Whole-genome views of chromatin structure (original) (raw)

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Abstract

DNA in eukaryotes is packed into chromatin. The basic component of chromatin is the nucleosome consisting of DNA wrapped around a histone octamer. Inside the cell nucleus, chromatin is folded into higher-order structures through various mechanisms, including repositioning of nucleosomes along the DNA, packing of nucleosomes into more condensed 3-dimensional configurations, looping of chromatin fibres, and tethering of chromosomal regions to nuclear structures. Over the past few years, new microarray-based methods have been developed for the genome-wide mapping of various aspects of chromatin structure. These methods are beginning to provide insights into the different types of chromatin and the architectural principles that govern the 3-dimensional organisation of the genome inside the nucleus.

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1. Netherlands Cancer Institute, Amsterdam, 1066CX, The Netherlands
   Martin Lodén & Bas van Steensel

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1. Martin Lodén
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2. Bas van Steensel
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Correspondence toBas van Steensel.

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Lodén, M., van Steensel, B. Whole-genome views of chromatin structure.Chromosome Res 13, 289–298 (2005). https://doi.org/10.1007/s10577-005-2166-z

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• Issue Date: April 2005
• DOI: https://doi.org/10.1007/s10577-005-2166-z

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