The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009 (original) (raw)
References
Ahmed, S., Reynolds, B. A., & Weiss, S. (1995). BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronalprecursors. Journal of Neuroscience, 15, 5765–5778. CASPubMed Google Scholar
Akaboshi, S., Hogema, B. M., Novelletto, A., Malaspina, P., Salomons, G. S., Maropoulos, G. D., et al. (2003). Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency. Human Mutation, 22, 442–450. CASPubMed Google Scholar
Allen, E. G., Sherman, S., Abramowitz, A., Leslie, M., Novak, G., Rusin, M., et al. (2005). Examination of the effect of the polymorphic CGG repeat in the FMR1 gene on cognitive performance. Behavior Genetics, 35, 435–445. PubMed Google Scholar
Almeida, O. P., Schwab, S. G., Lautenschlager, N. T., Morar, B., Greenop, K. R., Flicker, L., et al. (2008). KIBRA genetic polymorphism influences episodic memory in later life, but does not increase the risk of mild cognitive impairment. Journal of Cellular and Molecular Medicine, 12, 1672–1676. CASPubMed Google Scholar
Antonini, A., Leenders, K. L., Reist, H., Thomann, R., Beer, H. F., & Locher, J. (1993). Effect of age on D2 dopamine receptors in normal human brain measured by positron emission tomography and [11C] raclopride. Archives of Neurology, 50, 474–480. CASPubMed Google Scholar
Bäckman, L., Nyberg, L., Lindenberger, U., Li, S. C., & Farde, L. (2006). The correlative triad among aging, dopamine, and cognition: current status and future prospects. Neuroscience and Biobehavioral Reviews, 30, 791–807. PubMed Google Scholar
Ball, D., Hill, L., Eley, T. C., Chorney, M. J., Chorney, K., Thompson, L. A., et al. (1998). Dopamine markers and general cognitive ability. NeuroReport, 9, 347–349. CASPubMed Google Scholar
Bannon, M. J., & Whitty, C. J. (1997). Age-related and regional differences in dopamine mRNA expression in human midbrain. Neurology, 48, 969–977. CASPubMed Google Scholar
Barbaux, S., Plomin, R., & Whitehead, A. S. (2000). Polymorphisms of genes controlling homocysteine/folate metabolism and cognitive function. NeuroReport, 11, 1133–1136. CASPubMed Google Scholar
Barnett, J. H., Scoriels, L., & Munafò, M. R. (2008). Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism. Biological Psychiatry, 64, 137–144. CASPubMed Google Scholar
Bartrés-Faz, D., Junqué, C., Serra-Grabulosa, J. M., López-Alomar, A., Moya, A., Bargalló, N., et al. (2002). Dopamine DRD2 Taq I polymorphism associates with caudate nucleus volume and cognitive performance in memory impaired subjects. NeuroReport, 13, 1121–1125. PubMed Google Scholar
Barzilai, N., Atzmon, G., Derby, C. A., Bauman, J. M., & Lipton, R. B. (2006). A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology, 67, 2170–2175. CASPubMed Google Scholar
Bathum, L., von Bornemann Hjelmborg, J., Christiansen, L., McGue, M., Jeune, B., & Christensen, K. (2007). Methylenetetrahydrofolate reductase 677C > T and methionine synthase 2756A > G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 62, 196–201. Google Scholar
Batty, G. D., Wennerstad, K. M., Smith, G. D., Gunnell, D., Deary, I. J., & Tynelius, P. (2009). IQ in early adulthood and mortality by middle age: cohort study of 1 million Swedish men. Epidemiology, 20, 100–109. PubMed Google Scholar
Baune, B. T., Ponath, G., Rothermundt, M., Riess, O., Funke, H., & Berger, K. (2008). Association between genetic variants of IL-1beta, IL-6 and TNF-alpha cytokines and cognitive performance in the elderly general population of the MEMO-study. Psychoneuroendocrinology, 33, 68–76. CASPubMed Google Scholar
Bendixen, M. H., Nexø, B. A., Bohr, V. A., Frederiksen, H., McGue, M., Kølvraa, S., et al. (2004). A polymorphic marker in the first intron of the Werner gene associates with cognitive function in aged Danish twins. Experimental Gerontology, 39, 1101–1107. CASPubMed Google Scholar
Benson, M. A., Newey, S. E., Martin-Rendon, E., Hawkes, R., & Blake, D. J. (2001). Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. Journal of Biological Chemistry, 276, 24232–24241. CASPubMed Google Scholar
Berman, S. M., & Noble, E. P. (1995). Reduced visuospatial performance in children with the D2 dopamine receptor A1 allele. Behavior Genetics, 25, 45–58. CASPubMed Google Scholar
Blasi, P., Boyl, P. P., Ledda, M., Novelletto, A., Gibson, K. M., Jakobs, C., et al. (2002). Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms. Molecular Genetics and Metabolism, 76, 348–362. CASPubMed Google Scholar
Blinkhorn, S. (2005). Intelligence: a gender bender. Nature, 438, 31–32. CASPubMed Google Scholar
Bochdanovits, Z., Gosso, F. M., van den Berg, L., Rizzu, P., Polderman, T. J., Pardo, L. M., et al. (2009). A Functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderly. Behavior Genetics, 39, 15–23. PubMed Google Scholar
Bombin, I., Arango, C., Mayoral, M., Castro-Fornieles, J., Gonzalez-Pinto, A., Gonzalez-Gomez, C., et al. (2008). DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents. Am J Med Genet B Neuropsychiatr Genet, 147B, 873–879. PubMed Google Scholar
Borg, J., Henningsson, S., Saijo, T., Inoue, M., Bah, J., Westberg, L., et al. (2009). Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans. Int J Neuropsychopharmacol, 1-10, (in press) PMID: 19500776.
