Center for Disease Control and Prevention (CDC): Annual smoking-attributable mortality, years of potential life lost, and productivity losses—United States, 1997–2001. MMWR Morb Mortal Wkly Rep 2005, **54:**625–628. Google Scholar
Centers for Disease Control and Prevention (CDC): Annual smoking-attributable mortality, years of potential life lost, and economic costs—United States, 1995–1999. MMWR Morb Mortal Wkly Rep 2002, **51:**300–303. Google Scholar
Centers for Disease Control and Prevention (CDC): Cigarette smoking among adults—United States, 2004. MMWR Morb Mortal Wkly Rep 2005, **54:**1121–1124. Google Scholar
Nestler EJ: Is there a common molecular pathway for addiction?Nat Neurosci 2005, **8:**1445–1449. ArticlePubMedCAS Google Scholar
Laviolette SR, van der Kooy D: The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour. Nat Rev Neurosci 2004, **5:**55–65. ArticlePubMedCAS Google Scholar
Barik J, Wonnacott S: Indirect modulation by alpha7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawal. Mol Pharmacol 2006, **69:**618–628. ArticlePubMedCAS Google Scholar
Boyadjieva NI, Sarkar DK: The secretory response of hypothalamic beta-endorphin neurons to acute and chronic nicotine treatments and following nicotine withdrawal. Life Sci 1997, **61:**59–66. Article Google Scholar
Ho MK, Tyndale RF: Overview of the pharmacogenomics of cigarette smoking. Pharmacogenomics J 2007, **7:**81–98. ArticlePubMedCAS Google Scholar
Li MD, Cheng R, Ma JZ, Swan GE: A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 2003, **98:**23–31. ArticlePubMed Google Scholar
Sullivan PF, Kendler KS: The genetic epidemiology of smoking. Nicotine Tob Res 1999, **1(Suppl 2):**S51–S57. ArticlePubMed Google Scholar
Hamilton AS, Lessóv-Schlaggar CN, Cockburn MG, et al.: Gender differences in determinants of smoking initiation and persistence in California twins. Cancer Epidemiol Biomarkers Prev 2006, **15:**1189–1197. ArticlePubMed Google Scholar
Li MD: The genetics of smoking related behavior: a brief review. Am J Med Sci 2003, **326:**168–173. ArticlePubMed Google Scholar
Osler M, Holst C, Prescott E, Sorensen TI: Influence of genes and family environment on adult smoking behavior assessed in an adoption study. Genet Epidemiol 2001, **21:**193–200. ArticlePubMedCAS Google Scholar
Haberstick BC, Timberlake D, Ehringer MA, et al.: Genes, time to first cigarette and nicotine dependence in a general population sample of young adults. Addiction 2007, **102:**655–665. ArticlePubMed Google Scholar
Hopfer CJ, Crowley TJ, Hewitt JK: Review of twin and adoption studies of adolescent substance use. J Am Acad Child Adolesc Psychiatry 2003, **42:**710–719. ArticlePubMed Google Scholar
Vink JM, Willemsen G, Boomsma DI: Heritability of smoking initiation and nicotine dependence. Behav Genet 2005, **35:**397–406. ArticlePubMed Google Scholar
Xian H, Scherrer JF, Madden PA, et al.: The heritability of failed smoking cessation and nicotine withdrawal in twins who smoked and attempted to quit. Nicotine Tob Res 2003, **5:**245–254. ArticlePubMedCAS Google Scholar
Hardie TL, Moss HB, Lynch KG: Genetic correlations between smoking initiation and smoking behaviors in a twin sample. Addict Behav 2006, **31:**2030–2037. ArticlePubMed Google Scholar
Malaiyandi V, Sellers EM, Tyndale RF: Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. Clin Pharm Ther 2005, **77:**145–158. ArticleCAS Google Scholar
O’Loughlin J, Paradis G, Kim W, et al.: Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers. Tob Control 2004, **13:**422–428. ArticlePubMedCAS Google Scholar
Huang S, Cook DG, Hinks LJ, et al.: CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents. Pharmacogenet Genomics 2005, **15:**839–850. PubMedCAS Google Scholar
Audrain-McGovern J, Koudsi N, Rodriguez D, et al.: The role of CYP2A6 in the emergence of nicotine dependence in adolescents. Pediatrics 2007, **119:**264–274. Article Google Scholar
Audrain-McGovern J, Rodriguez D, Cuevas J, et al.: Identifying and characterizing adolescent smoking trajectories. Cancer Epidemiol Biomarkers Prev 2004, **13:**2023–2034. PubMed Google Scholar
