Gender-Dependent Modulation of Brain Monoamines and Anxiety-like Behaviors in Mice with Genetic Serotonin Transporter and BDNF Deficiencies (original) (raw)
REFERENCES
Allen, A. L., and McCarson, K. E. (2005). Estrogen increases nociception-evoked brain-derived neurotrophic factor gene expression in the female rat. Neuroendocrinology **81:**193–199. PubMedCAS Google Scholar
Andrews, A. M., and Murphy, D. L. (1993). Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2′aminophenyl)- 1,2,3,6-tetrahydropyridine (2′-NH2–MPTP): A comparative study with 2′-CH3-MPTP and MPTP. J. Neurochem. **60:**1167–1170. PubMedCAS Google Scholar
Armando, I., Tjurmina, O. A., Li, Q., Murphy, D. L., and Saavedra, J. M. (2003). The serotonin transporter is required for stress-evoked increases in adrenal catecholamine synthesis and angiotension II AT(2) receptor expression. Neuroendocrinology **78:**217–225. PubMedCAS Google Scholar
Axelrod, J. (2003). Journey of a late blooming biochemical neuroscientist. J. Biol. Chem. **278:**367–373. Google Scholar
Axelrod, J., and Kopin, I. J. (1969). The uptake, storage, release and metabolism of noradrenaline in sympathetic nerves. Prog. Brain Res. **31:**21–32. ArticlePubMedCAS Google Scholar
Becker, J. B. (1999). Gender differences in dopamine function in striatum and nucleus accumbens. Pharmacol. Biochem. Behav. **64:**803–812. PubMedCAS Google Scholar
Bengel, D., Murphy, D. L., Andrews, A. M., Wichems, C. H., Feltner, D., Heils, A., Mossner, R., Westphal, H., and Lesch, K.-P. (1998). Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxy-methamphetamine (“Ecstasy”) in serotonin transporter-deficient mice. Mol. Pharmacol. **53:**649–655. PubMedCAS Google Scholar
Berchtold, N. C., Kesslak, J. P., Pike, C. J., Adiard, P. A., and Cotmau, C. W. (2001). Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus. Eur. J. Neurosci. **14:**1992–2002. PubMedCAS Google Scholar
Berton, O., McClung, C. A., Dileone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., Monteggia, L. M., Self, D. W., and Nestler, E. J. (2006). Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science **311:**864–868. PubMedCAS Google Scholar
Bonhoeffer, T. (1996). Neurotrophins and activity-dependent development of the neocortex. Curr. Opin. Neurobiol. **6:**119–126. PubMedCAS Google Scholar
Brito, V. I., Carrer, H. F., and Cambiasso, M. J. (2004). Inhibition of tyrosine kinase receptor type B synthesis blocks axogenic effect of estradiol on rat hypothalamic neuron in vitro. Eur. J. Neurosci. **20:**331–337. PubMedCAS Google Scholar
Carroll, P., Lewin, G. R., Koltzenburg, M., Toyka, K. V., and Thoenen, H. (1998). A role for BDNF in mechanosensation. Nat. Neurosci. **1:**42–46. PubMedCAS Google Scholar
Carter, A. R., Chen, C., Schwartz, P. M., and Segal, R. A. (2002). Brain-derived neurotrophic factors, cerebellar plasticity, and synaptic ultrastructure. J. Neurosci.22(4):1316–1327. PubMedCAS Google Scholar
Caspi, A., Sugden, K., Moffitt, T. E., Tayor, A., Craig, I. W., Harrington, J. M., Mill, J., Martin, J., Braithwaite, A., and Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science **301:**386–389. PubMedCAS Google Scholar
Castren, E., Thoenen, H., and Lindholm, D. (1995). Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and increased by osmotic stimulation in the paraventricular nucleus. Neuroscience **64:**71–80. PubMedCAS Google Scholar
Chen, J. J., Li, Z., Pan, H., Murphy, D. L., Tamir, H., Koepsell, H., and Gershon, M. D. (2001). Maintence of serotonin in the interestinal mucosa and ganglion of that lack the high-affinity serotonin transporter: Abnormal interestinal motility and the expression of cation transporters. J. Neurosci.21(16):6348–6361. PubMedCAS Google Scholar