Bouchard, T. J., Jr., & McGue, M. (2003). Genetic and environmental influences on human psychological differences. Journal of Neurobiology, 54, 4–45. PubMed Google Scholar
Brandi, M. L., Becherini, L., Gennari, L., Racchi, M., Bianchetti, A., Nacmias, B., et al. (1999). Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease. Biochemical and Biophysical Research Communications, 265, 335–338. CASPubMed Google Scholar
Brosh, R. M., Jr., Opresko, P. L., & Bohr, V. A. (2006). Enzymatic mechanism of the WRN helicase/nuclease. Methods in Enzymology, 409, 52–85. CASPubMed Google Scholar
Broughton, S., & Partridge, L. (2009). Insulin/IGF-like signalling, the central nervous system and aging. Biochemical Journal, 418, 1–12. CASPubMed Google Scholar
Bueller, J. A., Aftab, M., Sen, S., Gomez-Hassan, D., Burmeister, M., & Zubieta, J. K. (2006). BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biological Psychiatry, 59, 812–815. CASPubMed Google Scholar
Burdick, K. E., Lencz, T., Funke, B., Finn, C. T., Szeszko, P. R., Kane, J. M., et al. (2006). Genetic variation in DTNBP1 influences general cognitive ability. Human Molecular Genetics, 15, 1563–1568. CASPubMed Google Scholar
Butcher, L. M., Meaburn, E., Knight, J., Sham, P. C., Schalkwyk, L. C., Craig, I. W., et al. (2005). SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children. Human Molecular Genetics, 14, 1315–1325. CASPubMed Google Scholar
Butcher, L. M., Davis, O. S., Craig, I. W., & Plomin, R. (2008). Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500 K single nucleotide polymorphism microarrays. Genes Brain and Behavior, 7, 435–446. CAS Google Scholar
Büther, K., Plaas, C., Barnekow, A., & Kremerskothen, J. (2004). KIBRA is a novel substrate for protein kinase Czeta. Biochemical and Biophysical Research Communications, 317, 703–707. PubMed Google Scholar
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389. CASPubMed Google Scholar
Caspi, A., Williams, B., Kim-Cohen, J., Craig, I. W., Milne, B. J., Poulton, R., et al. (2007). Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proceedings of the National Academy of Sciences of the United States of America, 104, 18860–18865. CASPubMed Google Scholar
Chen, Z. Y., Patel, P. D., Sant, G., Meng, C. X., Teng, K. K., Hempstead, B. L., et al. (2004). Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. Journal of Neuroscience, 24, 4401–4411. CASPubMed Google Scholar
Chorney, M. J., Chorney, K., Seese, N., Owen, M. J., Daniels, J., McGuffin, P., et al. (1998). A quantitative trait locus associated with cognitive ability in children. Psychological Science, 9, 159–166. Google Scholar
Comas-Herrera, A., Wittenberg, R., Pickard, L., & Knapp, M. (2007). Cognitive impairment in older people: future demand for long-term care services and the associated costs. International Journal of Geriatric Psychiatry, 22, 1037–1045. PubMed Google Scholar
Comings, D. E., Comings, B. G., Muhleman, D., Dietz, G., Shahbahrami, B., Tast, D., et al. (1991). The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA, 266, 1793–1800. CASPubMed Google Scholar
Comings, D. E., Wu, S., Rostamkhani, M., McGue, M., Lacono, W. G., Cheng, L. S., et al. (2003). Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition. Molecular Psychiatry, 8, 10–11. CASPubMed Google Scholar
Cook, E. H., Jr., & Scherer, S. W. (2008). Copy-number variations associated with neuropsychiatric conditions. Nature, 455, 919–923. CASPubMed Google Scholar
Cope, N., Harold, D., Hill, G., Moskvina, V., Stevenson, J., Holmans, P., et al. (2005). Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. American Journal of Human Genetics, 76, 581–591. CASPubMed Google Scholar
Corneveaux, J. J., Liang, W. S., Reiman, E. M., Webster, J. A., Myers, A. J., Zismann, V. L., et al. (2009). Evidence for an association between KIBRA and late-onset Alzheimer's disease. Neurobiol Aging, (in press) PMID: 18789830.
Craig, I., & Plomin, R. (2006). Quantitative trait loci for IQ and other complex traits: single-nucleotide polymorphism genotyping using pooled DNA and microarrays. Genes Brain Behav, 5(Suppl 1), 32–37. CASPubMed Google Scholar
Crawford, D. C., Acuna, J. M., & Sherman, S. L. (2001). FMR1 and the fragile X syndrome: human genome epidemiology review. Genetics in Medicine, 3, 359–371. CASPubMed Google Scholar
Deary, I. J. (2001). Human intelligence differences: a recent history. Trends in Cognitive Sciences, 5, 127–130. PubMed Google Scholar
Deary, I. J., Hamilton, G., Hayward, C., Whalley, L. J., Powell, J., Starr, J. M., et al. (2005). Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing. Neuroscience Letters, 373, 110–114. CASPubMed Google Scholar
Deary, I. J., Johnson, W., & Houlihan, L. M. (2009). Genetic foundations of human intelligence. Hum Genet, (in press) PMID: 19294424.
Dempster, E. L., Toulopoulou, T., McDonald, C., Bramon, E., Walshe, M., Wickham, H., et al. (2006). Episodic memory performance predicted by the 2 bp deletion in exon 6 of the “alpha 7-like” nicotinic receptor subunit gene. American Journal of Psychiatry, 163, 1832–1834. PubMed Google Scholar
Deshmukh, A., Rodrigue, K. M., Kennedy, K. M., Land, S., Jacobs, B. S., & Raz, N. (2009). Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation. Biological Psychology, 80, 240–245. PubMed Google Scholar
de Blasi, S., Montesanto, A., Martino, C., Dato, S., De Rango, F., Bruni, A. C., et al. (2009). APOE polymorphism affects episodic memory among non demented elderly subjects. Experimental Gerontology, 44, 224–227. PubMed Google Scholar
de Frias, C. M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., & Nilsson, L. G. (2004). COMT gene polymorphism is associated with declarative memory in adulthood and old age. Behavior Genetics, 34, 533–539. PubMed Google Scholar
de Frias, C. M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., & Nilsson, L. G. (2005). Catechol O-methyltransferase Val158Met polymorphism is associated with cognitive performance in nondemented adults. Journal of Cognitive Neuroscience, 17, 1018–1025. PubMed Google Scholar
de Lau, L. M., van Meurs, J. B., Uitterlinden, A. G., Smith, A. D., Refsum, H., Johnston, C.,et al. (2009). Genetic variation in homocysteine metabolism, cognition, and white matter lesions. Neurobiol Aging, 2009, (in press) PMID: 19019492.
