Human C-reactive protein (CRP) 1059G/C polymorphism (original) (raw)

Journal of Human Genetics volume 45, pages 100–101 (2000)Cite this article

Abstract

We found a novel G → C change at nucleotide 1059 within exon 2 of the CRP gene encoding the C-reactive protein. The CRP 1059G/C polymorphism could be detected by digestion with endonuclease _Mae_III. The frequency of the CRP 1059C allele was 0.109 in Caucasians, but it was absent from Canadian Oji-Cree. Because of the importance of the CRP gene product in inflammation and its recent association with ischemic heart disease syndromes, this polymorphism may be useful in the association studies of atherosclerosis and its related phenotypes.

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  1. Blackburn Cardiovascular Genetics Laboratory, John P. Robarts Research Institute, 406-100 Perth Drive London, Ontario, Canada N6A 5K8 Tel. +1-519-663-3461; Fax 519-663-3789 email: robert.hegele@rri.on.ca, Canada
    Henian Cao & Robert A. Hegele

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  1. Henian Cao
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  2. Robert A. Hegele
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Received: November 8, 1999 / Accepted: November 15, 1999

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Cao, H., Hegele, R. Human C-reactive protein (CRP) 1059G/C polymorphism.J Hum Genet 45, 100–101 (2000). https://doi.org/10.1007/s100380050022

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