Chen, Z. Y., Patel, P. D., Sant, G., Meng, C. X., Teng, K. K., Hempstead, B., and Lee, F. S. (2004). Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J. Neurosci.24(18):4401–4411. PubMedCAS Google Scholar
Conover, J. C., Erickson, J. T., Kate, D. M., Bianchi, L. M., Poueymirou, W. T., McClain, J., Pan, L., Helgren, M., Ip, N. Y., Boland, P., Friendman, B., Weigand, S., Vejsada, R., Kate, A. C., DeChiara, T. M., and Yancopoulos, G. D. (1995). Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Nature **375:**235–238. PubMedCAS Google Scholar
Cooke, B. M., and Woolley, C. S. (2005). Gonadal hormone modulation of dendrites in the mammalian CNS. J. Neurobiol.64(1):34–46. PubMedCAS Google Scholar
Davies, A. M., Thoenen, H., and Barde, Y.-A. (1986). The response of chick sensory neurons to brain-derived neurotrophic factor. J. Neurosci.6(7):1897–1904. PubMedCAS Google Scholar
Dluzen, D. E., Anderson, L. I., McDermott, J. L., Kucera, J., and Walro, J. M. (2002). Striatal dopamine output is compromised within ± BDNF mice. Synapse **43:**112–117. PubMedCAS Google Scholar
Eaton, M. J., Staley, J. K., Globus, M. Y., and Whittemore, S. R. (1995). Developmental regulation of early serotonergic neuronal differentiation: The role of brain-derived neurotrophic factor and membrane depolarization. Dev. Biol.170(1):169–182. PubMedCAS Google Scholar
Eaton, M. J., and Whittemore, S. R. (1996). Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS. Exp. Neurol. **140:**105–114. PubMedCAS Google Scholar
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B., and Weinberger, D. R. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell **112:**257–269. PubMedCAS Google Scholar
Ernfors, P., Merlio, J. P., and Persson, H. (1992). Cells expressing mRNA for neurotrophins and their receptors during embryonic rat development. Eur. J. Neurosci. **4:**1140–1158. PubMed Google Scholar
Ernfors, P., Lee, K. F., and Jaenish, R. (1994). Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature **368:**147–150. PubMedCAS Google Scholar
Fanous, A. H., Neale, M. C., Straub, R. E., Webb, B. T., O’Neill, A. F., Walsh, D., and Kendles, K. S. (2004). Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: A family based association study. Am. J. Med. Genet. B Neuropsychiatr. Genet. **125:**69–78. PubMed Google Scholar
Franklin, T. B., and Perrot-Sinal, T. S. (2006). Sex and ovarian steroids modulate brain-derived neurotrophic factor (BDNF) protein levels in rat hippocampus under stressful and non-stressful conditions. Psychoneuroendocrinology **31:**38–48. PubMedCAS Google Scholar
Frechilla, D., Insausti, R., Ruiz-Golvano, P., Garcia-Osta, A., Rubio, M. P., Almendral, J. M., and Del Rio, J. (2000). Implanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum. Brain Res. Mol. Brain Res.76(2):306–314. PubMedCAS Google Scholar
Gainetdinov, R. R., Sotnikova, T. D., and Caron, M. G. (2002). Monoamine transporter pharmacology and mutant mice. Trends Pharmacol. Sci.23(8):367–373. PubMedCAS Google Scholar
Galter, D., and Unsicker, K. (2000). Brain-derived neurotrophic factor and TrkB are essential for cAMP-mediated induction of the serotonergic neuronal phenotype. J. Neurosci. Res.61(3):295–301. PubMedCAS Google Scholar
Gibbs, R. B. (1998). Levels of TrkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement. Brain Res. **787:**259–268. PubMedCAS Google Scholar
Gibbs, R. B. (1999). Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain. Brain Res. **844:**20–27. PubMedCAS Google Scholar
Goggi, J., Pullar, I. A., Carney, S. L., and Bradford, H. F. (2002). Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro. Brain Res.941(1–2):34–42. PubMedCAS Google Scholar
