Overexpression of E2F1 associated with LOH at RB locus and hyperphosphorylation of RB in non-small cell lung carcinoma (original) (raw)
References
Bookstein R, Lai C-C, To H, Lee WH (1990) PCR-based detection of polymorphic BamHI site in intron 1 of the human retinoblastoma (RB) gene. Nucl Acids Res 18:1660 Google Scholar
Brambilla E, Moro D, Gazzeri S, Brambilla C (1999) Alterations of expression of Rb p16 (INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance. J Pathol 188:351–360 ArticleCASPubMed Google Scholar
Chen JT, Chen YC, Wang YC, Tseng RC, Chen CY, Wang YC (2002) Alterations of the p16(ink4a) gene in resected nonsmall cell lung tumors and exfoliated cells within sputum. Int J Cancer 98:724–731 ArticleCASPubMed Google Scholar
Dyson N (1995) The regulation of E2F by pRB-family proteins. Genes Dev 12:2245–2262 Google Scholar
Eymin B, Gazzeri S, Brambilla C, Brambilla E (2001) Distinct pattern of E2F1 expression in human lung tumors: E2F1 is upregulated in small lung carcinoma. Oncogene 20:1678–1687 ArticleCASPubMed Google Scholar
Gorgoulis VG, Zacharatos P, Mariatos G, Kotsinas A, Bouda M, Kletsas D, Asimacopoulos PJ, Agnantis N, Kittas C, Papavassiliou AG (2002) Transcriptional factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. J Pathol 198:142–156 ArticleCASPubMed Google Scholar
Gouyer V, Gazzeri S, Brambilla E, Bolon I, Moro D, Perron P, Benabid AL, Brambilla C (1994) Loss of heterozygosity at the RB locus correlates with loss of RB protein in primary malignant neuroendocrine lung carcinomas. Int J Cancer 58:818–824 CASPubMed Google Scholar
Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A (1992) A cDNA encoding a pRB-binding protein with protein with properties of the transcription factor E2F. Cell 70:337–350 CASPubMed Google Scholar
Higashiyama M, Doi O, Kodama K, Yokouchi H, Tateishi R (1994) Retinoblastoma protein expression in lung cancer: an immunohistochemical analysis. Oncology 51:544–551 CASPubMed Google Scholar
Ikeda M, Orimo H, Moriyama H, Nakajima E, Matsubara N, Mibu R, Tanaka N, Shimada T, Kimura A, Shimizu K (1998) Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability. Cancer Res 58:594–598 CASPubMed Google Scholar
Johnson DG, Cress WD, Jakoi L, Nevins JR (1994a) Oncogenic capacity of the E2F1 gene. Proc Natl Acad Sci USA 91:12823–12827 CASPubMed Google Scholar
Johnson DG, Ohtani K, Nevins JR (1994b) Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev 8:1514–1525 CASPubMed Google Scholar
Kawahara E, Okada Y, Nakanishi I, Iwata K, Kojima S, Kumagai S, Yamamoto E (1993) The expression of invasive behavior of differentiated squamous carcinoma cell line evaluated by an in vitro invasion model. Jpn J Cancer Res 84:409–418 CASPubMed Google Scholar
Kaye FJ (2002) RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer. Oncogene 21:6908–6914 ArticleCASPubMed Google Scholar
Kurakawa E, Shimamoto T, Utsumi K, Hirano T, Kato H, Ohyashiki K (2001) Hypermethylation of p16 (INK4a) and p15 (INK4b) genes in non-small cell lung cancer. Int J Oncol 19:277–281 CASPubMed Google Scholar
Lai R, Medeiros LJ, Coupl R, McCourty A, Brynes RK (1998) Immunohistochemical detection of E2F1 in non-Hodgkin’s lymphomas a survey of 124 cases. Mod Pathol 11:457–463 CASPubMed Google Scholar
Lee C, Chang JH, Lee HS, Cho Y (2002) Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev 16:3199–3212 ArticleCASPubMed Google Scholar
Liu Y, Szekely L, Grandér D, Söderhäll S, Juliusson G, Gahrton G, Linder S, Einhorn S (1993) Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus. Proc Natl Acad Sci USA 90:8697–8701 CASPubMed Google Scholar
