Sudheesh K Shukla, PhD | LOVELY PROFESSIONAL UNIVERSITY (original) (raw)

Papers by Sudheesh K Shukla, PhD

Molecular Biology Reports

Advanced Materials Letters, 2021

Nanoparticles (NPs) are strong colloidal particles with diameters ranging from 1nm-100 nm. They c... more Nanoparticles (NPs) are strong colloidal particles with diameters ranging from 1nm-100 nm. They comprise of macromolecular materials and can be utilized therapeutically as adjuvant in immunizations or as medication transporters. In this paper two fundamental sorts of nanoparticles are discussed i.e., metallic nanoparticle and polymeric nanoparticle. Metallic nanoparticle is nanosized metals with measurements (length, width, thickness) inside the size range of 1nm-100nm. The properties, advantages, disadvantages and characteristics of metal nanomaterials are discussed in brief in this review. Polymers are the most common materials for constructing nanoparticle-based drug carriers. Polymers used to form nanoparticles can be both synthetic and natural polymers. This review summarizes the synthesis and fabrication of nanomaterials. It describes about synthesis of metallic and polymeric nanomaterials as well as synthesis of quantum dots. It gives insights of fabrication of nanomaterials. Applications of nanomaterials are also included in this review mainly focusing on biosensor, gas sensor, wastewater treatment and environmental applications. The tunable surface and optical properties of nanomaterials make the perfect contender for biosensing including the analysis of ailments, cellular imaging of cancerous cell and so on. Gas sensors have been utilized in numerous applications like monitoring the oxygen content in fuel mixture, observing food decay, health monitoring etc. Nanomaterials offer the potential for the productive expulsion of pollutants and biological contaminants thus extremely valuable in environment and wastewater treatment. Nanomaterials are highly recommended in future for these properties, mainly for their use in healthcare sector.

Talanta, 2018

In vivo monitoring of the neurotransmitter dopamine can potentially improve the diagnosis of neur... more In vivo monitoring of the neurotransmitter dopamine can potentially improve the diagnosis of neurological disorders and elucidate their underlying biochemical mechanisms. While electrochemical sensors can detect unlabeled dopamine molecules, their sensing performance is dramatically reduced by electrochemical currents generated by other, interfering molecules (e.g., uric acid) in the biological environment. To overcome this caveat, the surface of the sensor is often modified with electrocatalytic materials, which are encapsulated inside a polymeric film; however, the effect of the encapsulating film on the sensing performance of the electrode has not been systematically studied. This study characterizes the effect of loading carbon nanotubes (CNTs) onto a chitosan film on the electrochemical sensing performance of dopamine in the presence of uric acid. Higher CNT loading increases the diffusion and electron transfer rate coefficients of the sensor and, in the presence of uric acid, ...

ChemInform, 2013

In general aryl iodides and bromides can be applied with iodide leading to the products with high... more In general aryl iodides and bromides can be applied with iodide leading to the products with higher yields.

Authorea (Authorea), Feb 10, 2023

This a preprint and has not been peer reviewed. Data may be preliminary.

Chemical Engineering Journal, 2021

The recent outbreak of COVID-19 has created much inconvenience and fear that the virus can seriou... more The recent outbreak of COVID-19 has created much inconvenience and fear that the virus can seriously affect humans, causing health hazards and death. This pandemic has created much worry and as per the report by World Health Organization (WHO), more than 43 million individuals in 215 countries and territories were affected. People around the world are still struggling to overcome the problems associated with this pandemic. Of all the available methods, reverse-transcriptase polymerase chain reaction (RT-PCR) has been widely practiced for the pandemic detection even though several diagnostic tools are available having varying accuracy and sensitivity. The method offers many advantages making it a life-saving tool, but the method has the limitation of transporting to the nearest pathology lab, thus limiting its application in resource limited settings. This has a risen a crucial need for point-of-care devices for on-site detection. In this venture, biosensors have been used, since they can be applied immediately at the point-of-care. This review will discuss about the available diagnostic methods and biosensors for COVID-19 detection.

Journal of Inorganic and Organometallic Polymers and Materials, May 8, 2018

Photodecolorization of naphthol blue black dye through the use of Cu 2 O nanoparticles capped wit... more Photodecolorization of naphthol blue black dye through the use of Cu 2 O nanoparticles capped with a biopolymer matrix containing gum ghatti (Gg) grafted with acrylic acid (AA) and acrylamide (AAm) (Cu 2 O/Gg-AAm-AA) has been studied. While the homogeneous co-precipitation method was adopted for the synthesis of the Cu 2 O nanoparticle, its incorporation into the biopolymer matrix (Gg-AAm-AA) was performed through the graft copolymerization method. The synthesized Cu 2 O and Cu 2 O/Gg-AAm-AA were characterized using SEM, TEM, XRD, EDX and UV-Vis spectroscopies, and BET surface area analysis. The photodecolorization experiment was performed using simulated ultraviolet and visible light irradiations, and these results compared with that of adsorption studies. The influence of pH, catalyst dose and dye concentration on the decolorization efficiency were also taken into consideration. The results revealed the Cu 2 O/Gg-AAm-AA to be an excellent photocatalyst for effective elimination of naphthol blue black dye from water. The process was observed to be pH dependent, with pH 6 being the optimum value. The photodecolorization process increased with increasing catalyst concentration but decreased beyond the optimum value of 0.3 g L −1. The process also decreased with increasing dye concentration. The result of the recyclability study indicates that the Cu 2 O/Gg-AAm-AA nanocomposite can be effectively recycled and re-used over a number cycles.

