Ashril Yusof - Profile on Academia.edu (original) (raw)

Vol 2, No 2 (2014) by Ashril Yusof

The purpose of this study was to examine the effects of the 11+ and HarmoKnee warm-up programs on... more The purpose of this study was to examine the effects of the 11+ and HarmoKnee warm-up programs on performance measures in professional soccer players. Thirty-six male professional soccer players (age: 18.9 ± 1.4 years) were divided into 3 groups, the 11+, HarmoKnee and control group (n = 12 per group). The experimental groups performed the programs 3 times per week for 2 months (24 sessions), whereas the control group only performed their regular soccer training. The performance tests carried out were: 10m speed tests with and without a ball, 20m single sprint, vertical jump, Wall-Volley and Illinois agility tests. The 11+ group demonstrated significant increases from pre-to-post time points in the vertical jump (3.7%), Wall-Volley (5.4%) and Illinois agility tests (1.7%), while the HarmoKnee group showed a significant increase in Wall-Volley test, with a 5.2% increase. The repeated measures analysis revealed differences between the groups (large effect size) in the 11+ and HarmoKnee groups, compared to the control group, in 10m speed tests with and without a ball, 20m single sprint and Illinois agility tests (p < 0.05). Thus 8-weeks performing the 11+ warm-up program can enhance jump height, agility and soccer skill while the HarmoKnee program generally only improves soccer skill in young professional male soccer players.

Introduction: The impact of musculoskeletal injuries often caused loss time in sport participatio... more Introduction: The impact of musculoskeletal injuries often caused loss time in sport participation. Athletes who suffered from these injuries experienced a decrease in performance and physical disability. Although a variety of treatments have been implemented to the muscle injuries, the administration of autologous blood injection is replacing the conventional rehabilitation to expedite the process of muscle recovery. Platelet-rich plasma (PRP) is relatively new in muscle injury treatment and there is lack of evidence of the satisfaction of PRP treatment in muscle injuries. Purposes: The study aimed to investigate the patient satisfaction in the administration of PRP treatment and rehabilitation program for acute hamstring strain injury. Methods: Participants (competitive, semi-competitive and recreational athletes) with acute hamstring strain injury (Grade II) were recruited. Participants were randomly divided into either the PRP treatment or rehabilitation program. Participants were required to attend weekly follow up assessment for recovery evaluation. All the participants were required to complete a patient satisfaction questionnaire (PSQ-18) at the end of study. The questionnaire is divided into seven sub-scales: general satisfaction, technical quality, interpersonal manner, communication, financial aspect, time spent with doctor, accessibility and convenience. Results: Participants were 22.35 ± 3.41 years. Duration from injury to first presentation in clinic ranged from two to ten days. Mean duration of recovery was 5.64 weeks. No statistically significant difference in the patient satisfaction sub-scales score between the two groups (p>0.05). Conclusion: The present study demonstrates that PRP treatment is as satisfactory as conventional rehabilitation program in managing acute hamstring strain injury. Both modalities are correspondingly safe and have high degree of satisfaction. Given the acceptable outcomes, patients are likely to accept PRP as an effective treatment.

