Sci USA 86:4897–4901 ArticleCASPubMedPubMed Central Google Scholar
Rupprecht R, Holsboer F (1999) Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 22:410–416 ArticleCASPubMed Google Scholar
Stoffel-Wagner B (2001) Neurosteroid metabolism in the human brain. Eur J Endocrinol 145:669–679 ArticleCASPubMed Google Scholar
Papadopoulos V, Liu J, Culty M (2007) Is there a mitochondrial signaling complex facilitating cholesterol import? Mol Cell Endocrinol 265–266:59–64 ArticlePubMed Google Scholar
Melcangi RC, Celotti F, Martini L (1994) Progesterone 5-alpha-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes. Brain Res 639:202–206 ArticleCASPubMed Google Scholar
Melcangi RC, Poletti A, Cavarretta I, Celotti F, Colciago A, Magnaghi V, Motta M, Negri-Cesi P, Martini L (1998) The 5 alpha-reductase in the central nervous system: expression and modes of control. J Steroid Biochem Mol Biol 65:295–299 ArticleCASPubMed Google Scholar
Tsuruo Y (2005) Topography and function of androgen-metabolizing enzymes in the central nervous system. Anat Sci Int 80:1–11 ArticleCASPubMed Google Scholar
Agis-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci USA 103:14602–14607 ArticleCASPubMedPubMed Central Google Scholar
Nakamura K, Fukunishi I, Nakamoto Y, Iwahashi K, Yoshii M (2002) Peripheral-type benzodiazepine receptors on platelets are correlated with the degrees of anxiety in normal human subjects. Psychopharmcol 162:301–303 ArticleCAS Google Scholar
Nudmamud S, Siripurkpong P, Chindaduangratana C, Harnyuttanakorn P, Lotrakul P, Laarbboonsarp W, Srikiatkhachorn A, Kotchabhakdi N, Casalotti S (2000) Stress, anxiety and peripheral benzodiazepine receptor mRNA levels in human lymphocytes. Life Sci 67:2221–2231 ArticleCASPubMed Google Scholar
Rocca P, Beoni AM, Eva C, Ferrero P, Zanalda E, Ravizza P (1998) Peripheral benzodiazepine receptor messenger RNA is decreased in lymphocytes of generalized anxiety disorder patients. Biol Psychiatry 43:767–773 ArticleCASPubMed Google Scholar
Johnson MR, Marazziti D, Brawman-Mintzer O, Emmanuel NP, Ware MR, Morton WA, Rossi A, Cassano GB, Lydiard RB (1998) Abnormal peripheral benzodiazepine receptor density associated with generalized social phobia. Biol Psychiatry 43:306–309 ArticleCASPubMed Google Scholar
Gavish M, Laor N, Bidder M, Fisher D, Fonia O, Muller U, Reiss A, Wolmer L, Karp L, Weizman R (1996) Altered platelet peripheral-type benzodiazepine receptor in posttraumatic stress disorder. Neuropsychopharmacology 14:181–186 ArticleCASPubMed Google Scholar
Pini S, Martini C, Abelli M, Muti M, Gesi C, Montali M, Cassano GB (2005) Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms. Psychopharmcol 181:407–411 ArticleCAS Google Scholar
Ritsner M, Modai I, Gibel A, Leschiner S, Silver H, Tsinovoy G, Weizman A, Gavish M (2003) Decreased platelet peripheral-type benzodiazepine receptors in persistently violent schizophrenia patients. J Psychiatr Res 37:549–556 ArticlePubMed Google Scholar
Uusi-Oukari M, Korpi ER (2010) Regulation of GABA(A) receptor subunit expression by pharmacological agents. Pharmacol Rev 62:97–135 ArticleCASPubMed Google Scholar
Bandelow B, Zohar J, Hollander E, Kasper S, Moller HJ, Allgulander C et al (2008) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders—first revision. World J Biol Psychiatry 9:248–312 ArticlePubMed Google Scholar
Sheehan DV (2002) The management of panic disorder. J Clin Psychiatry 63(Suppl 14):17–21 CASPubMed Google Scholar
Eser D, Baghai TC, Schule C, Nothdurfter C, Rupprecht R (2008) Neuroactive steroids as endogenous modulators of anxiety. Curr Pharm Des 14:3525–3533 ArticleCASPubMed Google Scholar
Rupprecht R (2003) Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinol 28:139–168 ArticleCAS Google Scholar
Li H, Papadopoulos V (1998) Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139:4991–4997 CASPubMed Google Scholar
Li H, Yao Z, Degenhardt B, Teper G, Papadopoulos V (2001) Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. Proc Natl Acad Sci USA 98:1267–1272 ArticleCASPubMedPubMed Central Google Scholar
Anzini M, Cappelli A, Vomero S, Seeber M, Menziani MC, Langer T, Hagen B, Manzoni C, Bourguignon JJ (2001) Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling. J Med Chem 44:1134–1150 ArticleCASPubMed Google Scholar
