Life-threatening complications of transient abnormal myelopoiesis in neonates with Down syndrome (original) (raw)

• Marcus Krüger1,

• Roland Hentschel1,

• Regina Rasenack2,

• Brigitte Strahm1,

• Udo Kontny1 &

• …

• Charlotte Niemeyer1

• 525 Accesses

• 22 Citations

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An Erratum to this article was published on 15 February 2005

Abstract

Neonates with Down syndrome can present with a haematological disorder called transient abnormal myelopoiesis (TAM). While TAM is usually a self-limiting disease, patients with severe complications such as hydrops fetalis, cardiorespiratory failure and liver fibrosis have been described. Here, we present five consecutive neonates with trisomy 21 and TAM, four of whom were critically ill and were therefore treated with cytosine-arabinoside. All five patients survived. _Conclusion:_severely affected neonates with Down syndrome and transient abnormal myelopoiesis might benefit from early cytostatic treatment with cytosine-arabinoside.

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Abbreviations

Ara-C :

cytosine-arabinoside

DS :

Down syndrome

TAM :

transient abnormal myelopoiesis

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Authors and Affiliations

1. Department of Paediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106 , Freiburg, Germany
   Sabine Dormann, Marcus Krüger, Roland Hentschel, Brigitte Strahm, Udo Kontny & Charlotte Niemeyer
2. Department of Obstetrics and Gynaecology, University of Freiburg, Hugstetterstrasse 55, 79106, Freiburg, Germany
   Regina Rasenack

Authors

1. Sabine Dormann
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2. Marcus Krüger
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3. Roland Hentschel
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4. Regina Rasenack
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5. Brigitte Strahm
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6. Udo Kontny
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7. Charlotte Niemeyer
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Corresponding author

Correspondence toSabine Dormann.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00431-004-1617-4

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Dormann, S., Krüger, M., Hentschel, R. et al. Life-threatening complications of transient abnormal myelopoiesis in neonates with Down syndrome.Eur J Pediatr 163, 374–377 (2004). https://doi.org/10.1007/s00431-004-1452-7

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• Received: 22 January 2004
• Accepted: 11 March 2004
• Published: 28 April 2004
• Issue Date: July 2004
• DOI: https://doi.org/10.1007/s00431-004-1452-7

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