Papers by Ashril Yusof

Revista Brasileira de Ortopedia, Feb 1, 2024

► articulação do joelho ► ciclo menstrual ► hormônio esteroide sexual ► relaxina ► atletas Objeti... more ► articulação do joelho ► ciclo menstrual ► hormônio esteroide sexual ► relaxina ► atletas Objetivo: Nosso estudo investigou alterações na lassidão do joelho em atletas e não atletas do sexo feminino e a relação entre a lassidão do joelho e esteroides sexuais nas fases do ciclo menstrual. Métodos: Quarenta e seis mulheres saudáveis, vinte e quatro atletas e vinte e duas não atletas, sem uso de pílulas anticoncepcionais hormonais, sem lesões anteriores no joelho e com ciclos menstruais regulares por 3 meses consecutivos, participaram do estudo. A lassidão medial e lateral do joelho foi determinada por testes de varo-valgo nas fases folicular, ovulatória e lútea. Os níveis séricos de relaxina, estrógeno, progesterona e testosterona foram determinados por ensaio imunoenzi mático (ELISA) e radioimunoensaio. Resultados: A lassidão do joelho em atletas e não atletas em 0°e 20°de flexão foi maior na fase lútea; as não atletas apresentavam maior lassidão do que as atletas. Houve uma correlação positiva entre os níveis de progesterona e relaxina e a lassidão do joelho. Além disso, os níveis desses dois hormônios foram maiores na fase lútea. Conclusão: O aumento da lassidão medial e lateral do joelho em atletas e não atletas, associado a altos níveis séricos de progesterona e relaxina na fase lútea, pode contribuir para o aumento do risco de lesão sem contato no joelho. No entanto, a menor lassidão do joelho em atletas do que em não atletas sugere que o exercício pode ser um fator protetor. recebido 09 de dezembro de 2022 aceito 07 de fevereiro de 2023

British Journal of Nutrition, Mar 16, 2020

Given the common view that pre-exercise nutrition/breakfast is important for performance, the pre... more Given the common view that pre-exercise nutrition/breakfast is important for performance, the present study investigated whether breakfast influences resistance exercise performance via a physiological or psychological effect. Twenty-two resistance-trained, breakfast-consuming men completed three experimental trials, consuming water-only (WAT), or semi-solid breakfasts containing 0 g/kg (PLA) or 1•5 g/kg (CHO) maltodextrin. PLA and CHO meals contained xanthan gum and low-energy flavouring (approximately 122 kJ), and subjects were told both 'contained energy'. At 2 h post-meal, subjects completed four sets of back squat and bench press to failure at 90 % ten repetition maximum. Blood samples were taken pre-meal, 45 min and 105 min post-meal to measure serum/plasma glucose, insulin, ghrelin, glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations. Subjective hunger/fullness was also measured. Total back squat repetitions were greater in CHO (44 (SD 10) repetitions) and PLA (43 (SD 10) repetitions) than WAT (38 (SD 10) repetitions; P < 0•001). Total bench press repetitions were similar between trials (WAT 37 (SD 7) repetitions; CHO 39 (SD 7) repetitions; PLA 38 (SD 7) repetitions; P = 0•130). Performance was similar between CHO and PLA trials. Hunger was suppressed and fullness increased similarly in PLA and CHO, relative to WAT (P < 0•001). During CHO, plasma glucose was elevated at 45 min (P < 0•05), whilst serum insulin was elevated (P < 0•05) and plasma ghrelin suppressed at 45 and 105 min (P < 0•05). These results suggest that breakfast/pre-exercise nutrition enhances resistance exercise performance via a psychological effect, although a potential mediating role of hunger cannot be discounted.

Journal of Strength and Conditioning Research, Oct 1, 2010

The purpose of this study was to investigate enduring effect of static stretching, dynamic stretc... more The purpose of this study was to investigate enduring effect of static stretching, dynamic stretching and no stretching methods on power and agility in collegian soccer players. Fifteen collegiate soccer players (height: 173.07 ± 7.81 m; mass: 67.60 ± 8.73 kg; age: 24.73 ± 4.59 years; experience: 7.27 ± 2.09) were tested for agility performance using the Illinois agility test and also for power using vertical jump test after warm up completion and at 15 minutes later. Different warm-ups protocols included static stretching, dynamic stretching and no stretching. The current findings showed significant differences on height jump and agility time as compare to static and no stretching methods. There were no significant differences between the first and second posttests after dynamic, static and no stretching methods. We concluded that collegian soccer players probably perform better agility and power after dynamic stretching as compare to static stretching and their muscular performances could be able to sustain in higher level as compare to static stretching.

