Comparison of CD44 expression in early colorectal carcinomas of the de novo and ex adenoma types (original) (raw)

Abstract

Small colorectal carcinomas without morphological evidence of origin from an adenoma have been called ”de novo” carcinomas. As changes in the expression of the adhesion molecule CD44 and its variants have been described along the adenoma-carcinoma sequence in colorectal carcinoma, we compared patterns of CD44 expression in early de novo and ex-adenoma colorectal carcinomas by staining specimens from a group of early (pT1) colorectal carcinomas by immunohistochemistry for CD44 (standard and variant forms v3, v5, v6, v7, v7/8, v10). We evaluated carcinoma, adenoma (ex-adenoma cases), transitional mucosal areas and apparently nonneoplastic mucosa peripheral to the lesions (when present). A marked increase was seen in numbers and intensity of standard and variant forms of CD44 in carcinomatous areas compared with nonneoplastic mucosa in both groups, with no significant difference between the groups. However, adenoma areas of the ex-adenoma cases and the transitional mucosa of the de novo carcinomas had nearly identical staining patterns. Together with data from other molecular studies, this may be interpreted as evidence for an adenoma-type precursor lesion in so-called de novo colorectal carcinomas.

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Authors and Affiliations

  1. Institute of Pathology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, , , , , , DE
    E. Mueller & Heinz Höfler
  2. Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, D-81675 Munich, Germany e-mail: jd.mueller@lrz.tu-muenchen.de Tel.: +49-89-4140-2147, Fax: +49-89-4140-4915, , , , , , DE
    J. D. Mueller & Karl-Heinz Heider
  3. Institute of Pathology, University of Vienna, Vienna, Austria, , , , , , AT
    Georg Oberhuber
  4. Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany, , , , , , DE
    Birgit Bethke & Manfred Stolte

Authors

  1. J. D. Mueller
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  2. Karl-Heinz Heider
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  3. Georg Oberhuber
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  4. E. Mueller
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  5. Birgit Bethke
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  6. Manfred Stolte
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  7. Heinz Höfler
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Received: 11 May 1998 / Accepted: 9 June 1998

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Mueller, J., Heider, KH., Oberhuber, G. et al. Comparison of CD44 expression in early colorectal carcinomas of the de novo and ex adenoma types.Virchows Archiv 433, 407–414 (1998). https://doi.org/10.1007/s004280050267

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