de Quervain, D. J., Henke, K., Aerni, A., Coluccia, D., Wollmer, M. A., Hock, C., et al. (2003). A functional genetic variation of the 5-HT2a receptor affects human memory. Nature Neuroscience, 6, 1141–1142. PubMed Google Scholar
de Rango, F., Leone, O., Dato, S., Novelletto, A., Bruni, A. C., Berardelli, M., et al. (2008). Cognitive functioning and survival in the elderly: the SSADH C538T polymorphism. Annals of Human Genetics, 72, 630–635. PubMed Google Scholar
Dick, D. M., Aliev, F., Kramer, J., Wang, J. C., Hinrichs, A., Bertelsen, S., et al. (2007). Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. Behavior Genetics, 37, 265–272. PubMed Google Scholar
Dickstein, D. L., Kabaso, D., Rocher, A. B., Luebke, J. I., Wearne, S. L., & Hof, P. R. (2007). Changes in the structural complexity of the aged brain. Aging Cell, 6, 275–284. CASPubMed Google Scholar
Dröge, W., & Schipper, H. M. (2007). Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell, 6, 361–370. PubMed Google Scholar
Durga, J., van Boxtel, M. P., Schouten, E. G., Bots, M. L., Kok, F. J., & Verhoef, P. (2006). Folate and the methylenetetrahydrofolate reductase 677C− > T mutation correlate with cognitive performance. Neurobiology of Aging, 27, 334–343. CASPubMed Google Scholar
Duron, E., & Hanon, O. (2008). Vascular risk factors, cognitive decline, and dementia. Vascular Health and Risk Management, 4, 363–381. CASPubMed Google Scholar
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., et al. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257–269. CASPubMed Google Scholar
Epstein, C. J., Martin, G. M., Schultz, A. L., & Motulsky, A. G. (1966). Werner’s syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine, 45, 177–221. CASPubMed Google Scholar
Erickson, K. I., Kim, J. S., Suever, B. L., Voss, M. W., Francis, B. M., & Kramer, A. F. (2008). Genetic Contributions to Age-Related Decline in Executive Function: A 10-Year Longitudinal Study of COMT and BDNF Polymorphisms. Frontiers in Human Neuroscience, 2, 11. PubMed Google Scholar
Espeseth, T., Greenwood, P. M., Reinvang, I., Fjell, A. M., Walhovd, K. B., Westlye, L. T., et al. (2006). Interactive effects of APOE and CHRNA4 on attention and white matter volume in healthy middle-aged and older adults. Cognitive Affective & Behavioral Neuroscience, 6, 31–43. Google Scholar
Finkel, D., Reynolds, C. A., McArdle, J. J., & Pedersen, N. L. (2005). The longitudinal relationship between processing speed and cognitive ability: genetic and environmental influences. Behavior Genetics, 35, 535–549. PubMed Google Scholar
Finkel, D., Reynolds, C. A., Berg, S., & Pedersen, N. L. (2006). Surprising lack of sex differences in normal cognitive aging in twins. International Journal of Aging and Human Development, 62, 335–357. PubMed Google Scholar
Finkel, D., Reynolds, C. A., McArdle, J. J., & Pedersen, N. L. (2007). Age changes in processing speed as a leading indicator of cognitive aging. Psychology and Aging, 22, 558–568. PubMed Google Scholar
Finkel, D., Reynolds, C. A., McArdle, J. J., Hamagami, F., & Pedersen, N. L. (2009). Genetic Variance in Processing Speed Drives Variation in Aging of Spatial and Memory Abilities. Developmental Psychology, 45, 820–834. PubMed Google Scholar
Fisher, P. J., Turic, D., Williams, N. M., McGuffin, P., Asherson, P., Ball, D., et al. (1999). DNA pooling identifies QTLs on chromosome 4 for general cognitive ability in children. Human Molecular Genetics, 8, 915–922. CASPubMed Google Scholar
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 313, 1419–1420. Google Scholar
Francks, C., Paracchini, S., Smith, S. D., Richardson, A. J., Scerri, T. S., Cardon, L. R., et al. (2004). A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Am J Hum Genet, 75, 1046 –1058. Google Scholar
Frodl, T., Schule, C., Schmitt, G., Born, C., Baghai, T., Zill, P., et al. (2007). Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Archives of General Psychiatry, 64, 410–416. CASPubMed Google Scholar
Froehlich, T. E., Lanphear, B. P., Dietrich, K. N., Cory-Slechta, D. A., Wang, N., & Kahn, R. S. (2007). Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Biological Psychiatry, 62, 243–249. CASPubMed Google Scholar
Fuster, J. M. (2001). The prefrontal cortex - an update: Time is of the essence. Neuron, 30, 319–333. CASPubMed Google Scholar
Gelernter, J., Yu, Y., Weiss, R., Brady, K., Panhuysen, C., Yang, B. Z., et al. (2006). Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Human Molecular Genetics, 15, 3498–3507. CASPubMed Google Scholar
Gibson, K. M. (2005). Gamma-hydroxybutyric aciduria: a biochemist’s education from a heritable disorder of GABA metabolism. Journal of Inherited Metabolic Disease, 28, 247–265. CASPubMed Google Scholar
Glymour, M. M., Weuve, J., & Chen, J. T. (2008). Methodological challenges in causal research on racial and ethnic patterns of cognitive trajectories: measurement, selection, and bias. Neuropsychology Review, 18, 194–213. PubMed Google Scholar
Goldman-Rakic, P. S., Muly, E. C., & Williams, G. V. (2000). D(1) receptors in prefrontal cells and circuits. Brain Research Brain Research Reviews, 31, 295–301. CASPubMed Google Scholar
Gosso, M. F., van Belzen, M., de Geus, E. J., Polderman, J. C., Heutink, P., Boomsma, D. I., et al. (2006a). Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families. Genes Brain and Behavior, 5, 577–584. CAS Google Scholar
Gosso, M. F., de Geus, E. J., van Belzen, M. J., Polderman, T. J., Heutink, P., Boomsma, D. I., et al. (2006b). The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts. Molecular Psychiatry, 11, 878–886. CASPubMed Google Scholar
Gosso, F. M., de Geus, E. J., Polderman, T. J., Boomsma, D. I., Posthuma, D., & Heutink, P. (2007). Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study. BMC Medical Genetics, 8, 66. PubMed Google Scholar
Gosso, M. F., de Geus, E. J., Polderman, T. J., Boomsma, D. I., Heutink, P., & Posthuma, D. (2008). Common variants underlying cognitive ability: further evidence for association between the SNAP-25 gene and cognition using a family-based study in two independent Dutch cohorts. Genes Brain and Behavior, 7, 355–364. CAS Google Scholar
Göthert, M., Propping, P., Bönisch, H., Brüss, M., & Nöthen, M. M. (1998). Genetic variation in human 5-HT receptors: potential pathogenetic and pharmacological role. Annals of the New York Academy of Sciences, 861, 26–30. PubMed Google Scholar
Goto, M. (1997). Hierarchical deterioration of body systems in Werner’s syndrome: implications for normal aging. Mechanisms of Ageing and Development, 98, 239–254. CASPubMed Google Scholar
Goto, M., Miller, R. W., Ishikawa, Y., & Sugano, H. (1996). Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiology, Biomarkers and Prevention, 5, 239–246. CASPubMed Google Scholar
Greenwood, P. M., Lin, M. K., Sundararajan, R., Fryxell, K. J., & Parasuraman, R. (2009). Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory. Proceedings of the National Academy of Sciences of the United States of America, 106, 3633–3638. CASPubMed Google Scholar
Gustafson, D., Rothenberg, E., Blennow, K., Steen, B., & Skoog, I. (2003). An 18-year follow-up of overweight and risk of Alzheimer disease. Archives of Internal Medicine, 163, 1524–1528. PubMed Google Scholar
Hall, J., Whalley, H. C., Job, D. E., Baig, B. J., McIntosh, A. M., Evans, K. L., et al. (2006). A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nature Neuroscience, 9, 1477–1478. CASPubMed Google Scholar
