Improvement of visual acuity after transcorneal electrical stimulation in case of Best vitelliform macular dystrophy (original) (raw)

Abstract

Purpose

To report an improvement of the visual acuity after transcorneal electrical stimulation (TES) in a case of Best vitelliform macular dystrophy (BVMD).

Patient and methods

A 26-year-old woman diagnosed with BVMD presented with reduced vision. Her best corrected visual acuity (BCVA) was reduced to 20/200 in the right eye, and TES was performed once a month for two sessions. The current of the biphasic pulses (anodic first; duration, 10 msec; frequency, 20 Hz) was delivered using a DTL-electrode, and the duration of the TES was 30 min.

Results

The BCVA in the right eye slowly improved after the TES, and 6 months later the BCVA was 20/25. The results of Humphrey visual field tests (VF) and multifocal ERGs (mfERGs) were only slightly changed. Two years later, the BCVA decreased, and it was improved again after another session of TES with the same parameters of the electrical pulses.

Conclusion

The improvement of the visual acuity in our case of BVMD indicates that TES should be tried in other cases of retinal dystrophy. Further clinical and laboratory studies on TES are needed.

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References

  1. Potts AM, Inoue J, Buffum D (1968) The electrically evoked response of the visual system (EER). Investig Ophthalmol 7:269–278
    CAS Google Scholar
  2. Shimazu K, Miyake Y, Watanabe S (1999) Retinal ganglion cell response properties in the transcorneal electrically evoked response of the visual system. Vis Res 39:2251–2260
    Article PubMed CAS Google Scholar
  3. Fujikado T, Morimoto T, Matsushita K, Shimojo H, Okawa Y, Tano Y (2006) Effect of transcorneal electrical stimulation in patients with nonarteritic ischemic optic neuropathy or traumatic optic neuropathy. Jpn J Ophthalmol 50:266–273
    Article PubMed Google Scholar
  4. Inomata K, Shinoda K, Ohde H, Tsunoda K, Hanazono G, Kimura I, Yuzawa M, Tsubota K, Miyake Y (2007) Transcorneal electrical stimulation of retina to treat longstanding retinal artery occlusion. Graefes Arch Clin Exp Ophthalmol 245:1773–1780
    Article PubMed Google Scholar
  5. Schatz A, Röck T, Naycheva L, Willmann G, Wilhelm B, Peters T, Bartz-Schmidt KU, Zrenner E, Messias A, Gekeler F (2011) Transcorneal electrical stimulation for patients with retinitis pigmentosa—a prospective, randomized, sham-controlled exploratory study. Investig Ophthalmol Vis Sci 52:4485–4496
    Article Google Scholar
  6. Fedorov A, Jobke S, Bersnev V, Chibisova A, Chibisova Y, Gall C, Sabel BA (2011) Restoration of vision after optic nerve lesions with noninvasive transorbital alternating current stimulation: a clinical observational study. Brain Stimul 4:189–201
    Article PubMed CAS Google Scholar
  7. Morimoto T, Miyoshi T, Matsuda S, Tano Y, Fujikado T, Fukuda Y (2005) Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system. Investig Ophthalmol Vis Sci 46:2147–2155
    Article Google Scholar
  8. Ni YQ, Gan DK, Xu HD, Xu GZ, Da CD (2009) Neuroprotective effect of transcorneal electrical stimulation on light-induced photoreceptor degeneration. Exp Neurol 219:439–452
    Article PubMed Google Scholar
  9. Morimoto T, Miyoshi T, Sawai H, Fujikado T (2010) Optimal parameters of transcorneal electrical stimulation (TES) to be neuroprotective of axotomized RGCs in adult rats. Exp Eye Res 90:285–291
    Article PubMed CAS Google Scholar
  10. Inomata K, Tsunoda K, Hanazono G, Kazato Y, Shinoda K, Yuzawa M, Tanifuji M, Miyake Y (2008) Distribution of retinal responses evoked by transscleral electrical stimulation detected by intrinsic signal imaging in macaque monkeys. Investig Ophthalmol Vis Sci 49:2193–2200
    Article Google Scholar
  11. Fujikado T, Morimoto T, Kanda H, Kusaka S, Nakauchi K, Ozawa M, Matsushita K, Sakaguchi H, Ikuno Y, Kamei M, Tano Y (2007) Evaluation of phosphenes elicited by extraocular stimulation in normals and by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 245:1411–1419
    Article PubMed Google Scholar

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Acknowledgments

No author has a financial or proprietary interest in any material or method mentioned. Support of this study was provided by Research Grants on Sensory and Communicative Disorders from the Ministry of Health, Labor, and Welfare, Japan.

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Authors and Affiliations

  1. Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Naoki Ozeki, Kei Shinoda, Hisao Ohde, Susumu Ishida & Kazuo Tsubota
  2. Department of Ophthalmology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 186-8605, Japan
    Kei Shinoda
  3. Makuhari Ode Eye Clinic, Chiba, Japan
    Hisao Ohde
  4. Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Susumu Ishida

Authors

  1. Naoki Ozeki
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  2. Kei Shinoda
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  3. Hisao Ohde
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  4. Susumu Ishida
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  5. Kazuo Tsubota
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Corresponding author

Correspondence toKei Shinoda.

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Ozeki, N., Shinoda, K., Ohde, H. et al. Improvement of visual acuity after transcorneal electrical stimulation in case of Best vitelliform macular dystrophy.Graefes Arch Clin Exp Ophthalmol 251, 1867–1870 (2013). https://doi.org/10.1007/s00417-013-2341-4

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