Healthcare

Elbow pain (EP) in overhead sports is a common phenomenon. Swimming is classified as an overhead ... more Elbow pain (EP) in overhead sports is a common phenomenon. Swimming is classified as an overhead sport, but a lack of attention regarding EP in swimming has created a gap in the knowledge around elite freestyle swimming in Tianjin, China. The purpose of this study was to identify the distribution and prevalence of EP among elite freestyle swimmers in Tianjin, China. The methodology involved a total of 311 qualified participants who volunteered to undertake all measurements. The main findings showed that 183 of the elite freestyle swimmers in this study had EP (accounting for 58.84% of the total 311 participants), with 147 in slight pain and 36 in critical pain. The characteristics of a heavier body weight, taller height, longer left/right forearm length, and longer weekly average training hours serve as contributing factors to the occurrence of EP issues. Gender, age, weekly average training hours, and left/right forearm length are the primary factors correlating with and influencin...

Proceedings of the 5th International Seminar of Public Health and Education, ISPHE 2020, 22 July 2020, Universitas Negeri Semarang, Semarang, Indonesia, 2020

To determine the effectiveness of FIFA 11+ kids as an injury prevention program in male youth foo... more To determine the effectiveness of FIFA 11+ kids as an injury prevention program in male youth football players. In addition, this study will evaluate the implementation of FIFA 11+ as warming up and injury prevention for the youth football club. The quasi experimental and descriptive survey study design was conducted in this study. 24 football clubs in Semarang were observed and analyzed using interviews and questioner. From 24 football clubs, just 20 football clubs have kid's teams between the ages of 9 and 12 in January 2018-June 2020. The total youth athlete is 980 kids. The average time each warming up is 15-20 minutes. The rate of injury during a competition in each game base on how many athletes were injured was fifty. The coach age was sufficient for implementing the program-the coach's license was also an active variable for the success injury prevention program in their athletes.

Interleukin-6, Creatine Kinase, and Antioxidant Enzyme Activities following Platelet-Rich Plasma Treatment on Muscle Injury: A Pilot Study

The aim of this study was to investigate the effect of autologous platelet-rich plasma (PRP) trea... more The aim of this study was to investigate the effect of autologous platelet-rich plasma (PRP) treatment alongside rehabilitation compared with rehabilitation alone on inflammatory cytokine (interleukin-6, IL-6), creatine kinase muscle type (CKM), and antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT) following hamstring injury. This study was a randomised control trial. Participants diagnosed with grade-2 acute hamstring injury (n=16) were divided into 2 groups of PRP treatment with rehabilitation program (PRP-T) and rehabilitation program (CON). Blood samples were collected at baseline, and 2 fortnightly for the various biochemical assessments. Participants were certified to have recovered upon fulfilling return to play (RTP) criteria. Level of IL-6 and the activities of CKM, SOD, and CAT were measured. PRP-T group benefited from earlier time to RTP with significantly lower IL-6 level and CAT activity compared to CON group. There was no significant difference in CKM and ...

kuwait journal of science, 2019

An aqueous extract of Eurycoma longifolia Jack, or natively known in Malay as Tongkat Ali, roots ... more An aqueous extract of Eurycoma longifolia Jack, or natively known in Malay as Tongkat Ali, roots is traditionally used to overcome plethora of health conditions especially andrological maladies. As compiling evidences corroborate the therapeutic effects of this plant extract as efficacious concoction, it is noteworthy that novel potential for the use of the plant extract in regulating fat metabolism is being unravelled. Due to studies that investigated the effects of Tongkat Ali on in vivo models and clinical subjects where the measurable parameters were the end stage of response, this study adopts an in vitro model to investigate whether Tongkat Ali root extract possesses lipid lowering potential or the changes was a side-effect of the supplementation. Human hepatic cell line WRL-68 was used in this study and treated with various concentrations (1, 2, 4 and 8 µg/ml) of the aqueous Tongkat Ali root extract were conducted on fatty liver cells. Results demonstrated reduced intracellul...

