Mitogen Activated Protein kinase signal transduction pathways in the prostate (original) (raw)

• Magi-Galluzzi C, Mishra R, Fiorentino M, Montironi R, Yao H, Capodieci P, Wishnow K, Kaplan I, Stork PJ, Loda M: Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis. Lab Invest. 1997, 76 (1): 37-51.
  CAS PubMed Google Scholar
• Magi-Galluzzi C, Montironi R, Cangi MG, Wishnow K, Loda M: Mitogen-activated protein kinases and apoptosis in PIN. Virchows Arch. 1998, 432 (5): 407-413. 10.1007/s004280050184.
  CAS PubMed Google Scholar
• Royuela M, Arenas MI, Bethencourt FR, Sanchez-Chapado M, Fraile B, Paniagua R: Regulation of proliferation/apoptosis equilibrium by mitogen-activated protein kinases in normal, hyperplastic, and carcinomatous human prostate. Hum Pathol. 2002, 33 (3): 299-306. 10.1053/hupa.2002.32227.
  CAS PubMed Google Scholar
• Gioeli D, Mandell JW, Petroni GR, Frierson HF, Weber MJ: Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Res. 1999, 59 (2): 279-284.
  CAS PubMed Google Scholar
• van Bokhoven A, Caires A, Maria MD, Schulte AP, Lucia MS, Nordeen SK, Miller GJ, Varella-Garcia M: Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines. Prostate. 2003, 57 (3): 226-244. 10.1002/pros.10291.
  CAS PubMed Google Scholar
• Culig Z, Hobisch A, Cronauer MV, Radmayr C, Hittmair A, Zhang J, Thurnher M, Bartsch G, Klocker H: Regulation of prostatic growth and function by peptide growth factors. Prostat. 1996, 28 (6): 392-405. 10.1002/(SICI)1097-0045(199606)28:6<392::AID-PROS9>3.0.CO;2-C.
  CAS Google Scholar
• Konety BR, Nelson JB: Nonandrogenic mediators of prostatic growth. Hematol Oncol Clin North Am. 2001, 15 (3): 459-476.
  CAS PubMed Google Scholar
• Kim HG, Kassis J, Souto JC, Turner T, Wells A: EGF receptor signaling in prostate morphogenesis and tumorigenesis. Histol Histopatho. 1999, 14 (4): 1175-1182.
  CAS Google Scholar
• Guo C, Luttrell LM, Price DT: Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines. J Urol. 2000, 163 (3): 1027-1032.
  CAS PubMed Google Scholar
• Peterziel H, Mink S, Schonert A, Becker M, Klocker H, Cato AC: Rapid signalling by androgen receptor in prostate cancer cells. Oncogene. 1999, 18 (46): 6322-6329. 10.1038/sj.onc.1203032.
  CAS PubMed Google Scholar
• Bell WC, Myers RB, Hosein TO, Oelschlager DK, Grizzle WE: The response of extracellular signal-regulated kinase (ERK) to androgen-induced proliferation in the androgen-sensitive prostate cancer cell line, LNCaP. Biotech Histochem. 2003, 78 (1): 11-16.
  CAS PubMed Google Scholar
• Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F: Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003, 374 (Pt 1): 1-20. 10.1042/BJ20030407.
  PubMed Central CAS PubMed Google Scholar
• Culig Z, Bartsch G, Hobisch A: Interleukin-6 regulates androgen receptor activity and prostate cancer cell growth. Mol Cell Endocrinol (Review). 2002, 197 (1–2): 231-238. 10.1016/S0303-7207(02)00263-0.
  CAS Google Scholar
• Yang L, Wang L, Lin HK, Kan PY, Xie S, Tsai MY, Wang PH, Chen YT, Chang C: Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells. Biochem Biophys Res Commun. 2003, 305 (3): 462-469. 10.1016/S0006-291X(03)00792-7.
  CAS PubMed Google Scholar
• Ueda T, Mawji NR, Bruchovsky N, Sadar MD: Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. J Biol Chem. 2002, 277 (41): 38087-38094. 10.1074/jbc.M203313200.
