Drug-naive patients with Parkinson’s disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]β-CIT SPECT (original) (raw)

Abstract

Ten healthy subjects and 16 patients with early Parkinson’s disease (PD) were examined with single photon emission computed tomography (SPECT) and [123I]β-CIT, a ligand for the dopamine (DA) transporter. Only drug-naive patients were examined since the expression of and binding to DA transporters may be influenced by dopaminergic medication. The main finding was a significant reduction in [123I]β-CIT binding in the ipsi- and contralateral striatal regions, especially in the putamen, which showed a mean reduction of 65% of the control mean. Discriminant function analysis of the putaminal [123I]β-CIT binding measures classified 100% of the cases in the correct group. Disease severity correlated negatively and highly significantly with the binding measures. Tremor ratings did not correlate with the SPECT measures, whereas rigidity, and to a lesser extent bradykinesia, did. Patients with unilateral PD showed a bilateral loss of striatal DA transporters. Our findings indicate that with [123I]β-CIT SPECT it is possible to diagnose PD in subjects with very mild symptoms and signs. Moreover, finding a bilateral loss of striatal DA transporters in patients with unilateral PD also suggests that it may be possible to identify subjects in the preclinical phase of the disease.

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Authors and Affiliations

  1. Academisch Ziekenhuis Vrije Universiteit, Department of Neurology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands Tel.: +31-20 4442997, Fax: +31-20 4442800, , , , , , NL
    G. Tissingh, P. Bergmans, A. Winogrodzka, J. C. Stoof & E. C. Wolters
  2. Graduate School for Neurosciences Amsterdam, Department of Nuclear Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands, , , , , , NL
    J. Booij & E. A. van Royen

Authors

  1. G. Tissingh
  2. P. Bergmans
  3. J. Booij
  4. A. Winogrodzka
  5. E. A. van Royen
  6. J. C. Stoof
  7. E. C. Wolters

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Received: 12 February 1997 Received in revised form: 12 September 1997 Accepted: 16 September 1997

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Tissingh, G., Bergmans, P., Booij, J. et al. Drug-naive patients with Parkinson’s disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]β-CIT SPECT.J Neurol 245, 14–20 (1997). https://doi.org/10.1007/s004150050168

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