Mohamed M Aboelnaga | Mansoura University (original) (raw)

Papers by Mohamed M Aboelnaga

Endocrine, Metabolic & Immune Disorders - Drug Targets

Background: Hypovitaminosis D and low testosterone levels are common in men with T2DM, and vitami... more Background: Hypovitaminosis D and low testosterone levels are common in men with T2DM, and vitamin D has been proposed to regulate pituitary-testicular function. Objective: We investigated the association between testosterone levels and the circulating vitamin D among type 2 diabetic males. Methodology: We recruited 95 type 2 diabetic males in this cross-sectional study, and investigated the circulating form of vitamin D which is 25-hydroxyvitamin D (25(OH) D). 25(OH) D level <30 ng/mL was used to define vitamin D insufficiency and 25(OH) D level <20 ng/ml defined deficiency. Testosterone deficiency was defined as a total testosterone level less than300 ng/dl. Result: Testosterone deficiency prevalence in type 2 diabetic males was 46.3%. Testosterone deficient diabetics had significantly lower 25(OH) D levels than patients with normal testosterone. We observed a higher prevalence of vitamin D deficiency in testosterone deficient diabetics compared with testosterone sufficient ...

Archivio Italiano di Urologia e Andrologia

Background and aims: it is unclear whether male hypogonadism is ascribable to the diabetic state ... more Background and aims: it is unclear whether male hypogonadism is ascribable to the diabetic state per se, or because of other factors, such as obesity or age. We aimed to investigate the prevalence and identify the predictors for testosterone deficiency among non-obese type 2 diabetic males. Methods: This cross-sectional study was conducted on 95 nonobese type 2 diabetic males with BMI below 30. We evaluated the total testosterone (TT) levels to determine prevalence and risk factors of testosterone deficiency. Serum TT ≤ 300 ng/dl defined testosterone deficiency. Results: The prevalence of testosterone deficiency was 29.1%. Testosterone deficient patients had statistically significantly higher visceral adiposity index (VAI), waist, and triglyceride in comparison with normal testosterone patients. TT level correlated with VAI, waist, BMI, LH, and age. VAI was the only significant predictor of TT levels even after adjustment for age and BMI in regression analysis. Furthermore, VAI was ...

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2021

AIMS We aimed to evaluate urinary CysC (cystanin c) as an early marker of diabetic nephropathy in... more AIMS We aimed to evaluate urinary CysC (cystanin c) as an early marker of diabetic nephropathy in patients with type 2 diabetes and investigate the correlation of urinary CysC with albuminuria and GFR. METHODOLOGY This case-controlled study was conducted on 66 type 2 diabetic patients who were classified according to albuminuria into 3 groups and consisting of 20 healthy subjects as the control group. We assessed urinary CysC, urinary albumin excretion rate (UACR). RESULTS Urinary CysC levels were significantly higher in normoalbuminuric diabetic compared with healthy control and there was a progressive linear increase in urinary CysC levels with increasing albuminuria in the diabetic patients. Despite insignificant deference in creatinine between participants groups, we observed significant differences between these groups as regard eGFR, urinary CysC, and UACR. Urinary CysC did not have significant correlations with any clinical or biochemical parameters. Moreover, urinary CysC had a statistically significant association with albuminuria and eGFR. CONCLUSION Urinary CysC levels correlated with UACR and GFR. It is linked to subclinical tubular injury and can be an earlier marker of kidney involvement, even before albuminuria and it is less influenced by non-renal factors. Therefore, Urinary CysC is useful biomarker for early diagnosis of diabetic nephropathy.