Hansell, N. K., James, M. R., Duffy, D. L., Birley, A. J., Luciano, M., Geffen, G. M., et al. (2007). Effect of the BDNF V166M polymorphism on working memory in healthy adolescents. Genes Brain and Behavior, 6, 260–268. CAS Google Scholar
Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology, 11, 298–300. CASPubMed Google Scholar
Harris, S. E., Fox, H., Wright, A. F., Hayward, C., Starr, J. M., Whalley, L. J., et al. (2006). The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills. Molecular Psychiatry, 11, 505–513. CASPubMed Google Scholar
Harris, S. E., Fox, H., Wright, A. F., Hayward, C., Starr, J. M., Whalley, L. J., et al. (2007). A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. BMC Genetics, 8, 43. PubMed Google Scholar
Hattersley, A. T., & McCarthy, M. I. (2005). What makes a good genetic association study? Lancet, 366, 1315–1323. PubMed Google Scholar
Hattiangady, B., Rao, M. S., Shetty, G. A., & Shetty, A. K. (2005). Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus. Experimental Neurology, 195, 353–371. CASPubMed Google Scholar
Heiman, G. A., Hodge, S. E., Gorroochurn, P., Zhang, J., & Greenberg, D. A. (2004). Effect of population stratification on case-control association studies. I. Elevation in false positive rates and comparison to confounding risk ratios (a simulation study). Human Heredity, 58, 30–39. PubMed Google Scholar
Hill, L., Chorney, M. J., Lubinski, D., Thompson, L. A., & Plomin, R. (2002). A quantitative trait locus not associated with cognitive ability in children: a failure to replicate. Psychological Science, 13, 561–562. PubMed Google Scholar
Houlihan, L. M., Harris, S. E., Luciano, M., Gow, A. J., Starr, J. M., Visscher, P. M., et al. (2009). Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936. Genes Brain and Behavior, 8, 238–247. CAS Google Scholar
Hranilovic, D., Stefulj, J., Schwab, S., Borrmann-Hassenbach, M., Albus, M., Jernej, B., et al. (2004). Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biological Psychiatry, 55, 1090–1094. CASPubMed Google Scholar
Huang, W., Payne, T. J., Ma, J. Z., Beuten, J., Dupont, R. T., Inohara, N., et al. (2009a). Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Neuropsychopharmacology, 34, 319–330. CASPubMed Google Scholar
Huang, L., Li, Y., Singleton, A. B., Hardy, J. A., Abecasis, G., Rosenberg, N. A., et al. (2009b). Genotype-imputation accuracy across worldwide human populations. American Journal of Human Genetics, 84, 235–250. CASPubMed Google Scholar
Huppert, F. A., Cabelli, S. T., & Matthews, F. E. (2005). MRC Cognitive Function and Ageing Study. Brief cognitive assessment in a UK population sample — distributional properties and the relationship between the MMSE and an extended mental state examination. BMC Geriatric, 5, 7. Google Scholar
Iizuka, Y., Sei, Y., Weinberger, D. R., & Straub, R. E. (2007). Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization. Journal Neuroscience, 27, 12390–12395. CAS Google Scholar
Irwing, P., & Lynn, R. (2005). Sex differences in means and variability on the progressive matrices in university students: a meta-analysis. British Journal of Psychology, 96, 505–524. PubMed Google Scholar
Irwing, P., & Lynn, R. (2006). Intelligence: is there a sex difference in IQ scores? Nature, 442, E1–E2. CASPubMed Google Scholar
Izumi, A., Iijima, Y., Noguchi, H., Numakawa, T., Okada, T., Hori, H., et al. (2008). Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions. Neuropsychopharmacology, 33, 3237–3245. CASPubMed Google Scholar
Johannsen, S., Duning, K., Pavenstädt, H., Kremerskothen, J., & Boeckers, T. M. (2008). Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA. Neuroscience, 155, 1165–1173. CASPubMed Google Scholar
Johnson, W., Harris, S. E., Collins, P., Starr, J. M., Whalley, L. J., & Deary, I. J. (2007). No association of CETP genotype with cognitive function or age-related cognitive change. Neuroscience Letters, 420, 189–192. CASPubMed Google Scholar
Johnson, W., Harris, S. E., Starr, J. M., Whalley, L. J., & Deary, I. J. (2008). PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes. Neuroscience Letters, 434, 50–55. CASPubMed Google Scholar
Kaasinen, V., Vilkman, H., Hietala, J., Nagren, K., Helenius, H., Olsson, H., et al. (2000). Age-related D2/D3 receptor loss in extrastriatal regions of the human brain. Neurobiology of Aging, 21, 683–688. CASPubMed Google Scholar
Kachiwala, S. J., Harris, S. E., Wright, A. F., Hayward, C., Starr, J. M., Whalley, L. J., et al. (2005). Genetic influences on oxidative stress and their association with normal cognitive ageing. Neuroscience Letters, 386, 116–120. CASPubMed Google Scholar
Kavvoura, F. K., & Ioannidis, J. P. (2008). Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. Human Genetics, 123, 1–14. PubMed Google Scholar
Kearney-Schwartz, A., Rossignol, P., Bracard, S., Felblinger, J., Fay, R., Boivin, J. M., et al. (2009). Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke, 40, 1229–1236. PubMed Google Scholar
Kim, J. H., Ellwood, P. E., & Asher, M. I. (2009). Diet and asthma: looking back, moving forward. Respiratory Research, 10, 49. PubMed Google Scholar
Kirov, G., Grozeva, D., Norton, N., Ivanov, D., Mantripragada, K. K., Holmans, P., et al. (2009). Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Human Molecular Genetics, 18, 1497–1503. CASPubMed Google Scholar
Kloppenborg, R. P., van den Berg, E., Kappelle, L. J., & Biessels, G. J. (2008). Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review. European Journal of Pharmacology, 585, 97–108. CASPubMed Google Scholar
Komulainen, P., Pedersen, M., Hänninen, T., Bruunsgaard, H., Lakka, T. A., Kivipelto, M., et al. (2008). BDNF is a novel marker of cognitive function in ageing women: the DR’s EXTRA Study. Neurobiology of Learning and Memory, 90, 596–603. CASPubMed Google Scholar
Kudlow, B. A., Kennedy, B. K., & Monnat, R. J., Jr. (2007). Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nature Reviews Molecular Cell Biology, 8, 394–404. CASPubMed Google Scholar
Kumar, R. A., & Christian, S. L. (2009). Genetics of autism spectrum disorders. Current Neurology and Neuroscience Reports, 9, 188–197. PubMed Google Scholar
Kuningas, M., Slagboom, P. E., Westendorp, R. G., & van Heemst, D. (2006). Impact of genetic variations in the WRN gene on age related pathologies and mortality. Mechanisms of Ageing and Development, 127, 307–313. CASPubMed Google Scholar
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y. M., Szumlanski, C. L., & Weinshilboum, R. M. (1996). Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6, 243–250. CASPubMed Google Scholar
Lambert, J. C., Ferreira, S., Gussekloo, J., Christiansen, L., Brysbaert, G., Slagboom, E., et al. (2007). Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly. Molecular Psychiatry, 12, 870–880. CASPubMed Google Scholar
Lin, B. K., Clyne, M., Walsh, M., Gomez, O., Yu, W., Gwinn, M., et al. (2006). Tracking the epidemiology of human genes in the literature: the HuGE Published Literature database. American Journal of Epidemiology, 164, 1–4. PubMed Google Scholar
Lind, P. A., Luciano, M., Horan, M., Marioni, R. E., Wright, M. J., Montgomery, G. W., et al. (2009). No association between cholinergic muscarinic receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples. Beh Genet, (in press) PMID: 19418213.
