Central l-arginine reduced stress responses are mediated by l-ornithine in neonatal chicks (original) (raw)

Summary.

Recently, we observed that central administration of l-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of l-arginine may be due to l-arginine itself and/or its metabolites, excluding NO. To clarify the mechanism, the effect of intracerebroventricular (i.c.v.) injection of l-arginine metabolites on behavior under social separation stress was investigated. The i.c.v. injection of agmatine, a guanidino metabolite of l-arginine, had no effect during a 10 min behavioral test. In contrast, the i.c.v. injection of l-ornithine clearly attenuated the stress response in a dose-dependent manner, and induced sleep-like behavior. The l-ornithine concentration in the telencephalon and diencephalon increased following the i.c.v. injection of l-arginine. In addition, several free amino acids including L-alanine, glycine, l-proline and l-glutamic acid concentrations increased in the telencephalon. In conclusion, it appears that l-ornithine, produced by arginase from l-arginine in the brain, plays an important role in the sedative and hypnotic effects of l-arginine observed during a stress response. In addition, several other amino acids having a sedative effect might partly participate in the sedative and hypnotic effects of l-arginine.

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References

• S Al-Rejaie MS Dar (2006)ArticleTitleAntagonism of ethanol ataxia by intracerebellar nicotine: possible modulation by mouse cerebellar nitric oxide and cGMP_Brain Res Bull_ 69 187–196Occurrence Handle16533669Occurrence Handle10.1016/j.brainresbull.2005.12.002Occurrence Handle1:CAS:528:DC%2BD28Xit1yms7w%3D
  Article PubMed CAS Google Scholar
• JL Davis DT Masuoka LK Gerbrandt A Cherkin (1979)ArticleTitleAutoradiographic distribution of L-proline in chicks after intracerebral injection_Physiol Behav_ 22 693–695Occurrence Handle482410Occurrence Handle10.1016/0031-9384(79)90233-6Occurrence Handle1:STN:280:Bi%2BD3MzkvVY%3D
  Article PubMed CAS Google Scholar
• MW Feltenstein LC Lambdin M Ganzera H Ranjith W Dharmaratne NP Nanayakkara IA Khan KJ Sufka (2003)ArticleTitleAnxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure_Phytother Res_ 17 210–216Occurrence Handle12672148Occurrence Handle10.1002/ptr.1107
  Article PubMed Google Scholar
• HS Han Y Qiao M Karabiyikoglu RG Giffard MA Yenari (2002)ArticleTitleInfluence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation_J Neurosci_ 22 3921–3928Occurrence Handle12019311Occurrence Handle1:CAS:528:DC%2BD38XjvVaiur4%3D
  PubMed CAS Google Scholar
• Y Koga H Takahashi D Oikawa T Tachibana DM Denbow M Furuse (2005)ArticleTitleBrain creatine functions to attenuate acute stress responses through GABAnergic system in chicks_Neuroscience_ 132 65–71Occurrence Handle15780467Occurrence Handle10.1016/j.neuroscience.2005.01.004Occurrence Handle1:CAS:528:DC%2BD2MXisVCnsbs%3D
  Article PubMed CAS Google Scholar
• T Koutoku H Takahashi S Tomonaga D Oikawa S Saito T Tachibana L Han K Hayamizu DM Denbow M Furuse (2005)ArticleTitleCentral administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks_Neurochem Int_ 47 183–189Occurrence Handle15916832Occurrence Handle10.1016/j.neuint.2005.03.006Occurrence Handle1:CAS:528:DC%2BD2MXlsl2ktrg%3D
  Article PubMed CAS Google Scholar
• WJ Kuenzel M Masson (1988) A stereotaxic atlas of the brain of the chick (Gallus domesticus) Johns Hopkins University Press Baltimore, MD
  Google Scholar
• I Kurauchi M Asechi T Tachibana L Han K Hayamizu DM Denbow M Furuse (2006)ArticleTitleIntracerebroventricular injection of L-alanine induces a sedative effect under an acute stressful condition in neonatal chicks_J Poult Sci_ 43 384–387Occurrence Handle10.2141/jpsa.43.384Occurrence Handle1:CAS:528:DC%2BD28Xht1aktLbO
