- Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, Ting JP (2001) TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 4:1116-122
Article CAS PubMed Google Scholar
- Arnett HA, Fancy SP, Alberta JA et al. (2004) bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306:2111-115
Article CAS PubMed Google Scholar
- Back SA, Tuohy TM, Chen H et al. (2005) Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nat Med 11:966-72
CAS PubMed Google Scholar
- Barnett MH, Prineas JW (2004) Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol 55:458-68
Article PubMed Google Scholar
- Barres BA, Hart IK, Coles HS, Burne JF, Voyvodic JT, Richardson WD, Raff MC (1992) Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70:31-6
Article CAS PubMed Google Scholar
- Barres BA, Jacobson MD, Schmid R, Sendtner M, Raff MC (1993) Does oligodendrocyte survival depend on axons? Curr Biol 3:489-97
Article CAS PubMed Google Scholar
- Benninger Y, Colognato H, Thurnherr T et al. (2006) Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination. J Neurosci 26:7665-673
Article CAS PubMed Google Scholar
- Burne JF, Staple JK, Raff MC (1996) Glial cells are increased proportionally in transgenic optic nerves with increased numbers of axons. J Neurosci 16:2064-073
CAS PubMed Google Scholar
- Butt AM, Hornby MF, Kirvell S, Berry M (1997) Platelet-derived growth factor delays oligodendrocyte differentiation and axonal myelination in vivo in the anterior medullary velum of the developing rat. J Neurosci Res 48:588-96
Article CAS PubMed Google Scholar
- Buttery PC, ffrench-Constant C (1999) Laminin-2/integrin interactions enhance myelin membrane formation by oligodendrocytes. Mol Cell Neurosci 14:199-12
Article CAS PubMed Google Scholar
- Cai J, Qi Y,Hu X, Tan M, Liu Z, Zhang J, Li Q, Sander M, Qiu M (2005) Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron 45:41-3
Article CAS PubMed Google Scholar
- Cannella B, Hoban CJ, Gao YL et al. (1998) The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis. Proc Natl Acad Sci USA 95:10100-0105
Article CAS PubMed Google Scholar
- Chang A, Tourtellotte WW, Rudick R, Trapp BD (2002) Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 346:165-73
Article PubMed Google Scholar
- Chun SJ, Rasband MN, Sidman RL, Habib AA,Vartanian T (2003) Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination. J Cell Biol 163:397-08
Article CAS PubMed Google Scholar
- Colognato H, Baron W, Avellana-Adalid V, Relvas JB, Baron-Van Evercooren A, Georges-Labouesse E, ffrench-Constant C (2002) CNS integrins switch growth factor signalling to promote target-dependent survival. Nat Cell Biol 4:833-41
Article CAS PubMed Google Scholar
- Colognato H, Ramachandrappa S, Olsen IM, ffrench-Constant C (2004) Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development. J Cell Biol 167:365-75
Article CAS PubMed Google Scholar
- Compston A, Coles A (2002) Multiple sclerosis. Lancet 359:1221-231
Article PubMed Google Scholar
- Farina L, Morandi L, Milanesi I, Ciceri E, Mora M, Moroni I, Pantaleoni C, Savoiardo M (1998) Congenital muscular dystrophy with merosin deficiency: MRI findings in five patients. Neuroradiology 40:807-11
Article CAS PubMed Google Scholar
- Ferguson B, Matyszak MK, Esiri MM, Perry VH (1997) Axonal damage in acute multiple sclerosis lesions. Brain 120:393-99
Article PubMed Google Scholar
- Fernandez PA, Tang DG, Cheng L, Prochiantz A, Mudge AW, Raff MC (2000) Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve. Neuron 28:81-0
Article CAS PubMed Google Scholar
- Fogarty M, Richardson WD, Kessaris N (2005) A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord. Development 132:1951-959
Article CAS PubMed Google Scholar
- Franklin RJ (2002) Why does remyelination fail in multiple sclerosis? Nat Rev Neurosci 3:705-14
Article CAS PubMed Google Scholar