  CAS PubMed Google Scholar
• Steiner H, Godoy-Tundidor S, Rogatsch H, Berger AP, Fuchs D, Comuzzi B, Bartsch G, Hobisch A, Culig Z: Accelerated in vivo growth of prostate tumors that up-regulate interleukin-6 is associated with reduced retinoblastoma protein expression and activation of the mitogen-activated protein kinase pathway. Am J Pathol. 2003, 162 (2): 655-663.
  PubMed Central CAS PubMed Google Scholar
• Zi X, Singh RP, Agarwal R: Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells. Carcinogenesis. 2000, 21 (12): 2225-2235. 10.1093/carcin/21.12.2225.
  CAS PubMed Google Scholar
• Murillo H, Schmidt LJ, Tindall DJ: Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-2. Cancer Res. 2001, 61 (20): 7408-7412.
  CAS PubMed Google Scholar
• Unlu A, Leake RE: The effect of EGFR-related tyrosine kinase activity inhibition on the growth and invasion mechanisms of prostate carcinoma cell lines. Int J Biol Markers. 2003, 18 (2): 139-146.
  CAS PubMed Google Scholar
• Raj GV, Barki-Harrington L, Kue PF, Daaka Y: Guanosine phosphate binding protein coupled receptors in prostate cancer: a review. J Urol. 2002, 167 (3): 1458-1463.
  CAS PubMed Google Scholar
• Kue PF, Taub JS, Harrington LB, Polakiewicz RD, Ullrich A, Daaka Y: Lysophosphatidic acid-regulated mitogenic ERK signaling in androgen-insensitive prostate cancer PC-3 cells. Int J Cancer. 2002, 102 (6): 572-579. 10.1002/ijc.10734.
  CAS PubMed Google Scholar
• Xiao D, Qu X, Weber HC: Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells. Cell Signal. 2003, 15 (10): 945-953. 10.1016/S0898-6568(03)00059-7.
  CAS PubMed Google Scholar
• Daaka Y: Mitogenic action of LPA in prostate. Biochim Biophys Acta Review. 2002, 1582 (1–3): 265-269.
  CAS Google Scholar
• Kue PF, Daaka Y: Essential role for G proteins in prostate cancer cell growth and signaling. J Urol. 2000, 164 (6): 2162-2167.
  CAS PubMed Google Scholar
• Li H, He C, Zheng J: [Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential]. Zhonghua Yi Xue Za Zh (Chinese). 2001, 81 (4): 197-200.
  CAS Google Scholar
• O'Flaherty JT, Rogers LC, Chadwell BA, Owen JS, Rao A, Cramer SD, Daniel LW: (S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism. Cancer Res. 2002, 62 (23): 6817-6829.
  PubMed Google Scholar
• Jiang C, Ganther H, Lu J: Monomethyl selenium – specific inhibition of MMP-2 and VEGF expression: implications for angiogenic switch regulation. Mol Carcinog. 2000, 29 (4): 236-250. 10.1002/1098-2744(200012)29:4<236::AID-MC1006>3.0.CO;2-E.
  CAS PubMed Google Scholar
• Deocampo ND, Huang H, Tindall DJ: The role of PTEN in the progression and survival of prostate cancer (review). Minerva Endocrinol. 2003, 28 (2): 145-153.
  CAS PubMed Google Scholar
• Ling MT, Wang X, Ouyang XS, Lee TK, Fan TY, Xu K, Tsao SW, Wong YC: Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth. Oncogene. 2002, 21 (55): 8498-8505. 10.1038/sj.onc.1206007.
  CAS PubMed Google Scholar
• Zhou J, Scholes J, Hsieh JT: Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer. J Biol Chem. 2003, 278 (9): 6936-6941. 10.1074/jbc.M210628200.
  CAS PubMed Google Scholar
• Wu D, Foreman TL, Gregory CW, McJilton MA, Wescott GG, Ford OH, Alvey RF, Mohler JL, Terrian DM: Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer. Cancer Res. 2002, 62 (8): 2423-2429.
  CAS PubMed Google Scholar
• Kiefer JA, Farach-Carson MC: Type I collagen-mediated proliferation of PC3 prostate carcinoma cell line: implications for enhanced growth in the bone microenvironment. Matrix Biol. 2001, 20 (7): 429-437. 10.1016/S0945-053X(01)00159-7.
