Valmore Bermudez | La Universidad del Zulia (original) (raw)

Uploads

Papers by Valmore Bermudez

Research paper thumbnail of Estudio Piloto

Research paper thumbnail of Archivos Venezolanos de Farmacología y Terapéutica Sociedad Venezolana de Farmacología Clínica y Terapéutica

Research paper thumbnail of Chlamydia trachomatis infection in females consulting health centres in Maracaibo, Venezuela

Revista de salud pública (Bogotá, Colombia)

Research paper thumbnail of Trimetazidine diminishes fasting glucose in rats with fasting hyperglycemia: a preliminary study

American journal of therapeutics

Research paper thumbnail of AMPK as Target for Intervention in Childhood and Adolescent Obesity

Research paper thumbnail of Latent Autoimmune Diabetes in Adults: a case report

American journal of therapeutics

Research paper thumbnail of Introductory remarks

American journal of therapeutics

Research paper thumbnail of Sweeteners and beta-glucans improve metabolic and anthropometrics variables in well controlled type 2 diabetic patients

American journal of therapeutics

Research paper thumbnail of Effects of metoclopramide and metoclopramide/dopamine on blood pressure and insulin release in normotensive, hypertensive, and type 2 diabetic subjects

American journal of therapeutics

Research paper thumbnail of Obesity genetics: a monopoly game of genes

American journal of therapeutics

Obesity is a complex disease that affects all ethnic populations worldwide. The etiology of this ... more Obesity is a complex disease that affects all ethnic populations worldwide. The etiology of this disease is based on the interaction of genetic factors, environment and lifestyles indicators. Genetic contribution to the epidemic has gained attention from 2 sources: monogenic syndromes that display severe obesity, and the polygenic model of common obesity. Single mutations can render a syndrome with severe obesity resulting from alteration in central o peripheral appetite control mechanisms. The interaction of several polymorphisms and epigenetic modifications constitute the basic plot for common obesity, molecular ingredients that should not confuse the investigator-they make this riddle even harder to decipher.

Research paper thumbnail of 3'UTR +62G>A polymorphism of the RETN gene coding resistin and its association with metabolic syndrome components

Research paper thumbnail of Introductory remarks for the First Interamerican Congress of Diabetes Maracaibo-Venezuela, July 2010

American journal of therapeutics

Research paper thumbnail of Variations of lipoprotein(a) levels in the metabolic syndrome: a report from the Maracaibo City Metabolic Syndrome Prevalence Study

Journal of diabetes research, 2013

Research paper thumbnail of Determination of non-HDL cholesterol in diabetic and hypertensive patients

American journal of therapeutics

Research paper thumbnail of Targeting hypertension in patients with cardiorenal metabolic syndrome

Current hypertension reports, 2012

Diabetes mellitus coexisting with hypertension is greater than chance alone would predict. Hypert... more Diabetes mellitus coexisting with hypertension is greater than chance alone would predict. Hypertensive patients have been shown to have altered composition of skeletal muscle tissue, decreased blood flow to skeletal muscle and post-receptor signaling alterations in the IRS insulin pathway, all inducing insulin resistance states, which partially explains why blood pressure goals in DM patients are lower than in normoglycemic patients. Although optimal first-step antihypertensive drug therapy in type 2 DM or impaired fasting glucose levels (IFG) should be individualized for each patient, converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) have been demonstrated in some but not all studies to decrease the rate of development of proteinuria and diabetic renal disease. According to the ACCF/AHA 2011 Expert Consensus, elderly persons with diabetes, hypertension, and nephropathy should be initially treated with ACEIs or ARBs, although the choice of a specific antihypertensive may also depend on other associated comorbidities.