Laucht M, Becker K, El-Faddagh M, et al.: Association of the DRD4 exon III polymorphism with smoking in fifteen-year-olds: a mediating role for novelty seeking?J Am Acad Child Adolesc Psychiatry 2005, **44:**477–484. ArticlePubMed Google Scholar
Anney RJ, Olsson CA, Lotfi-Miri M, et al.: Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism. Pharmacogenetics 2004, **14:**73–81. ArticlePubMedCAS Google Scholar
Olsson C, Anney R, Forrest S, et al.: Association between dependent smoking and a polymorphism in the tyrosine hydroxylase gene in a prospective population-based study of adolescent health. Behav Genet 2004, **34:**85–91. ArticlePubMed Google Scholar
Liebich I, Bode J, Reuter I, Wingender E: Evaluation of sequence motifs found in scaffold/matrix-attached regions (S/MARs). Nucleic Acids Res 2002, **30:**3433–3442. ArticlePubMedCAS Google Scholar
Timberlake DS, Haberstick BC, Lessem JM, et al.: An association between the DAT1 polymorphism and smoking behavior in young adults from the National Longitudinal Study of Adolescent Health. Health Psychol 2006, **25:**190–197. ArticlePubMed Google Scholar
Gerra G, Garofano L, Zaimovic A, et al.: Association of the serotonin transporter promoter polymorphism with smoking behavior among adolescents. Am J Med Genet 2005, **135:**73–78. ArticleCAS Google Scholar
Skowronek MH, Laucht M, Hohm E, et al.: Interaction between the dopamine D4 receptor and the serotonin transporter promoter polymorphisms in alcohol and tobacco use among 15-year-olds. Neurogenetics 2006, **7:**239–246. ArticlePubMedCAS Google Scholar
Audrain-McGovern J, Rodriguez D, Wileyto EP, et al.: Effect of team sport participation on genetic predisposition to adolescent smoking progression. Arch Gen Psychiatry 2006, **63:**433–441. ArticlePubMed Google Scholar
Pianezza M, Sellers E, Tyndale R: Nicotine metabolism defect reduces smoking. Nature 1998, **393:**750. ArticlePubMedCAS Google Scholar
Malaiyandi V, Lerman C, Benowitz NL, et al.: Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy. Mol Psychiatry 2006, **11:**400–409. ArticlePubMedCAS Google Scholar
Strasser A, Malaiyandi V, Hoffmann E, et al.: An association of CYP2A6 genotype and smoking topography. Nicotine Tob Res 2007, **9:**511–518. ArticlePubMedCAS Google Scholar
Kubota T, Nakajima-Taniguchi C, Fukuda T, et al.: CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation. Pharmacogenomics J 2006, **6:**115–119. ArticlePubMedCAS Google Scholar
Howard LA, Ahluwalia JS, Lin SK, et al.: CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence. Pharmacogenetics 2003, **13:**321–328. ArticlePubMedCAS Google Scholar
Gu DF, Hinks LJ, Morton NE, Day IN: The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit. Ann Hum Genet 2000, **64:**383–390. ArticlePubMedCAS Google Scholar
Sellers EM, Tyndale RF: Mimicking gene defects to treat drug dependence. Ann N Y Acad Sci 2000, **909:**233–246. ArticlePubMedCAS Google Scholar
Picciotto M, Zoli M, Rimondini R, et al.: Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature 1998, **391:**173–177. ArticlePubMedCAS Google Scholar
Li MD, Beuten J, Ma JZ, et al.: Ethnic-and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Hum Mol Genet 2005, **14:**1211–1219. ArticlePubMedCAS Google Scholar
Silverman M, Neale M, Sullivan P, et al.: Haplotypes of four novel single nucleotide polymorphisms in the nicotine acetylcholine receptor b2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. Am J Med Genet 2000, **96:**646–653. ArticlePubMedCAS Google Scholar
Lou XY, Ma JZ, Payne TJ, et al.: Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. Hum Genet 2006, **120:**381–389. ArticlePubMedCAS Google Scholar
Saccone SF, Hinrichs AL, Saccone NL, et al.: Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 2007, **16:**36–49. ArticlePubMedCAS Google Scholar
Comings D, Ferry L, Bradshaw-Robinson S, et al.: The dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking. Pharmacogenetics 1996, **6:**73–79. ArticlePubMedCAS Google Scholar
Bierut L, Rice J, Edenberg H, et al.: Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking. Am J Med Genet 2000, **90:**299–302. ArticlePubMedCAS Google Scholar
Lerman C, Caporaso N, Audrain J, et al.: Evidence suggesting the role of specific genetic factors in cigarette smoking. Health Psychol 1999, **18:**14–20. ArticlePubMedCAS Google Scholar
