Michele Compagno | Lund University (original) (raw)

Papers by Michele Compagno

Methods This is a single centre retrospective study comprising 334 LN renal biopsies. Clinical an... more Methods This is a single centre retrospective study comprising 334 LN renal biopsies. Clinical and biochemical parameters at the time of biopsy were noted and their association with his-topathological class, activity and chronicity scores (AS/CS) (ISN/RPS classification) were evaluated. Complete, partial or no response(CR, PR, NR) for the renal outcome (EULAR/ EDTA) at 1 year were calculated for 293 patients. Binary logistic regression was done to look for the predictors of NR. Results Class III/IV LN was seen in 240(71.8%). Hypertension was seen in (52.1%) of class III/IV and <25% each with class II, V and combined class(p<0.001). Class III/IV had lower eGFR [87.6(62.75-118.8)] (p<0.001) than the other classes. Nephrotic range proteinuria was seen in 32% of class V and 21% in class III/IV (p=0.004) Among class-III/IV AS had weak correlation with baseline UPCR (r=0.31) and eGFR (r=-0.172) (p<0.01). CS had weak negative correlation with eGFR (r=-0.212,p<0.01). NR at 1 year was higher in males (OR-4.6,95%CI-1.9-10.8,p<0.001), those with abnormal serum creatinine (OR-3.3,95%:CI1.6-7.02, p-0.001), higher renal SLEDAI (p<0.05), higher AS, CS (p<0.001), interstitial inflammation and tubular atrophy(p<0.005) (Table-1). On binary logistic regression a combined clinico-histopathological model comprising of serum creatinine, UPCR, male sex and CS performed best in predicting NR (figure 1). Conclusion Clinical and biochemical parameters can predict the renal histological class to a fair extent but have limited value in predicting the activity and chronicity parameters. Since a combination of clinical and histopathology parameters are better in predicting renal outcomes, performing renal biopsies should be encouraged in LN.

Speaker abstracts 2001, 2001

Rheumatology

Objectives To examine the relationship between adherence to dietary guidelines and the risk of de... more Objectives To examine the relationship between adherence to dietary guidelines and the risk of developing RA. Methods Participants in the Malmö Diet and Cancer Study (MDCS) cohort diagnosed with RA were identified through register linkage and validated in a structured review. Four controls per case were selected, matched for sex, year of birth, and year of inclusion in the MDCS. Diet was assessed at baseline (1991–1996) using a validated diet history method. A Diet Quality Index (DQI) based on adherence to the Swedish dietary guidelines including intakes of fibre, vegetables and fruits, fish and shellfish, saturated fat, polyunsaturated fat, and sucrose, was used. The associations between the DQI and its components and the risk of RA were assessed using conditional logistic regression analysis, adjusting for total energy intake, smoking, leisure time physical activity and alcohol consumption. Results We identified 172 validated cases of incident RA in the cohort. Overall adherence t...

Annals of the Rheumatic Diseases

BackgroundDiet has received much attention as a factor that may contribute to the development of ... more BackgroundDiet has received much attention as a factor that may contribute to the development of rheumatoid arthritis (RA). Several different nutrients, food components and dietary patterns have been studied in different populations. There is limited information on the importance of compliance with diet recommendations in this context.ObjectivesThe aim of this study was to investigate the relation between overall dietary quality, diet components, and the risk of RA.MethodsParticipants in a population-based survey conducted in 1991-1996 who were subsequently diagnosed with RA (from inclusion until December 2004) were identified through register linkage and validated in a structured process. Four controls for each case, matched for sex, year of birth, and year of inclusion, were selected from the study cohort. The controls were alive and RA-free when the index person was diagnosed with RA. At inclusion, diet was assessed using a modified diet history method, consisting of a seven-day ...