- Friede RL (1972) Control of myelin formation by axon caliber (with a model of the control mechanism). J Comp Neurol 144:233-52
Article CAS PubMed Google Scholar
- Ji B, Li M,Wu WT et al. (2006) LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury. Mol Cell Neurosci 33:311-20
Article CAS PubMed Google Scholar
- Kessaris N, Fogarty M, Iannarelli P, Grist M, Wegner M, Richardson WD (2006) Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. Nat Neurosci 9:173-79
Article CAS PubMed Google Scholar
- Kim JY, Sun Q, Oglesbee M, Yoon SO (2003) The role of ErbB2 signaling in the onset of terminal differentiation of oligodendrocytes in vivo. J Neurosci 23:5561-571
CAS PubMed Google Scholar
- Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJ (2001) Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 35:204-12
Article CAS PubMed Google Scholar
- Lee KK, de Repentigny Y, Saulnier R, Rippstein P, Macklin WB, Kothary R (2006) Dominant-negative beta1 integrin mice have region-specific myelin defects accompanied by alterations in MAPK activity. Glia 53:836-44
Article PubMed Google Scholar
- Ligon KL, Fancy SP, Franklin RJ, Rowitch DH (2006) Olig gene function in CNS development and disease. Glia 54:1-0
Article PubMed Google Scholar
- Linington C, Engelhardt B, Kapocs G, Lassman H (1992) Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody. J Neuroimmunol 40:219-24
Article CAS PubMed Google Scholar
- Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH (2002) Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109:75-6
Article CAS PubMed Google Scholar
- Lu QR, Yuk D, Alberta JA, Zhu Z, Pawlitzky I, Chan J, McMahon AP, Stiles CD, Rowitch DH (2000) Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 25:317-29
Article CAS PubMed Google Scholar
- Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (1999) A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases. Brain 122:2279-295
Article PubMed Google Scholar
- Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47:707-17
Article CAS PubMed Google Scholar
- Ludwin SK (1980) Chronic demyelination inhibits remyelination in the central nervous system.An analysis of contributing factors. Lab Invest 43:382-87
CAS PubMed Google Scholar
- Marchionni MA, Cannella B,Hoban C et al. (1999) Neuregulin in neuron/glial interactions in the central nervous system. GGF2 diminishes autoimmune demyelination, promotes oligodendrocyte progenitor expansion, and enhances remyelination. Adv Exp Med Biol 468:283-95
CAS PubMed Google Scholar
- Mason JL, Suzuki K, Chaplin DD, Matsushima GK (2001) Interleukin-1beta promotes repair of the CNS. J Neurosci 21:7046-052
CAS PubMed Google Scholar
- Matute C, Perez-Cerda F (2005) Multiple sclerosis: novel perspectives on newly forming lesions. Trends Neurosci 28:173-75
Article CAS PubMed Google Scholar
- Mi S, Miller RH, Lee X et al. (2005) LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci 8:745-51
Article CAS PubMed Google Scholar
- Michailov GV, Sereda MW, Brinkmann BG et al. (2004) Axonal neuregulin-1 regulates myelin sheath thickness. Science 304:700-03
Article CAS PubMed Google Scholar
- Milner R (1997) Understanding the molecular basis of cell migration; implications for clinical therapy in multiple sclerosis. Clin Sci (Lond) 92:113-22
CAS Google Scholar
- Penderis J, Shields SA, Franklin RJ (2003) Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system. Brain 126:1382-391
Article PubMed Google Scholar
- Penderis J, Woodruff RH, Lakatos A, Li WW, Dunning MD, Zhao C, Marchionni M, Franklin RJ (2003) Increasing local levels of neuregulin (glial growth factor-2) by direct infusion into areas of demyelination does not alter remyelination in the rat CNS. Eur J Neurosci 18:2253-264
Article PubMed Google Scholar
