Emerging Linezolid-Resistant Enterococcus faecalis and Enterococcus faecium Isolated from Two Austrian Patients in the Same Intensive Care Unit (original) (raw)

Abstract.

Of two patients in the same intensive care unit who were treated with linezolid, one yielded linezolid-resistant Enterococcus faecalis, whereas the other yielded linezolid-resistant Enterococcus faecium. In each case, molecular typing indicated that the resistant isolates were related to linezolid-susceptible isolates from the same patient, but differed from them by the same G2576U ribosomal RNA mutation. This is the first clinical case report of emerging resistance to linezolid among Enterococcus faecalis and also the first report of resistance involving vancomycin-susceptible rather than vancomycin-resistant enterococci. The linezolid-resistant isolates showed cross-resistance to the experimental oxazolidinone AZD2563, suggesting that oxazolidinone resistance might be a class effect.

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Authors and Affiliations

1. Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, Colindale, London NW9 5HT, UK, , , , ,
   A. Johnson, L. Tysall, M. Stockdale, N. Woodford, M. Warner & D. Livermore
2. Laboratory of Hospital Infection, Central Public Health Laboratory, Colindale, London NW9 5HT, UK, , , , ,
   M. Kaufmann
3. Federal Public Health Laboratory, Schoepfstrasse 41, 6020 Innsbruck, Austria, , , , ,
   F. Asboth & F. Allerberger

Authors

1. A. Johnson
2. L. Tysall
3. M. Stockdale
4. N. Woodford
5. M. Kaufmann
6. M. Warner
7. D. Livermore
8. F. Asboth
9. F. Allerberger

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Johnson, .A., Tysall, .L., Stockdale, .M. et al. Emerging Linezolid-Resistant Enterococcus faecalis and Enterococcus faecium Isolated from Two Austrian Patients in the Same Intensive Care Unit.Eur J Clin Microbiol Infect Dis 21, 751–754 (2002). https://doi.org/10.1007/s10096-002-0807-0

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• Issue date: October 2002
• DOI: https://doi.org/10.1007/s10096-002-0807-0

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