Human nephron number: implications for health and disease (original) (raw)

References

  1. Brenner BM, Garcia DL, Anderson S (1988) Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1:335–347
    Article CAS Google Scholar
  2. Moritz KM, Wintour EM, Black MJ, Bertram JF, Caruana G (2008) Factors influencing mammalian kidney development: implications for health in adult life. Adv Anat Embryol Cell Biol 196:1–78
    CAS PubMed Google Scholar
  3. Puelles VG, Hoy WE, Hughson MD, Diouf B, Douglas-Denton RN, Bertram JF (2011) Glomerular number and size variability and risk for kidney disease. Curr Opin Nephrol Hypertens 20:7–15
    Article Google Scholar
  4. Bertram JF, Soosaipillai MC, Ricardo SD, Ryan GB (1992) Total numbers of glomeruli and individual glomerular cell types in the normal rat kidney. Cell Tissue Res 270(1):37–45
    Article CAS Google Scholar
  5. Bertram JF (1995) Analyzing renal glomeruli with the new stereology. Int Rev Cytol 161:111–172
    Article CAS Google Scholar
  6. Nyengaard JR (1999) Stereologic methods and their application in kidney research. J Am Soc Nephrol 10(5):1100–1123
    CAS PubMed Google Scholar
  7. Nyengaard JR, Bendtsen TF (1992) Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 232:194–201
    Article CAS Google Scholar
  8. Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hypertension. N Engl J Med 348:101–108
    Article Google Scholar
  9. Douglas-Denton RN, McNamara BJ, Hoy WE, Hughson MD, Bertram JF (2006) Does nephron number matter in the development of kidney disease? Ethn Dis 16(S2):40–45
    Google Scholar
  10. Hoy WE, Douglas-Denton RN, Hughson MD, Cass A, Johnson K, Bertram JF (2003) A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int Suppl 83:S31–S37
    Article Google Scholar
  11. Hoy WE, Hughson MD, Bertram JF, Douglas-Denton R, Amann K (2005) Nephron number, hypertension, renal disease, and renal failure. J Am Soc Nephrol 16(9):2557–2564
    Article Google Scholar
  12. Hoy WE, Hughson MD, Singh GR, Douglas-Denton R, Bertram JF (2006) Reduced nephron number and glomerulomegaly in Australian Aborigines: a group at high risk for renal disease and hypertension. Kidney Int 70:104–110
    Article CAS Google Scholar
  13. Hoy WE, Bertram JF, Douglas-Denton R, Zimanyi M, Samuel T, Hughson MD (2008) Nephron number, glomerular volume, renal disease and hypertension. Curr Opin Nephrol Hypertens 17:258–265
    Article Google Scholar
  14. Hoy WE, Ingelfinger JR, Hallan S, Hughson MD, Mott SA, Bertram JF (2010) The early development of the kidney and the implications for future health. J Dev Orig Health Dis 1:216–233
    Article CAS Google Scholar
  15. Hoy WE, Hughson MD, Zimanyi M, Samuel T, Douglas-Denton R, Holden L, Mott S, Bertram JF (2010) Distribution of volumes of individual glomeruli in kidneys at autopsy: Association with age, nephron number, birth weight and body mass index. Clin Nephrol 74:S105–S112
    PubMed Google Scholar
  16. Hughson M, Farris AB 3rd, Douglas-Denton R, Hoy WE, Bertram JF (2003) Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int 63:2113–2122
    Article Google Scholar
  17. Hughson MD, Douglas-Denton R, Bertram JF, Hoy WE (2006) Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States. Kidney Int 69:671–678
    Article CAS Google Scholar
  18. Hughson MD, Gobe GC, Hoy WE, Manning RD Jr, Douglas-Denton R, Bertram JF (2008) Associations of glomerular number and birth weight with clinicopathological features of African Americans and whites. Am J Kidney Dis 52(1):18–28
    Article Google Scholar
