Treatment of Idiopathic Pulmonary Fibrosis with Losartan: A Pilot Project (original) (raw)

Abstract

Background

Idiopathic pulmonary fibrosis is a progressive interstitial lung disease with no current effective therapies. Treatment has focused on antifibrotic agents to stop proliferation of fibroblasts and collagen deposition in the lung. We present the first clinical trial data on the use of losartan, an antifibrotic agent, to treat idiopathic pulmonary fibrosis. The primary objective was to evaluate the effect of losartan on progression of idiopathic pulmonary fibrosis measured by the change in percentage of predicted forced vital capacity (%FVC) after 12 months. Secondary outcomes included the change in forced expiratory volume at 1 second, diffusing capacity of carbon monoxide, 6-minute walk test distance, and baseline/transition dyspnea index.

Methods

Patients with idiopathic pulmonary fibrosis and a baseline %FVC of ≥50 % were treated with losartan 50 mg by mouth daily for 12 months. Pulmonary function testing, 6-minute walk, and breathlessness indices were measured every 3 months.

Results

Twenty participants with idiopathic pulmonary fibrosis were enrolled and 17 patients were evaluable for response. Twelve patients had a stable or improved %FVC at study month 12. Similar findings were observed in secondary end-point measures, including 58, 71, and 65 % of patients with stable or improved forced expiratory volume at 1 second, diffusing capacity for carbon monoxide, and 6-minute walk test distance, respectively. No treatment-related adverse events that resulted in early study discontinuation were reported.

Conclusion

Losartan stabilized lung function in patients with idiopathic pulmonary fibrosis over 12 months. Losartan is a promising agent for the treatment of idiopathic pulmonary fibrosis and has a low toxicity profile.

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Acknowledgments

This work was supported by the SunCoast CCOP Research Base (award No. U10CA081920 from the National Cancer Institute). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.

Conflict of interest

The authors have no conflicts of interest or financial ties to disclose.

Ethical standards

The experiment complies with the current laws of the United States of America.

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Authors and Affiliations

  1. Division of Pulmonology, Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL, USA
    Marisa Couluris
  2. Division of Pulmonary and Critical Care, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Brent W. Kinder & Ralph J. Panos
  3. Division of Epidemiology, Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL, USA
    Ping Xu, Margaret Gross-King & Jeffrey Krischer
  4. Department of Pediatrics, University of South Florida, 3650 Spectrum Blvd., Suite 100, Tampa, FL, 33612, USA
    Marisa Couluris

Authors

  1. Marisa Couluris
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  2. Brent W. Kinder
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  3. Ping Xu
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  4. Margaret Gross-King
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  5. Jeffrey Krischer
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  6. Ralph J. Panos
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Corresponding author

Correspondence toMarisa Couluris.

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Couluris, M., Kinder, B.W., Xu, P. et al. Treatment of Idiopathic Pulmonary Fibrosis with Losartan: A Pilot Project.Lung 190, 523–527 (2012). https://doi.org/10.1007/s00408-012-9410-z

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