Origins and Effects of Extracellular α-synuclein: Implications in Parkinson’s Disease (original) (raw)
References
Ahn, K. J., Paik, S. R., Chung, K. C., & Kim, J. (2006). Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. Journal of Neurochemistry, 97, 265–279. ArticlePubMedCAS Google Scholar
Albani, D., Peverelli, E., Rametta, R., Batelli, S., Veschini, L., Negro, A., et al. (2004). Protective effect of TAT-delivered alpha-synuclein: Relevance of the C-terminal domain and involvement of HSP70. FASEB Journal, 18, 1713–1715. PubMedCAS Google Scholar
Bodles, A. M., Guthrie, D. J., Harriott, P., Campbell, P., & Irvine, G. B. (2000). Toxicity of non-Abeta component of Alzheimer’s disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils. European Journal of Biochemistry, 267, 2186–2194. ArticlePubMedCAS Google Scholar
Borghi, R., Marchese, R., Negro, A., Marinelli, L., Forloni, G., Zaccheo, D., et al. (2000). Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson’s disease and normal subjects. Neuroscience Letters, 287, 65–67. ArticlePubMedCAS Google Scholar
Braak, H., Ghebremedhin, E., Rub, U., Bratzke, H., & Del Tredici, K. (2004). Stages in the development of Parkinson’s disease-related pathology. Cell & Tissue Research, 318, 121–134. Article Google Scholar
Caughey, B. (2000). Transmissible spongiform encephalopathies, amyloidoses and yeast prions: Common threads? Nature Medicine, 6, 751–754. ArticlePubMedCAS Google Scholar
Chartier-Harlin, M. C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., et al. (2004). Alpha-synuclein locus duplication as a cause of familial Parkinson’s disease. Lancet, 364, 1167–1169. ArticlePubMedCAS Google Scholar
Cohlberg, J. A., Li, J., Uversky, V. N., & Fink, A. L. (2002). Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro. Biochemistry, 41, 1502–1511. ArticlePubMedCAS Google Scholar
Conway, K. A., Lee, S.-J., Rochet, J. C., Ding, T. T., Williamson, R. E., & Lansbury Jr., P. T. (2000). Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson’s disease: Implications for pathogenesis and therapy. Proceedings of the National Academy of Sciences of the United States of America, 97, 571–576. ArticlePubMedCAS Google Scholar
Du, H. N., Tang, L., Luo, X. Y., Li, H. T., Hu, J., Zhou, J. W., et al. (2003). A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein. Biochemistry, 42, 8870–8878. ArticlePubMedCAS Google Scholar
El-Agnaf, O. M., Jakes, R., Curran, M. D., Middleton, D., Ingenito, R., Bianchi, E., et al. (1998). Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments. FEBS Letters, 440, 71–75. ArticlePubMedCAS Google Scholar
El-Agnaf, O. M., Salem, S. A., Paleologou, K. E., Cooper, L. J., Fullwood, N. J., Gibson, M. J., et al. (2003). Alpha-synuclein implicated in Parkinson’s disease is present in extracellular biological fluids, including human plasma. FASEB Journal, 17, 1945–1947. PubMedCAS Google Scholar
El-Agnaf, O. M., Salem, S. A., Paleologou, K. E., Curran, M. D., Gibson, M. J., Court, J. A., et al. (2006). Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson’s disease. FASEB Journal, 20, 419–425. ArticlePubMedCAS Google Scholar
Fahn, S., & Sulzer, D. (2004). Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx, 1, 139–154. ArticlePubMed Google Scholar
Fevrier, B., & Raposo, G. (2004). Exosomes: Endosomal-derived vesicles shipping extracellular messages. Current Opinion in Cell Biology, 16, 415–421. ArticlePubMedCAS Google Scholar
Forloni, G., Bertani, I., Calella, A. M., Thaler, F., & Invernizzi, R. (2000). Alpha-synuclein and Parkinson’s disease: Selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo. Annals of Neurology, 47, 632–640. ArticlePubMedCAS Google Scholar
Forno, L. S. (1996). Neuropathology of Parkinson’s disease. Journal of Neuropathology and Experimental Neurology, 55, 259–272. PubMedCAS Google Scholar
Fortin, D. L., Nemani, V. M., Voglmaier, S. M., Anthony, M. D., Ryan, T. A., Edwards, R. H. (2005). Neural activity controls the synaptic accumulation of {alpha}-synuclein. Journal of Neuroscience, 25, 10913–10921. ArticlePubMedCAS Google Scholar
Greenbaum, E. A., Graves, C. L., Mishizen-Eberz, A. J., Lupoli, M. A., Lynch, D. R., Englander, S. W., et al. (2005). The E46K mutation in alpha-synuclein increases amyloid fibril formation. Journal of Biological Chemistry, 280, 7800–7807. ArticlePubMedCAS Google Scholar
Hoyer, W., Antony, T., Cherny, D., Heim, G., Jovin, T. M., & Subramaniam, V. (2002). Dependence of alpha-synuclein aggregate morphology on solution conditions. Journal of Molecular Biology, 322, 383–393. ArticlePubMedCAS Google Scholar
Ibanez, P., Bonnet, A. M., Debarges, B., Lohmann, E., Tison, F., Pollak, P., et al. (2004). Causal relation between alpha-synuclein gene duplication and familial Parkinson’s disease. Lancet, 364, 1169–1171. ArticlePubMedCAS Google Scholar