Farges R, Joseph-Liauzun E, Shire D, Caput D, Le FG, Ferrara P (1994) Site-directed mutagenesis of the peripheral benzodiazepine receptor: identification of amino acids implicated in the binding site of Ro5-4864. Mol Pharmacol 46:1160–1167 CASPubMed Google Scholar
Rupprecht R, Papadopoulos V, Rammes G, Baghai TC, Fan J, Akula N, Groyer G, Adams D, Schumacher M (2010) Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov 9:971–988 ArticleCASPubMed Google Scholar
Chauveau F, Boutin H, Van CN, Dolle F, Tavitian B (2008) Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers. Eur J Nucl Med Mol Imaging 35:2304–2319 ArticlePubMed Google Scholar
Nguyen N, Fakra E, Pradel V, Jouve E, Alquier C, Le Guern M, Micallef J, Blin O (2006) Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice. Hum Psychopharmacol 21:139–149 ArticleCASPubMed Google Scholar
Schlichter R, Rybalchenko V, Poisbeau P, Verleye M, Gillardin J (2000) Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine. Neuropharmacology 39:1523–1535 ArticleCASPubMed Google Scholar
Verleye M, Akwa Y, Liere P, Ladurelle N, Pianos A, Eychenne B, Schumacher M, Gillardin JM (2005) The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain. Pharmacol Biochem Behav 82:712–720 ArticleCASPubMed Google Scholar
Kita A, Kinoshita T, Kohayakawa H, Furukawa K, Akaike A (2009) Lack of tolerance to anxiolysis and withdrawal symptoms in mice repeatedly treated with AC-5216, a selective TSPO ligand. Prog Neuropsychopharmacol Biol Psychiatry 33:1040–1045 ArticleCASPubMed Google Scholar
Rupprecht R, Rammes G, Eser D, Baghai TC, Schule C, Nothdurfter C, Troxler T, Gentsch C, Kalkman HO, Chaperon F, Uzunov V, McAllister KH, Bertaina-Anglade V, La Rochelle CD, Tuerck D, Floesser A, Kiese B, Schumacher M, Landgraf R, Holsboer F, Kucher K (2009) Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science 325:490–493 ArticleCASPubMed Google Scholar
Karchewski LA, Bloechlinger S, Woolf CJ (2004) Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons. Eur J Neurosci 20:671–683 ArticlePubMed Google Scholar
Mills CD, Bitler JL, Woolf CJ (2005) Role of the peripheral benzodiazepine receptor in sensory neuron regeneration. Mol Cell Neurosci 30:228–237 ArticleCASPubMed Google Scholar
Lacor P, Gandolfo P, Tonon MC, Brault E, Dalibert I, Schumacher M, Benavides J, Ferzaz B (1999) Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis. Brain Res 815:70–80 ArticleCASPubMed Google Scholar
Ferzaz B, Brault E, Bourliaud G, Robert JP, Poughon G, Claustre Y, Marguet F, Liere P, Schumacher M, Nowicki JP, Fournier J, Marabout B, Sevrin M, George P, Soubrie P, Benavides J, Scatton B (2002) SSR180575 (7-chloro-N, N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1 -acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair. J Pharmacol Exp Ther 301:1067–1078 ArticleCASPubMed Google Scholar
Bordet T, Buisson B, Michaud M, Abitbol JL, Marchand F, Grist J, Andriambeloson E, Malcangio M, Pruss RM (2008) Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy. J Pharmacol Exp Ther 326:623–632 ArticleCASPubMed Google Scholar
Giatti S, Pesaresi M, Cavaletti G, Bianchi R, Carozzi V, Lombardi R, Maschi O, Lauria G, Garcia-Segura LM, Caruso D, Melcangi RC (2009) Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy. Neuroscience 164:520–529 ArticleCASPubMed Google Scholar
Girard C, Liu S, Cadepond F, Adams D, Lacroix C, Verleye M, Gillardin JM, Baulieu EE, Schumacher M, Schweizer-Groyer G (2008) Etifoxine improves peripheral nerve regeneration and functional recovery. Proc Natl Acad Sci USA 105:20505–20510 ArticleCASPubMedPubMed Central Google Scholar
Papadopoulos V, Lecanu L (2009) Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma. Exp Neurol 219:53–57 ArticleCASPubMedPubMed Central Google Scholar
Kunduzova OR, Escourrou G, De La Farge F, Salvayre R, Seguelas MH, Leducq N, Bono F, Herbert JM, Parini A (2004) Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion. J Am Soc Nephrol 15:2152–2160 ArticleCASPubMed Google Scholar
Ji B, Maeda J, Sawada M, Ono M, Okauchi T, Inaji M, Zhang MR, Suzuki K, Ando K, Staufenbiel M, Trojanowski JQ, Lee VM, Higuchi M, Suhara T (2008) Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer’s and other CNS pathologies. J Neurosci 28:12255–12267 ArticleCASPubMedPubMed Central Google Scholar