Research paper thumbnail of Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes

American journal of therapeutics

It has already been a decade and a half since the discovery of adiponectin and its role as an ins... more It has already been a decade and a half since the discovery of adiponectin and its role as an insulin sensitizer and only 7 years since its receptors, AdipoR1 and AdipoR2, were described. A single-nucleotide polymorphism (SNP) is a DNA sequence variation that affects only one nucleotide; it may vary from one population to another with different predisposing factors to diseases and other ailments. Once some of the effects of adiponectin and its receptors were known, it was not long until an effort was made to find the associations between specific SNPs of the genes of this hormone and its receptors as genetic risk factors for insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, although these genes were investigated as possible candidates related to the development of these metabolic disorders. All of these possible associations were studied in different populations from France, Finland, the United Kingdom, North America, and Japan, showing hardly concluding results, and because of that it is highly controversial to directly associate one of the genes mentioned above to insulin resistance, type 2 diabetes mellitus, and metabolic syndrome. All of these inconsistencies lead to a review that summarizes the SNPs of the genes of adiponectin, AdipoR1, and AdipoR2 that are mostly related to insulin resistance syndrome, type 2 diabetes mellitus, and metabolic syndrome, although presenting the possible factors that should be taken into account to homogenize the results obtained until now.

Research paper thumbnail of International physical activity questionnaire overestimation is ameliorated by individual analysis of the scores

American journal of therapeutics

Physical inactivity is a global concern, but diverse physical activity measures in use prevent in... more Physical inactivity is a global concern, but diverse physical activity measures in use prevent international comparisons. The International Physical Activity Questionnaire (IPAQ) was developed as an instrument for cross-national monitoring of physical activity and inactivity. Between 1997 and 1998, an International Consensus Group developed four long and four short forms of the IPAQ instruments (administered by telephone interview or self-administration, with two alternate reference periods, either the "last 7 d" or a "usual week" of recalled physical activity). During 2000, 14 centers from 12 countries collected reliability and/or validity data on at least two of the eight IPAQ instruments. Test-retest repeatability was assessed within the same week. Concurrent (inter-method) validity was assessed at the same administration, and criterion IPAQ validity was assessed against the CSA (now MTI) accelerometer. Spearman's correlation coefficients are reported, based on the total reported physical activity. Overall, the IPAQ questionnaires produced repeatable data (Spearman's rho clustered around 0.8), with comparable data from short and long forms. Criterion validity had a median rho of about 0.30, which was comparable to most other self-report validation studies. The…

Research paper thumbnail of Epidemiologic behavior of obesity in the Maracaibo City metabolic syndrome prevalence study

Research paper thumbnail of Evidence of zoonotic Chlamydophila psittaci transmission in a population at risk in Zulia state, Venezuela

Revista de salud pública (Bogotá, Colombia)

Research paper thumbnail of The role of adiponectin in endothelial dysfunction and hypertension

Current hypertension reports, 2014

It has been two decades since the discovery of adiponectin, and today its role in insulin resista... more It has been two decades since the discovery of adiponectin, and today its role in insulin resistance, inflammation, and atherosclerosis are areas of major interest. Production of adiponectin is reduced in all inflammatory processes and states of insulin resistance such as obesity, type 2 diabetes mellitus, and coronary artery disease. Adiponectin regulates carbohydrate metabolism, and may also regulate vascular homeostasis by affecting important signaling pathways in endothelial cells and modulating inflammatory responses in the subendothelial space. Clinical studies have demonstrated a relationship between serum adiponectin concentrations and the activity of the renin-angiotensin-aldosterone system (RAAS), causing changes in blood pressure. Antihypertensive therapy with angiotensin II receptor blockers (ARBs) has been demonstrated to increase adiponectin levels in 3-6 months. Adiponectin has also been shown to play a role in cardiac injury in modulation of pro-survival reactions, cardiac energy metabolism, and inhibition of hypertrophic remodeling. The effects of adiponectin on the cardiovascular system are believed to be partially mediated by the activation of 5’ adenosine monophosphate-activated protein kinase (AMPK) and cyclooxygenase-2 (COX-2) pathways, reducing endothelial cell apoptosis, promoting nitric oxide production, decreasing tumor necrosis factor-alpha (TNF-α) activity, and preventing atherosclerotic proliferation and smooth muscle cell migration. Further evaluation of biologically active forms of adiponectin and its receptor should help to clarify how obesity affects the cardiovascular system.