ReumaBulletinen; 145(2), pp 28-31 (2021), Apr 28, 2021

Seminars in Arthritis and Rheumatism

The Journal of Rheumatology

ObjectiveThe aim of the present study was to investigate whether the relationship between sex and... more ObjectiveThe aim of the present study was to investigate whether the relationship between sex and clinical outcomes in early rheumatoid arthritis (RA) varies by autoantibody status.MethodsTwo inception cohorts of consecutive patients with early RA (ie, symptom duration ≤ 12 months) in the southern region of Sweden were investigated. Patients were stratified by anticitrullinated peptide antibody (ACPA) status. The primary outcome was remission (Disease Activity Score in 28 joints [DAS28] < 2.6) at 12 months. Secondary outcomes were remission at 6 months and European Alliance of Associations for Rheumatology good response at 6 and 12 months compared to baseline. In logistic regression models, which were adjusted for age, DAS28 values, and Health Assessment Questionnaire values at baseline, the relationship between sex and clinical outcomes, stratified by ACPA status, was investigated.ResultsIn total, 426 patients with early RA were included: 160 patients were ACPA negative and 266 ...

Journal of Clinical Medicine

The complement system constitutes a crucial part of the innate immunity, mediating opsonization, ... more The complement system constitutes a crucial part of the innate immunity, mediating opsonization, lysis, inflammation, and elimination of potential pathogens. In general, there is an increased activity of the complement system during pregnancy, which is essential for maintaining the host’s defense and fetal survival. Unbalanced or excessive activation of the complement system in the placenta is associated with pregnancy complications, such as miscarriage, preeclampsia, and premature birth. Nonetheless, the actual clinical value of monitoring the activation of the complement system during pregnancy remains to be investigated. Unfortunately, normal reference values specifically for pregnant women are missing, and for umbilical cord blood (UCB), data on complement protein levels are scarce. Herein, complement protein analyses (C1q, C3, C4, C3d levels, and C3d/C3 ratio) were performed in plasma samples from 100 healthy, non-medicated and non-smoking pregnant women, collected during diffe...

Lupus, 2021

Objective The progress of accelerated atherosclerosis in systemic lupus erythematosus (SLE) is in... more Objective The progress of accelerated atherosclerosis in systemic lupus erythematosus (SLE) is incompletely understood. Circulating osteopontin (OPN) is increased in autoimmune conditions, e.g. SLE, and its serum concentration was recently reported to associate with subclinical atherosclerosis in SLE, as measured by carotid intima-media thickness. The aim of this study was to investigate whether OPN may be used as a surrogate biomarker of subclinical atherosclerosis in SLE patients with different disease phenotypes. Methods We recruited 60 well-characterised SLE cases and 60 age- and sex-matched healthy controls. The SLE cases were divided into three different disease phenotypes: SLE with antiphospholipid syndrome (APS), lupus nephritis, and isolated skin and joint involvement. Plasma OPN was detected by ELISA (Quantikine®, R&D Systems). Common carotid arteries intima media thickness was compared between the studied groups in relation to OPN levels and risk factors for vascular chan...

Clinica Terapeutica, 1996

Supplemental material, sj-pdf-1-lup-10.1177_09612033211013898 for Plasma osteopontin versus intim... more Supplemental material, sj-pdf-1-lup-10.1177_09612033211013898 for Plasma osteopontin versus intima media thickness of the common carotid arteries in well-characterised patients with systemic lupus erythematosus by Lina Wirestam, Muna Saleh, Christina Svensson, Michele Compagno, Helene Zachrisson, Jonas Wetterö and Christopher Sjöwall in Lupus

Additional file 1. Additional tables. Tables with additional data and analysis.

Additional file 3. Proportions of patients achieving LUNDEX corrected DAS 28 remission by previou... more Additional file 3. Proportions of patients achieving LUNDEX corrected DAS 28 remission by previous bDMARD exposure. *p

Additional file 4. Proportions of patients achieving LUNDEX corrected DAS 28 low disease activity... more Additional file 4. Proportions of patients achieving LUNDEX corrected DAS 28 low disease activity by previous bDMARD exposure. *p

Additional file 2 Proportions of patients achieving LUNDEX corrected EULAR moderate response by p... more Additional file 2 Proportions of patients achieving LUNDEX corrected EULAR moderate response by previous bDMARD exposure. *p

Additional file 3. Proportions of patients achieving LUNDEX corrected DAS 28 remission by previou... more Additional file 3. Proportions of patients achieving LUNDEX corrected DAS 28 remission by previous bDMARD exposure. *p

Additional file 2 Proportions of patients achieving LUNDEX corrected EULAR moderate response by p... more Additional file 2 Proportions of patients achieving LUNDEX corrected EULAR moderate response by previous bDMARD exposure. *p

Additional file 1. Additional tables. Tables with additional data and analysis.

