Gastric emptying and orocecal transit time in pregnancy (original) (raw)

Purpose.

To evaluate the effects of pregnancy on gastrointestinal function, we determined gastric emptying time, orocecal transit time, and fasting gastrointestinal hormone levels (cholecystokinin, gastrin, pancreatic polypeptide, neurotensin) in 11 women with mild dyspeptic symptoms during the first and third trimesters of their pregnancies, and again 4–6 months after delivery. Methods. After the women ingested a disaccharide solution, orocecal transit time was determined by monitoring breath hydrogen concentrations at 10-min intervals, and values were compared with the postpartum value. Ultrasound examinations of gastric emptying were performed during the same intervals. Results. The half-emptying time and the final gastric emptying time did not differ in the first and third trimesters and postpartum, but gastrointestinal transit time was significantly longer in the third trimester of pregnancy than postpartum ([100.0 min (range, 50.5–240.0 min] vs 70.0 min [range, 40.5–240.0 min; P < 0.05]), respectively. Mean plasma pancreatic polypeptide values were lower in the third trimester of pregnancy than postpartum, and a negative correlation was observed between pancreatic polypeptide levels and transit time in the third trimester (r = −0.65; P = 0.0261). The plasma levels of other gastrointestinal hormones did not differ in the various periods studied. Conclusions. Our study shows that, despite evident dyspeptic symptoms, there were no significant alterations in gastric emptying or orocecal transit time during the first trimester of pregnancy. Conversely, in the third trimester, orocecal transit time was significantly longer.

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Authors and Affiliations

1. Laboratory of Experimental Pathophysiology, I.R.C.C.S. "S. de Bellis", Via F. Valente, 4, 70013 Castellana Grotte, Bari, Italy, , , , , , IT
   Marisa Chiloiro & Giuseppe Riezzo
2. Division of Obstetrics and Gynecology, I.R.C.C.S., "S. de Bellis", Castellana Grotte, Bari, Italy, , , , , , IT
   Giuseppe Darconza
3. Gastroenterological Pathophysiology Unit, I.R.C.C.S., "S. de Bellis", Castellana Grotte, Bari, Italy, , , , , , IT
   Elettra Piccioli & Massimo De Carne
4. Laboratory of Experimental Biochemistry, I.R.C.C.S., "S. de Bellis", Castellana Grotte, Bari, Italy, , , , , , IT
   Caterina Clemente

Authors

1. Marisa Chiloiro
2. Giuseppe Darconza
3. Elettra Piccioli
4. Massimo De Carne
5. Caterina Clemente
6. Giuseppe Riezzo

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Received: October 6, 2000 / Accepted: February 23, 2001

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Chiloiro, M., Darconza, G., Piccioli, E. et al. Gastric emptying and orocecal transit time in pregnancy.J Gastroenterol 36, 538–543 (2001). https://doi.org/10.1007/s005350170056

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• Issue date: August 2001
• DOI: https://doi.org/10.1007/s005350170056