vivek gharpure | Maharashtra University Of Health Sciences,Nashik (original) (raw)
Papers by vivek gharpure
Journal of Neonatal Surgery, 2012
This section is meant for residents to check their understanding regarding a particular topic.
Journal of Neonatal Surgery, 2012
Journal of Neonatal Surgery, 2012
This section is meant for residents to check their understanding regarding a particular topic) QU... more This section is meant for residents to check their understanding regarding a particular topic) QUESTIONS 1. What are the principles governing management of Gastroschisis?
Journal of Neonatal Surgery, 2013
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2009
Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infan... more Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and inflammatory responses of immature enterocytes leading to a unique vulnerability of the preterm gut. In addition the possible therapeutic potential of factors in human milk and probiotic bacteria is discussed.
Journal of Indian Association of Pediatric Surgeons
1. What clinical and sonographic features should make one suspect esophageal atresia in a pregnan... more 1. What clinical and sonographic features should make one suspect esophageal atresia in a pregnancy? 2. What is the quickest method of diagnosing esophageal atresia, with or without tracheo-esophageal fistula (TEF)? 3. What management principles should be fol-lowed in a newborn with esophageal atresia ± TEF till surgery is carried out? 4. What difficulties are encountered in a newborn with esophageal atresia ± TEF and right aortic arch? 5. What are advantages and disadvantages of trans-anastomotic tubes in esophageal atresia ± TEF? 6. What are the management options in anasto-motic leak in esophageal atresia ± TEF repair? 7. What immediate postoperative care is recom-mended in a neonate operated for esophageal atresia ± TEF? 8. What long term follow-up is recommended in a survival of esophageal atresia? 9. What management options are available in a child who develops stricture at anastomotic site following esophageal atresia ± TEF repair? 10. What are different investigations in a c...
Journal of Neonatal Surgery, 2013
This section is meant for residents to check their understanding regarding a particular topic) QU... more This section is meant for residents to check their understanding regarding a particular topic) QUESTIONS 1. Discuss the epidemiology of pyloric atresia. 2. Describe the etiology of pyloric atresia. 3. What anomalies are associated with pyloric atresia? 4. Discuss the genetics of pyloric atresia. 5. How can pyloric atresia be antenatally diagnosed? 6. What are clinical features of pyloric atresia? 7. What investigations will be necessary in a patient with pyloric atresia? 8. How should a patient with pyloric atresia be handled? 9. What surgical interventions are done in pyloric atresia? 10. How parents of a baby with pyloric atresia should be counseled?
Journal of Neonatal Surgery, 2012
Journal of Neonatal Surgery, 2014
Journal of Neonatal Surgery, Jul 1, 2013
Journal of Neonatal Surgery, Jul 1, 2012
2. Describe the etiology of pyloric atresia. 3. What anomalies are associated with pyloric atresi... more 2. Describe the etiology of pyloric atresia. 3. What anomalies are associated with pyloric atresia? 4. Discuss the genetics of pyloric atresia. 5. How can pyloric atresia be antenatally diag-nosed? 6. What are clinical features of pyloric atresia? 7. What investigations will be necessary in a patient with pyloric atresia? 8. How should a patient with pyloric atresia be handled? 9. What surgical interventions are done in py-loric atresia? 10. How parents of a baby with pyloric atresia should be counseled?
Background: Congenital malformations of lung, such as congenital lobar emphysema, cystic adenomat... more Background: Congenital malformations of lung, such as congenital lobar emphysema, cystic adenomatoid malformation, bronchial cyst, pulmonary sequestration are of rare occurrence. However, our hospital being in a rural area attracts a large number of patients with complex malformations. Method: This retrospective analysis is done to evaluate diagnostic accuracy, safety and efficacy and outcomes of open lung resections at a rural hospital. Results: 16 children with congenital lung malformation underwent open resection in a rural hospital, with no mortality and minimal morbidity, no complications and more than 24 months follow-up. Conclusion: Open lung resections are found to be safe, effective in a rural setting also.
APSP Journal of Case Reports, Dec 1, 2010
Most of us are not good at mathematics. We tend to forget that ‘evidence’ is not the ‘proof’. Evi... more Most of us are not good at mathematics. We tend to forget that ‘evidence’ is not the ‘proof’. Evidence is information in support of a hypothesis. Scientific theories and rules have exceptions, considered as special cases. A theory that explains special cases is a better theory. Einstein’s general theory of relativity was verified on the basis of observations and it clarified special cases of Newton’s theory of gravity. Hard science works with hard facts. Hard facts prove hypotheses right or wrong. Scientific theories of biology and medicine are based on soft facts, thus need soft evidences. Observer bias enters in physics experiments too. It enters even more in biological observations. It can be fallacious to depend too much upon evidence in soft sciences.
Choice of anesthetic is a difficult decision considering the many options available these days. E... more Choice of anesthetic is a difficult decision considering the many
options available these days. Each technique has its unique set of
difficulties and complications. Anesthesia technique has to be chosen depending upon type of surgery, condition of patient, duration
of surgery, safety, and finally cost. It should be possible to select a
technique which provides optimum effect at the least possible cost,
without compromising safety at any point.