  CAS PubMed Google Scholar
• Shack S, Gorospe M, Fawcett TW, Hudgins WR, Holbrook NJ: Activation of the cholesterol pathway and Ras maturation in response to stress. Oncogene. 1999, 18 (44): 6021-6028. 10.1038/sj.onc.1203002.
  CAS PubMed Google Scholar
• Danesi R, Nardini D, Basolo F, Del Tacca M, Samid D, Myers CE: Phenylacetate inhibits protein isoprenylation and growth of the androgen-independent LNCaP prostate cancer cells transfected with the T24 Ha-ras oncogene. Mol Pharmacol. 1996, 49 (6): 972-979.
  CAS PubMed Google Scholar
• Ravi RK, McMahon M, Yangang Z, Williams JR, Dillehay LE, Nelkin BD, Mabry M: Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells. J Cell Biochem. 1999, 72 (4): 458-469. 10.1002/(SICI)1097-4644(19990315)72:4<458::AID-JCB2>3.0.CO;2-C.
  CAS PubMed Google Scholar
• Fu Z, Smith PC, Zhang L, Rubin MA, Dunn RL, Yao Z, Keller ET: Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst. 2003, 95 (12): 878-889. 10.1093/jnci/95.12.878.
  CAS PubMed Google Scholar
• Sheta EA, Harding MA, Conaway MR, Theodorescu D: Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor. J Natl Cancer Inst. 2000, 92 (13): 1065-1073. 10.1093/jnci/92.13.1065.
  CAS PubMed Google Scholar
• Hsi LC, Wilson LC, Eling TE: Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma. J Biol Chem. 2002, 277 (43): 40549-40556. 10.1074/jbc.M203522200.
  CAS PubMed Google Scholar
• Franco OE, Onishi T, Yamakawa K, Arima K, Yanagawa M, Sugimura Y, Kawamura J: Mitogen-activated protein kinase pathway is involved in androgen-independent PSA gene expression in LNCaP cells. Prostate. 2003, 56 (4): 319-325. 10.1002/pros.10258.
  CAS PubMed Google Scholar
• Liu XH, Kirschenbaum A, Lu M, Yao S, Dosoretz A, Holland JF, Levine AC: Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line. J Biol Chem. 2002, 277 (51): 50081-50086. 10.1074/jbc.M201095200.
  CAS PubMed Google Scholar
• Udayakumar TS, Stratton MS, Nagle RB, Bowden GT: Fibroblast growth factor-1 induced promatrilysin expression through the activation of extracellular-regulated kinases and STAT3. Neoplasia. 2002, 4 (1): 60-67. 10.1038/sj.neo.7900207.
  PubMed Central CAS PubMed Google Scholar
• Yacoub A, Park JS, Qiao L, Dent P, Hagan MP: MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion. Int J Radiat Biol. 2001, 77 (10): 1067-1078. 10.1080/09553000110069317.
  CAS PubMed Google Scholar
• Onishi T, Yamakawa K, Franco OE, Kawamura J, Watanabe M, Shiraishi T, Kitazawa S: Mitogen-activated protein kinase pathway is involved in alpha6 integrin gene expression in androgen-independent prostate cancer cells: role of proximal Sp1 consensus sequence. Biochim Biophys Acta. 2001, 1538 (2–3): 218-227.
  CAS PubMed Google Scholar
• Zhang J, Liu L, Pfeifer GP: Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene. Oncogene. 2003, 22 (43): 6704-6716. 10.1038/sj.onc.1206764.
  CAS PubMed Google Scholar
• Lin HY, Shih A, Davis FB, Tang HY, Martino LJ, Bennett JA, Davis PJ: Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. J Urol. 2002, 168 (2): 748-755.
  CAS PubMed Google Scholar
• Xiao D, Singh SV: Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases. Cancer Res. 2002, 62 (13): 3615-3619.
  CAS PubMed Google Scholar
• Tuohimaa P, Lyakhovich A, Aksenov N, Pennanen P, Syvala H, Lou YR, Ahonen M, Hasan T, Pasanen P, Blauer M, Manninen T, Miettinen S, Vilja P, Ylikomi T: Vitamin D and prostate cancer. J Steroid Biochem Mol Biol. 2001, 76 (1–5): 125-134. 10.1016/S0960-0760(00)00141-2.