Kayed, R., Sokolov, Y., Edmonds, B., McIntire, T. M., Milton, S. C., Hall, J. E., et al. (2004). Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. Journal of Biological Chemistry, 279, 46363–46366. ArticlePubMedCAS Google Scholar
Kim, Y. S., Laurine, E., Woods, W., & Lee, S. J. (2006). A novel mechanism of interaction between alpha-synuclein and biological membranes. Journal of Molecular Biology, 360, 386–397. ArticlePubMedCAS Google Scholar
Klegeris, A., Giasson, B. I., Zhang, H., Maguire, J., Pelech, S., & McGeer, P. L. (2006). Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. FASEB Journal, 20, 2000–2008. ArticlePubMedCAS Google Scholar
Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., et al. (1998). Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease. Nature Genetics, 18, 106–108. ArticlePubMedCAS Google Scholar
Lee, E. N., Cho, H. J., Lee, C. H., Lee, D., Chung, K. C., & Paik, S. R. (2004). Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein. Biochemistry, 43, 3704–3715. ArticlePubMedCAS Google Scholar
Lee, H. J., Patel, S., & Lee, S. J. (2005). Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. Journal of Neuroscience, 25, 6016–6024. ArticlePubMedCAS Google Scholar
Lee, P. H., Lee, G., Park, H. J., Bang, O. Y., Joo, I. S., & Huh, K. (2006). The plasma alpha-synuclein levels in patients with Parkinson’s disease and multiple system atrophy. Journal of Neural Transmission, 113, 1435–1439. ArticlePubMedCAS Google Scholar
Lowe, R., Pountney, D. L., Jensen, P. H., Gai, W. P., & Voelcker, N. H. (2004). Calcium(II) selectively induces alpha-synuclein annular oligomers via interaction with the C-terminal domain. Protein Science, 13, 3245–3252. ArticlePubMedCAS Google Scholar
Maries, E., Dass, B., Collier, T. J., Kordower, J. H., & Steece-Collier, K. (2003). The role of alpha-synuclein in Parkinson’s disease: Insights from animal models. Nature Reviews Neuroscience, 4, 727–738. ArticlePubMedCAS Google Scholar
Masliah, E., Rockenstein, E., Adame, A., Alford, M., Crews, L., Hashimoto, M., et al. (2005). Effects of alpha-synuclein immunization in a mouse model of Parkinson’s disease. Neuron, 46, 857–868. ArticlePubMedCAS Google Scholar
Meyer-Luehmann, M., Coomaraswamy, J., Bolmont, T., Kaeser, S., Schaefer, C., Kilger, E., et al. (2006). Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science, 313, 1781–1784. ArticlePubMedCAS Google Scholar
Nickel, W. (2003). The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. European Journal of Biochemistry, 270, 2109–2119. ArticlePubMedCAS Google Scholar
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., et al. (1997). Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science, 276, 2045–2047. ArticlePubMedCAS Google Scholar
Seo, J. H., Rah, J. C., Choi, S. H., Shin, J. K., Min, K., Kim, H. S., et al. (2002). Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway. FASEB Journal, 16, 1826–1828. PubMedCAS Google Scholar
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., et al. (2003). alpha-Synuclein locus triplication causes Parkinson’s disease. Science, 302, 841. ArticlePubMedCAS Google Scholar
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., Goedert, M. (1998). alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with lewy bodies. Proceedings of the National Academy of Sciences of the United States of America, 95, 6469–6473. ArticlePubMedCAS Google Scholar
Sung, J. Y., Kim, J., Paik, S. R., Park, J. H., Ahn, Y. S., & Chung, K. C. (2001). Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein. Journal of Biological Chemistry, 276, 27441–27448. ArticlePubMedCAS Google Scholar
Sung, J. Y., Park, S. M., Lee, C. H., Um, J. W., Lee, H. J., Kim, J., et al. (2005). Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. Journal of Biological Chemistry, 280, 25216–25224. ArticlePubMedCAS Google Scholar
Tokuda, T., Salem, S. A., Allsop, D., Mizuno, T., Nakagawa, M., Qureshi, M. M., et al. (2006). Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease. Biochemical and Biophysical Research Communications, 349, 162–166. ArticlePubMedCAS Google Scholar
Volles, M. J., & Lansbury Jr., P. T. (2003). Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson’s disease. Biochemistry, 42, 7871–7878. ArticlePubMedCAS Google Scholar
Volles, M. J., Lee, S.-J., Rochet, J. C., Shtilerman, M. D., Ding, T. T., Kessler, J. C., et al. (2001). Vesicle permeabilization by protofibrillar alpha-synuclein: Implications for the pathogenesis and treatment of Parkinson’s disease. Biochemistry, 40, 7812–7819. ArticlePubMedCAS Google Scholar
Zarranz, J. J., Alegre, J., Gomez-Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., et al. (2004). The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Annals of Neurology, 55, 164–173. ArticlePubMedCAS Google Scholar
Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., et al. (2005). Aggregated alpha-synuclein activates microglia: A process leading to disease progression in Parkinson’s disease. FASEB Journal, 19, 533–542. ArticlePubMedCAS Google Scholar