Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathway (original) (raw)

• Fryer RA, Galustian C, Dalgelish AG. Recent advances and developments in treatment strategies against pancreatic cancer. Curr Clin Pharmacol. 2009;4(2):102–12.
  Article CAS PubMed Google Scholar
• Jonckheere N, et al. Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression. Br J Cancer. 2009;101(4):637–44.
  Article CAS PubMed Google Scholar
• Nickoloff BJ, Osborne BA, Miele L. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene. 2003;22(42):6598–608.
  Article CAS PubMed Google Scholar
• Miyamoto A, Lau R, Hein PW, Shipley JM, Weinmaster G. Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. J Biol Chem. 2006;281(15):10089–97.
  Article CAS PubMed Google Scholar
• Radtke F, Wilson A, Mancini SJ, MacDonald HR. Notch regulation of lymphocyte development and function. Nat Immunol. 2004;5(3):247–53.
  Article CAS PubMed Google Scholar
• Maillard I, Adler SH, Pear WS. Notch and the immune system. 1. Immunity. 2003;19(6):781–91.
  Article CAS PubMed Google Scholar
• Maillard I, Fang T, Pear WS. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol. 2005;23:945–74.
  Article CAS PubMed Google Scholar
• Real PJ, Ferrando AA. NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia. Leukemia. 2009;23(8):1374–7.
  Article CAS PubMed Google Scholar
• Roy M, Pear WS, Aster JC. The multifaceted role of Notch in cancer. Curr Opin Genet Dev. 2007;17(1):52–9.
  Article CAS PubMed Google Scholar
• Dotto GP. Notch tumor suppressor function. Oncogene. 2008;27(38):5115–23.
  Article CAS PubMed Google Scholar
• Baek SH, et al. Zinc-induced downregulation of Notch signaling is associated with cytoplasmic retention of Notch1-IC and RBP-Jk via PI3k-Akt signaling pathway. Cancer Lett. 2007;255(1):117–26.
  Article CAS PubMed Google Scholar
• Meurette O, et al. Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer Res. 2009;69(12):5015–22.
  Article CAS PubMed Google Scholar
• Kurreck J. RNA interference: from basic research to therapeutic applications. Angew Chem Int Ed Engl. 2009;48(8):1378–98.
  Article CAS PubMed Google Scholar
• Hu Y, et al. Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan. Mol Cancer Ther. 2009;8(8):2329–38.
  Article CAS PubMed Google Scholar
• Pauwels B, et al. The role of apoptotic cell death in the radiosensitising effect of gemcitabine. Br J Cancer. 2009;101(4):628–36.
  Article CAS PubMed Google Scholar
• Zhou H, Li XM, Meinkoth J, Pittman RN. Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol. 2000;151(3):483–94.
  Article CAS PubMed Google Scholar
• Simon PO Jr, et al. Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma. Int J Cancer. 2009;125(4):942–51.
  Article CAS PubMed Google Scholar
• Gramantieri L, et al. Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma. Liver Int. 2007;27(7):997–1007.
  Article CAS PubMed Google Scholar
• Doucas H, et al. Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt. J Surg Oncol. 2008;97(1):63–8.
  Article PubMed Google Scholar
• Dang L, et al. Notch3 signaling initiates choroid plexus tumor formation. Oncogene. 2006;25(3):487–91.
  CAS PubMed Google Scholar
• Akiyoshi T, et al. Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells. Gastroenterology. 2008;134(1):131–44.
  Article CAS PubMed Google Scholar
• Gazzaniga P, et al. Gemcitabine-induced apoptosis in 5637 cell line: an in vitro model for high-risk superficial bladder cancer. Anticancer Drugs. 2007;18(2):179–85.
  Article CAS PubMed Google Scholar
• Nefedova Y, Sullivan DM, Bolick SC, Dalton WS, Gabrilovich DI. Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy. Blood. 2008;111(4):2220–9.
  Article CAS PubMed Google Scholar
• Tassone P, et al. Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br J Cancer. 2003;88(12):1971–8.
  Article CAS PubMed Google Scholar