  CAS PubMed Google Scholar
• Gschwend JE, Fair WR, Powell CT: Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha. Mol Pharmacol. 2000, 57 (6): 1224-1234.
  CAS PubMed Google Scholar
• Shimada K, Nakamura M, Ishida E, Kishi M, Yonehara S, Konishi N: Contributions of mitogen-activated protein kinase and nuclear factor kappa B to N-(4-hydroxyphenyl)retinamide-induced apoptosis in prostate cancer cells. Mol Carcinog. 2002, 35 (3): 127-137. 10.1002/mc.10084.
  CAS PubMed Google Scholar
• Shimada K, Nakamura M, Ishida E, Kishi M, Konishi N: Requirement of c-jun for testosterone-induced sensitization to N-(4-hydroxyphenyl)retinamide-induced apoptosis. Mol Carcinog. 2003, 36 (3): 115-122. 10.1002/mc.10107.
  CAS PubMed Google Scholar
• Bhatia N, Agarwal R: Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells. Prostate. 2001, 46 (2): 98-107. 10.1002/1097-0045(20010201)46:2<98::AID-PROS1013>3.3.CO;2-B.
  CAS PubMed Google Scholar
• McKinstry R, Qiao L, Yacoub A, Dai Y, Decker R, Holt S, Hagan MP, Grant S, Dent P: Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells. Cancer Biol Ther. 2002, 1 (3): 243-253.
  CAS PubMed Google Scholar
• Hagan M, Wang L, Hanley JR, Park JS, Dent P: Ionizing radiation-induced mitogen-activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest. Radiat Res. 2000, 153 (4): 371-383.
  CAS PubMed Google Scholar
• Qiao L, Yacoub A, McKinstry R, Park JS, Caron R, Fisher PB, Hagan MP, Grant S, Dent P: Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms. Cancer Biol Ther. 2002, 1 (2): 168-176.
  CAS PubMed Google Scholar
• Yacoub A, McKinstry R, Hinman D, Chung T, Dent P, Hagan MP: Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling. Radiat Res. 2003, 159 (4): 439-452.
  CAS PubMed Google Scholar
• Basu A, Haldar S: Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. FEBS Lett. 2003, 538 (1–3): 41-47. 10.1016/S0014-5793(03)00131-5.
  CAS PubMed Google Scholar
• Chen YR, Zhou G, Tan TH: c-Jun N-terminal kinase mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide. Mol Pharmacol. 1999, 56 (6): 1271-1279.
  CAS PubMed Google Scholar
• Torrisi R, Decensi A, Formelli F, Camerini T, De Palo G: Chemoprevention of breast cancer with fenretinide (review). Drugs. 2001, 61 (7): 909-918.
  CAS PubMed Google Scholar
• Ghosh J: Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. Biochem Biophys Res Commun. 2003, 307 (2): 342-349. 10.1016/S0006-291X(03)01201-4.
  CAS PubMed Google Scholar
• Wartenberg M, Ling FC, Schallenberg M, Baumer AT, Petrat K, Hescheler J, Sauer H: Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. J Biol Chem. 2001, 276 (20): 17420-17428. 10.1074/jbc.M100141200.
  CAS PubMed Google Scholar
• Yu R, Mandlekar S, Ruben S, Ni J, Kong AN: Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells. Cancer Res. 2000, 60 (9): 2384-2389.
  CAS PubMed Google Scholar
• Sah NK, Munshi A, Kurland JF, McDonnell TJ, Su B, Meyn RE: Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase. J Biol Chem. 2003, 278 (23): 20593-20602. 10.1074/jbc.M211010200.
  CAS PubMed Google Scholar
• Garcia-Cao I, Lafuente MJ, Criado LM, Diaz-Meco MT, Serrano M, Moscat J: Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38. EMBO Rep. 2003, 4 (3): 307-312. 10.1038/sj.embor.embor769.
  PubMed Central CAS PubMed Google Scholar
• Bowen C, Birrer M, Gelmann EP: Retinoblastoma protein-mediated apoptosis after gamma-irradiation. J Biol Chem. 2002, 277 (47): 44969-44979. 10.1074/jbc.M202000200.
