Resveratrol Protects Against Neurotoxicity Induced by Kainic Acid (original) (raw)

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

Increased oxidative stress has been implicated in the mechanisms of excitotoxicity in hippocampus induced by kainic acid (KA), an excitatory glutamate receptor agonist. Resveratrol, a polyphenolic antioxidant compound enriched in grape, is regarded as an important ingredient in red wine to offer cardiovascular and neural protective effects. This study was designed to investigate whether resveratrol treatment may ameliorate neuronal death after KA administration. Adult Sprague Dawley male rats were treated with KA (8 mg/kg) daily for 5 days and another group was treated similarly with KA plus resveratrol (30 mg/kg/day). Three hr after the last treatment protocol, animals were sacrificed, and brain sections were obtained for histochemical and immunohistochemical identification of neurons, astrocytes and microglial cells. After KA administration, significant neuronal death and activation of astrocytes and microglial cells were observed in the hippocampal CA1, CA3 and polymorphic layer (hilar) of the dentate gyrus (DG) (P < 0.001). The KA-induced hippocampal neuronal damage was significantly attenuated by treatment with resveratrol (P < 0.001). Resveratrol also suppressed KA-induced activation of astrocytes and microglial cells. Since increased oxidative stress is a key factor for KA-induced neurotoxicity, this study demonstrated the ability of resveratrol to act as free radical scavenger to protect against neuronal damage caused by excitotoxic insults.

Access this article

Log in via an institution

Subscribe and save

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Medical Pharmacology and Physiology, University of Missouri, 65212, Columbia, MO, USA
    Qun Wang & Albert Y. Sun
  2. Department of Biochemistry, University of Missouri, 65212, Columbia, MO, USA
    Sue Yu, Agnes Simonyi & Grace Y. Sun
  3. Department of Veterinary Medical Diagnostic Laboratory, University of Missouri, 65212, Columbia, MO, USA
    George Rottinghaus

Authors

  1. Qun Wang
    You can also search for this author inPubMed Google Scholar
  2. Sue Yu
    You can also search for this author inPubMed Google Scholar
  3. Agnes Simonyi
    You can also search for this author inPubMed Google Scholar
  4. George Rottinghaus
    You can also search for this author inPubMed Google Scholar
  5. Grace Y. Sun
    You can also search for this author inPubMed Google Scholar
  6. Albert Y. Sun
    You can also search for this author inPubMed Google Scholar

Additional information

Special issue dedicated to Dr. Lawrence F. Eng.

Rights and permissions

About this article

Cite this article

Wang, Q., Yu, S., Simonyi, A. et al. Resveratrol Protects Against Neurotoxicity Induced by Kainic Acid.Neurochem Res 29, 2105–2112 (2004). https://doi.org/10.1007/s11064-004-6883-z

Download citation

Keywords