Effect of Eurycoma Longifolia Jack Extract on Lipolysis in Collegiate Athletes: Pilot study

IFMBE Proceedings, 2017

Studies have shown that usage of EL could promote lipid lowering and improvement in muscle streng... more Studies have shown that usage of EL could promote lipid lowering and improvement in muscle strength. In view of that, lipid mobilization and utilizations would be the main mechanisms involved. The purpose of the investigation was to determine whether acute consumption of Eurycoma longifolia Jack extract would influence lipolysis among athletes. Ten male athletes were randomly assigned either to Eurycoma longifolia Jack group (EL, n = 5) or placebo group (PG, n = 5). Athletes from both groups ingested 1.7 mg/kg of body weight of either EL or PG for three days prior to the treadmill exercise test (65% of VO2max) for an hour. Plasma free fatty acid (FFA), glycerol and triglycerides (TG) levels were measured at pre-exercise and post-exercise on days 0 and 3. Plasma FFA in EL group was significantly lower than that in PG after 3 days (p < 0.05), and plasma glycerol level was significantly increased in EL compared to PG (p < 0.05). The results of this study suggest that EL supplementation could promote fat lipolysis, resulting towards better energy yield. Therefore, EL can be considered as an ergogenic aid to improve performances and to boost energy production.

Biology of Sport, 2013

The study investigates the effects of the 11+ and HarmoKnee injury prevention programmes on knee ... more The study investigates the effects of the 11+ and HarmoKnee injury prevention programmes on knee strength in male soccer players. Under-21-year-old players (n=36) were divided equally into: the 11+, HarmoKnee and control groups. The programmes were performed for 24 sessions (20-25 min each). The hamstrings and quadriceps strength were measured bilaterally at 60°•s-1 , 180°•s-1 and 300°•s-1. The concentric quadriceps peak torque (PT) of the 11+ increased by 27.7% at 300°•s-1 in the dominant leg (p<0.05). The concentric quadriceps PT of HarmoKnee increased by 36.6%, 36.2% and 28% in the dominant leg, and by 31.3%, 31.7% and 20.05% at 60°•s-1 , 180°•s-1 and 300°•s-1 in the non-dominant leg respectively. In the 11+ group the concentric hamstring PT increased by 22%, 21.4% and 22.1% at 60°•s-1 , 180°•s-1 and 300°•s-1 , respectively in the dominant leg, and by 22.3%, and 15.7% at 60°•s-1 and 180°•s-1 , in the non-dominant leg. In the HarmoKnee group the hamstrings in the dominant leg showed an increase in PT by 32.5%, 31.3% and 14.3% at 60°•s-1 , 180°•s-1 and 300°•s-1 , and in the non-dominant leg hamstrings PT increased by 21.1% and 19.3% at 60°•s-1 and 180°•s-1 respectively. The concentric hamstrings strength was significantly different between the 11+ and control groups in the dominant (p=0.01) and non-dominant legs (p=0.02). The HarmoKnee programme enhanced the concentric strength of quadriceps. The 11+ and HarmoKnee programmes are useful warm-up protocols for improving concentric hamstring strength in young professional male soccer players. The 11+ programme is more advantageous for its greater concentric hamstring strength improvement compared to the HarmoKnee programme.

Life, Jul 6, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Effects of Self-management Program as Adjunctive to Usual Rehabilitation Exercise on Pain and Functional Outcomes in Knee Osteoarthritis: A Randomized Controlled Trial