- Powell SK, Williams CC, Nomizu M, Yamada Y, Kleinman HK (1998) Laminin-like proteins are differentially regulated during cerebellar development and stimulate granule cell neurite outgrowth in vitro. J Neurosci Res 54:233-47
Article CAS PubMed Google Scholar
- Prineas JW, Barnard RO, Kwon EE, Sharer LR, Cho ES (1993) Multiple sclerosis: remyelination of nascent lesions. Ann Neurol 33:137-51
Article CAS PubMed Google Scholar
- Prineas JW, Barnard RO, Revesz T, Kwon EE, Sharer L, Cho ES (1993) Multiple sclerosis. Pathology of recurrent lesions. Brain 116:681-93
Article PubMed Google Scholar
- Raine CS, Wu E (1993) Multiple sclerosis: remyelination in acute lesions. J Neuropathol Exp Neurol 52:199-04
Article CAS PubMed Google Scholar
- Relvas JB, Setzu A, Baron W, Buttery PC, LaFlamme SE, Franklin RJ, ffrench-Constant C (2001) Expression of dominant-negative and chimeric subunits reveals an essential role for beta1 integrin during myelination. Curr Biol 11:1039-043
Article CAS PubMed Google Scholar
- Richardson WD, Kessaris N, Pringle N (2006) Oligodendrocyte wars. Nat Rev Neurosci 7:11-8
Article CAS PubMed Google Scholar
- Rowitch DH (2004) Glial specification in the vertebrate neural tube. Nat Rev Neurosci 5:409-19
Article CAS PubMed Google Scholar
- Scolding N, Franklin R, Stevens S, Heldin CH, Compston A, Newcombe J (1998) Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis. Brain 121:2221-228
Article PubMed Google Scholar
- Setzu A, Ffrench-Constant C, Franklin RJ (2004) CNS axons retain their competence for myelination throughout life. Glia 45:307-11
Article PubMed Google Scholar
- Setzu A, Lathia JD, Zhao C,Wells K, Rao MS, Ffrench-Constant C, Franklin RJ (2006) Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells. Glia 54:297-03
Article PubMed Google Scholar
- Sobel RA, Chen M, Maeda A, Hinojoza JR (1995) Vitronectin and integrin vitronectin receptor localization in multiple sclerosis lesions. J Neuropathol Exp Neurol 54:202-13
Article CAS PubMed Google Scholar
- Sperber BR, Boyle-Walsh EA, Engleka MJ et al (2001) A unique role for Fyn in CNS myelination. J Neurosci 21:2039-047
CAS PubMed Google Scholar
- Trapp BD, Nishiyama A, Cheng D, Macklin W (1997) Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. J Cell Biol 137:459-68
Article CAS PubMed Google Scholar
- Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278-85
Article CAS PubMed Google Scholar
- Vallstedt A, Klos JM, Ericson J (2005) Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 45:55-7
Article CAS PubMed Google Scholar
- Vartanian T, Fischbach G, Miller R (1999) Failure of spinal cord oligodendrocyte development in mice lacking neuregulin. Proc Natl Acad Sci USA 96:731-35
Article CAS PubMed Google Scholar
- Viehover A, Miller RH, Park SK, Fischbach G, Vartanian T (2001) Neuregulin: an oligodendrocyte growth factor absent in active multiple sclerosis lesions. Dev Neurosci 23:377-86
Article CAS PubMed Google Scholar
- Wang AG, Yen MY, Hsu WM, Fann MJ (2006) Induction of vitronectin and integrin alphav in the retina after optic nerve injury. Mol Vis 12:76-4
PubMed Google Scholar
- Waxman SG (1998) Demyelinating diseases–new pathological insights, new therapeutic targets. N Engl J Med 338:323-25
Article CAS PubMed Google Scholar
- Xin M, Yue T, Ma Z, Wu FF, Gow A, Lu QR (2005) Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice. J Neurosci 25:1354-365
Article CAS PubMed Google Scholar
- Yin Y, Cui Q, Li Y, Irwin N, Fischer D, Harvey AR, Benowitz LI (2003) Macrophage-derived factors stimulate optic nerve regeneration. J Neurosci 23:2284-293
CAS PubMed Google Scholar
- Yin Y, Henzl MT, Lorber B, Nakazawa T, Thomas TT, Jiang F, Langer R, Benowitz LI (2006) Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci 9:843-52
Article CAS PubMed Google Scholar
- Zhou Q, Anderson DJ (2002) The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109:61-3
Article CAS PubMed Google Scholar