Jeyoung Jung | The University of Manchester (original) (raw)

Papers by Jeyoung Jung

Research paper thumbnail of Impact of lingual gyrus volume on antidepressant response and neurocognitive functions in Major Depressive Disorder: a voxel-based morphometry study

Journal of affective disorders, 2014

Voxel-based morphometry (VBM) has demonstrated structural brain changes between patients with Maj... more Voxel-based morphometry (VBM) has demonstrated structural brain changes between patients with Major Depressive Disorder (MDD) and healthy individuals. The initial response to antidepressants is crucial to predict prognosis in the treatment of MDD. The aim of the present study was to investigate gray matter abnormalities predicting antidepressant responsiveness and the relationships between volumetric differences and clinical/cognitive traits in MDD patients. Fifty MDD patients who received 8 week period antidepressant treatment and 29 healthy controls participated in this study. VBM was applied to assess structural changes between MDD groups and control group. Neuropsychological tests were conducted on all participants. Both treatment responsive and non-responsive patients showed a significant volume reduction of the left insular, but only non-responsive patients had decreased volume in the right superior frontal gyrus compared to healthy controls. The comparison between treatment r...

Research paper thumbnail of Cognitive control over motor output in Tourette syndrome

Neuroscience & Biobehavioral Reviews, 2013

Please cite this article in press as: Jung, J., et al., Cognitive control over motor output in To... more Please cite this article in press as: Jung, J., et al., Cognitive control over motor output in Tourette syndrome. Neurosci. Biobehav. Rev. (2012), http://dx.

Research paper thumbnail of Compensatory Neural Reorganization in Tourette Syndrome

Current Biology, 2011

Children with neurological disorders may follow unique developmental trajectories whereby they un... more Children with neurological disorders may follow unique developmental trajectories whereby they undergo compensatory neuroplastic changes in brain structure and function that help them gain control over their symptoms . We used behavioral and brain imaging techniques to investigate this conjecture in children with Tourette syndrome (TS). Using a behavioral task that induces high levels of intermanual conflict, we show that individuals with TS exhibit enhanced control of motor output. Then, using structural (diffusion-weighted imaging) brain imaging techniques, we demonstrate widespread differences in the white matter (WM) microstructure of the TS brain that include alterations in the corpus callosum and forceps minor (FM) WM that significantly predict tic severity in TS. Most importantly, we show that task performance for the TS group (but not for controls) is strongly predicted by the WM microstructure of the FM pathways that lead to the prefrontal cortex and by the functional magnetic resonance imaging blood oxygen level-dependent response in prefrontal areas connected by these tracts. These results provide evidence for compensatory brain reorganization that may underlie the increased self-regulation mechanisms that have been hypothesized to bring about the control of tics during adolescence.

Research paper thumbnail of Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression

Background: The uncertainty over the true morphological changes in brains with major depressive d... more Background: The uncertainty over the true morphological changes in brains with major depressive disorder (MDD) underlines the necessity of comprehensive studies with multimodal structural brain imaging analyses. This study aimed to evaluate the differences in cortical thickness, cortical and subcortical volume, and white matter integrity between first episode, medication-naïve MDD patients and healthy controls. Methods: Subjects with their first episode of MDD whose illness duration had not exceeded 6 months (n ¼20) were enrolled in this study and were compared to age-, sex-, and education level-matched healthy controls (n ¼22). All participants were subjected to T1-weighted structural magnetic resonance imaging (MRI). We used an automated procedure of FreeSurfer and Tract-based spatial statistics (TBSS) to analyze differences in cortical thickness, cortical and subcortical volume, and white matter integrity between two groups. Results: The patients with first episode MDD exhibited significantly reduced cortical volume in the caudal anterior cingulate gyrus (P o0.0015) compared to healthy controls. We also observed altered white matter integrity in the body of the corpus callosum (Po 0.01), reduced cortical volume of the caudal middle frontal gyrus and medial orbitofrontal gyrus, and enlarged hippocampal volume in the first episode MDD patients. Limitations: We relied on a relatively small sample size and cortical volume reduction in several brain regions was not replicated in the analysis of cortical thickness. Conclusions: Using multimodal imaging analyses on medication-naïve first episode MDD patients, we demonstrated fundamental structural alteration of brain gray and white matter, such as reduced cortical volume of the caudal ACC and white matter integrity in the body of the corpus callosum.