Journal of research in health sciences, Mar 30, 2023

Background: Home-based exercise (HBE) and patient education (EDU) have been reported as beneficia... more Background: Home-based exercise (HBE) and patient education (EDU) have been reported as beneficial additions to usual knee osteoarthritis (KOA) rehabilitation. However, previous trials mostly examined the effects of HBE and EDU separately. Thus, this study aimed to evaluate the effects of a structured combined HBE and EDU program in addition to usual KOA rehabilitation on pain score, functional mobility, and disability level. Study Design: A parallel-group, single-blinded randomized controlled trial. Methods: Eighty adults with KOA were randomly allocated to experimental (n=40) and control (n=40) groups. All participants underwent their usual physiotherapy care weekly for eight weeks. The experimental group received a structured HBE+EDU program to their usual care, while the control group performed home stretching exercises to equate treatment time. The Knee Injury and Osteoarthritis Outcome Score (KOOS) for the disability level, visual analogue scale (VAS) for pain, and timed up-and-go test (TUG) for mobility were measured pre-post intervention. Results: After eight weeks, the experimental group demonstrated significant improvements in the KOOS (all subscales), pain VAS, and TUG scores compared to baseline (P<0.001); meanwhile, only KOOS (activities of daily living and sports subscales) was significant in the control group. Relative to the control, the experimental group presented higher improvements (P<0.001) by 22.2%, 44.1%, and 15.7% for KOOS, pain VAS, and TUG, respectively. Conclusion: Integrating the HBE+EDU program into usual KOA rehabilitation could reduce pain and disability, while it improved functional mobility. The finding of this study suggests a combination of a structured HBE and EDU program to be considered as part of mainstream KOA management.

Food & Nutrition Research, 2015

Background/objective: The purpose of the present study was to evaluate the effect of fenugreek se... more Background/objective: The purpose of the present study was to evaluate the effect of fenugreek seed extract in combination with swimming exercise compared to glibenclamide consumption on type 2 diabetic rats. Design: The acute toxicity test was carried out to choose the safe doses and identify the toxicity effects of the fenugreek seed extract. To investigate the hypoglycemic effect of the extract and its effect in combination with swimming training, 80 Wistar Kyoto male streptozotocin-induced diabetic rats were divided randomly into eight groups: diabetic control (C); fenugreek seed extract 0.8 g/kg (F1); fenugreek extract 1.6 g/kg (F2); swimming training (S); swimming training plus fenugreek extract 0.8 g/kg (SF1); swimming training plus fenugreek extract 1.6 g/kg (SF2); glibenclamide (G) and swimming training plus glibenclamide (SG). The rats were orally administrated with the treatments once a day with the respective treatment, and the training groups were subjected to swimming training every day for 60 min. Fasting blood samples were collected to measure fasting blood glucose, lipid profile, adiponectin, leptin, and insulin concentrations. Results: The results obtained from acute toxicity study showed no toxicity effect of fenugreek seed extract on the tested dose. Biochemical analysis showed significant improvements in all of the groups compared to the control group (p B0.05). Plasma insulin concentration and insulin resistance (HOMA-IR) was significantly reduced in treated groups compared with the diabetic control group. Plasma leptin were significantly decreased in treated groups compared with the control group; while adiponectin had markedly increased (p B0.05). Conclusion: The findings suggest that fenugreek seed consuming, alongside swimming exercise, has a strong therapeutic effect on the improvement of diabetic parameters.

Background: Low-level (LLLT) and high-intensity laser therapy (HILT) can be beneficial additions ... more Background: Low-level (LLLT) and high-intensity laser therapy (HILT) can be beneficial additions to knee osteoarthritis (KOA) rehabilitation exercises; however, it is still being determined which modality is more effective. Aim: To compare the effects of LLLT and HILT as adjuncts to rehabilitation exercise (LL+EX and HL+EX) on clinical outcomes in KOA. Methods: Thirty-four adults with mild to moderate KOA were randomly allocated to either LL+EX (n = 17) or HL+EX (n = 17) groups. All participants underwent their designated laser treatment combined with rehabilitation exercises weekly for twelve consecutive weeks. The Knee Injury and Osteoarthritis Outcome Score (KOOS), Numerical Pain Rating Scale (NPRS), active knee flexion, and Timed Up-and-Go test (TUG) were assessed at baseline and immediately post-intervention. Results: Post-intervention, both groups significantly improved their KOOS, NPRS, active knee flexion, and TUG scores compared to baseline (p < 0.01). The mean differenc...

