Evidence for an association between markers on chromosome 19q and non-syndromic cleft lip with or without cleft palate in two groups of multiplex families (original) (raw)

Abstract

It has been reported that BCL3 on chromosome 19q, or a nearby gene, may play a role in the etiology of non-syndromic cleft lip with or without cleft palate (NSCL/P) in some families. We tested 30 USA and 11 Mexican multiplex NSCL/P families for four markers on chromosome 19q: D19S178, APOC2/AC1, APOC2/007, and BCL3. While likelihood-based linkage analysis failed to show significant evidence of linkage, the transmission disequilibrium test indicated highly significant deviation from independent assortment of allele 3 at the BCL3 marker in both data sets (USA:P = 0.001; Mexican: P = 0.018; both combined: P < 0.001) and for allele 13 of the D19S178 marker in the Mexican data set (P = 0.004). These results support an association, possibly due to linkage disequilibrium, between chromosome 19 markers and a putative NSCL/P locus.

Access this article

Log in via an institution

Subscribe and save

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA Tel.: +1 410 955-7961; Fax: +1 410 955-0863 e-mail: dfw@welchlink.welch.jhu.edu, , , , , , TP
    D. F. Wyszynski, Nancy Maestri & Terri H. Beaty
  2. Department of Pediatrics, School of Medicine, The Johns Hopkins University, Baltimore, USA, , , , , , TP
    Amy F. Lewanda
  3. Department of Medicine, School of Medicine, The Johns Hopkins Universitiy, Baltimore, USA, , , , , , TP
    Iain McIntosh & E. Anne Smith
  4. Department of Medical Genetics, Hospital Infantil de Mexico “Federico Gomez”, Mexico, DF, , , , , , MX
    Constanza Garcia-Delgado
  5. Department of Plastic and Reconstructive Surgery, Hospital Infantil de Mexico “Federico Gomez”, Mexico, DF, , , , , , MX
    Enrique Vinageras-Guarneros
  6. Division of Human Genetics, University of Maryland at Baltimore, Baltimore, Maryland, USA, , , , , , TP
    Eric Wulfsberg

Authors

  1. D. F. Wyszynski
    You can also search for this author inPubMed Google Scholar
  2. Nancy Maestri
    You can also search for this author inPubMed Google Scholar
  3. Iain McIntosh
    You can also search for this author inPubMed Google Scholar
  4. E. Anne Smith
    You can also search for this author inPubMed Google Scholar
  5. Amy F. Lewanda
    You can also search for this author inPubMed Google Scholar
  6. Constanza Garcia-Delgado
    You can also search for this author inPubMed Google Scholar
  7. Enrique Vinageras-Guarneros
    You can also search for this author inPubMed Google Scholar
  8. Eric Wulfsberg
    You can also search for this author inPubMed Google Scholar
  9. Terri H. Beaty
    You can also search for this author inPubMed Google Scholar

Additional information

Received: 10 May 1996 / Revised: 31 July 1996

Rights and permissions

About this article

Cite this article

Wyszynski, D., Maestri, N., McIntosh, I. et al. Evidence for an association between markers on chromosome 19q and non-syndromic cleft lip with or without cleft palate in two groups of multiplex families.Hum Genet 99, 22–26 (1996). https://doi.org/10.1007/s004390050303

Download citation

Keywords