Research paper thumbnail of Impact of lingual gyrus volume on antidepressant response and neurocognitive functions in Major Depressive Disorder: a voxel-based morphometry study

Journal of affective disorders, 2014

Voxel-based morphometry (VBM) has demonstrated structural brain changes between patients with Maj... more Voxel-based morphometry (VBM) has demonstrated structural brain changes between patients with Major Depressive Disorder (MDD) and healthy individuals. The initial response to antidepressants is crucial to predict prognosis in the treatment of MDD. The aim of the present study was to investigate gray matter abnormalities predicting antidepressant responsiveness and the relationships between volumetric differences and clinical/cognitive traits in MDD patients. Fifty MDD patients who received 8 week period antidepressant treatment and 29 healthy controls participated in this study. VBM was applied to assess structural changes between MDD groups and control group. Neuropsychological tests were conducted on all participants. Both treatment responsive and non-responsive patients showed a significant volume reduction of the left insular, but only non-responsive patients had decreased volume in the right superior frontal gyrus compared to healthy controls. The comparison between treatment r...

Research paper thumbnail of Cognitive control over motor output in Tourette syndrome

Neuroscience & Biobehavioral Reviews, 2013

Please cite this article in press as: Jung, J., et al., Cognitive control over motor output in To... more Please cite this article in press as: Jung, J., et al., Cognitive control over motor output in Tourette syndrome. Neurosci. Biobehav. Rev. (2012), http://dx.

Research paper thumbnail of Compensatory Neural Reorganization in Tourette Syndrome

Current Biology, 2011

Children with neurological disorders may follow unique developmental trajectories whereby they un... more Children with neurological disorders may follow unique developmental trajectories whereby they undergo compensatory neuroplastic changes in brain structure and function that help them gain control over their symptoms . We used behavioral and brain imaging techniques to investigate this conjecture in children with Tourette syndrome (TS). Using a behavioral task that induces high levels of intermanual conflict, we show that individuals with TS exhibit enhanced control of motor output. Then, using structural (diffusion-weighted imaging) brain imaging techniques, we demonstrate widespread differences in the white matter (WM) microstructure of the TS brain that include alterations in the corpus callosum and forceps minor (FM) WM that significantly predict tic severity in TS. Most importantly, we show that task performance for the TS group (but not for controls) is strongly predicted by the WM microstructure of the FM pathways that lead to the prefrontal cortex and by the functional magnetic resonance imaging blood oxygen level-dependent response in prefrontal areas connected by these tracts. These results provide evidence for compensatory brain reorganization that may underlie the increased self-regulation mechanisms that have been hypothesized to bring about the control of tics during adolescence.

Research paper thumbnail of Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression

Background: The uncertainty over the true morphological changes in brains with major depressive d... more Background: The uncertainty over the true morphological changes in brains with major depressive disorder (MDD) underlines the necessity of comprehensive studies with multimodal structural brain imaging analyses. This study aimed to evaluate the differences in cortical thickness, cortical and subcortical volume, and white matter integrity between first episode, medication-naïve MDD patients and healthy controls. Methods: Subjects with their first episode of MDD whose illness duration had not exceeded 6 months (n ¼20) were enrolled in this study and were compared to age-, sex-, and education level-matched healthy controls (n ¼22). All participants were subjected to T1-weighted structural magnetic resonance imaging (MRI). We used an automated procedure of FreeSurfer and Tract-based spatial statistics (TBSS) to analyze differences in cortical thickness, cortical and subcortical volume, and white matter integrity between two groups. Results: The patients with first episode MDD exhibited significantly reduced cortical volume in the caudal anterior cingulate gyrus (P o0.0015) compared to healthy controls. We also observed altered white matter integrity in the body of the corpus callosum (Po 0.01), reduced cortical volume of the caudal middle frontal gyrus and medial orbitofrontal gyrus, and enlarged hippocampal volume in the first episode MDD patients. Limitations: We relied on a relatively small sample size and cortical volume reduction in several brain regions was not replicated in the analysis of cortical thickness. Conclusions: Using multimodal imaging analyses on medication-naïve first episode MDD patients, we demonstrated fundamental structural alteration of brain gray and white matter, such as reduced cortical volume of the caudal ACC and white matter integrity in the body of the corpus callosum.