Research paper thumbnail of Estudio Piloto

Research paper thumbnail of Archivos Venezolanos de Farmacología y Terapéutica Sociedad Venezolana de Farmacología Clínica y Terapéutica

Research paper thumbnail of Chlamydia trachomatis infection in females consulting health centres in Maracaibo, Venezuela

Revista de salud pública (Bogotá, Colombia)

Research paper thumbnail of Trimetazidine diminishes fasting glucose in rats with fasting hyperglycemia: a preliminary study

American journal of therapeutics

Research paper thumbnail of AMPK as Target for Intervention in Childhood and Adolescent Obesity

Research paper thumbnail of Latent Autoimmune Diabetes in Adults: a case report

American journal of therapeutics

Research paper thumbnail of Introductory remarks

American journal of therapeutics

Research paper thumbnail of Sweeteners and beta-glucans improve metabolic and anthropometrics variables in well controlled type 2 diabetic patients

American journal of therapeutics

Research paper thumbnail of Effects of metoclopramide and metoclopramide/dopamine on blood pressure and insulin release in normotensive, hypertensive, and type 2 diabetic subjects

American journal of therapeutics

Research paper thumbnail of Obesity genetics: a monopoly game of genes

American journal of therapeutics

Obesity is a complex disease that affects all ethnic populations worldwide. The etiology of this ... more Obesity is a complex disease that affects all ethnic populations worldwide. The etiology of this disease is based on the interaction of genetic factors, environment and lifestyles indicators. Genetic contribution to the epidemic has gained attention from 2 sources: monogenic syndromes that display severe obesity, and the polygenic model of common obesity. Single mutations can render a syndrome with severe obesity resulting from alteration in central o peripheral appetite control mechanisms. The interaction of several polymorphisms and epigenetic modifications constitute the basic plot for common obesity, molecular ingredients that should not confuse the investigator-they make this riddle even harder to decipher.

Research paper thumbnail of 3'UTR +62G>A polymorphism of the RETN gene coding resistin and its association with metabolic syndrome components

Research paper thumbnail of Introductory remarks for the First Interamerican Congress of Diabetes Maracaibo-Venezuela, July 2010

American journal of therapeutics

Research paper thumbnail of Variations of lipoprotein(a) levels in the metabolic syndrome: a report from the Maracaibo City Metabolic Syndrome Prevalence Study

Journal of diabetes research, 2013

Research paper thumbnail of Determination of non-HDL cholesterol in diabetic and hypertensive patients

American journal of therapeutics

Research paper thumbnail of Targeting hypertension in patients with cardiorenal metabolic syndrome

Current hypertension reports, 2012

Diabetes mellitus coexisting with hypertension is greater than chance alone would predict. Hypert... more Diabetes mellitus coexisting with hypertension is greater than chance alone would predict. Hypertensive patients have been shown to have altered composition of skeletal muscle tissue, decreased blood flow to skeletal muscle and post-receptor signaling alterations in the IRS insulin pathway, all inducing insulin resistance states, which partially explains why blood pressure goals in DM patients are lower than in normoglycemic patients. Although optimal first-step antihypertensive drug therapy in type 2 DM or impaired fasting glucose levels (IFG) should be individualized for each patient, converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) have been demonstrated in some but not all studies to decrease the rate of development of proteinuria and diabetic renal disease. According to the ACCF/AHA 2011 Expert Consensus, elderly persons with diabetes, hypertension, and nephropathy should be initially treated with ACEIs or ARBs, although the choice of a specific antihypertensive may also depend on other associated comorbidities.