  19. Hughson MD, Hoy WE, Douglas-Denton RN, Zimanyi MA, Bertram JF (2010) Towards a definition of glomerulomegaly: clinical-pathological and methodological considerations. Nephrol Dial Transplant. doi:https://doi.org/10.1093/ndt/gfq688
  20. McNamara BJ, Diouf B, Hughson MD, Douglas-Denton RN, Hoy WE, Bertram JF (2008) Renal pathology, glomerular number and volume in a West African urban community. Nephrol Dial Transplant 23:2576–2585
    Article Google Scholar
  21. McNamara BJ, Diouf B, Hughson MD, Hoy WE, Bertram JF (2009) Associations between age, body size and nephron number with individual glomerular volumes in urban West African males. Nephrol Dial Transplant 24:1500–1506
    Article Google Scholar
  22. McNamara BJ, Diouf B, Douglas-Denton RN, Hughson MD, Hoy WE, Bertram JF (2010) A comparison of nephron number, glomerular volume and kidney weight in Senegalese Africans and African Americans. Nephrol Dial Transplant 25:1514–1520
    Article Google Scholar
  23. Merlet-Bénichou C, Gilbert T, Vilar J, Moreau E, Freund N, Lelièvre-Pégorier M (1999) Nephron number: variability is the rule. Causes and consequences. Lab Invest 79:515–527
    PubMed Google Scholar
  24. Zhang Z, Quinlan J, Hoy W, Hughson MD, Lemire M, Hudson T, Hueber PA, Benjamin A, Roy A, Pascuet E, Goodyer M, Raju C, Houghton F, Bertram J, Goodyer P (2008) A common RET variant is associated with reduced newborn kidney size and function. J Am Soc Nephrol 19:2027–2034
    Article CAS Google Scholar
  25. Beeman SC, Zhang M, Gubhaju L, Frakes D, Bertram JF, Wu T, Bennett K (2011) Measuring whole kidney nephron endowment using MRI. Proc 19th Ann Mtg Int Soc Mag Reson Med, Montreal
  26. Zimanyi MA, Hoy WE, Douglas-Denton RN, Hughson MD, Holden LM, Bertram JF (2009) Nephron number and individual glomerular volumes in male Caucasian and African American subjects. Nephrol Dial Transplant 24:2428–2433
    Article Google Scholar
  27. Manalich R, Reyes L, Herrera M, Melendi C, Fundora I (2000) Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int 58:770–773
    Article Google Scholar
  28. Hoy WE, Rees M, Kile E, Mathews JD, Wang Z (1999) A new dimension to the Barker hypothesis: low birthweight and susceptibility to renal disease. Kidney Int 56:1072–1077
    Article CAS Google Scholar
  29. Hallan S, Euser AM, Irgens LM, Finken MJ, Holmen J, Dekker FW (2008) Effect of intrauterine growth restriction on kidney function at young adult age: the Nord Trondelag Health (HUNT 2) Study. Am J Kidney Dis 51:10–20
    Article Google Scholar
  30. Keijzer-Veen MG, Schrevel M, Finken MJ, Dekker FW, Nauta J, Hille ET, Frölich M, van der Heijden BJ, Dutch POPS-19 Collaborative Study Group (2005) Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation. J Am Soc Nephrol 16:2762–2768
    Article CAS Google Scholar
  31. Lackland DT, Bendall HE, Osmond C, Egan BM, Barker DJ (2000) Low birth weights contribute to high rates of early-onset chronic renal failure in the Southeastern United States. Arch Intern Med 160:1472–1476
    Article CAS Google Scholar
  32. Vikse BE, Irgens LM, Leivestad T, Hallan S, Iversen BM (2008) Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol 19:151–157
    Article Google Scholar
  33. White SL, Perkovic V, Cass A, Chang CL, Poulter NR, Spector T, Haysom L, Craig JC, Salmi IA, Chadban SJ, Huxley RR (2009) Is low birth weight an antecedent of CKD in later life? A systematic review of observational studies. Am J Kidney Dis 54:248–261
    Article Google Scholar
  34. Hodgin JB, Rasoulpour M, Markowitz GS, D'Agati VD (2009) Very low birth weight is a risk factor for secondary focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 4:71–76
    Article Google Scholar

Download references