Lindenberger, U., Nagel, I. E., Chicherio, C., Li, S. C., Heekeren, H. R., & Bäckman, L. (2008). Age-related decline in brain resources modulates genetic effects on cognitive functioning. Frontiers in Neuroscience, 2, 234–244. CASPubMed Google Scholar
Luciano, M., Lind, P. A., Duffy, D. L., Castles, A., Wright, M. J., Montgomery, G. W., et al. (2007). A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability. Biological Psychiatry, 62, 811–817. CASPubMed Google Scholar
Luciano, M., Lind, P. A., Deary, I. J., Payton, A., Posthuma, D., Butcher, L. M., et al. (2008). Testing replication of a 5-SNP set for general cognitive ability in six population samples. European Journal of Human Genetics, 16, 1388–1395. CASPubMed Google Scholar
Luciano, M., Miyajima, F., Lind, P. A., Bates, T. C., Horan, M., Harris, S. E., et al. (2009a). Variation in the Dysbindin gene and normal cognitive function in three independent population samples. Genes Brain and Behavior, 8, 218–227. CAS Google Scholar
Luciano, M., Gow, A. J., Taylor, M. D., Hayward, C., Harris, S. E., Campbell, H., et al. (2009b). Apolipoprotein E is not related to memory abilities at 70 years of age. Behavior Genetics, 39, 6–14. PubMed Google Scholar
Luo, Y., & Roth, G. S. (2000). The roles of dopamine oxidative stress and dopamine receptor signaling in aging and age-related neurodegeneration. Antiox Redox Signal, 2, 449–460. CAS Google Scholar
Ma, S. Y., Ciliax, B. J., Stebbins, G., Jaffar, S., Joyce, J. N., Cochran, E. J., et al. (1999). Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra. Journal of Comparative Neurology, 409, 25–37. CASPubMed Google Scholar
Marshall, F. H. (2008). The role of GABA(B) receptors in the regulation of excitatory neurotransmission. Results and Problems in Cell Differentiation, 44, 87–98. CASPubMed Google Scholar
Maruyama, H., Toji, H., Harrington, C. R., Sasaki, K., Izumi, Y., Ohnuma, T., et al. (2000). Lack of an association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer disease. Archives of Neurology, 57, 236–240. CASPubMed Google Scholar
Mattson, M. P., Chan, S. L., & Duan, W. (2002). Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiological Reviews, 82, 637–672. CASPubMed Google Scholar
McAllister, T. W., Flashman, L. A., Harker-Rhodes, C., Tyler, A. L., Moore, J. H., Saykin, A. J., et al. (2008). Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. Brain Injury, 22, 705–714. PubMed Google Scholar
McArdle, J. J., Prescott, C. A., Hamagami, F., & Horn, J. L. (1998). A contempory method for developmental-genetic analysis of age changes in intellectual abilities. Developmental Neuropsychology, 14, 69–114. Article Google Scholar
McGue, M., & Christensen, K. (2002). The heritability of level and rate-of-change in cognitive functioning in Danish twins aged 70 years and older. Experimental Aging Research, 28, 435–451. PubMed Google Scholar
MacKenzie, A., & Quinn, J. (1999). A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proceedings of the National Academy of Sciences of the United States of America, 96, 15251–15255. CASPubMed Google Scholar
Meaburn, E. L., Harlaar, N., Craig, I. W., Schalkwyk, L. C., & Plomin, R. (2008). Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100 K SNP microarrays in a sample of 5760 children. Molecular Psychiatry, 13, 729–740. CASPubMed Google Scholar
Meneses, A. (1999). 5-HT system and cognition. Neuroscience and Biobehavioral Reviews, 23, 1111–1125. CASPubMed Google Scholar
Meyer-Lindenberg, A., Straub, R. E., Lipska, B. K., Verchinski, B. A., Goldberg, T., Callicott, J. H., et al. (2007). Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. Journal of Clinical Investigation, 117, 672–682. CASPubMed Google Scholar
Miyajima, F., Ollier, W., Mayes, A., Jackson, A., Thacker, N., Rabbitt, P., et al. (2008a). Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly. Genes Brain Behav, 7, 411–417. CASPubMed Google Scholar
Miyajima, F., Quinn, J. P., Horan, M., Pickles, A., Ollier, W. E., Pendleton, N., et al. (2008b). Additive effect of BDNF and REST polymorphisms is associated with improved general cognitive ability. Genes Brain and Behavior, 7, 714–719. CAS Google Scholar
Moises, H. W., Frieboes, R. M., Spelzhaus, P., Yang, L., Köhnke, M., Herden-Kirchhoff, O., et al. (2001). No association between dopamine D2 receptor gene (DRD2) and human intelligence. Journal of Neural Transmission, 108, 115–121. CASPubMed Google Scholar
Morales, E., Sunyer, J., Castro-Giner, F., Estivill, X., Julvez, J., Ribas-Fitó, N., et al. (2008). Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by p, p’-DDT among preschoolers. Environmental Health Perspectives, 116, 1581–1585. CASPubMed Google Scholar
Mori, E., Hirono, N., Yamashita, H., Imamura, T., Ikejiri, Y., Ikeda, M., et al. (1997). Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer’s disease. American Journal of Psychiatry, 154, 18–24. CASPubMed Google Scholar
Morrison, J. H., & Hof, P. R. (1997). Life and death of neurons in the aging brain. Science, 278, 412–419. CASPubMed Google Scholar
Nacmias, B., Bessi, V., Bagnoli, S., Tedde, A., Cellini, E., Piccini, C., et al. (2008). KIBRA gene variants are associated with episodic memory performance in subjective memory complaints. Neuroscience Letters, 436, 145–147. CASPubMed Google Scholar
Nagel, I. E., Chicherio, C., Li, S. C., von Oertzen, T., Sander, T., Villringer, A., et al. (2008). Human aging magnifies genetic effects on executive functioning and working memory. Frontiers in Human Neuroscience, 2, 1. PubMed Google Scholar
Need, A. C., Attix, D. K., McEvoy, J. M., Cirulli, E. T., Linney, K. N., Wagoner, A. P., et al. (2008). Failure to replicate effect of Kibra on human memory in two large cohorts of European origin. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 667–668. CAS Google Scholar
Neubauer, A. C., Grabner, R. H., Fink, A., & Neuper, C. (2005). Intelligence and neural efficiency: further evidence of the influence of task content and sex on the brain-IQ relationship. Brain Research Cognitive Brain Research, 25, 217–225. PubMed Google Scholar