Vandenbergh DJ, Bennett CJ, Grant MD, et al.: Smoking status and the human dopamine transporter variable number of tandem repeats (VNTR) polymorphism: failure to replicate and finding that never-smokers may be different. Nicotine Tob Res 2002, **4:**333–340. ArticlePubMed Google Scholar
Lerman C, Shields PG, Wileyto EP, et al.: Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial. Health Psychol 2003, **22:**541–548. ArticlePubMed Google Scholar
Redden DT, Shields PG, Epstein L, et al.: Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results. Cancer Epidemiol Biomarkers Prev 2005, **14:**1384–1389. ArticlePubMedCAS Google Scholar
Colilla S, Lerman C, Shields PG, et al.: Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women. Pharmacogenet Genomics 2005, **15:**393–398. ArticlePubMedCAS Google Scholar
David SP, Johnstone E, Griffiths SE, et al.: No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation. Pharmacogenetics 2002, **12:**265–268. ArticlePubMedCAS Google Scholar
Beuten J, Payne T, Ma JZ, Li MD: Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. Neuropsychopharmacology 2006, **31:**675–684. ArticlePubMedCAS Google Scholar
Hutchison KE, LaChance H, Niaura R, et al.: The DRD4 VNTR polymorphism influences reactivity to smoking cues. J Abnorm Psychol 2002, **111:**134–143. ArticlePubMed Google Scholar
Shields P, Lerman C, Audrain J, et al.: Dopamine D4 receptors and the risk of cigarette smoking in African-Americans and Caucasians. Cancer Epidemiol Biomarkers Prev 1998, **7:**453–458. PubMedCAS Google Scholar
Johnstone EC, Yudkin PL, Hey K, et al.: Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch. Pharmacogenetics 2004, **14:**83–90. ArticlePubMedCAS Google Scholar
Ishikawa H, Ohtsuki T, Ishiguro H, et al.: Association between serotonin transporter gene polymorphism and smoking among Japanese. Cancer Epidemiol Biomarkers Prev 1999, **8:**831–833. PubMedCAS Google Scholar
Lerman C, Caporaso N, Audrain J, et al.: Interacting effects of the serotonin transporter gene and neuroticism in smoking practices and nicotine dependence. Mol Psychiatry 2000, **5:**189–192. ArticlePubMedCAS Google Scholar
Trummer O, Koppel H, Wascher TC, et al.: The serotonin transporter gene polymorphism is not associated with smoking behavior. Pharmacogenomics J 2006, **6:**397–400. ArticlePubMedCAS Google Scholar
Schinka JA, Town T, Abdullah L, et al.: A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. Mol Psychiatry 2002, **7:**224–228. ArticlePubMedCAS Google Scholar
Zhang L, Kendler KS, Chen X: The mu-opioid receptor gene and smoking initiation and nicotine dependence. Behav Brain Funct 2006, **4:**28. ArticleCAS Google Scholar
Uhl GR, Liu QR, Drgon T, et al.: Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. BMC Genet 2007, **8:**10. ArticlePubMedCAS Google Scholar
Bierut LJ, Madden PA, Breslau N, et al.: Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet 2007, **16:**24–35. ArticlePubMedCAS Google Scholar
Bergen AW, Korczak JF, Weissbecker K, Goldstein AM: A genome-wide search for loci contributing to smoking and alcoholism. Genet Epidemiol 1999, **17:**S55–S60. PubMed Google Scholar
Bierut LJ, Rice JP, Goate A, et al.: A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence. Am J Med Genet 2004, **124:**19–27. Article Google Scholar
Straub RE, Sullivan PF, Ma Y, et al.: Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study. Mol Psychiatry 1999, **4:**129–144. ArticlePubMedCAS Google Scholar
Li MD, Ma JZ, Cheng R, et al.: A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. BMC Genet 2003, **4:**S103. ArticlePubMed Google Scholar
Wang D, Ma JZ, Li MD: Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysis. Pharmacogenomics J 2005, **5:**166–172. ArticlePubMedCAS Google Scholar
Swan GE, Hops H, Wilhelmsen K, et al.: A genome-wide screen for nicotine dependence susceptibility loci. Am J Med Genet 2006, **141:**354–360. Article Google Scholar
Zhang H, Ye Y, Wang X, et al.: DOPA decarboxylase gene is associated with nicotine dependence. Pharmacogenomics 2006, **7:**1159–1166. ArticlePubMedCAS Google Scholar
Li MD, Payne TJ, Ma JZ, et al.: A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. Am J Hum Genet 2006, **79:**745–751. ArticlePubMedCAS Google Scholar
