Efficacy of an experimental fasciolicide against immature and mature Fasciola hepatica in artificially infected calves (original) (raw)
Abstract
The efficacy of 5-chloro-2-methylthio-6-(1-naphthyloxy)-_1H-_benzimidazole, called “alpha”, was tested against Fasciola hepatica. Fluke-free calves (_n_=32) were divided into 8 groups and infected with 150 metacercariae per animal. All animals subsequently received a second infection with another 150 metacercariae, given at different time intervals aimed to produce flukes of differing ages within the experimental animals. When the flukes reached the required age in the animals, four groups were treated with a single oral dose of 12 mg/kg of compound alpha and the remaining ones served as non-treated controls. Two weeks after treatment the animals of all groups were sacrificed and the livers were removed to determine the numbers of parasites present in the treated and untreated controls. In the treated groups the fluke reduction for the 3 day/2 week group was 100%, for the 3 week/4 week group it was 96.4%, for the 6 week/8 week group it was 99.2% and for the 10 week/12 week group it was 100%.
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Acknowledgements
The study reported here was partially supported by the projects PAPIIT-DEGPA, UNAM, No. IN227998 (México) and CONACyT No. 34942-B, (México). This study complies with the current laws of Mexico.
Author information
Authors and Affiliations
- Depto. de Parasitología, FMVZ-UNAM, Cd. Universitaria 04510, Mexico City, Mexico
Y. Vera Montenegro, F. Ibarra Velarde & H. Quiroz Romero - CENID-Pavet, INIFAP, Km 12.5, Cuernavaca-Cuautla, Edo. de Morelos, Mexico
E. Liébano Hernández - Depto. de Farmacia, Facultad de Química, UNAM, Cd. Universitaria 04510, Mexico City, Mexico
R. Castillo Bocanegra & A. Hernández Campos - Depto. de Estadística, FMVZ-UNAM, Cd. Universitaria 04510, Mexico City, Mexico
P. Ochoa Galván
Authors
- Y. Vera Montenegro
- F. Ibarra Velarde
- E. Liébano Hernández
- H. Quiroz Romero
- R. Castillo Bocanegra
- A. Hernández Campos
- P. Ochoa Galván
Corresponding author
Correspondence toF. Ibarra Velarde.
Additional information
Taken in part from the PhD thesis of Yolanda Vera Montenegro
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Vera Montenegro, Y., Ibarra Velarde, F., Liébano Hernández, E. et al. Efficacy of an experimental fasciolicide against immature and mature Fasciola hepatica in artificially infected calves.Parasitol Res 92, 211–214 (2004). https://doi.org/10.1007/s00436-003-1007-2
- Received: 20 July 2003
- Accepted: 08 September 2003
- Published: 03 December 2003
- Issue date: February 2004
- DOI: https://doi.org/10.1007/s00436-003-1007-2