Nutrients

Arterial stiffness, an age-dependent phenomenon, is improved with exercise, which in turn may pre... more Arterial stiffness, an age-dependent phenomenon, is improved with exercise, which in turn may prevent cardiovascular diseases in women. However, there is a lack of consolidated information on the impact of exercise on arterial stiffness among healthy women. The aim of this review was to (i) analyse the effect of exercise on arterial stiffness in healthy young, middle-aged, and older women, and (ii) recommend types, intensity, and frequency for each age group. Database searches on PubMed, ScienceDirect, Web of Science, and Scopus were conducted using PRISMA guidelines until September 2022. The keywords were: exercise, women/female, and arterial stiffness. The inclusion criteria were: healthy women, supervised exercise, and arterial stiffness measures. Study quality and bias were assessed using the PEDro scale. Fifty-one papers were classified into young (n = 15), middle-aged (n = 14), and older (n = 22) women. Improvements in arterial stiffness were observed among: young women (Pulse...

Healthcare

The publications on elbow pain (EP) in overhead sports are increasing. The results of previous st... more The publications on elbow pain (EP) in overhead sports are increasing. The results of previous studies mostly focus on the influence of EP in the ball game and throwing sports. Thus, a bibliometric analysis of these publications may show the direction of hot topics and future research trends. The purpose of this study is to identify the research trends on EP in overhead sports. For the methods, the first step is to use the main keywords of ‘Elbow pain’ and ‘Overhead sport’ merging auxiliary vocabulary to reach the relevant global publications between 1970 and 2022 in the Web of Science (WoS) database. The literature data set is imported into EndNote literature manager software to remove duplication. Secondly, the duplication-reduced articles are imported to an Excel sheet according to the inclusion and exclusion criteria of this study. In the third step, VOSviewer software is applied as the main analysis tool in extracting data for analysis from the articles. Then, the main research...

Interaction of hand orientations during familiarization of a goal-directed aiming task

Human Movement Science

sj-docx-2-sph-10.1177_1941738120986803 – Supplemental material for Effects of 8 Weeks of Balance Training, Virtual Reality Training, and Combined Exercise on Lower Limb Muscle Strength, Balance, and Functional Mobility Among Older Men: A Randomized Controlled Trial

Supplemental material, sj-docx-2-sph-10.1177_1941738120986803 for Effects of 8 Weeks of Balance T... more Supplemental material, sj-docx-2-sph-10.1177_1941738120986803 for Effects of 8 Weeks of Balance Training, Virtual Reality Training, and Combined Exercise on Lower Limb Muscle Strength, Balance, and Functional Mobility Among Older Men: A Randomized Controlled Trial by Hassan Sadeghi, Deborah A. Jehu, Abdolhamid Daneshjoo, Elham Shakoor, Mohsen Razeghi, Alireza Amani, Muhammad Nazrul Hakim and Ashril Yusof in Sports Health: A Multidisciplinary Approach

Antitumour activity of local ulam against KB cells

Revista Brasileira de Ortopedia, Feb 1, 2024

British Journal of Nutrition, Mar 16, 2020

Journal of Strength and Conditioning Research, Oct 1, 2010

Healthcare

Proceedings of the 5th International Seminar of Public Health and Education, ISPHE 2020, 22 July 2020, Universitas Negeri Semarang, Semarang, Indonesia, 2020

Interleukin-6, Creatine Kinase, and Antioxidant Enzyme Activities following Platelet-Rich Plasma Treatment on Muscle Injury: A Pilot Study

kuwait journal of science, 2019

Effect of Eurycoma Longifolia Jack Extract on Lipolysis in Collegiate Athletes: Pilot study

IFMBE Proceedings, 2017

Biology of Sport, 2013

Life, Jul 6, 2023

Effects of Self-management Program as Adjunctive to Usual Rehabilitation Exercise on Pain and Functional Outcomes in Knee Osteoarthritis: A Randomized Controlled Trial