Hall, D., Dhilla, A., Charambous, A., Gogos, J. A., and Karayiorgou, M. (2003). Sequence variants of the BDNF-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am. J. Hum. Genet.73(2):370–376. PubMedCAS Google Scholar
Holmes, A., Yang, R. J., Murphy, D. L., and Crawley, J. N. (2001). Abnormal emotional behaviors and age-related obesity in 5-HT transporter deficient mice. Soc. Neurosci. Abstr. **27:**985.7. Google Scholar
Holmes, A., Murphy, D. L., and Crawley, J. N. (2002). Reduced aggression in mice lacking the 5-HT transporter. Psychopharmacology **161:**160–167. PubMedCAS Google Scholar
Holmes, A., Yang, R. J., Crawley, J. N., Lesch, K.-P., and Murphy, D. L. (2003). Mice lacking the serotonin transporter exhibit 5-HT 1A receptor-mediated abnormalites in anxiety-like and exploratory behavior. Neuropsychopharmacology **28:**2077–2088. PubMedCAS Google Scholar
Hyman, C., Hofer, M., Barde, Y.-A., Juhasz, M., Yancopoulos, R. M., Squinto, S. P., and Lindsay, R. M. (1991). BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature **350:**230–232. PubMedCAS Google Scholar
Jones, K. R., Farnas, I., Backus, C., and Reichardt, L. F. (1994). Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell **76:**989–999. PubMedCAS Google Scholar
Jones, M. D., and Lucki, I. (2005). Sex differences in the regulation of serotonergic transmission and behavior in 5-HT receptor knockout mice. Neuropsychopharmacology **30:**1039–1047. PubMedCAS Google Scholar
Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., Krystal, J. H., and Gelernter, J. (2006). Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol. Psychiatry [E-pub. ahead of print].
Karege, F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., and Aubry, J.-M. (2002). Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. **109:**143–148. PubMedCAS Google Scholar
Katoh-Semba, R., Takeuchi, I. K., Semba, R., and Kato, K. (1997). Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain. J. Neurochem. **69:**34–42. ArticlePubMedCAS Google Scholar
Kernie, S. G., Liebl, D. J., and Parada, L. F. (2000). BDNF regulates eating behavior and locomotor activity in mice. EMBO J. **19:**1290–1300. PubMedCAS Google Scholar
Kim, D. K., Tolliver, T. J., Huang, S. J., Martin, B. J., Andrews, A. M., Wichems, C., Holmes, A., Lesch, K. P., and Murphy, D. L. (2005). Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology **49:**798–810. PubMedCAS Google Scholar
Kolbeck, R., Bartke, I., Eberle, W., and Brade, Y.-A. (1999). Brain-derived neurotrophic factor levels in the nervous system of wild-type and neurotrophic gene mutant mice. J. Neurochem.72(5):1930–1938. PubMedCAS Google Scholar
Koliatsos, V. E., Clatterbuck, R. E., Winslow, J. W., Cayouette, M. H., and Price, D. L. (1993). Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron. **10:**359–367. PubMedCAS Google Scholar
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., and Bonhoeffer, T. (1995). Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA **92:**8856–8860. PubMedCAS Google Scholar
Lewin, G. R., and Barde, Y. A. (1996). Physiology of neurotrophins. Annu. Rev. Neurosci. **19:**289–317. PubMedCAS Google Scholar
Licinio, J., and Wong, M.-L. (2002). Brain-derived neurotrophic factor (BDNF) in stress and affective disorders (Editorial). Mol. Psychiatry **7:**519. PubMedCAS Google Scholar
Linnarsson, S., Bjorklund, A., and Ernfors, P. (1997). Learning deficit in BDNF mutant mice. Eur. J. Neurosci. **9:**2581–2587. PubMedCAS Google Scholar
Lister, R. G. (1987). The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology **92:**180–185. PubMedCAS Google Scholar