Neville, M. J., Johnstone, E. C., & Walton, R. T. (2004). Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Human Mutation, 23, 540–545. CASPubMed Google Scholar
Nicodemus, K. K., Luna, A., Vakkalanka, R., Goldberg, T., Egan, M., Straub, R. E., et al. (2006). Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls. Molecular Psychiatry, 11, 1062–1065. CASPubMed Google Scholar
Okada, T., Hashimoto, R., Numakawa, T., Iijima, Y., Kosuga, A., Tatsumi, M., et al. (2006). A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity. Molecular Psychiatry, 11, 695–703. CASPubMed Google Scholar
Opgen-Rhein, C., Lencz, T., Burdick, K. E., Neuhaus, A. H., DeRosse, P., Goldberg, T. E., et al. (2008). Genetic variation in the DAOA gene complex: impact on susceptibility for schizophrenia and on cognitive performance. Schizophrenia Research, 103, 169–177. PubMed Google Scholar
Papassotiropoulos, A., Henke, K., Aerni, A., Coluccia, D., Garcia, E., Wollmer, M. A., et al. (2005). Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory. NeuroReport, 16, 839–842. CASPubMed Google Scholar
Papassotiropoulos, A., Stephan, D. A., Huentelman, M. J., Hoerndli, F. J., Craig, D. W., Pearson, J. V., et al. (2006). Common Kibra alleles are associated with human memory performance. Science, 314, 475–478. CASPubMed Google Scholar
Parasuraman, R., Greenwood, P. M., Kumar, R., & Fossella, J. (2005). Beyond heritability: neurotransmitter genes differentially modulate visuospatial attention and working memory. Psychological Science, 16, 200–207. PubMed Google Scholar
Payton, A., Holland, F., Diggle, P., Rabbitt, P., Horan, M., Davidson, Y., et al. (2003). Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population. Molecular Psychiatry, 8, 14–18. CASPubMed Google Scholar
Payton, A., Gibbons, L., Davidson, Y., Ollier, W., Rabbitt, P., Worthington, J., et al. (2005). Influence of serotonin transporter gene polymorphisms on cognitive decline and cognitive abilities in a non-demented elderly population. Molecular Psychiatry, 10, 1133–1139. CASPubMed Google Scholar
Payton, A., Horan, M., Davidson, Y., Gibbons, L., Ollier, W., Rabbitt, P., et al. (2006). Influence and interactions of cathepsin D, HLA-DRB1 and APOE on cognitive abilities in an older non-demented population. Genes Brain and Behavior, 5, 23–31. CAS Google Scholar
Peper, J. S., Brouwer, R. M., Boomsma, D. I., Kahn, R. S., & Hulshoff, H. E. (2007). Genetic influences on human brain structure: a review of brain imaging studies in twins. Human Brain Mapping, 28, 464–473. PubMed Google Scholar
Peters, K., Wiltshire, S., Henders, A. K., Dragović, M., Badcock, J. C., Chandler, D., et al. (2008). Comprehensive analysis of tagging sequence variants in DTNBP1 shows no association with schizophrenia or with its composite neurocognitive endophenotypes. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , 147B, 1159–1166. CAS Google Scholar
Petrill, S. A., Plomin, R., McClearn, G. E., Smith, D. L., Vignetti, S., Chorney, M. J., et al. (1997). No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene. Behavior Genetics, 27, 29–31. CASPubMed Google Scholar
Petryshen, T. L., Kaplan, B. J., Liu, M. F., & Field, L. L. (2000). Absence of significant linkage between phonological coding dyslexia and chromosome 6p23-21.3, as determined by use of quantitative-trait methods: confirmation of qualitative analyses. American Journal of Human Genetics, 66, 708–714. CASPubMed Google Scholar
Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., et al. (2004). The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. Journal of Neuroscience, 24, 10099–10102. CASPubMed Google Scholar
Pfefferbaum, A., Sullivan, E. V., Swan, G. E., & Carmelli, D. (2000). Brain structure in men remains highly heritable in the seventh and eighth decades of life. Neurobiology of Aging, 21, 63–74. CASPubMed Google Scholar
Pierce, G. L., Lesniewski, L. A., Lawson, B. R., Beske, S. D., & Seals, D. R. (2009). Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation, 119, 1284–1292. CASPubMed Google Scholar
Pietiläinen, O. P., Paunio, T., Loukola, A., Tuulio-Henriksson, A., Kieseppä, T., Thompson, P., et al. (2009). Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B, 683–692. Google Scholar
Platko, J. V., Wood, F. B., Pelser, I., Meyer, M., Gericke, G. S., O’Rourke, J., et al. (2008). Association of reading disability on chromosome 6p22 in the Afrikaner population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 1278–1287. Google Scholar
Plomin, R. (2003). Genetics, genes, genomics and g. Molecular Psychiatry, 8, 1–5. CASPubMed Google Scholar
Plomin, R., Turic, D. M., Hill, L., Turic, D. E., Stephens, M., Williams, J., et al. (2004). A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability. Molecular Psychiatry, 9, 582–586. CASPubMed Google Scholar
Poo, M. M. (2001). Neurotrophins as synaptic modulators. Nature Reviews Neuroscience, 2, 24–32. CASPubMed Google Scholar
Posthuma, D., Baaré, W. F., Hulshoff Pol, H. E., Kahn, R. S., Boomsma, D. I., & De Geus, E. J. (2003). Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed. Twin Research, 6, 131–139. PubMed Google Scholar
Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., & Timmusk, T. (2007). Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics, 90, 397–406. CASPubMed Google Scholar
Qi, L., & Cho, Y. A. (2008). Gene-environment interaction and obesity. Nutrition Reviews, 66, 684–694. PubMed Google Scholar
Rabbitt, P., & Lowe, C. (2000). Patterns of cognitive ageing. Psychological Research, 63, 308–316. CASPubMed Google Scholar
Rabbitt, P., Diggle, P., Holland, F., & McInnes, L. (2004a). Practice and drop-out effects during a 17-year longitudinal study of cognitive aging. Journal of Gerontology B Psychological Sciences Social Sciences, 59, 84–97. Google Scholar
Rabbitt, P. M. A., Diggle, P., Holland, F., McInnes, L., Bent, N., Abson, V., et al. (2004b). The University of Manchester longitudinal study of cognition in normal healthy old age, 1983 through 2003. Aging, Neuropsychology and Cognition, 11, 245–279. Google Scholar