Journal of research in health sciences, Mar 30, 2023

Food & Nutrition Research, 2015

Nutrients

Healthcare

Interaction of hand orientations during familiarization of a goal-directed aiming task

Human Movement Science

Antitumour activity of local ulam against KB cells

Antiviral activity of a standardized root water extract of Eurycoma longifolia (Physta®) against dengue virus

Tropical biomedicine, 2019

The aim of this study was to investigate the antiviral property of Eurycoma longifolia Jack (EL) ... more The aim of this study was to investigate the antiviral property of Eurycoma longifolia Jack (EL) against dengue virus. A propriety standardized extract of Eurycoma longifolia Jack (Physta®) was tested for anti-viral activity after viral adsorption in Vero cell line. Viral yield was measured by qRT-PCR in four serotypes of dengue virus. The antiviral activity was further investigated in an in vivo AG129 mouse model for dengue inhibitory candidates. 100 mg/kg EL extract was fed twice daily and challenged with a lethal dose of (~1x105 PFU per mouse) of DENV-2 over a period of six days. Antiviral activity with IC50 of 33.84, 33.55, 58.35 and 119 µg/ml for DENV-1, DENV-2, DENV-3 and DENV-4 serotypes respectively was observed. The selectivity index (SI) values determined as the ratio of cytotoxic concentration (CC50) to inhibitory concentration (IC50) was the lowest for DENV-2 at 28.9. The dengue virus (DENV) replication measured by qRT-PCR showed a reduction of 100% for DENV-1, DENV-2, D...

Food & Nutrition Research, 2018

Background: The use of alternative and complementary medicines to alleviate stress has increased ... more Background: The use of alternative and complementary medicines to alleviate stress has increased to avoid the negative effects of pharmaceutical drugs. Objective: This study investigated the safety and efficacy of Eurycoma longifolia in combination with multivitamins (EL+MV) versus placebo on improving quality of life (QoL), mood and stress in moderately stressed healthy participants. Methods: This randomised, double-blind, placebo-controlled 24-week study enrolled 93 participants aged 25-65 years, with a body mass index of 18-30 kg/m 2 , scoring ≤18 in tension and ≤14 in fatigue subscale of Profiles of Mood Scores (POMS) questionnaire and supplemented with EL+MV or placebo. The primary endpoints were QoL measured by 12-Item Short Form Health Survey (SF-12) questionnaire and mood measured by POMS. The secondary endpoint was stress measured by Multi-Modal Stress Questionnaire (MMSQ). The safety of the intervention product was measured by complete metabolic panel, lipid and renal analysis including several immune parameters. Results: While there were no significant between-group differences, within-group improvements were observed in the SF-12 QoL, POMS and MMSQ domains. In the SF-12 domain, improvements were seen in role limitation due to emotional health (P = 0.05), mental component domain (P < 0.001), emotional well-being (P < 0.001), social functioning (P = 0.002) as well as vitality (P = 0.001) at week 12. An increasing trend in POMS-vigour domain was also observed in the EL+MV group at week 12. A 15% decrease in physical stress domain (P < 0.05) compared with 0.7% in the placebo group was also observed in MMSQ. When the subjects were subgrouped according to age, 25-45 and 46-65 years of age, for primary outcomes, between-group significance was observed in the 25-45 year group in the social functioning domain of SF-12 (P = 0.021) and POMS-vigour (P = 0.036) in the 46-65 year group. No significant changes were observed in vital signs and complete metabolic panel. Regarding immune parameters, the lymphocytes increased significantly in the active group (P≤0.05). In total, 13 adverse events were reported: six on placebo and seven on EL+MV. Conclusion: EL+MV may support the QoL, mood, stress and immune parameters in healthy participants. Trial registration: This study has been registered at clinicaltrials.gov (NCT02865863).