  CAS PubMed Google Scholar
• Costa-Pereira AP, McKenna SL, Cotter TG: Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis. Br J Cancer. 2000, 82 (11): 1827-1834. 10.1054/bjoc.2000.1149.
  PubMed Central CAS PubMed Google Scholar
• Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD: PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization. Biol Chem. 2000, 275 (6): J4311-4322. 10.1074/jbc.275.6.4311.
  Google Scholar
• Kauffman EC, Robinson VL, Stadler WM, Sokoloff MH, Rinker-Schaeffer CW: Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site (review). J Urol. 2003, 169 (3): 1122-1133.
  PubMed Google Scholar
• Chen YR, Han J, Kori R, Kong AN, Tan TH: Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J Biol Chem. 2002, 277 (42): 39334-39342. 10.1074/jbc.M202070200.
  CAS PubMed Google Scholar
• Srikanth S, Franklin CC, Duke RC, Kraft RS: Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis. Mol Cell Biochem. 1999, 199 (1–2): 169-178. 10.1023/A:1006980326855.
  CAS PubMed Google Scholar
• Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, Pantazis P, Aggarwal BB: Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene. 2001, 20 (52): 7597-7609. 10.1038/sj.onc.1204997.
  CAS PubMed Google Scholar
• Curtin JF, Cotter TG: Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis. Br J Cancer. 2002, 87 (10): 1188-1194. 10.1038/sj.bjc.6600612.
  PubMed Central CAS PubMed Google Scholar
• Potapova O, Anisimov SV, Gorospe M, Dougherty RH, Gaarde WA, Boheler KR, Holbrook NJ: Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression. Cancer Res. 2002, 62 (11): 3257-3263.
  CAS PubMed Google Scholar
• Eandi JA, Yang JC, Evans CP: Signal transduction-mediated regulation of urokinase gene expression in human prostate cancer. Biochem Biophys Res Commun. 2001, 288 (3): 521-527. 10.1006/bbrc.2001.5803.
  CAS PubMed Google Scholar
• Grosch S, Tegeder I, Schilling K, Maier TJ, Niederberger E, Geisslinger G: Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. FASEB J. 2003, 17 (10): 1316-1318.
  CAS PubMed Google Scholar
• Shabsigh A, Ghafar MA, de la Taille A, Burchardt M, Kaplan SA, Anastasiadis AG, Buttyan R: Biomarker analysis demonstrates a hypoxic environment in the castrated rat ventral prostate gland. J Cell Biochem. 2001, 81 (3): 437-444. 10.1002/1097-4644(20010601)81:3<437::AID-JCB1057>3.3.CO;2-Y.
  CAS PubMed Google Scholar
• Yang YM, Bost F, Charbono W, Dean N, McKay R, Rhim JS, Depatie C, Mercola D: C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma. Clin Cancer Res. 2003, 9 (1): 391-401.
  CAS PubMed Google Scholar
• Gjerset R, Haghighi A, Lebedeva S, Mercola D: Gene therapy approaches to sensitization of human prostate carcinoma to cisplatin by adenoviral expression of p53 and by antisense jun kinase oligonucleotide methods (review). Methods Mol Biol. 2001, 175: 495-520. 10.1385/1-59259-235-X:495.
  CAS PubMed Google Scholar
• Uzgare AR, Kaplan PJ, Greenberg NM: Differential expression and/or activation of P38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer. Prostate. 2003, 55 (2): 128-139. 10.1002/pros.10212.
  CAS PubMed Google Scholar
• Mehta PB, Robson CN, Neal DE, Leung HY: Keratinocyte growth factor activates p38 MAPK to induce stress fibre formation in human prostate DU145 cells. Oncogene. 2001, 20 (38): 5359-5365. 10.1038/sj.onc.1204688.
  CAS PubMed Google Scholar
• Kim J, Adam RM, Freeman MR: Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation. Cancer Res. 2002, 62 (5): 1549-1554.