Liu, Y., Fowler, C. D., Young, L. J., Yan, Q., Insel, T. R., and Wang, Z. (2001). Expression and estrogen regulation of brain-derived neurotrophic factor gene and protein in the forebrain of female prairie voles. J. Comp. Neurol. **433:**499–514. PubMedCAS Google Scholar
Lohoff, F. W., Sander, T., Ferraro, T. N., Dahl, J. P., Gallinat, J., and Berrettini, W. H. (2005). Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. Am. J. Med. Genet. B **139B:**51–53. CAS Google Scholar
Loudes, C., Petit, F., Kordon, C., and Faivre-Bauman, A. (2000). Brain-derived neurotrophic factor but not neurotrophin-3 enhances differentiation of somatostain neurons in hypothalamus cultures. Neuroendocrinology **72:**144–153. PubMedCAS Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. **193:**265–275. PubMedCAS Google Scholar
Luine, V. N. (1997). Steroid hormone modulation of hippocampal-dependent spatial memory. Stress **2:**21–36. ArticlePubMedCAS Google Scholar
Lyon, M. F., and Searle, A. G. (eds.) (1989). Genetic Variant and Strains of the Laboratory Mouse, 2nd edn., Oxford University Press, Oxford. Google Scholar
Lyons, W. E., Mamounas, L. A., Ricaurt, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., and Tessarollo, L. (1999). Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in connection with brain serotonin abnormalities. Proc. Natl. Acad. Sci. USA **96:**15239–15244. PubMedCAS Google Scholar
MacQueen, G. M., and Ramakrishnan, K. (2001). Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavior analogues of anxiety, nociception, and depression. Behav. Neurosci.115(5):1145–1153. PubMedCAS Google Scholar
Malmberg, A. B. (1999). Model of nociception: Hot plate, tail flick, and formalin tests in rodents. In Current Protocols in Neuroscience, Wiley, New York, pp. 8.9.1–8.9.16. Google Scholar
Mamounas, L. A., Altar, C. A., Blu, M. E., Kaplan, D. R., Tessarollo, L., and Lyons, W. E. (2000). BDNF promotes the regenerative sprouting, but not survival, of serotonergic axons in the adult rat brain. J. Neurosci.20(2):771–782. PubMedCAS Google Scholar
Mamounas, L. A., Blu, M. E., Siuciak, J. A., and Altar, C. A. (1995). Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J. Neurosci. **15:**7929–7939. PubMedCAS Google Scholar
Marmigere, F., Rage, F., Tapia-Arancibia, L., and Arancibia, S. (1998). Expression of mRNAs encoding BDNF and its receptors in adult rat hypothalamus. Neuroreport **9:**1159–1163. PubMedCAS Google Scholar
Marmigere, F., Choby, C., Rage, F., Richard, S., and Tapia-Arancibia, L. (2001). Rapid stimulatory effects of brain-derived neurotrophic factor and neurotrophin-3 on somatostatin release and intracellular calcium rise in primary hypothalamus cell cultures. Neuroendocrinology **74:**43–54. PubMedCAS Google Scholar
Maswood, S., Truitt, W., Hotema, M., Caldarol-Pastuszka, M., and Uphouse, L. (1999). Estrous cycle modulation of extracellular serotonin in mediobasal hypothalamus: Role of the serotonin transporter and terminal autoreceptors. Brain Res. **831:**146–154. PubMedCAS Google Scholar
Maswood S, Stewart G, Uphouse L. (1995). Gender and estrous cycle effects of the 5-HT1A agonist, 8-OH-DPAT, on hypothalamic serotonin. Pharmacol Biochem Behav.51(4):804–813. Google Scholar
Mathews, T. A., Fedele, D. E., Coppelli, F. M., Avila, A. M., Murphy, D. L., and Andrews, A. M. (2004). Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J. Neurosci. Methods **140:**169–181. PubMedCAS Google Scholar
McAllister, A. K., Katz, L. C., and Lo, D. C. (1999). Neurotrophins and synaptic plasticity. Annu. Rev. Neurosci. **22:**295–318. PubMedCAS Google Scholar
Mefford, I. N. (1981). Application of high performance liquid chromatography with electrochemical detection to neurochemical analysis: Measurement of catecholamines, serotonin, and metabolites in rat brain. J. Neurosci. Methods **3:**207–224. PubMedCAS Google Scholar