Electroanalysis, Jul 18, 2018

We introduce a hybrid two-dimensional nanointerface structure for bioelectronic systems. We fabri... more We introduce a hybrid two-dimensional nanointerface structure for bioelectronic systems. We fabricated smart hierarchically self-assembled 2D electrobiocatalytic interface system based on the combination of gold nanoparticles doped graphene oxide (GO)-molybdenum disulfide (MoS 2) layered nanohybrid, conjugated with poly (N-isopropylacrylamide, PNIPAAm) resulting in GO/AuNPs/MoS 2 /PNIPAAm interface. Horseradish peroxidase (HRP) was subsequently immobilized on the GO/AuNPs/MoS 2 /PNIPAAm interface through electrostatic interactions giving GO/AuNPs/MoS 2 /PNIPAAm/ Peroxidase electrobiocatalytic interface system as a platform for electrobiocatalysis reactions for biosensing and bioelectronic applications. The electrobiocatalytic activity of the nanohybrid interface structure was studied using hydrogen peroxide (H 2 O 2) as a model analyte. Cyclic Voltammetry showed diffusion controlled electron transfer properties at the interface. The fabricated bioelectrode exhibits a wide linear response to the detection of H 2 O 2 from 1.57 to 11.33 mM, with a detection limit of 3.34 mM (S/N = 3) and a capacitance of 8.6 F/cm 2 .

ChemistrySelect, Jan 29, 2018

Organic pollutants from the industries and anthropogenic sources pose severe problems to both the... more Organic pollutants from the industries and anthropogenic sources pose severe problems to both the environment and human health. Hence, there is the need to eliminate these pollutants from our water bodies, as safe drinking water is a major prerequisite for healthy life and also as precious resources for human civilisation. In this study, a photocatalyst (La-ZnO-GO) with improved photocatalytic properties is synthesised using co-precipitation approach. The photocatalytic activities, morphologies and structures of the photocatalyst are investigated by means of advanced technologies such as Ultraviolet-Visible spectroscopy, X-ray diffraction, Raman spectroscopy, transmission electron microscopy, scanning electron microscopy. Under visible light irradiation, Eosin Yellow (EY) dye was used to calculate the photocatalytic behaviour of La-ZnO-GO composite. The photocatalytic outcome shows that the 0.3% La-ZnO-GO photocatalyst displayed a better photoactivity towards the degradation of organic pollutant. This effective photodegradation of EY dye solution is ascribed to the mutual effect of La and graphene oxide, as well as the improved visible light absorbance and the separation of electron-hole pairs. The total organic carbon result shows a significant mineralisation of EY dye, which drops the formation of potentially harmful degradation by-products. The stability results show a recyclability of the 0.3% La-ZnO-GO composites with 89% degradation efficiency after the five (5) cycles.

Chemistry Africa, Aug 18, 2022

Springer eBooks, Jun 21, 2018

Pharmaceutical products are produced purposely for the treatment of diseases with the aim of impr... more Pharmaceutical products are produced purposely for the treatment of diseases with the aim of improving human health. Despite their usefulness to human and animal health, pharmaceuticals are now being regarded as emerging environmental pollutants. This is due to their increased use and the fact that they are indiscriminately discharged into the aquatic environment from hospitals, households, industries, pharmacies, as well as leakages and leachates from municipal wastewater treatment plants and landfill sites. Moreover, the conventional methods of wastewater treatment were not designed with these emerging pollutants in mind resulting in the discharge of untreated or incomplete treated wastewater into water bodies. Pharmaceuticals in water are believed to exert deleterious effects on humans and aquatic organisms. The concern to remove these pharmaceutical wastes and their metabolites from wastewater before their final discharge into water bodies has culminated in the development of a wide variety of other treatment technologies such as adsorption, chemical oxidation, liquid extraction, biodegradation, and so on. However, because these pharmaceuticals are mostly water soluble and non-biodegradable, most of the treatment techniques are inappropriate for their effective removal. The deployment of an appropriate technique for effective degradation of pharmaceutical wastes in water has therefore become a necessary requirement. This chapter therefore provides a detailed discussion on pharmaceuticals in general, their occurrence in water and their health consequences. It also delved into the photocatalytic degradation of these chemicals in water with emphasis on the use of graphene based materials.

Bulletin of Materials Science, Nov 14, 2016

Photocatalysts consisting of nickel-doped ZnS/ZnO core shell nanocomposites with varying concentr... more Photocatalysts consisting of nickel-doped ZnS/ZnO core shell nanocomposites with varying concentrations of ZnO was synthesized through chemical precipitation method. The catalyst was deployed in photocatalytic degradation of indigo carmine dye as a model organic pollutant. Characterization of the samples was achieved through the use of X-ray powder diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, UV-vis spectroscopy and energy dispersive spectroscopy. The composites consist of wurtzite ZnO phase deposited on cubic ZnS. Optical absorption, crystallite sizes and photocatalytic degradation efficiency increased with increasing ZnO concentration. Bandgap values of ZnS also decreased appreciably with increase in ZnO concentration. Ni-doped ZnS/(0.5 M ZnO) was identified as the most efficient catalyst with 91% dye degradation efficiency at a rate of 15.38 × 10 −3 min −1 in 180 min. Meanwhile, the pristine ZnS degraded 25% of the dye at the rate of 1.53 × 10 −3 min −1 within the same time. The Ni-doped Zns/(0.5 M ZnO) was used to degrade the dye on the basis of influence of factors such as solution temperature, hydrogen peroxide (H 2 O 2) and ethanol contents. Dye degradation increased with increase in temperature, but decreased with ethanol content. H 2 O 2 content initially caused enhanced dye degradation but the efficiency decreased with higher H 2 O 2 content.