Ultrastructural observations on oral ingestion and trans-tegumental uptake of clorsulon by the liver fluke, Fasciola hepatica (original) (raw)

Access this article

Log in via an institution

Subscribe and save

• Starting from 10 chapters or articles per month
• Access and download chapters and articles from more than 300k books and 2,500 journals
• Cancel anytime View plans

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

• Anderson HR (1989) Studies on the mode of action of the fasciolicide diamphenethide (“Coriban”). PhD Thesis, The Queen’s University of Belfast, Belfast
• Anderson HR, Fairweather I (1995) Fasciola hepatica: ultrastructural changes to the tegument of juvenile flukes following incubation in vitro with the deacetylated (amine) metabolite of diamphenethide. Int J Parasitol 25:319–333
  Article Google Scholar
• Boray JC (1990) Drug resistance in Fasciola hepatica. In: Boray JC, Martin PJ, Roush RT (eds) Resistance of parasites to antiparasitic drugs. MSD AGVET, Rahway, N.J., pp 51–60
• Buchanan JF, Fairweather I, Brennan GP, Trudgett A, Hoey EM (2003) Fasciola hepatica: surface and internal tegumental changes induced by treatment in vitro with the sulphoxide metabolite of albendazole (“Valbazen”). Parasitology 126:141–153
  Article CAS PubMed Google Scholar
• Fairweather I, Holmes SD, Threadgold LT (1984) Fasciola hepatica: motility response to fasciolicides in vitro. Exp Parasitol 57:209–224
  Article CAS PubMed Google Scholar
• Fairweather I, Anderson HR, Threadgold LT (1986) Fasciola hepatica: tegumental changes induced in vitro by the deacetylated (amine) metabolite of diamphenethide. Exp Parasitol 62:336–348
  Article Google Scholar
• Kane HA, Behm CA, Bryant C (1980) Metabolic studies on the new fasciolicidal drug, closantel. Mol Biochem Parasitol 1:347–355
  Article Google Scholar
• Malone JB, Ramsey RT, Loyacano AF (1984) Efficacy of clorsulon for treatment of mature naturally acquired and 8-week-old experimentally induced Fasciola hepatica infections in cattle. Am J Vet Res 45:851–854
  Google Scholar
• Meaney M, Fairweather I, Brennan GP, McDowell LSL, Forbes AB (2003) Fasciola hepatica: effects of the fasciolicide clorsulon in vitro and in vivo on the tegumental surface, and a comparison of the effects on young- and old-mature flukes. Parasitol Res 91:238–250
  Article CAS PubMed Google Scholar
• Meaney M, Fairweather I, Brennan GP, Forbes AB (2004) Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res 92:232–241
  Article CAS PubMed Google Scholar
• Meaney M, Haughey S, Brennan GP, Fairweather I (2005) A scanning electron microscope study on the route of entry of clorsulon into the liver fluke, Fasciola hepatica. Parasitol Res (in press)
• Ostlind DA, Campbell WC, Riek, RF, Baylis P, Cifelli S, Hartman, RK, Lang RK, Butler RW, Mrozik H, Bochis RJ, Eskola P, Matzuk A, Waksminski FS, Olen LE, Schwartzkopf G, Grodski A, Linn BO, Lusi A, Wu MT, Shunk CH, Peterson LH, Milkowski JD, Hoff DR, Kulsa P, Harmon RE (1977) The efficacy of 4-amino-6-trichloroethenyl-1,3-benzenedisulphonamide against liver fluke in sheep and cattle. Br Vet J 133:211–214
  Google Scholar
• Richards RJ, Bowen FL, Essenwein F, Steiger RF, Buscher G (1990) The efficacy of triclabendazole and other anthelmintics against Fasciola hepatica in controlled studies in cattle. Vet Rec 126:213–216
  Google Scholar
• Robinson G, Threadgold LT (1975) Electron microscope studies of Fasciola hepatica. XII. The fine structure of the gastrodermis. Exp Parasitol 37:20–36
  Article Google Scholar
• Robinson MW, Trudgett A, Hoey EM, Fairweather I (2002) Triclabendazole-resistant Fasciola hepatica: β-tubulin and response to in vitro treatment with triclabendazole. Parasitology 124:325–338
  Article CAS PubMed Google Scholar
• Rohrer SP, Saz HJ, Nowak T (1986) 31P-NMR studies of the metabolism of the parasitic helminths Ascaris suum and Fasciola hepatica. Arch Biochem Biophys 248:200–209
  Article Google Scholar
• Schulman MD, Valentino D (1980) Fasciola hepatica: effect of 4-amino-6-trichloroethen yl-1,3-benzenedisulfonamide on glycolysis in vitro. Exp Parasitol 49:206–215
  Article Google Scholar
• Schulman MD, Valentino D (1982) Purification, characterization and inhibition by MK-401of Fasciola hepatica phosphoglyceromutase. Mol Biochem Parasitol 5:321–332
  Article Google Scholar
• Schulman MD, Valentino D, Cifelli S, Lang R, Ostlind DA (1979) A pharmacokinetic basis for the efficacy of 4-amino-6-trichlororoethenyl-1,3-benzenedisulfonamide against Fasciola hepatica in the rat. J Parasitol 65: 555–561
  CAS PubMed Google Scholar
• Schulman MD, Valentino D, Cifelli S, Ostlind DA (1982a) Dose-dependent pharmacokinetics and efficacy of MK-401 against old, and young-mature infections of Fasciola hepatica in the rat. J Parasitol 68:603–608
  Google Scholar
• Schulman MD, Ostlind DA, Valentino D (1982b) Mechanism of action of MK-401 against Fasciola hepatica: inhibition of phosphoglycerate kinase. Mol Biochem Parasitol 5:133–145
  Article Google Scholar
• Skuce PJ, Fairweather I (1990) The effect of the hydrogen ionophore closantel upon the pharmacology and ultrastructure of the adult liver fluke Fasciola hepatica. Parasitol Res 76:241–250
  Article Google Scholar
• Skuce PJ, Anderson HR, Fairweather I (1987) The interaction between the deacetylated (amine) metabolite of diamphenethide (DAMD) and cytochemically demonstrable Na+/K+-ATPase activity in the tegument of Fasciola hepatica. Parasitol Res 74:161–167
  Google Scholar
• Stitt AW, Fairweather I (1994) The effect of the sulphoxide metabolite of triclabendazole (“Fasinex”) on the tegument of mature and immature stages of the liver fluke, Fasciola hepatica. Parasitology 108:555–567
  CAS PubMed Google Scholar
• Sundlof SF, Whitlock TW (1992) Clorsulon pharmacokinetics in sheep and goats following oral and intravenous administration. J Vet Pharmacol Ther 15:282–291
  Google Scholar
• Verheyen A, Vanparijs O, Lauwers H, Thienpont D (1980) The influence of closantel administration to sheep on the ultrastructure of the adult liver fluke, Fasciola hepatica L. In: Van den Bossche H (ed) The host-invader interplay. Elsevier/North Holland, Amsterdam, pp 705–708
• Walker SM, McKinstry B, Boray JC, Brennan GP, Trudgett A, Hoey EM, Fletcher H, Fairweather I (2004) Response of two isolates of Fasciola hepatica to treatment with triclabendazole in vivo and in vitro. Parasitol Res 94:427–438
  Article Google Scholar
• Yazwinski TA, Kilgore RL, Presson BL, Williams ML, Fulton RK, Pote L, Greenway TE (1985) Efficacy of oral clorsulon in the treatment of Fasciola hepatica infections in calves. Am J Vet Res 46:163–164
  Google Scholar

Download references