Journal of Endocrinology and Metabolism, 2021

Background: Recent studies reported lower androgen levels in coronavirus disease 2019 (COVID-19) ... more Background: Recent studies reported lower androgen levels in coronavirus disease 2019 (COVID-19) hospitalized patients which linked to a worse prognosis. However, these studies were conducted in patients with active disease and long-term consequences are still not yet known. Therefore, we aimed to evaluate the late impact of COVID-19 pneumonia on testosterone levels in late recovered, post-hospitalized males. Methods: We enrolled 55 COVID-19 pneumonia-recovered, posthospitalized male patients after an average of 60 days of discharge from the hospital and 40 age, body mass index (BMI), and waistmatched participants enrolled in this case-control study. The total testosterone cutoff point was set as 300 ng/dL and the cutoff point for luteinizing hormone (LH) was set as 9.4 IU/L. Results: Testosterone deficiency prevalence was 50.9%, and testosterone deficiency was mainly hypogonadotropic (60.7%). Late recovered COVID-19 pneumonia patients had significantly lower total testosterone and calculated free testosterone and higher testosterone to LH ratio and prevalence of testosterone deficiency in comparison with the control group. Testosterone-deficient COVID-19 pneumonia patients had significantly higher anthropometric parameters such as waist circumference and BMI, higher Charlson Comorbidity Index, and longer hospitalization time in comparison with testosterone-sufficient patients. Visceral obesity estimated with waist circumference was a significant predictor for total testosterone levels in COVID patients in regression analysis. Conclusion: Late recovered post-hospitalized COVID-19 pneumonia patients still have lower androgen levels and a higher prevalence of testosterone deficiency in comparison with matched control participants. Moreover, visceral obesity was the most significant predictor of low testosterone levels in recovered COVID-19 patients.

International Journal of Research in Medical Sciences, 2016

Diabetes mellitus (DM) affects an estimated 285 million people worldwide. This number is expected... more Diabetes mellitus (DM) affects an estimated 285 million people worldwide. This number is expected to reach 438 million by the year 2030. 1 On the other hand, Male hypogonadism (MHG) is a clinical syndrome that results from failure to produce physiological concentrations of testosterone. 2 MHG is significantly associated with various comorbidities reduced libido, erectile dysfunction, increased adiposity, low energy and fatigue. 3 Muscle weakness and low bone mass, Depression, anxiety loss of libido, and erectile dysfunction and decreased quality, abnormal lipid profile, CVS pathophysiologic change. 4-7 The association between low serum testosterone (LST) and diabetes (DM) has recently received substantial attention; studies have reported that male patients with ABSTRACT Background: Diabetes mellitus (DM) affects an estimated 285 million people worldwide. This number is expected to reach 438 million by the year 2030. The aim of this study was to determine the prevalence of male hypogonadism among Egyptian patients with type 2 diabetes and to identify the risk factors may be associated with low serum testosterone concentrations in men with type 2 diabetes. Methods: 140 male patients with type 2 diabetes were recruited in this cross-sectional study. This study WAS conducted from January 2012 to January 2016 in the endocrinology and metabolism unit, Mansoura University, Egypt. Results: We found 48 (34.2%) patients with hypogonadism (defined as TT ≤300 ng/dl) among 140 male patients with type 2 diabetes. 7 out of 48 (14.5%) patients with TT ≤300 ng/dl had high abnormal gondotrophins hormones levels while 41 patients out of 48 (85.5%) had normal gondotrophins hormones levels. We found BMI, WC, Hba1c, UACR, retinopathy ratio, nephropathy ratio, smoker ratio and patient on insulin therapy ratio were increased in the low TT group with statistically significance, but non statistically significant difference in age, diabetic duration, FSH, LH, Prolactin and lipid profile. In this study by using Pearson correlation, we found a statistically significant correlation between TT levels with BMI, WC, FSH, LH, Hba1c, and UACR (P value<0.05). Also by using stepwise multiple regression analysis, we found BMI, WC, LH, Hba1c, and UACR were statistically significant predictors of TT levels. In logistic regression analysis, we found Hba1c, UACR, and WC were statistically significant risk factors for MHG. Conclusions: Visceral obesity, higher Hba1c, and degree of albuminuria are independent risk factors for hypogonadism in Egyptian male patients with type 2 diabetes.

Journal of Endocrinology and Metabolism

Background: Despite thyroid nodules mostly have benign nature, there are always malignancy risks.... more Background: Despite thyroid nodules mostly have benign nature, there are always malignancy risks. Therefore, understanding the mechanisms influencing this potential malignant transformation is highly important in thyroid cancer prevention strategies. We aimed in this case-control study to investigate the relationship of anthropometric parameters, and insulin resistance with thyroid nodules and the malignancy risk in nodular thyroid patients. Methods: This single-center case-control study included 81 patients with thyroid nodules who were divided into two groups according to post-thyroidectomy pathology: the malignant group included 36 differentiated thyroid carcinoma patients and the benign group included 45 patients. We compared the anthropometric and radiological parameters, homeostasis model assessment of insulin resistance (HOMA-IR), and insulin levels between both groups. Results: We observed significant differences as regard HOMA-IR, insulin levels and waist circumference between both groups. Benign thyroid nodules volume correlated with weight, waist, body mass index (BMI), fat percentage, age, HOMA-IR, and insulin levels. Malignant thyroid nodules volume did not correlate with any parameters apart from weight. We found that the final significant risk factor was HOMA-IR in stepwise logistic regression analysis. Conclusions: Malignant thyroid nodules are associated with higher insulin resistance, visceral obesity, and hyperinsulinemia. Furthermore, higher HOMA-IR is a significant risk factor for differentiated thyroid carcinoma.