Journal of Indian Association of Pediatric Surgeons
Journal of Neonatal Surgery, 2012
This section is meant for residents to check their understanding regarding a particular topic.
Journal of Neonatal Surgery, 2012
Journal of Neonatal Surgery, 2012
This section is meant for residents to check their understanding regarding a particular topic) QU... more This section is meant for residents to check their understanding regarding a particular topic) QUESTIONS 1. What are the principles governing management of Gastroschisis?
Journal of Neonatal Surgery, 2013
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2009
Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infan... more Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and inflammatory responses of immature enterocytes leading to a unique vulnerability of the preterm gut. In addition the possible therapeutic potential of factors in human milk and probiotic bacteria is discussed.
Journal of Indian Association of Pediatric Surgeons
1. What clinical and sonographic features should make one suspect esophageal atresia in a pregnan... more 1. What clinical and sonographic features should make one suspect esophageal atresia in a pregnancy? 2. What is the quickest method of diagnosing esophageal atresia, with or without tracheo-esophageal fistula (TEF)? 3. What management principles should be fol-lowed in a newborn with esophageal atresia ± TEF till surgery is carried out? 4. What difficulties are encountered in a newborn with esophageal atresia ± TEF and right aortic arch? 5. What are advantages and disadvantages of trans-anastomotic tubes in esophageal atresia ± TEF? 6. What are the management options in anasto-motic leak in esophageal atresia ± TEF repair? 7. What immediate postoperative care is recom-mended in a neonate operated for esophageal atresia ± TEF? 8. What long term follow-up is recommended in a survival of esophageal atresia? 9. What management options are available in a child who develops stricture at anastomotic site following esophageal atresia ± TEF repair? 10. What are different investigations in a c...
Journal of Neonatal Surgery, 2013
This section is meant for residents to check their understanding regarding a particular topic) QU... more This section is meant for residents to check their understanding regarding a particular topic) QUESTIONS 1. Discuss the epidemiology of pyloric atresia. 2. Describe the etiology of pyloric atresia. 3. What anomalies are associated with pyloric atresia? 4. Discuss the genetics of pyloric atresia. 5. How can pyloric atresia be antenatally diagnosed? 6. What are clinical features of pyloric atresia? 7. What investigations will be necessary in a patient with pyloric atresia? 8. How should a patient with pyloric atresia be handled? 9. What surgical interventions are done in pyloric atresia? 10. How parents of a baby with pyloric atresia should be counseled?
Journal of Neonatal Surgery, 2012
Journal of Neonatal Surgery, 2014
Journal of Neonatal Surgery, Jul 1, 2013
Journal of Neonatal Surgery, Jul 1, 2012
2. Describe the etiology of pyloric atresia. 3. What anomalies are associated with pyloric atresi... more 2. Describe the etiology of pyloric atresia. 3. What anomalies are associated with pyloric atresia? 4. Discuss the genetics of pyloric atresia. 5. How can pyloric atresia be antenatally diag-nosed? 6. What are clinical features of pyloric atresia? 7. What investigations will be necessary in a patient with pyloric atresia? 8. How should a patient with pyloric atresia be handled? 9. What surgical interventions are done in py-loric atresia? 10. How parents of a baby with pyloric atresia should be counseled?
Background: Congenital malformations of lung, such as congenital lobar emphysema, cystic adenomat... more Background: Congenital malformations of lung, such as congenital lobar emphysema, cystic adenomatoid malformation, bronchial cyst, pulmonary sequestration are of rare occurrence. However, our hospital being in a rural area attracts a large number of patients with complex malformations. Method: This retrospective analysis is done to evaluate diagnostic accuracy, safety and efficacy and outcomes of open lung resections at a rural hospital. Results: 16 children with congenital lung malformation underwent open resection in a rural hospital, with no mortality and minimal morbidity, no complications and more than 24 months follow-up. Conclusion: Open lung resections are found to be safe, effective in a rural setting also.
APSP Journal of Case Reports, Dec 1, 2010
Most of us are not good at mathematics. We tend to forget that ‘evidence’ is not the ‘proof’. Evi... more Most of us are not good at mathematics. We tend to forget that ‘evidence’ is not the ‘proof’. Evidence is information in support of a hypothesis. Scientific theories and rules have exceptions, considered as special cases. A theory that explains special cases is a better theory. Einstein’s general theory of relativity was verified on the basis of observations and it clarified special cases of Newton’s theory of gravity. Hard science works with hard facts. Hard facts prove hypotheses right or wrong. Scientific theories of biology and medicine are based on soft facts, thus need soft evidences. Observer bias enters in physics experiments too. It enters even more in biological observations. It can be fallacious to depend too much upon evidence in soft sciences.
Choice of anesthetic is a difficult decision considering the many options available these days. E... more Choice of anesthetic is a difficult decision considering the many
options available these days. Each technique has its unique set of
difficulties and complications. Anesthesia technique has to be chosen depending upon type of surgery, condition of patient, duration
of surgery, safety, and finally cost. It should be possible to select a
technique which provides optimum effect at the least possible cost,
without compromising safety at any point.
Journal of Indian Association of Pediatric Surgeons