Ravaglia, G., Forti, P., Maioli, F., Scali, R. C., Arnone, G., Talerico, T., et al. (2004). Common polymorphisms in methylenetetrahydrofolate reductase (MTHFR): relationships with plasma homocysteine concentrations and cognitive status in elderly northern italian subjects. Archives Gerontology and Geriatrics Supplement, 9, 339–348. CAS Google Scholar
Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., Land, S. J., & Jacobs, B. S. (2008). Brain-derived neurotrophic factor Val66Met and blood glucose: a synergistic effect on memory. Frontiers in Human Neuroscience, 2, 12. PubMed Google Scholar
Raz, N., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2009). Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension. Neuropsychology, 23, 105–116. PubMed Google Scholar
Reeves, S., Bench, C., & Howard, R. (2002). Aging and the nigrostriatal dopamine system. International Journal of Geriatric Psychiatry, 17, 359–370. CASPubMed Google Scholar
Rehman, H. U., & Masson, E. A. (2001). Neuroendocrinology of ageing. Age and Ageing, 30, 279–287. CASPubMed Google Scholar
Reynolds, C. A., Finkel, D., Gatz, M., & Pedersen, N. L. (2002). Sources of influence on rate of cognitive change over time in Swedish twins: an application of latent growth models. Experimental Aging Research, 28, 407–433. PubMed Google Scholar
Reynolds, C. A., Jansson, M., Gatz, M., & Pedersen, N. L. (2006). Longitudinal change in memory performance associated with HTR2A polymorphism. Neurobiology of Aging, 27, 150–154. CASPubMed Google Scholar
Ridley, M. (2003). Nature via nurture. New York: Harper Collins. Google Scholar
Rinne, J. O., Lonnberg, P., & Marjamaki, P. (1990). Age-dependent decline of dopamine-D1 and dopamine-D2 receptor. Brain Research, 508, 349–352. CASPubMed Google Scholar
Rodgers, J. T., Lerin, C., Haas, W., Cygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005). Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature, 434, 113–118. CASPubMed Google Scholar
Rodriguez-Murillo, L., & Greenberg, D. A. (2008). Genetic association analysis: a primer on how it works, its strengths and its weaknesses. International Journal of Andrology, 31, 546–556. PubMed Google Scholar
Rodríguez-Rodríguez, E., Infante, J., Llorca, J., Mateo, I., Sánchez-Quintana, C., García-Gorostiaga, I., et al. (2009). Age-dependent association of KIBRA genetic variation and Alzheimer’s disease risk. Neurobiology of Aging, 30, 322–324. PubMed Google Scholar
Ropers, H. H., & Hamel, B. C. (2005). X-linked mental retardation. Nature Reviews Genetics, 6, 46–57. CASPubMed Google Scholar
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009). Lasting epigenetic influence of early-life adversity on the BDNF gene. Biological Psychiatry, 65, 760–769. CASPubMed Google Scholar
Rujescu, D., Hartmann, A. M., Gonnermann, C., Möller, H. J., & Giegling, I. (2003). M129V variation in the prion protein may influence cognitive performance. Molecular Psychiatry, 8, 937–941. CASPubMed Google Scholar
Salthouse, T. A. (1996). The processing-speed theory of adult age differences in cognition. Psychological Review, 103, 403–428. CASPubMed Google Scholar
Sanderson, T. H., Kumar, R., Sullivan, J. M., & Krause, G. S. (2008). Insulin blocks cytochrome c release in the reperfused brain through PI3-K signaling and by promoting Bax/Bcl-XL binding. Journal of Neurochemistry, 106, 1248–1258. CASPubMed Google Scholar
Sarter, M., & Bruno, J. P. (2004). Developmental origins of the age-related decline in cortical cholinergic function and associated cognitive abilities. Neurobiology of Aging, 25, 1127–1139. CASPubMed Google Scholar
Savitz, J., Solms, M., & Ramesar, R. (2006). Apolipoprotein E variants and cognition in healthy individuals: a critical opinion. Brain Research Reviews, 51, 125–135. CASPubMed Google Scholar
Schaper, K., Kolsch, H., Popp, J., Wagner, M., & Jessen, F. (2008). KIBRA gene variants are associated with episodic memory in healthy elderly. Neurobiology of Aging, 29, 1123–1125. CASPubMed Google Scholar
Seshadri, S., DeStefano, A. L., Au, R., Massaro, J. M., Beiser, A. S., Kelly-Hayes, M., et al. (2007). Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. BMC Medical Genetics, 8, S15. PubMed Google Scholar
Sgaravatti, A. M., Sgarbi, M. B., Testa, C. G., Durigon, K., Pederzolli, C. D., Prestes, C. C., et al. (2007). Gamma-hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats. Neurochemistry International, 50, 564–570. CASPubMed Google Scholar
Shenkin, S. D., Rivers, C. S., Deary, I. J., Starr, J. M., & Wardlaw, J. M. (2009). Maximum (prior) brain size, not atrophy, correlates with cognition in community-dwelling older people: a cross-sectional neuroimaging study. BMC Geriatric, 9, 12. Google Scholar
Shepherd, C. E., Piguet, O., Broe, G. A., Creasey, H., Waite, L. M., Brooks, W. S., et al. (2004). Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects. Journal of Neuroimmunology, 148, 178–182. CASPubMed Google Scholar
Shimokata, H., Ando, F., Niino, N., Miyasaka, K., & Funakoshi, A. (2005). Cholecystokinin A receptor gene promoter polymorphism and intelligence. Annals of Epidemiology, 15, 196–201. PubMed Google Scholar
Sild, M., Koca, C., Bendixen, M. H., Frederiksen, H., McGue, M., Kølvraa, S., et al. (2006). Possible associations between successful aging and polymorphic markers in the Werner gene region. Annals of the New York Academy of Sciences, 1067, 309–310. CASPubMed Google Scholar
Spearman, C. (1904). ‘General Intelligence’ objectively determined and measured. American Journal of Psychology, 15, 201–293. Google Scholar
Starr, J. M., Fox, H., Harris, S. E., Deary, I. J., & Whalley, L. J. (2007). COMT genotype and cognitive ability: a longitudinal aging study. Neuroscience Letters, 421, 57–61. CASPubMed Google Scholar
Stefanis, N. C., Trikalinos, T. A., Avramopoulos, D., Smyrnis, N., Evdokimidis, I., Ntzani, E. E., et al. (2007). Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level. Biological Psychiatry, 62, 784–792. CASPubMed Google Scholar
Sullivan, E. V., Pfefferbaum, A., Swan, G. E., & Carmelli, D. (2001). Heritability of hippocampal size in elderly twin men: equivalent influence from genes and environment. Hippocampus, 11, 754–762. CASPubMed Google Scholar