Lou XY, Ma JZ, Sun D, et al.: Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans. Hum Mol Genet 2007, **16:**142–153. ArticlePubMedCAS Google Scholar
Li MD, Sun D, Lou XY, et al.: Linkage and association studies in African-and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. Mol Psychiatry 2007, **12:**462–473. ArticlePubMedCAS Google Scholar
Gelernter J, Liu X, Hesselbrock V, et al.: Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. Am J Med Genet 2004, **128:**94–101. Article Google Scholar
Gelernter J, Panhuysen C, Weiss R, et al.: Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus. Biol Psychiatry 2007, **61:**119–126. ArticlePubMedCAS Google Scholar
Vink JM, Beem AL, Posthuma D, et al.: Linkage analysis of smoking initiation and quantity in Dutch sibling pairs. Pharmacogenomics J 2004, **4:**274–282. ArticlePubMedCAS Google Scholar
Lerman C, Tyndale R, Patterson F, et al.: Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation. Clin Pharmacol Ther 2006, **79:**600–608. ArticlePubMedCAS Google Scholar
Yudkin P, Munafo M, Hey K, et al.: Effectiveness of nicotine patches in relation to genotype in women vs. men: randomised controlled trial. BMJ 2004, **328:**989–990. ArticlePubMed Google Scholar
Munafo MR, Murphy MF, Johnstone EC: Smoking cessation, weight gain, and DRD4-521 genotype. Am J Med Genet 2006, **141:**398–402. ArticleCAS Google Scholar
Lerman C, Jepson C, Wileyto EP, et al.: Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials. Neuropsychopharmacology 2006, **31:**231–242. PubMedCAS Google Scholar
Dahl JP, Jepson C, Levenson R, et al.: Interaction between variation in the D2 dopamine receptor (DRD2) and the neuronal calcium sensor-1 (FREQ) genes in predicting response to nicotine replacement therapy for tobacco dependence. Pharmacogenomics J 2006, **6:**194–199. ArticlePubMedCAS Google Scholar
Munafo MR, Johnstone EC, Wileyto EP, et al.: Lack of association of 5-HTTLPR genotype with smoking cessation in a nicotine replacement therapy randomized trial. Cancer Epidemiol Biomarkers Prev 2006, **15:**398–400. ArticlePubMedCAS Google Scholar
David SP, Munafo MR, Murphy MF, et al.: The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial. Nicotine Tob Res 2007, **9:**225–231. ArticlePubMedCAS Google Scholar
Lerman C, Wileyto EP, Patterson F, et al.: The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial. Pharmacogenomics J 2004, **4:**184–192. ArticlePubMedCAS Google Scholar
Ray R, Jepson C, Wileyto EP, et al.: Genetic variation in mu opioid receptor interacting proteins and smoking cessation in a nicotine replacement therapy trial. Nicotine Tob Res 2007, In press.
Munafo MR, Elliot KM, Murphy MF, et al.: Association of the mu-opioid receptor gene with smoking cessation. Pharmacogenomics J 2007, In press.
Lerman C, Shields PG, Wileyto EP, et al.: Pharmacogenetic investigation of smoking cessation treatment. Pharmacogenetics 2002, **12:**627–634. ArticlePubMedCAS Google Scholar
Lee AM, Jepson C, Hoffmann E, et al.: CYP2B6 genotype alters abstinence rates in a bupropion smoking cessation trial. Biol Psychiatry 2007, In press.
Swan GE, Valdes AM, Ring HZ, et al.: Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR. Pharmacogenomics J 2005, **5:**21–29. ArticlePubMedCAS Google Scholar
David SP, Lloyd-Richardson EE, Munafo MR, et al.: Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation. Nicotine Tob Res 2007, In press.
Berrettini WH, Wileyto EP, Epstein L, et al.: Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence. Biol Psychiatry 2006, **16:**111–118. Google Scholar
Shields A, Lerman C, Sullivan P: Translating emerging research on the genetics of smoking into clinical practice: ethical and social considerations. Nicotine Tob Res 2004, **6:**675–688. ArticlePubMed Google Scholar
Comings DE, Comings BG, Muhleman D, et al.: The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA 1991, **266:**1793–1800. ArticlePubMedCAS Google Scholar
Shields AE, Blumenthal D, Weiss KB, et al.: Barriers to translating emerging genetic research on smoking into clinical practice. Perspectives of primary care physicians. J Gen Intern Med 2005, **20:**131–138. ArticlePubMed Google Scholar