  CAS PubMed Google Scholar
• Grasso AW, Wen D, Miller CM, Rhim JS, Pretlow TG, Kung HJ: ErbB kinases and NDF signaling in human prostate cancer cells. Oncogene. 1997, 15 (22): 2705-2716. 10.1038/sj.onc.1201447.
  CAS PubMed Google Scholar
• Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG: Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J Biol Chem. 2003, 278 (36): 33753-33762. 10.1074/jbc.M303313200.
  CAS PubMed Google Scholar
• Shimada K, Nakamura M, Ishida E, Kishi M, Konishi N: Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis. 2003, 24 (6): 1067-1075. 10.1093/carcin/bgg058.
  CAS PubMed Google Scholar
• Permpongkosol S, Wang JD, Takahara S, Matsumiya K, Nonomura N, Nishimura K, Tsujimura A, Kongkanand A, Okuyama A: Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis. Int J Cancer. 2002, 98 (2): 167-172. 10.1002/ijc.10178.
  CAS PubMed Google Scholar
• Gao N, Jiang BH, Leonard SS, Corum L, Zhang Z, Roberts JR, Antonini J, Zheng JZ, Flynn DC, Castranova V, Shi X: p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells. J Biol Chem. 2002, 277 (47): 45041-45048. 10.1074/jbc.M202775200.
  CAS PubMed Google Scholar
• Lin DL, Whitney MC, Yao Z, Keller ET: Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression. Clin Cancer Res. 2001, 7 (6): 1773-17781.
  CAS PubMed Google Scholar
• Edlund S, Landstrom M, Heldin CH, Aspenstrom P: Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell. 2002, 13 (3): 902-914. 10.1091/mbc.01-08-0398.
  PubMed Central CAS PubMed Google Scholar
• Aguirre-Ghiso JA, Estrada Y, Liu D, Ossowski L: ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). Cancer Res. 2003, 63 (7): 1684-1695.
  CAS PubMed Google Scholar
• Putz T, Culig Z, Eder IE, Nessler-Menardi C, Bartsch G, Grunicke H, Uberall F, Klocker H: Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines. Cancer Res. 1999, 59 (1): 227-233.
  CAS PubMed Google Scholar
• Price DT, Rocca GD, Guo C, Ballo MS, Schwinn DA, Luttrell LM: Activation of extracellular signal-regulated kinase in human prostate cancer. J Urol. 1999, 162 (4): 1537-1542.
  CAS PubMed Google Scholar
• Huynh H, Nguyen TT, Chan E, Tran E: Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation. Int J Onco. 2003, 23 (3): 821-829.
  CAS Google Scholar
• Wetterau LA, Francis MJ, Ma L, Cohen P: Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells. J Clin Endocrinol Metab. 2003, 88 (7): 3354-3359. 10.1210/jc.2002-021326.
  CAS PubMed Google Scholar
• Udayakumar TS, Bair EL, Nagle RB, Bowden GT: Pharmacological inhibition of FGF receptor signaling inhibits LNCaP prostate tumor growth, proliferation, and PSA expression. Mol Carcinog. 2003, 38 (2): 70-77. 10.1002/mc.10146.
  CAS PubMed Google Scholar
• Deeble PD, Murphy DJ, Parsons SJ, Cox ME: Interleukin-6- and cyclic AMP-mediated signaling potentates Neuroendocrine differentiation of LNCaP prostate tumor cells. Mol Cell Biol. 2001, 21 (24): 8471-8482. 10.1128/MCB.21.24.8471-8482.2001.
  PubMed Central CAS PubMed Google Scholar
• Xie Y, Gibbs TC, Mukhin YV, Meier KE: Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells. J Biol Chem. 2002, 277 (36): 32516-32526. 10.1074/jbc.M203864200.
  CAS PubMed Google Scholar
• Barki-Harrington L, Daaka Y: Bradykinin induced mitogenesis of androgen independent prostate cancer cells. J Urol. 2001, 165 (6 Pt 1): 2121-2125.
  CAS PubMed Google Scholar
• Sauer H, Klimm B, Hescheler J, Wartenberg M: Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP. FASEB J. 2001, 15 (13): 2539-2541.
  CAS PubMed Google Scholar
• Lee YF, Lin WJ, Huang J, Messing EM, Chan FL, Wilding G, Chang C: Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells. Cancer Res. 2002, 62 (21): 6039-6044.