Background: low 25-hydroxyvitamin have been identified in pathogenesis of colorectal cancer (CRC)... more Background: low 25-hydroxyvitamin have been identified in pathogenesis of colorectal cancer (CRC) with survival affection. Visceral fat tissue predisposes to chronic inflammation and release of growth factors that mediate colonic neoplasia.Aim of the work: to evaluate effect of vitamin D status and visceral obesity on cancer colon and to report the possible link between vitamin D and visceral obesity in those patients. Patients & Methods: Our patients were distributed in two groups; group 1 included cancer colon cases (no= 60) and 2nd group included control cases (no= 40). Clinical, anthropometric and pathological data were collected. Calculation of body mass index, visceral adiposity index (VAI) and detection of Vitamin D (25 OHD) serum level were performed to compare between groups. Results: There were significant differences in VAI and level of 25 OHD between both groups(P=0.011). We found significant higher prevalence of vitamin d deficiency in patient’ group [32 (53.3%) versus ...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016

Background: The present research explores the correlation of visceral obesity index with Rotterda... more Background: The present research explores the correlation of visceral obesity index with Rotterdam criteria (hyperandrogenism and/or hyperandrogenemia, oligomenorrhea and Ultrasound polycystic ovarian morphology) among Egyptian polycystic ovary syndrome patients. Methods: We enrolled one hundred female patients with polycystic ovary syndrome with age ranged 18-44 years (mean age 26.83±6.092 years). Results: VAI very strongly correlated with waist circumference, TG and HDL-c, also moderately correlated with systolic B.P, BMI, HOMA-IR and insulin levels, also we found only insulin, menstrual cycles per year number and FGS were significant predictors of hyperandrogenemia in PCOS patients. Only Ultrasound polycystic ovarian morphology was a significant risk factor for oligomenorrhea in PCOS patients in logistic regression analysis. VAI, TT and Farman gallawy score can significantly predict number of the menstrual cycles per year number (p <0.05). In logistic regression analysis, only oligomenorrhea was a significant independent risk factor for PCOM (p <0.05). In addition, only VAI was a significant independent (p <0.05) risk factor for metabolic syndrome. Conclusions: VAI was an independent significant predictor for metabolic syndrome in patients with PCOS and a good marker of cardiometabolic risk in PCOS patients. In addition, VAI was significant predictors of annual menusteral cycle but not testosterone levels or polycystic ovarian morphology in PCOS. This study confirms the value of VAI in identification of patient with risk for metabolic syndrome and cardiometabolic risk in PCOS patients, but not found a role for VAI in diagnosis of PCOS.

Objectives: The aim of this study was to evaluate the prevalence and the risk factors of prolonge... more Objectives: The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Egyptian patients with type 2 diabetes. Patients and methods: We enrolled in this cross-sectional study from June 2011 to December 2015, a total of 220 patients (108 male & 112 female) with mean age 50.42± 7.453years diagnosed with type 2 DM. Results: In this study, we found (33.6%) 74 T2 DM patients with QTc>440 ms had statistically significant longer diabetes duration and, diastolic BP, Total cholesterol. LDL-C and UACR with 146 type 2 DM patients with ≤ 440QTc ms (P value ≤ 0.05). Also statistically significant higher incidence of insulin therapy, retinopathy and nephropathy has been founded in 74 T2 DM patients with QTc>440 Ms. By Pearson correlation, we found QTc interval significantly correlated with diabetes duration, Diastolic BP, TC , LDL-C and UACR., also by using multiple regression analysis we found LDL-c, diabetic duration and UACR were statistical...

