Paul Pumpens | University of Latvia (original) (raw)

Papers by Paul Pumpens

CRC Press eBooks, Feb 3, 2020

CRC Press eBooks, Apr 4, 2022

CRC Press eBooks, Feb 3, 2020

CRC Press eBooks, Apr 4, 2022

CRC Press eBooks, Feb 3, 2020

Virus-Like Particles: A Comprehensive Guide, 2022

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This book represents the first complete and systematic guide to the virus-like particles (VLPs) and their applications as vaccines, therapeutic tools, nanomaterials, and nanodevices. The grouping of the VLPs follows the most recent virus taxonomy and the traditional Baltimore classification of viruses, which are based on the genome structure and mechanism of mRNA synthesis. Within each of the seven Baltimore classes, the order taxon serves as a framework of the chapter’s arrangement. The term "VLP" is used as a universal designation for the virus-, core-, or capsid-like structures, which became an important part of the modern molecular virology. The 3D structures, expression systems, and nanotechnological applications are described for VLPs in the context of the original viruses and uncover their evolving potential as novel vaccines and medical interventions.

Key Features

Presents the first full guide to the VLP nanotechnology, classified by current viral taxonomy
Outlines specific structural properties and interconnection of the virions and VLPs
Explains generation and characteristics of VLPs produced by various expression systems
Offers up-to-date summary of VLPs designed as vaccines and delivery tools
Unveils interconnection of VLPs with novel organic and inorganic nanomaterials

Single-Stranded RNA Phages: From Molecular Biology to Nanotechnology, 2020

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This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols.

Key Features

Presents the first full guide to single-stranded RNA phages
Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences
Demonstrates how RNA phage-derived products have resulted in nanotechnological applications
Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies