Chanika Sritara | Mahidol University (original) (raw)

Papers by Chanika Sritara

Journal of Physical Therapy Science, 2010

Purpose] To investigate the efficacy of pursed lips breathing with forced expiration techniques (... more Purpose] To investigate the efficacy of pursed lips breathing with forced expiration techniques (PLB & FETs) and the active cycle of breathing technique (ACBT) on pulmonary mucus clearance in healthy subjects. [Methods] Three healthy subjects volunteered for the study. Pulmonary mucus clearance was measured over 70 minutes on three different days by a radioaerosol technique. Each subject attended three sessions, one each of control (normal breathing), PLB & FETs and ACBT. [Results] The efficacy of both airway clearance techniques was similar, but better than that of normal breathing. In the central lung zone, PLB & FETs demonstrated a slight enhancement of mucus clearance as compared with ACBT and normal breathing. In the intermediate and peripheral zones, PLB & FETs and ACBT resulted in a relatively high mucus clearance as compared with normal breathing. Overall mucus clearance of normal lungs was remarkably improved by PLB & FETs and ACBT. [Conclusion] Enhanced mucus clearance in healthy subjects, particularly in the intermediate and peripheral lung zone, can be achieved by PLB & FETs and ACBT.

BMC Musculoskeletal Disorders, 2016

Background: Trabecular bone score (TBS), which has been proposed to be used in complementary with... more Background: Trabecular bone score (TBS), which has been proposed to be used in complementary with bone mineral density (BMD) to improve the assessment of fracture risk, is negatively associated with body mass index (BMI). The effect of soft tissue, which is expected to be thicker in subjects with high BMI, on TBS was studied using three scan types: Hologic with fast array mode (Hfa), Hologic with high definition mode (Hhd), and GE-Lunar iDXA. Methods: A spine phantom provided by Hologic for routine quality control procedure was scanned using three scan types: Hfa, Hhd, and iDXA. The phantom was scanned with an overlying soft tissue equivalent material (bolus used in radiotherapy) of 0 (without), 1, 2.5, 3.5, 5 and 7.5 cm thick. For each setting, 30 acquisitions were performed in the same way as for the quality control procedure. TBS was calculated using TBS iNsight® software version 2.1 on the same regions of interest as those used for lumbar spine BMD. Results: Mean ± SD TBS of the phantom (without overlying soft tissue) were 1.379 ± 0.018, 1.430 ± 0.009, and 1.423 ± 0.005 using Hfa, Hhd, and iDXA, respectively. A one-way repeated measures ANOVA showed that there were statistically differences in TBS due to different thicknesses of soft tissue equivalent materials for all three scan types (p < 0.001). A Tukey post-hoc test revealed that the decrease in TBS was statistically significant (p < 0.001) when the soft tissue thickness was 1 cm (−0.0246 ± 0.0044, −0.0319 ± 0.0036, and −0.0552 ± 0.0015 for Hfa, Hhd, and iDXA, respectively). Although to a lesser degree, the effects were also statistically significant for BMD (p < 0.05): an increase for Hfa and Hhd but a decrease for iDXA. However, these changes did not exceed the least significant change (LSC) derived from patients. Conclusions: Increased soft tissue thickness results in lower TBS value. Although BMD is also affected, it is unlikely to pose a clinical problem because the change is unlikely to exceed the patient-derived LSC.

Aim: This study assessed if onfFN mRNA in the peripheral blood of patients with DTC can identify ... more Aim: This study assessed if onfFN mRNA in the peripheral blood of patients with DTC can identify individuals with metastatic disease. Methods: Comparison of onfFN mRNA was made among 3 groups: disease-free, lymph node metastasis, and distant metastasis using real-time RT-PCR on 5 ml blood samples from each DTC patient. Results: Fifty-one patients were included: 30 (59%) were disease-free; 7 (13.7%) had lymph node metastasis; and but with a large overlap and the expression being highest in the disease-free group. Subgroup analysis of the metastatic groups did not show any effect of age, cell type, and serum TSH, Tg, and antiTg on onfFN mRNA. Conclusion: OnfFN mRNA in patients with DTC cannot identify those with metastatic disease.

Clinical Nuclear Medicine, 2015

A 72-year-old woman with papillary thyroid cancer post-total thyroidectomy was referred for post-... more A 72-year-old woman with papillary thyroid cancer post-total thyroidectomy was referred for post-I treatment whole-body scan. Images revealed focal uptake within the gallbladder. Cholecystectomy was subsequently performed, and the pathology report showed well-differentiated adenocarcinoma. Given a history of papillary thyroid cancer, the iodine uptake was reasonably explained as metastasis; however, gallbladder metastasis was extremely infrequent. Literature described the incidental radioiodine retention in the gallbladder as false-positive findings, which can be normal variants or benign hepatobiliary conditions. Primary gallbladder malignancy could be counted for another possibility despite controversial mechanism of uptake.

Background. High circulating vascular endothelial growth factor (VEGF) levels tend to reflect tum... more Background. High circulating vascular endothelial growth factor (VEGF) levels tend to reflect tumor aggressiveness for being associated with tumor progression and prognosis. Measurement of soluble VEGF receptor-1 (sVEGFR-1) may improve diagnostic power of VEGF assay. Methods. This study investigated regulation of plasma VEGF by sVEGFR-1 in 82 patients with head and neck squamous cell carcinoma compared with 32 healthy subjects to obtain information for assay characterization. Results. Normality or abnormality of VEGF/sVEGFR-1secretion patterns was rated into five diagnostic levels from definitely abnormal (likelihood ratios) (LRs = 4–∞) to definitely normal (LRs = 0–0.17). Because of ineffective VEGF regulation, high grade tumor had a greater chance (62.5%) than low grade tumor (20%) in expressing a definitely abnormal pattern and a lower chance to express the normal pattern (P = 0.007). VEGF alone had much lower diagnostic power in differentiating between normal (LRs = 0.3–0.9) and...

Journal of Clinical Densitometry, 2015

Trabecular bone score (TBS), which has been shown to discriminate patients with fractures from he... more Trabecular bone score (TBS), which has been shown to discriminate patients with fractures from healthy individuals, decreases with age. This study was conducted to derive an age-adjusted normative TBS curve for each gender aged 30e80 þ years to serve as reference data for Thai males and females. A cross-sectional study was conducted among employees from the Electricity Generating Authority of Thailand cohorts, after excluding those with conditions potentially affecting bone metabolism and analysis. The values of TBS at L1eL4 vertebrae were analyzed using a commercial software. Age-adjusted TBS curves were constructed using segmental linear regression analysis for each gender. Additional analysis was also performed on TBS with age, body mass index, and body mineral density (BMD) at L1eL4 vertebrae as covariates. A database of 848 healthy subjects (341 females and 507 males) aged 30e80þ years was created. The BMDs of both male and female subjects in the youngest decade were not statistically different from previous reports ( p 5 0.31 and 0.22 for females and males, respectively). In this age group, the mean TBS was higher in females, albeit not statistically significant ( p 5 0.12). Between the ages of 30e80þ years, female and male TBS dropped by 19.8% (0.40% per year) and 10.1% (0.20% per year), respectively. The association with TBS was weak for body mass index and moderate for BMD (coefficients of about À0.01 and 0.4e0.5, respectively). The age-adjusted reference curves for healthy Thai females and males aged 30e80þ years have been established.

Asian Pacific journal of cancer prevention : APJCP, 2012

This study assessed if onfFN mRNA in the peripheral blood of patients with DTC can identify indiv... more This study assessed if onfFN mRNA in the peripheral blood of patients with DTC can identify individuals with metastatic disease. Comparison of onfFN mRNA was made among 3 groups: disease-free, lymph node metastasis, and distant metastasis using real-time RT-PCR on 5 ml blood samples from each DTC patient. Fifty-one patients were included: 30 (59%) were disease-free; 7 (13.7%) had lymph node metastasis; and 14 (27.5%) had distant metastasis. OnfFN mRNA levels in the 3 groups were significantly different (P=0.001) but with a large overlap and the expression being highest in the disease-free group. Subgroup analysis of the metastatic groups did not show any effect of age, cell type, and serum TSH, Tg, and antiTg on onfFN mRNA. The within-run and between-run root mean square coefficients of variations were <2%. OnfFN mRNA in patients with DTC cannot identify those with metastatic disease.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2011

Delineate normal data in a Thai population for global left ventricular function, left ventricular... more Delineate normal data in a Thai population for global left ventricular function, left ventricular mass (LVM), and LV mass index (LVMI) by gated volumetric CT angiography (CTA). Two hundred twenty seven patients with intermediate risk factors for CAD were referred for CT coronary angiography. The non-hypertensive and non-diabetic asymptomatic group was selected with negative coronary CTA. Pre-condition of mild stenosis or less than 50% area stenosis was consistently met for inclusion in the present study. One hundred fifteen patients were included (31 males, 84 females, age range 38-76 years, mean 54.6 +/- 7.2 for males and 54.0 +/- 6.8 for females respectively). Mean EDV, ESV, SV, CO, and EF in male and females were EDV 122.6 +/- 17.3 vs. 94.9 +/- 16.6ml, ESV 48.2 +/- 9.9 vs. 34.1 +/- 9.1 ml, SV 74.5 +/- 14.2 vs. 60.8 +/- 10.6 ml, CO 4.2 +/- 0.8vs. 3.6 +/- 0.7 Land EF 60.6 +/- 6.6 vs. 64.3 +/- 5.6% respectively The mean LVM and LVMI were higher in males than females (LVM 134.6 +/- 2...

Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2009

The excellent prognostic value of a normal or near normal stress myocardial perfusion imaging (MP... more The excellent prognostic value of a normal or near normal stress myocardial perfusion imaging (MPI) has been confirmed in numerous studies. The aim of the present study was to determine the association of MPI findings and cardiac events. Consecutive patients referred from January 2003 to December 2004 by Nuclear Medicine Unit in Ramathibodi Hospital for myocardial perfusion imaging were studied. Visual scoring of perfusion images used 17-segments and a scale of 0-4 was done. Sum stress score (SSS) was generated Cardiac death, death from any cause and nonfatal acute myocardial infarction (MI) were considered major cardiac events, and chest pain and late revascularization > 60 days after testing were considered minor cardiac events. Of the 320 patients studied, 218 subjects who had complete 1-year follow-up, were enrolled. There were 99 patients with normal MPI (SSS < or = 3) and 119 patients with abnormal MPI (SSS > 3). Statistical significance between cardiac events in two ...

Nutrition Journal, 2015

Vitamin D-binding protein (DBP) may alter the biological activity of total 25-hydroxyvitamin D [2... more Vitamin D-binding protein (DBP) may alter the biological activity of total 25-hydroxyvitamin D [25(OH)D]; this could influence on the effects of vitamin D in relation to bone mineral density (BMD) and fractures. Emerging data suggest that fetuin-A may be involved in bone metabolism. We aimed to investigate the influence of DBP gene polymorphism on the relationship of vitamin D status and fetuin-A levels to BMD and bone markers. This cross-sectional study was part of a health survey of employees of the Electricity Generating Authority of Thailand (1,734 healthy subjects, 72% male). Fasting blood samples were assayed for 25(OH)D, fetuin-A, N-terminal propeptides of type 1 procollagen (P1NP), C-terminal cross-linking telopeptides of type I collagen (CTx-I), and DBP rs2282679 genotypes. L1-L4 lumbar spine and femoral BMD were measured using dual-energy X-ray absorptiometry. The DBP rs2282679 genotype distribution conformed to the Hardy-Weinberg equilibrium. There were no correlations between 25(OH)D levels and BMD and bone markers. But a trend of positive correlation was observed for the DBP genotypes with total hip BMD, and for the interaction between 25(OH)D and DBP genotypes with BMD at all femoral sites. We further analyzed data according to DBP genotypes. Only in subjects with the AA (common) genotype, 25(OH)D levels were positively related to BMD and bone markers, while fetuin-A was negatively related to total hip BMD, independently of age, gender and BMI. The interaction between vitamin D status, as measured by circulating 25(OH)D and DBP rs2282679 genotypes, modified the association between 25(OH)D and BMD and bone markers. Differences in DBP genotypes additionally influenced the correlation of fetuin-A levels with femoral BMD.

Purpose: After an administration of high dose I-131 in differentiated thyroid cancer, patients ar... more Purpose: After an administration of high dose I-131 in differentiated thyroid cancer, patients are potential sources of radiation. The aim of this study is to clarify radiation in the admitting room and associated surrounding of Ramathibodiûs new inpatient unit during hospitalization of a high dose I-131 treated thyroid cancer patient as well as radiation exposure to associated personnel. Materials and Methods: The radiation dose rate was measured using optically stimulated luminescence dosimeter (OSL) (Al 2 O 3 :C) which placed and interpreted in 22 different locations within and adjacent the admitting room prior and during admission of a high dose I-131 treated patient. Collections of the room air were performed using gamma counters, compared 2 durations with and without the occupied patient in the room. The direct exposure was recorded by digital semiconductor pocket dosimeters, which were carried by patientûs caregivers of every shift, namely morning, evening and night ones. Res...

Journal of Oncology, 2012

Journal of Cardiovascular Disease Research, 2014

Journal of Clinical Densitometry, 2012

Gynecologic and Obstetric Investigation, 2006

Clinical Endocrinology, 2013

Objective The causal effect of adipose tissue on bone mass and the direction of its net influence... more Objective The causal effect of adipose tissue on bone mass and the direction of its net influence have not been directly assessed in adult humans. Using the Mendelian randomization analysis, we assessed the causality of adiposity in measurements of bone mass in adult males and females. Design and Methods Subjects consisted of 2154 adults aged 25-54 years from a cross-sectional cohort of the employees of the Electricity Generating Authority of Thailand. Body composition was determined after at least 3 h of fasting using multifrequency bioelectrical impedance analysis. Bone mineral density (BMD) was assessed by dual energy X-ray absorptiometry. A polymorphism in the fat mass and obesity-associated gene (FTO rs9939609) was used as an instrument in the Mendelian randomization analysis. Results The genotype distribution of the FTO rs9939609 polymorphism was 61Á1% TT, 33Á9% AT and 5Á0% AA. The average body mass index (BMI), body fat mass and percentage body fat were 23Á9 kg/m 2 (SD = 3Á6), 17Á9 kg (SD = 6Á6) and 26Á8% (SD = 7Á2), respectively. The FTO rs9939609 polymorphism was significantly correlated with BMI (coefficient = 0Á673 kg/m 2 , P < 0Á001), body fat mass (coefficient = 0Á948 kg, P < 0Á001) and percentage body fat (coefficient = 0Á759%, P < 0Á01). An instrumental variable (IV) regression model, using BMI as the intermediate phenotype, suggested that FTO was a strong IV. Also, the FTO-BMI polymorphism was significantly associated with total hip and femoral neck BMD but was not correlated with total spine BMD, with estimated correlation coefficients of 0Á0189 (95% CI: 0Á0046, 0Á0332), 0Á0149 (95% CI: 0Á0030, 0Á0268) and 0Á0025 (95% CI: À0Á0131, 0Á0136) g/cm 2 , respectively. The variances of BMDs explained by the FTO-BMI were 19Á0%, 21Á3% and 1Á1%, respectively. Similar trends were also observed for the FTO-body fat mass and FTO-percentage body fat correlations. Conclusions Mendelian randomization analysis suggests that adiposity might be causally related to BMD at the femur but not at the spine.

Asian Pacific journal of cancer prevention : APJCP, 2015

The study aim was to assess factors that impact on the outcome of radioiodine therapy in patients... more The study aim was to assess factors that impact on the outcome of radioiodine therapy in patients diagnosed with differentiated thyroid carcinoma (DTC). We performed a retrospective cohort study on 256 patients with DTC who underwent thyroidectomy and received radioiodine therapy during December 2003 to January 2012. All patients were followed up for at least 1 year. They were considered disease- free by the criteria of the revised American Thyroid Association Management Guideline for Patients with Thyroid nodules and DTC (ATA guideline 2009). On Cox univariate analysis, factors associated with disease-free status were age<45, stage I tumor, low risk group by histopathology, unifocal tumor involvement, stimulated serum Tg level at 1st dose of radioiodine therapy and no distant metastasis from 1st post-treatment WBS (post RxWBS). On multivariate analysis, stage I tumor and stimulated serum Tg level at 1st dose of radioiodine therapy<30 ng/mL were the significant prognostic fact...

Clinical Nuclear Medicine, 2014

We present a 25-year-old woman who has a diagnosis of differentiated thyroid cancer, a 2.5-cm pap... more We present a 25-year-old woman who has a diagnosis of differentiated thyroid cancer, a 2.5-cm papillary carcinoma in the right lobe, and presence of minimal extrathyroid invasion. 131 I ablation and/or treatment of 150 mCi was given orally 3 months after total thyroidectomy. A fetus with radioiodine uptake in the fetal thyroid was unsuspectedly detected by SPECT/ CT after 131 I treatment.