other potential biomarkers in

Methods This is a single centre retrospective study comprising 334 LN renal biopsies. Clinical an... more Methods This is a single centre retrospective study comprising 334 LN renal biopsies. Clinical and biochemical parameters at the time of biopsy were noted and their association with his-topathological class, activity and chronicity scores (AS/CS) (ISN/RPS classification) were evaluated. Complete, partial or no response(CR, PR, NR) for the renal outcome (EULAR/ EDTA) at 1 year were calculated for 293 patients. Binary logistic regression was done to look for the predictors of NR. Results Class III/IV LN was seen in 240(71.8%). Hypertension was seen in (52.1%) of class III/IV and <25% each with class II, V and combined class(p<0.001). Class III/IV had lower eGFR [87.6(62.75-118.8)] (p<0.001) than the other classes. Nephrotic range proteinuria was seen in 32% of class V and 21% in class III/IV (p=0.004) Among class-III/IV AS had weak correlation with baseline UPCR (r=0.31) and eGFR (r=-0.172) (p<0.01). CS had weak negative correlation with eGFR (r=-0.212,p<0.01). NR at 1 year was higher in males (OR-4.6,95%CI-1.9-10.8,p<0.001), those with abnormal serum creatinine (OR-3.3,95%:CI1.6-7.02, p-0.001), higher renal SLEDAI (p<0.05), higher AS, CS (p<0.001), interstitial inflammation and tubular atrophy(p<0.005) (Table-1). On binary logistic regression a combined clinico-histopathological model comprising of serum creatinine, UPCR, male sex and CS performed best in predicting NR (figure 1). Conclusion Clinical and biochemical parameters can predict the renal histological class to a fair extent but have limited value in predicting the activity and chronicity parameters. Since a combination of clinical and histopathology parameters are better in predicting renal outcomes, performing renal biopsies should be encouraged in LN.

Speaker abstracts 2001, 2001

Rheumatology

Objectives To examine the relationship between adherence to dietary guidelines and the risk of de... more Objectives To examine the relationship between adherence to dietary guidelines and the risk of developing RA. Methods Participants in the Malmö Diet and Cancer Study (MDCS) cohort diagnosed with RA were identified through register linkage and validated in a structured review. Four controls per case were selected, matched for sex, year of birth, and year of inclusion in the MDCS. Diet was assessed at baseline (1991–1996) using a validated diet history method. A Diet Quality Index (DQI) based on adherence to the Swedish dietary guidelines including intakes of fibre, vegetables and fruits, fish and shellfish, saturated fat, polyunsaturated fat, and sucrose, was used. The associations between the DQI and its components and the risk of RA were assessed using conditional logistic regression analysis, adjusting for total energy intake, smoking, leisure time physical activity and alcohol consumption. Results We identified 172 validated cases of incident RA in the cohort. Overall adherence t...

Annals of the Rheumatic Diseases

BackgroundDiet has received much attention as a factor that may contribute to the development of ... more BackgroundDiet has received much attention as a factor that may contribute to the development of rheumatoid arthritis (RA). Several different nutrients, food components and dietary patterns have been studied in different populations. There is limited information on the importance of compliance with diet recommendations in this context.ObjectivesThe aim of this study was to investigate the relation between overall dietary quality, diet components, and the risk of RA.MethodsParticipants in a population-based survey conducted in 1991-1996 who were subsequently diagnosed with RA (from inclusion until December 2004) were identified through register linkage and validated in a structured process. Four controls for each case, matched for sex, year of birth, and year of inclusion, were selected from the study cohort. The controls were alive and RA-free when the index person was diagnosed with RA. At inclusion, diet was assessed using a modified diet history method, consisting of a seven-day ...

ReumaBulletinen; 145(2), pp 28-31 (2021), Apr 28, 2021

Seminars in Arthritis and Rheumatism

The Journal of Rheumatology

ObjectiveThe aim of the present study was to investigate whether the relationship between sex and... more ObjectiveThe aim of the present study was to investigate whether the relationship between sex and clinical outcomes in early rheumatoid arthritis (RA) varies by autoantibody status.MethodsTwo inception cohorts of consecutive patients with early RA (ie, symptom duration ≤ 12 months) in the southern region of Sweden were investigated. Patients were stratified by anticitrullinated peptide antibody (ACPA) status. The primary outcome was remission (Disease Activity Score in 28 joints [DAS28] < 2.6) at 12 months. Secondary outcomes were remission at 6 months and European Alliance of Associations for Rheumatology good response at 6 and 12 months compared to baseline. In logistic regression models, which were adjusted for age, DAS28 values, and Health Assessment Questionnaire values at baseline, the relationship between sex and clinical outcomes, stratified by ACPA status, was investigated.ResultsIn total, 426 patients with early RA were included: 160 patients were ACPA negative and 266 ...