Miknyoczki, S. J., Lang, D., Huang, L., Klein-Szanto, A. J., Dionne, C. A., and Ruggieri, B. A. (1999). Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: Expression patterns and effects on in vitro invasive behavior. Int. J. Cancer **81:**417–427. PubMedCAS Google Scholar
Miller, D. B., and O’Callaghan, J. P. (2002). Neuroendocrine aspects of the response to stress. Metabolism51(6 Suppl 1):5–10. PubMedCAS Google Scholar
Minichiello, L., Korte, M., Wolfer, D., Kuhu, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H. P., Bonhoeffer, T., and Klein, R. (1999). Essential role for TrkB receptors in hippocampus-mediated learning. Neuron **24:**401–414. PubMedCAS Google Scholar
Miranda, R. C., Sohrabji, F., and Toran-Allerand, D. (1994). Interactions of estrogen with the neurotrophins and their receptors during neural development. Horm. Behav. **28:**367–375. PubMedCAS Google Scholar
Montanez, S., Anthony Owens, W., Gould, G. G., Murphy, D. L., and Daws, L. C. (2003). Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. J. Neurochem. **86:**210–219. PubMedCAS Google Scholar
Mossner, R., Deniel, S., Albert, D., Heils, A., Okladnova, O., Schmitt, A., and Lesch, K.-P. (2000). Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF). Neurochem. Int.36(3):197–202. PubMedCAS Google Scholar
Murphy, D. L., Lerner, A., Rudnick, G., and Lesch, K. P. (2004). Serotonin transporter: Gene, genetic disorders, and pharmacogenetics. Mol. Interv. **4:**109–123. PubMedCAS Google Scholar
Murphy, D. L., Li Q, Engel S, Wichems C, Andrews A, Lesch K. P, Uhl G.(2001). Genetic perspectives on the serotonin transporter. Brain Res Bull.56(5):487–94. Google Scholar
Murphy, D. L., Uhl, G. R., Holmes, A., Ren-Patterson, R., Hall, F. S., Sora, I., Detera-Wadleigh, S., and Lesch, K.-P. (2003). Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic disorders. Gene. Brain Behav. **2:**350–364. CAS Google Scholar
Nawa, H., Carnahan, J., and Gall, C. (1995). BDNF protein measured by novel enzyme immunoassay in normal brain and after seizure: Partial disagreement with mRNA levels. Eur. J. Neurosci. **7:**1527–1535. PubMedCAS Google Scholar
Nestler, E. J., Barrot, M., and Di Leone, R. J. (2002). Neurology of depression. Neuron **28:**13–25. Google Scholar
Neves-Pereira, M., Cheung, J. K., Pasdar, A., Zhang, F., Breen, G., Yates, G., Sinclair, M., Crombie, C., Walker, N., and Clair, D. M. St. (2005). BDNF gene is a risk factor for schizophrenia in Scottish population. Mol. Psychiatry **10:**208–212. PubMedCAS Google Scholar
Oppenheim, R. W., Yin, Q. W., Prevette, D., and Yan, Q. (1992). Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death. Nature **360:**755–757. PubMedCAS Google Scholar
Pelleymounter, M. A., Cullen, M. J., and Wellman, C. L. (1995). Characteristics of BDNF-induced weight loss. Exp. Neurol. **131:**229–238. PubMedCAS Google Scholar
Pirvola, U., Ylikoski, J., Palgi, J., Lehtonen, E., Arumae, U., and Saarma, M. (1992). Brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the peripheral target fields of developing inner ear ganglia. Proc. Natl. Acad. Sci. USA **89:**9915–9919. PubMedCAS Google Scholar
Pozzo-Miller, L. D., Gottschalk, W., Zhang, L., McDermott, K., Du, J., Gopalakrishnan, R., Oho, C., Sheng, Z. H., and Lu, B. (1999). Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in hippocampus of BDNF knockout mice. J. Neurosci.19(12):4972–4983. PubMedCAS Google Scholar
Rage, F., Riteau, B., Alonso, G., and Tapia-Arancibia, L. (1999). Brain-derived neurotrophic factor and neurotropin-3 enhance somatostatin gene expression through a likely direct effect on hypothalamic somatostatin neurons. Endocrinology **140:**909–916. PubMedCAS Google Scholar