  CAS PubMed Google Scholar
• Tessier DM, Matsumura F: Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. Toxicol Sc. 2001, 60 (1): 38-43. 10.1093/toxsci/60.1.38.
  CAS Google Scholar
• Segawa N, Nakamura M, Nakamura Y, Mori I, Katsuoka Y, Kakudo K: Phosphorylation of mitogen-activated protein kinase is inhibited by calcitonin in DU145 prostate cancer cells. Cancer Res. 2001, 61 (16): 6060-6063.
  CAS PubMed Google Scholar
• Agarwal C, Sharma Y, Agarwal R: Anticarcinogenic effect of a polyphenolic fraction isolated from grape seeds in human prostate carcinoma DU145 cells: modulation of mitogenic signaling and cell-cycle regulators and induction of G1 arrest and apoptosis. Mol Carcinog. 2000, 28 (3): 129-138. 10.1002/1098-2744(200007)28:3<129::AID-MC1>3.0.CO;2-0.
  CAS PubMed Google Scholar
• Tyagi A, Agarwal R, Agarwal C: Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Oncogene. 2003, 22 (9): 1302-1316. 10.1038/sj.onc.1206265.
  CAS PubMed Google Scholar
• Wang Z, Jiang C, Lu J: Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol. Mol Carcinog. 2002, 34 (3): 113-120. 10.1002/mc.10056.
  CAS PubMed Google Scholar
• Jiang C, Wang Z, Ganther H, Lu J: Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells. Mol Cancer Ther. 2002, 1 (12): 1059-1066.
  CAS PubMed Google Scholar
• Sharma Y, Agarwal C, Singh AK, Agarwal R: Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells. Mol Carcinog. 2001, 30 (4): 224-236. 10.1002/mc.1032.
  CAS PubMed Google Scholar
• Wang S, DeGroff VL, Clinton SK: Tomato and soy polyphenols reduce insulin-like growth factor-I-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase. J Nut. 2003, 133 (7): 2367-2376.
  CAS Google Scholar
• Ogawa Y, Nakagami Y, Ishizaki R, Yoshida H, Parkinson KM, Robertson CN, Paulson DF: Heat shock protein 70 (HSP70) does not prevent the inhibition of cell growth in DU-145 cells treated with TGF-beta1. Anticancer Res. 2001, 21 (5): 3341-3347.
  CAS PubMed Google Scholar
• Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG: Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways. Oncogene. 2003, 22 (28): 4314-4332. 10.1038/sj.onc.1206478.
  CAS PubMed Google Scholar
• Bu S, Blaukat A, Fu X, Heldin NE, Landstrom M: Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. FEBS Lett. 2002, 531 (2): 141-151. 10.1016/S0014-5793(02)03478-6.
  CAS PubMed Google Scholar
• Drew L, Fine RL, Do TN, Douglas GP, Petrylak DP: The novel antimicrotubule agent cryptophycin 52 (LY355703) induces apoptosis via multiple pathways in human prostate cancer cells. Clin Cancer Res. 2002, 8 (12): 3922-3932.
  CAS PubMed Google Scholar
• Uzzo RG, Leavis P, Hatch W, Gabai VL, Dulin N, Zvartau N, Kolenko VM: Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents. Clin Cancer Res. 2002, 8 (11): 3579-3583.
  CAS PubMed Google Scholar
• Lu S, Hoestje SM, Choo EM, Epner DE: Methionine restriction induces apoptosis of prostate cancer cells via the c-Jun N-terminal kinase-mediated signaling pathway. Cancer Lett. 2002, 179 (1): 51-58. 10.1016/S0304-3835(01)00852-7.
  CAS PubMed Google Scholar
• Engedal N, Korkmaz CG, Saatcioglu F: C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP. Oncogene. 2002, 21 (7): 1017-1027. 10.1038/sj.onc.1205167.
  CAS PubMed Google Scholar
• Maeda H, Hori S, Nishitoh H, Ichijo H, Ogawa O, Kakehi Y, Kakizuka A: Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer. Cancer Res. 2001, 61 (14): 5432-5440.
  CAS PubMed Google Scholar