Journal of Clinical Medicine

The complement system constitutes a crucial part of the innate immunity, mediating opsonization, ... more The complement system constitutes a crucial part of the innate immunity, mediating opsonization, lysis, inflammation, and elimination of potential pathogens. In general, there is an increased activity of the complement system during pregnancy, which is essential for maintaining the host’s defense and fetal survival. Unbalanced or excessive activation of the complement system in the placenta is associated with pregnancy complications, such as miscarriage, preeclampsia, and premature birth. Nonetheless, the actual clinical value of monitoring the activation of the complement system during pregnancy remains to be investigated. Unfortunately, normal reference values specifically for pregnant women are missing, and for umbilical cord blood (UCB), data on complement protein levels are scarce. Herein, complement protein analyses (C1q, C3, C4, C3d levels, and C3d/C3 ratio) were performed in plasma samples from 100 healthy, non-medicated and non-smoking pregnant women, collected during diffe...

Lupus, 2021

Objective The progress of accelerated atherosclerosis in systemic lupus erythematosus (SLE) is in... more Objective The progress of accelerated atherosclerosis in systemic lupus erythematosus (SLE) is incompletely understood. Circulating osteopontin (OPN) is increased in autoimmune conditions, e.g. SLE, and its serum concentration was recently reported to associate with subclinical atherosclerosis in SLE, as measured by carotid intima-media thickness. The aim of this study was to investigate whether OPN may be used as a surrogate biomarker of subclinical atherosclerosis in SLE patients with different disease phenotypes. Methods We recruited 60 well-characterised SLE cases and 60 age- and sex-matched healthy controls. The SLE cases were divided into three different disease phenotypes: SLE with antiphospholipid syndrome (APS), lupus nephritis, and isolated skin and joint involvement. Plasma OPN was detected by ELISA (Quantikine®, R&D Systems). Common carotid arteries intima media thickness was compared between the studied groups in relation to OPN levels and risk factors for vascular chan...

Clinica Terapeutica, 1996

Supplemental material, sj-pdf-1-lup-10.1177_09612033211013898 for Plasma osteopontin versus intim... more Supplemental material, sj-pdf-1-lup-10.1177_09612033211013898 for Plasma osteopontin versus intima media thickness of the common carotid arteries in well-characterised patients with systemic lupus erythematosus by Lina Wirestam, Muna Saleh, Christina Svensson, Michele Compagno, Helene Zachrisson, Jonas Wetterö and Christopher Sjöwall in Lupus

Additional file 1. Additional tables. Tables with additional data and analysis.

Additional file 3. Proportions of patients achieving LUNDEX corrected DAS 28 remission by previou... more Additional file 3. Proportions of patients achieving LUNDEX corrected DAS 28 remission by previous bDMARD exposure. *p

Additional file 4. Proportions of patients achieving LUNDEX corrected DAS 28 low disease activity... more Additional file 4. Proportions of patients achieving LUNDEX corrected DAS 28 low disease activity by previous bDMARD exposure. *p

Additional file 2 Proportions of patients achieving LUNDEX corrected EULAR moderate response by p... more Additional file 2 Proportions of patients achieving LUNDEX corrected EULAR moderate response by previous bDMARD exposure. *p

Additional file 3. Proportions of patients achieving LUNDEX corrected DAS 28 remission by previou... more Additional file 3. Proportions of patients achieving LUNDEX corrected DAS 28 remission by previous bDMARD exposure. *p

Additional file 2 Proportions of patients achieving LUNDEX corrected EULAR moderate response by p... more Additional file 2 Proportions of patients achieving LUNDEX corrected EULAR moderate response by previous bDMARD exposure. *p

Additional file 1. Additional tables. Tables with additional data and analysis.

other potential biomarkers in