  Article CAS Google Scholar
• YF Li ZH Gong JB Cao HL Wang ZP Luo J Li (2003)ArticleTitleAntidepressant-like effect of agmatine and its possible mechanism_Eur J Pharmacol_ 469 81–88Occurrence Handle12782188Occurrence Handle10.1016/S0014-2999(03)01735-7Occurrence Handle1:CAS:528:DC%2BD3sXktFGltbg%3D
  Article PubMed CAS Google Scholar
• SM MorrisSuffixJr (2004)ArticleTitleEnzymes of arginine metabolism_J Nutr_ 134 2743S–2747SOccurrence Handle15465778Occurrence Handle1:CAS:528:DC%2BD2cXosVOjsrw%3D
  PubMed CAS Google Scholar
• A Neu H Neuhoff G Trube S Fehr K Ullrich J Roeper D Isbrandt (2002)ArticleTitleActivation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism_Neurobiol Dis_ 11 298–307Occurrence Handle12505422Occurrence Handle10.1006/nbdi.2002.0547Occurrence Handle1:CAS:528:DC%2BD38Xps12rtLs%3D
  Article PubMed CAS Google Scholar
• DJ Reis S Regunathan (2000)ArticleTitleIs agmatine a novel neurotransmitter in brain?Trends Pharmacol Sci 21 187–193Occurrence Handle10785653Occurrence Handle10.1016/S0165-6147(00)01460-7Occurrence Handle1:CAS:528:DC%2BD3cXjtVeqs7k%3D
  Article PubMed CAS Google Scholar
• LA Rubio (2003)ArticleTitleDetermination of diaminopimelic acid in rat feces by high-performance liquid chromatography using the Pico Tag method_J Chromatogr B Analyt Technol Biomed Life Sci_ 784 125–129Occurrence Handle12504190Occurrence Handle10.1016/S1570-0232(02)00781-XOccurrence Handle1:CAS:528:DC%2BD3sXhtFyqtbY%3D
  Article PubMed CAS Google Scholar
• Suenaga R, Tomonaga S, Yamane H, Kurauchi I, Tsuneyoshi Y, Sato H, Denbow DM, Furuse M (2008) Intracerebroventricular injection of l-arginine induces sedative and hypnotic effects under an acute stress in neonatal chicks. Amino Acids (in press)
• ELJM van Luijtelaar CPM van der Grinten HJ Blokhuis AML Coenen (1987)ArticleTitleSleep in the domestic hen (Gallus domesticus)Physiol Behav 41 409–414Occurrence Handle3432393Occurrence Handle10.1016/0031-9384(87)90074-6Occurrence Handle1:STN:280:BieC38rktFQ%3D
  Article PubMed CAS Google Scholar
• GS Watson JT Roach KJ Sufka (1999)ArticleTitleBenzodiazepine receptor function in the chick social separation-stress procedure_Exp Clin Psychopharmacol_ 7 83–89Occurrence Handle10340149Occurrence Handle10.1037/1064-1297.7.2.83Occurrence Handle1:CAS:528:DyaK1MXjsFyjtL4%3D
  Article PubMed CAS Google Scholar
• ADE Zomkowski ARS Santos ALS Rodrigues (2006)ArticleTitlePutrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice_Prog Neuropsychopharmacol Biol Psychiatry_ 30 1419–1425Occurrence Handle16822602Occurrence Handle10.1016/j.pnpbp.2006.05.016Occurrence Handle1:CAS:528:DC%2BD28XhtFCjsLnP
  Article PubMed CAS Google Scholar

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Authors and Affiliations

1. Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan
   R. Suenaga, H. Yamane, S. Tomonaga, M. Asechi, N. Adachi, Y. Tsuneyoshi, I. Kurauchi & M. Furuse
2. Ajinomoto Co. Inc., Kawasaki-ku, Kawasaki-shi, Japan
   H. Sato
3. Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, U.S.A.
   D. M. Denbow

Authors

1. R. Suenaga
2. H. Yamane
3. S. Tomonaga
4. M. Asechi
5. N. Adachi
6. Y. Tsuneyoshi
7. I. Kurauchi
8. H. Sato
9. D. M. Denbow
10. M. Furuse

Additional information

Authors’ address: M. Furuse, PhD, Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan

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Suenaga, R., Yamane, H., Tomonaga, S. et al. Central l-arginine reduced stress responses are mediated by l-ornithine in neonatal chicks.Amino Acids 35, 107–113 (2008). https://doi.org/10.1007/s00726-007-0617-x

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• Received: 15 August 2007
• Accepted: 04 October 2007
• Published: 25 January 2008
• Issue date: June 2008
• DOI: https://doi.org/10.1007/s00726-007-0617-x