Hoa Le | Loyola University Chicago (original) (raw)
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Papers by Hoa Le
Lubin Zeng, Dominic O'Brien and Hoa Le-Minh Department of Engineering Science Un... more Lubin Zeng, Dominic O'Brien and Hoa Le-Minh Department of Engineering Science University of Oxford lubin.zeng@eng.ox.ac.uk ... Kyungwoo Lee, Daekwang Jung and Yunje Oh Telecommunications Research and Development center Samsung Electronics Co Ltd kyungwoo72.lee@ ...
Journal of Food Engineering, 2002
International Journal for Parasitology, 2008
Journal of Neuroimmunology, 2001
We determined innate and adaptive immune responses in children with developmental regression and ... more We determined innate and adaptive immune responses in children with developmental regression and autism spectrum disorders (ASD, N=71), developmentally normal siblings (N=23), and controls (N=17). With lipopolysaccharide (LPS), a stimulant for innate immunity, peripheral blood mononuclear cells (PBMCs) from 59/71 (83.1%) ASD patients produced >2 SD above the control mean (CM) values of TNF-alpha, IL-1beta, and/or IL-6 produced by control PBMCs. ASD PBMCs produced higher levels of proinflammatory/counter-regulatory cytokines without stimuli than controls. With stimulants of phytohemagglutinin (PHA), tetanus, IL-12p70, and IL-18, PBMCs from 47.9% to 60% of ASD patients produced >2 SD above the CM values of TNF-alpha depending on stimulants. Our results indicate excessive innate immune responses in a number of ASD children that may be most evident in TNF-alpha production.
Lubin Zeng, Dominic O'Brien and Hoa Le-Minh Department of Engineering Science Un... more Lubin Zeng, Dominic O'Brien and Hoa Le-Minh Department of Engineering Science University of Oxford lubin.zeng@eng.ox.ac.uk ... Kyungwoo Lee, Daekwang Jung and Yunje Oh Telecommunications Research and Development center Samsung Electronics Co Ltd kyungwoo72.lee@ ...
Journal of Food Engineering, 2002
International Journal for Parasitology, 2008
Journal of Neuroimmunology, 2001
We determined innate and adaptive immune responses in children with developmental regression and ... more We determined innate and adaptive immune responses in children with developmental regression and autism spectrum disorders (ASD, N=71), developmentally normal siblings (N=23), and controls (N=17). With lipopolysaccharide (LPS), a stimulant for innate immunity, peripheral blood mononuclear cells (PBMCs) from 59/71 (83.1%) ASD patients produced >2 SD above the control mean (CM) values of TNF-alpha, IL-1beta, and/or IL-6 produced by control PBMCs. ASD PBMCs produced higher levels of proinflammatory/counter-regulatory cytokines without stimuli than controls. With stimulants of phytohemagglutinin (PHA), tetanus, IL-12p70, and IL-18, PBMCs from 47.9% to 60% of ASD patients produced >2 SD above the CM values of TNF-alpha depending on stimulants. Our results indicate excessive innate immune responses in a number of ASD children that may be most evident in TNF-alpha production.