Research paper thumbnail of Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes

American journal of therapeutics

It has already been a decade and a half since the discovery of adiponectin and its role as an ins... more It has already been a decade and a half since the discovery of adiponectin and its role as an insulin sensitizer and only 7 years since its receptors, AdipoR1 and AdipoR2, were described. A single-nucleotide polymorphism (SNP) is a DNA sequence variation that affects only one nucleotide; it may vary from one population to another with different predisposing factors to diseases and other ailments. Once some of the effects of adiponectin and its receptors were known, it was not long until an effort was made to find the associations between specific SNPs of the genes of this hormone and its receptors as genetic risk factors for insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, although these genes were investigated as possible candidates related to the development of these metabolic disorders. All of these possible associations were studied in different populations from France, Finland, the United Kingdom, North America, and Japan, showing hardly concluding results, and because of that it is highly controversial to directly associate one of the genes mentioned above to insulin resistance, type 2 diabetes mellitus, and metabolic syndrome. All of these inconsistencies lead to a review that summarizes the SNPs of the genes of adiponectin, AdipoR1, and AdipoR2 that are mostly related to insulin resistance syndrome, type 2 diabetes mellitus, and metabolic syndrome, although presenting the possible factors that should be taken into account to homogenize the results obtained until now.

Research paper thumbnail of International physical activity questionnaire overestimation is ameliorated by individual analysis of the scores

American journal of therapeutics

Physical inactivity is a global concern, but diverse physical activity measures in use prevent in... more Physical inactivity is a global concern, but diverse physical activity measures in use prevent international comparisons. The International Physical Activity Questionnaire (IPAQ) was developed as an instrument for cross-national monitoring of physical activity and inactivity. Between 1997 and 1998, an International Consensus Group developed four long and four short forms of the IPAQ instruments (administered by telephone interview or self-administration, with two alternate reference periods, either the "last 7 d" or a "usual week" of recalled physical activity). During 2000, 14 centers from 12 countries collected reliability and/or validity data on at least two of the eight IPAQ instruments. Test-retest repeatability was assessed within the same week. Concurrent (inter-method) validity was assessed at the same administration, and criterion IPAQ validity was assessed against the CSA (now MTI) accelerometer. Spearman's correlation coefficients are reported, based on the total reported physical activity. Overall, the IPAQ questionnaires produced repeatable data (Spearman's rho clustered around 0.8), with comparable data from short and long forms. Criterion validity had a median rho of about 0.30, which was comparable to most other self-report validation studies. The…

Research paper thumbnail of Epidemiologic behavior of obesity in the Maracaibo City metabolic syndrome prevalence study

Research paper thumbnail of Evidence of zoonotic Chlamydophila psittaci transmission in a population at risk in Zulia state, Venezuela

Revista de salud pública (Bogotá, Colombia)

Research paper thumbnail of The role of adiponectin in endothelial dysfunction and hypertension

Current hypertension reports, 2014

It has been two decades since the discovery of adiponectin, and today its role in insulin resista... more It has been two decades since the discovery of adiponectin, and today its role in insulin resistance, inflammation, and atherosclerosis are areas of major interest. Production of adiponectin is reduced in all inflammatory processes and states of insulin resistance such as obesity, type 2 diabetes mellitus, and coronary artery disease. Adiponectin regulates carbohydrate metabolism, and may also regulate vascular homeostasis by affecting important signaling pathways in endothelial cells and modulating inflammatory responses in the subendothelial space. Clinical studies have demonstrated a relationship between serum adiponectin concentrations and the activity of the renin-angiotensin-aldosterone system (RAAS), causing changes in blood pressure. Antihypertensive therapy with angiotensin II receptor blockers (ARBs) has been demonstrated to increase adiponectin levels in 3-6 months. Adiponectin has also been shown to play a role in cardiac injury in modulation of pro-survival reactions, cardiac energy metabolism, and inhibition of hypertrophic remodeling. The effects of adiponectin on the cardiovascular system are believed to be partially mediated by the activation of 5’ adenosine monophosphate-activated protein kinase (AMPK) and cyclooxygenase-2 (COX-2) pathways, reducing endothelial cell apoptosis, promoting nitric oxide production, decreasing tumor necrosis factor-alpha (TNF-α) activity, and preventing atherosclerotic proliferation and smooth muscle cell migration. Further evaluation of biologically active forms of adiponectin and its receptor should help to clarify how obesity affects the cardiovascular system.