Ren-Patterson, R. F., Kim, D. K., Zheng, X., Sherrill, S., Huang, S. J., Tolliver, T., and Murphy, D. L. (2005). Serotonergic-like progenitor cells propagated from neural stem cells in vitro: Survival with SERT protein expression following implantation into brains of mice lacking SERT. FASEB J.19(11):1537, 1539. Google Scholar
Ren-Patterson, R. F., Lauren, W. C., Holmes, A., Sherrill, S., Huang, S.-J., Tolliver, T., Lesch, P. K., and Murphy, L. D. (2005). Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. J. Neurosci. Res. **79:**756–771. PubMedCAS Google Scholar
Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R. M., and Jaenisch, R. (2001). Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol. Endocrinol.15(10):1748–1757. PubMedCAS Google Scholar
Rumajogee, P., Madeira, A., Verge, D., Hamon, M., and Miquel, M. C. (2002). Up-regulation of the neuronal serotonergic phenotype in vitro: BDNF and cAMP share TrkB-dependent mechanisms. J. Neurochem.83(6):1525–1528. PubMedCAS Google Scholar
Rumajogee, P., Verge, D., and Hanoun, N., et al. (2004). Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: Involvement of BDNF and camp. Eur. J. Neurosci.19(4):937–944. PubMed Google Scholar
Rumajogee, P., Verge, D., and Darmon, M., et al. (2005). Rapid up-regulation of the neuronal serotoninergic phenotype by brain-derived neurotrophic factor and cyclic adenosine monophosphate: Relation with raphe astrocytes. J. Neurosci. Res.81(4):481–487. PubMedCAS Google Scholar
Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., and Burmeister, M. (2003). A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology **28:**397–401. PubMedCAS Google Scholar
Shimizu, E., Hashimoto, K., Okimura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., and Iyo, M. (2003). Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol. Psychiatry **54:**70–75. PubMedCAS Google Scholar
Smith, M. A., Makino, S., Kim, S. Y., and Kvetnansky, R. (1995). Stress increases brain-derived neurotrophic factor messenger ribonucleic acid in the hypothalamus and pituitary. Endocrinology **136:**3743–3750. PubMedCAS Google Scholar
Siuciak, J. A., Altar, C. A., Wiegand, S. J., and Lindsay, R. M. (1994). Antinoceptive effect of brain-derived neurotrophic factor and neurotrophin-3. Brain Res. **633:**326–330. PubMedCAS Google Scholar
Siuciak, J. A., Boylan, C., Fritsche, M., Altar, C. A., and Lindsay, R. M. (1996). BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain Res. **710:**11–20. PubMedCAS Google Scholar
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., and Lindsay, R. M. (1997). Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol. Biochem. Behav. **56:**131–137. PubMedCAS Google Scholar
Singh, M., Meyer, E. M., and Simpkins, J. W. (1995). The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology **136:**2320–2324. PubMedCAS Google Scholar
Sklar, P., Gabriel, S. B., Mclnnis, M. G., Bennett, P., Lim, Y.-M., Tsan, G., Schaffner, S., Kiorov, G., Jones, I., Owen, M., Craddock, N., DePaulo, J. R., and Lander, E. S. (2002). Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Mol. Psychiatry **7:**579–593. PubMedCAS Google Scholar
Smith, S. S. (1994). Female sex steroid hormones: From receptors to networks to performance-actions on the sensorimotor system. Prog. Neurobiol. **44:**55–86. PubMedCAS Google Scholar
Solum, D. T., and Handa, R. J. (2002). Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus. J. Neurosci.22(7):2650–2659. PubMedCAS Google Scholar