Tan, H. Y., Nicodemus, K. K., Chen, Q., Li, Z., Brooke, J. K., Honea, R., et al. (2008). Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. Journal of Clinical Investigation, 118, 2200–2208. CASPubMed Google Scholar
Tannenbaum, C., Mayo, N., & Ducharme, F. (2005). Older women's health priorities and perceptions of care delivery: results of the WOW health survey. Canadian Medical Association Journal, 173, 153–159. PubMed Google Scholar
Thompson, R. F., & Kim, J. J. (1996). Memory systems in the brain and localization of a memory. Proceedings of the National Academy of Sciences of the United States of America, 93, 13438–13444. CASPubMed Google Scholar
Thomson, P. A., Harris, S. E., Starr, J. M., Whalley, L. J., Porteous, D. J., & Deary, I. J. (2005). Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neuroscience Letters, 389, 41–45. CASPubMed Google Scholar
Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., et al. (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature, 452, 638–642. CASPubMed Google Scholar
Togsverd, M., Werge, T. M., Tankó, L. B., Bagger, Y. Z., Qin, G. G., Hansen, T., et al. (2007). Cognitive performance in elderly women: significance of the 19 bp insertion/deletion polymorphism in the 5' flank of the dopamine beta-hydroxylase gene, educational level, body fat measures, serum triglyceride, alcohol consumption and age. International Journal of Geriatric Psychiatry, 22, 883–889. PubMed Google Scholar
Tombaugh, T. N., & McIntyre, N. J. (1992). The mini-mental state examination: a comprehensive review. Journal of the American Geriatrics Society, 40, 922–935. CASPubMed Google Scholar
Tsai, S. J., Yu, Y. W., Lin, C. H., Chen, T. J., Chen, S. P., & Hong, C. J. (2002). Dopamine D2 receptor and N-methyl-D-aspartate receptor 2B subunit genetic variants and intelligence. Neuropsychobiology, 45, 128–130. CASPubMed Google Scholar
Tsai, S. J., Gau, Y. T., Liu, M. E., Hsieh, C. H., Liou, Y. J., & Hong, C. J. (2008). Association study of brain-derived neurotrophic factor and apolipoprotein E polymorphisms and cognitive function in aged males without dementia. Neuroscience Letters, 433, 158–162. CASPubMed Google Scholar
van den Berg, E., Kloppenborg, R. P., Kessels, R. P., Kappelle, L. J., & Biessels, G. J. (2009). Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition. Biochimica et Biophysica Acta, 1792, 470–481. PubMed Google Scholar
van Kesteren, R. E., & Spencer, G. E. (2003). The role of neurotransmitters in neurite outgrowth and synapse formation. Reviews in the Neurosciences, 14, 217–231. PubMed Google Scholar
Versijpt, J., Van Laere, K. J., Dumont, F., Decoo, D., Vandecapelle, M., Santens, P., et al. (2003). Imaging of the 5-HT2A system: age-, gender-, and Alzheimer's disease-related findings. Neurobiology of Aging, 24, 553–561. CASPubMed Google Scholar
Visscher, P. M., Tynan, M., Whiteman, M. C., Pattie, A., White, I., Hayward, C., et al. (2003). Lack of association between polymorphisms in angiotensin-converting-enzyme and methylenetetrahydrofolate reductase genes and normal cognitive ageing in humans. Neuroscience Letters, 347, 175–178. CASPubMed Google Scholar
Volkow, N. D., Gur, R. C., Wang, G. J., Fowler, J. S., Moberg, P. J., Ding, Y. S., et al. (1998). Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals. American Journal of Psychiatry, 155, 344–349. CASPubMed Google Scholar
Wacholder, S., Rothman, N., & Caporaso, N. (2002). Counterpoint: bias from population stratification is not a major threat to the validity of conclusions from epidemiological studies of common polymorphisms and cancer. Cancer Epidemiology Biomarkers Prevention, 11, 513–520. Google Scholar
Wang, H., Yuan, G., Prabhakar, N. R., Boswell, M., & Katz, D. M. (2006). Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling. Journal of Neurochemistry, 96, 694–705. CASPubMed Google Scholar
Wang, F. T., Hu, H., Schwartz, J., Weuve, J., Spiro, A. S., Sparrow, D., et al. (2007). Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline. Environmental Health Perspectives, 115, 1210–1215. ArticleCASPubMed Google Scholar
Webster, M. J., Weickert, C. S., Herman, M., & Kleinman, J. E. (2002). BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex. Developmental Brain Research, 139, 139–150. CASPubMed Google Scholar
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994). Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer’s disease. Lancet, 344, 769–772. CASPubMed Google Scholar
Whitmer, R. A., Gunderson, E. P., Quesenberry, C. P., Jr., Zhou, J., & Yaffe, K. (2007). Body mass index in midlife and risk of Alzheimer disease and vascular dementia. Current Alzheimer Research, 4, 103–109. CASPubMed Google Scholar
Wisdom, N. M., Callahan, J. L., & Hawkins, K. A. (2009). The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis. Neurobiol Aging, (in press) PMID: 19285755.
Yaffe, K., Kanaya, A. M., Lindquist, K., Hsueh, W. C., Cummings, S. R., Beamer, B., et al. (2008). Health ABC Study. PPAR-gamma Pro12Ala genotype and risk of cognitive decline in elders. Neurobiology of Aging, 29(1), 78–83. CASPubMed Google Scholar
Yaffe, K., Lindquist, K., Sen, S., Cauley, J., Ferrell, R., Penninx, B., et al. (2009). Estrogen receptor genotype and risk of cognitive impairment in elders: Findings from the Health ABC study. Neurobiology of Aging, 30, 607–614. CASPubMed Google Scholar
Yang, B. Z., Kranzler, H. R., Zhao, H., Gruen, J. R., Luo, X., & Gelernter, J. (2008). Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. Alcoholism, Clinical and Experimental Research, 32, 2117–2127. CASPubMed Google Scholar
Yu, Y. W., Tsai, S. J., Hong, C. J., Chen, M. C., Yang, C. W., & Chen, T. J. (2005). Association study of a functional MAOA-uVNTR gene polymorphism and cognitive function in healthy females. Neuropsychobiology, 52, 77–82. CASPubMed Google Scholar
Zinkstok, J. R., de Wilde, O., van Amelsvoort, T. A., Tanck, M. W., Baas, F., & Linszen, D. H. (2007). Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings. Behavioral and Brain Functions, 3, 19. PubMed Google Scholar