Matsumura K, Kallioniemi A, Kallioniemi O, Chen L, Smith HS, Pinkel D, Gray J, Waldman FM (1992) Deletion of chromosome 17q loci in breast cancer cells detected by fluorescence in situ hybridization. Cancer Res 52:3474–3477 CASPubMed Google Scholar
McGee TL, Cowley GS, Yandell DW, Dryja TP (1990) Detection of the XbaI RFLP within the retinoblastoma locus by PCR. Nucl Acids Res 18:207 CAS Google Scholar
Mori N, Yokota J, Akiyama T, Sameshima Y, Okamoto A, Mizoguchi H, Toyoshima K, Sugimura T, Terada M (1990) Variable mutations of the RB gene in small-cell lung carcinoma. Oncogene 5:1713–1717 CASPubMed Google Scholar
Nevins JR (1990) E2F: a link between the Rb tumor suppressor protein and viral oncoprotein. Science 258:424–429 Google Scholar
Noonan KE, Beck C, Holzmayer TA, Chin JE, Wunder JS, Andrulis IL, Gazdar AF, Willman CL, Griffith B, Von Hoff DD, Roninson IB (1990) Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc Natl Acad Sci USA 87:7160–7164 CASPubMed Google Scholar
Rabbani F, Richon VM, Orlow I, Lu M-L, Drobnjak M, Dudas M, Charytonowicz E, Dalbagni G, Cordon-Cardo C (1999) Prognostic significance of transcription factor E2F1 in bladder cancer genotypic and phenotypic characterization. J Natl Cancer Inst 91:874–881 ArticleCASPubMed Google Scholar
Reissmann PT, Koga H, Takahashi R, Figlin RA, Holmes C, Piantadosi S, Cordon-Cardo C, Slamon DJ, the Lung Cancer Study Group (1993) Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. Oncogene 8:1913–1919 CASPubMed Google Scholar
Riedy MC, Timm EA, Stewart CC (1995) Quantitative RT-PCR for measuring gene expression. Biotechniques 18:70–76 CASPubMed Google Scholar
Sachse R, Murakami Y, Shiraishi M, Hayashi K, Sekiya T (1994) DNA aberrations at the retinoblastoma gene locus in human squamous cell carcinomas of the lung. Oncogene 9:39–47 CASPubMed Google Scholar
Saito M, Helin K, Valentine MB, Griffith BB, Willman CL, Harlow E, Look AT (1995) Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. Genomics 25:130–138 ArticleCASPubMed Google Scholar
Sellers WR, Rodgers JW, Kaelin WG (1995) A potent trans-repression domain in the retinoblastoma protein induces cell cycle arrest when bound to E2F sites. Proc Natl Acad Sci USA 92:11544–11548 CASPubMed Google Scholar
Suzuki T, Yasui W, Yokozaki H, Naka K, Ishikawa T, Tahara E (1999) Expression of the E2F family in human gastrointestinal carcinomas. Int J Cancer 81:535–538 ArticleCASPubMed Google Scholar
Tamura K, Zhang X, Murakami Y, Hirohashi S, Xu H-J, Hu S-X, Benedict WF, Sekiya T (1997) Deletion of three distinct regions on chromosome 13q in human non-small-cell lung cancer. Int J Cancer 74:45–49 ArticleCASPubMed Google Scholar
Wadayama B, Toguchida J, Shimizu T, Ishizaki K, Sasaki MS, Kotoura Y, Yamamuro T (1994) Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res 54:3042–3048 CASPubMed Google Scholar
Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323–330 CASPubMed Google Scholar
Xu G, Livingston DM, Krek W (1995) Multiple members of the E2F transcription factor family are the products of oncogenes. Proc Natl Acad Sci USA 92:1357–1361 CASPubMed Google Scholar
Xu H-J, Hu S-X, Cagle PT, Moore GE, Benedict WF (1991) Absence of retinoblastoma protein expression in primary non-small cell lung carcinoma. Cancer Res 51:2735–2739 CASPubMed Google Scholar
Xu Q, Dyson N, Harlow E (1990) The regions of the retinoblastoma binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J 9:1147–1155 PubMed Google Scholar
Zhang SY, Liu SC, Al-Saleem LF, Holloran D, Babb J, Guo X, Klein-Szanto AJ (2000) E2F1: a proliferative marker of breast neoplasia. Cancer Epidemiol Biomarkers Prev 9:395–401 CASPubMed Google Scholar
Zöchbauer-Müller S, Gazdar AF, Minna JD (2002) Molecular pathogenesis of lung cancer. Ann Rev Physiol 64:681–708 Article Google Scholar