Martyna Kościuszko | The University of Manchester (original) (raw)
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Papers by Martyna Kościuszko
Clinica Chimica Acta, May 1, 2022
Translational Psychiatry, Feb 23, 2023
Depression is one of the leading causes of disability worldwide and is a major contributor to the... more Depression is one of the leading causes of disability worldwide and is a major contributor to the global burden of disease among older adults. The study aimed to investigate the interplay between socioeconomic markers (education and financial resources) and polygenic predisposition influencing individual differences in depressive symptoms and their change over time in older adults, which is of central relevance for preventative strategies. The sample encompassing n = 6202 adults aged ≥50 years old with a follow-up period of 14 years was utilised from the English Longitudinal Study of Ageing. Polygenic scores for depressive symptoms were calculated using summary statistics for (1) single-trait depressive symptoms (PGS-DS single), and (2) multi-trait including depressive symptoms, subjective well-being, neuroticism, loneliness, and self-rated health (PGS-DS multi-trait). The depressive symptoms over the past week were measured using the eight-item Centre for Epidemiologic Studies Depression Scale. One standard deviation increase in each PGS was associated with a higher baseline score in depressive symptoms. Each additional year of completed schooling was associated with lower baseline depression symptoms (β = −0.06, 95%CI = −0.07 to −0.05, p < 0.001); intermediate and lower wealth were associated with a higher baseline score in depressive symptoms. Although there was a weak interaction effect between PGS-DSs and socioeconomic status in association with the baseline depressive symptoms, there were no significant relationships of PGS-DSs, socioeconomic factors, and rate of change in the depressive symptoms during the 14-year follow-up period. Common genetic variants for depressive symptoms are associated with a greater number of depressive symptoms onset but not with their rate of change in the following 14 years. Lower socioeconomic status is an important factor influencing individual levels of depressive symptoms, independently from polygenic predisposition to depressive symptoms.
SSM Annual Scientific Meeting, Aug 1, 2022
Depression is one of the leading causes of disability worldwide and is a major contributor to the... more Depression is one of the leading causes of disability worldwide and is a major contributor to the global burden of disease among older adults. Therefore, the aims of the study were to investigate the interplay between socio-economic markers (education and financial resources) and polygenetic predisposition influencing individual differences in depressive symptoms and their change over time in older adults from the general population, which is of central relevance for preventative strategies. The sample encompassing n = 6202 adults aged ≥ 50 years old with a follow-up period of 14 years was utilised from the English Longitudinal Study of Ageing. Polygenic scores for depressive symptoms were calculated using summary statistics for 1) a single-trait depressive symptoms (PGS-DSsingle), and 2) a multi-trait including depressive symptoms, subjective well-being, neuroticism, loneliness, and self-rated health (PGS-DSmulti-trait). The depressive symptoms over the past week were measured usin...
Clinica Chimica Acta, May 1, 2022
Translational Psychiatry, Feb 23, 2023
Depression is one of the leading causes of disability worldwide and is a major contributor to the... more Depression is one of the leading causes of disability worldwide and is a major contributor to the global burden of disease among older adults. The study aimed to investigate the interplay between socioeconomic markers (education and financial resources) and polygenic predisposition influencing individual differences in depressive symptoms and their change over time in older adults, which is of central relevance for preventative strategies. The sample encompassing n = 6202 adults aged ≥50 years old with a follow-up period of 14 years was utilised from the English Longitudinal Study of Ageing. Polygenic scores for depressive symptoms were calculated using summary statistics for (1) single-trait depressive symptoms (PGS-DS single), and (2) multi-trait including depressive symptoms, subjective well-being, neuroticism, loneliness, and self-rated health (PGS-DS multi-trait). The depressive symptoms over the past week were measured using the eight-item Centre for Epidemiologic Studies Depression Scale. One standard deviation increase in each PGS was associated with a higher baseline score in depressive symptoms. Each additional year of completed schooling was associated with lower baseline depression symptoms (β = −0.06, 95%CI = −0.07 to −0.05, p < 0.001); intermediate and lower wealth were associated with a higher baseline score in depressive symptoms. Although there was a weak interaction effect between PGS-DSs and socioeconomic status in association with the baseline depressive symptoms, there were no significant relationships of PGS-DSs, socioeconomic factors, and rate of change in the depressive symptoms during the 14-year follow-up period. Common genetic variants for depressive symptoms are associated with a greater number of depressive symptoms onset but not with their rate of change in the following 14 years. Lower socioeconomic status is an important factor influencing individual levels of depressive symptoms, independently from polygenic predisposition to depressive symptoms.
SSM Annual Scientific Meeting, Aug 1, 2022
Depression is one of the leading causes of disability worldwide and is a major contributor to the... more Depression is one of the leading causes of disability worldwide and is a major contributor to the global burden of disease among older adults. Therefore, the aims of the study were to investigate the interplay between socio-economic markers (education and financial resources) and polygenetic predisposition influencing individual differences in depressive symptoms and their change over time in older adults from the general population, which is of central relevance for preventative strategies. The sample encompassing n = 6202 adults aged ≥ 50 years old with a follow-up period of 14 years was utilised from the English Longitudinal Study of Ageing. Polygenic scores for depressive symptoms were calculated using summary statistics for 1) a single-trait depressive symptoms (PGS-DSsingle), and 2) a multi-trait including depressive symptoms, subjective well-being, neuroticism, loneliness, and self-rated health (PGS-DSmulti-trait). The depressive symptoms over the past week were measured usin...