Spenger, C., Hyman, C., Studer, L., Egli, M., Evatouchenko, L., Jackson, C., Dahl-Jorgensen, A., Lindsay, R. M., and Seiler, R. W. (1995). Effects of BDNF on dopaminergic, serotonergic, and GABA-ergic neurons in cultures of human fetal ventral mesencephalon. Exp. Neurol.133(1):50–63. PubMedCAS Google Scholar
Suter-Crazzolara, C. A., Lachmund, Arab, S. F., and Unsicker, K. (1996). Expression of neurotrophins and their receptors in the developing and adult rat adrenal gland. Brain Res. Mol. Brain Res. **43:**351–355. PubMedCAS Google Scholar
Tjurmina, O. A., Armando, I., Saavedra, J. M., Goldstein, D. S., and Murphy, D. L. (2000). Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology143(12):4520–4526. Google Scholar
Tjurmina, O. A., Armando, I., Saavedra, J. M., Li, Q., and Murphy, D. L. (2004). Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress. Ann. NY Acad. Sci. **1018:**99–104. PubMedCAS Google Scholar
Tonra, J. R., Ono, M., and Liu, X. (1999). Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice. Diabetes **48:**588–594. PubMedCAS Google Scholar
Toran-Allerand, C. D., Singh, M., and Setalo, G., Jr. (1999). Novel mechanisms of estrogen action in the brain: New plays in an old story. Front. Neuroendocrinol. **20:**97–121. PubMedCAS Google Scholar
Torres, G. E., Gainetdinov, R. R., and Caron, M. G. (2003). Plasma membrane monoamine transporters: Structure, regulation and function. Nat. Rev. Neurosci.4(1):13–25. PubMedCAS Google Scholar
Vitalis, T., Cases, O., Gillies, K., Hanoun, N., Hamon, M., Seif, I., Gaspar, P., Kind, P., and Price, D. J. (2002). Interactions between TrkB signaling and serotonin excess in the developing murine somatosensory cortex: A role in tangential and radial organization of thalamocortical axons. J. Neurosci.22(12):4987–5000. PubMedCAS Google Scholar
Vogel, C., Mossner, R., Gerlach, M., Heinemann, T., Murphy, D. L., Riederer, P., Lesch, K.-P., and Sommer, C. (2003). Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J. Neurosci.23(2):708–715. PubMedCAS Google Scholar
Wichems, C. H., Li, Q., Holmes, A., Crawley, J. N., Tjurmina, O., Goldstein, D., Andrews, A. M., Lesch, K.-P., and Murphy, D. L. (2000). Mechanisms mediating the increased anxiety-like behavior and excessive responses to stress in mice lacking the serotonin transporter. Soc. Neurosci. Abstr. **26:**400. Google Scholar
Xu, B., Zang, K., Ruff, N. L., Zhang, Y. A., McConnel, S. K., Stryker, M. P., and Reichardt, L. F. (2000). Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron **26:**233–245. PubMedCAS Google Scholar
Yamada, K., Mizuno, M., and Nabeshima, T. (2002). Role for brain-derived neurotrophic factor in learning and memory. Life Sci. **70:**735–744. PubMedCAS Google Scholar
Yan, Q., Elliott, J., and Snider, W. D. (1992). Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature **360:**753–755. PubMedCAS Google Scholar
Yan, Q., Radeke, M. J., Matheson, C. R., Talvenheimo, J., Welcher, A. A., and Feinstein, S. C. (1997). Immunocytochemical localization of TrkB in the central nervous system of the adult. J. Comp. Neurol. **382:**546–547. Google Scholar
Young, A. H., Dow, R. C., Goodwin, G. M., and Fink, G. (1993). The effects of adrenalectomy and ovariectomy on the behavioral and hypothermic responses of rats to 8-hydroxy-2(DI-n-propylamino) tetralin (8-OH-DPAT). Neuropharmacology **32:**653–657. PubMedCAS Google Scholar
Zelena, D., Mergl, Z., Foldes, A., Kovacs, K. J., Toth, Z., and Makara, G. B. (2003). Role of hypothalamic inputs in maintaining pituitary–adrenal responsiveness in repeated restraint. Am. J. Physiol. Endocrinol. Metab.285(5):E1110–E1117. PubMedCAS Google Scholar
Zhou, J., and Lacovitti, L. (2000). Mechanism governing the differentiation of a serotonergic phenotype in culture. Brain Res.877(1):37–46. PubMedCAS Google Scholar