Quantitative analysis of inputs to somatostatin-immunoreactive descending interneurons in the myenteric plexus of the guinea-pig small intestine (original) (raw)

Abstract

Somatostatin immunoreactivity occurs in a specific subgroup of cholinergic descending interneurons in the myenteric plexus of the guinea-pig small intestine. In the present work, we made light- and electron-microscopic investigations of chemically defined inputs to these neurons, in order that the origins of the connections of other neurons with them could be deduced. Somatostatin-immunoreactive synapses and close contacts were found on the cell bodies and filamentous processes of somatostatin neurons; these were 84% of all inputs. It is thus confirmed that this class of interneuron forms chains that project anally. Descending interneurons with immunoreactivity for nitric oxide synthase provided 14% of inputs to somatostatin-immunoreactive descending interneurons. An antiserum against a calcium-binding protein, calbindin, was used as marker for the majority of intrinsic primary afferent neurons, AH/Dogiel type II neurons; this class of neurons provided only 2.5% of the inputs to somatostatin-immunoreactive descending interneurons. We conclude that somatostatin-immunoreactive descending interneurons are involved in the conduction of impulses distally along the full length of the small intestine, but receive only a minor input from calbindin-immunoreactive primary afferent neurons.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, University of Melbourne, Parkville 3052, Victoria, Australia Tel.: +61 3 9344 5804; Fax: +61 3 9347 5219; e-mail: john.furness@anatomy.unimelb.edu.au, , , , , , AU
    S. Pompolo & J. B. Furness

Authors

  1. S. Pompolo
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  2. J. B. Furness
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Received: 16 March 1998 / Accepted: 6 July 1998

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Pompolo, S., Furness, J. Quantitative analysis of inputs to somatostatin-immunoreactive descending interneurons in the myenteric plexus of the guinea-pig small intestine.Cell Tissue Res 294, 219–226 (1998). https://doi.org/10.1007/s004410051171

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