Journal of Endocrinology and Metabolism

Background: We aimed to evaluate the effect of visceral obesity and vitamin D status on colon can... more Background: We aimed to evaluate the effect of visceral obesity and vitamin D status on colon cancer and to investigate the possible link between visceral obesity and vitamin D in those patients. Methods: This case-control study included 60 colon cancer patients and 40 subjects as control. Clinical, anthropometric, and pathological data were collected. Calculation of visceral adiposity index (VAI) and detection of vitamin D (25(OH)D) levels were performed and compared between groups. Results: There were significant differences in VAI and level of 25(OH)D between both groups. Moreover, we found a significantly higher prevalence of vitamin D deficiency in the patient' group (53.3%) versus the control group (32.5%). There was a significant different mean of VAI in vitamin D deficient patients versus non-deficient patients (P = 0.024). We found a significantly different means of VAI and vitamin D in the patients' group with different TNM stages, as higher stages are associated with a lower level of vitamin D and higher VAI. Conclusions: VAI and 25(OH)D were different in colon cancer patients compared with control. Likewise, they had different means with different TNM stages. Vitamin D may augment the inflammatory status in visceral obesity which is involved in tumorigenesis of colon cancer.

Diabetes & Metabolic Syndrome: Clinical Research & Reviews

Endocrine, Metabolic & Immune Disorders - Drug Targets

Background: Hyperprolactinemia can lead to weight gain, insulin resistance, abnormal glucose home... more Background: Hyperprolactinemia can lead to weight gain, insulin resistance, abnormal glucose homeostasis and dyslipidemia. Reversibility of these changes after normalization of prolactin with dopamine agonists is still controversial and needs more clarification. Objective: We aimed to: 1) evaluate and compare metabolic and anthropometric profile in female with newly diagnosed prolactin-secreting adenoma versus female idiopathic hyperprolactinemic patients; 2) compare the effects of one year cabergoline therapy on the metabolic profile and anthropometric parameters (by using visceral adiposity index as index for evaluation of adipose tissue dysfunction) in females with prolactinoma to female idiopathic hyperprolactinemic patients. Patients and Methods: We enrolled 40 female patients with newly diagnosed prolactinoma and 40 female patients with idiopathic hyperprolactinemia, who were matched according to: age; weight; BMI; waist; and prolactin levels. We enrolled the participants in t...

Endocrine, metabolic & immune disorders drug targets, 2017

The present research explored the relationship of vitamin D status with prolactin levels and aden... more The present research explored the relationship of vitamin D status with prolactin levels and adenoma size in female patients with newly diagnosed prolactinoma and determination of hypovitaminosis D prevalence among female patients with prolactinoma. We enrolled 67 female patients with newly diagnosed prolactinoma (41 with micro adenoma and 26 with macro adenoma) in this case-control study at the time of presentation. We selected 45 female subjects as a control group who were matched according to age, weight, height, body mass index and waist circumference. We investigated 25-hydroxyvitamin D, the major circulating form of vitamin D. Prolactinoma patients had significantly lower 25-hydroxyvitamin D levels in comparison with control subjects. Also, macroadenoma patients showed significantly lower 25-hydroxyvitamin D levels as compared to microadenomoa patients. By contrast, microadenoma patients had nonsignificant lower 25-hydroxyvitamin D levels in comparison with control subjects. F...

Endocrinología y Nutrición, 2016

Although the prevalence of MNG is widespread throughout the world, its pathogenesis is poorly und... more Although the prevalence of MNG is widespread throughout the world, its pathogenesis is poorly understood, and the complex interactions of both genetic predisposition and the individuals&amp;amp;amp;amp;amp;amp;#39; environment are likely. However, to the best of our knowledge, it remains unknown whether there is a relationship between vitamin D status and prevalence or pathogenesis of euthyroid MNG. Therefore, the goal of the present study was determination of vitamin D status in euthyroid MNG as well as exploration of the correlation between vitamin D status &amp;amp;amp;amp;amp;amp;amp; TSH levels. A total of 77 patients diagnosed with euthyroid MNG and 50 subjects without goiter were matched according to age, weight and BMI as control group in this case control study. We found that patients with euthyroid MNG had statistically significant lower mean of [25(OH)D] (24.21±8.68ng/mL) in comparison with its mean in control subjects (28.37±10.91ng/mL, P value=0.019). The 28 sufficient vitamin D MNG patients had statistically significant lower level of TSH than 49 insufficient vitamin D MNG patients. Vitamin D and TSH levels correlate with vitamin D levels in MNG patients in Pearson correlation. Also 25 OH vitamin D was a significant independent predictor for TSH levels among euthyroid MNG patients in regression analysis. Patients with euthyroid MNG have lower levels of vitamin D and TSH levels correlate with vitamin D levels in euthyroid MNG patients. In addition, 25 OH vitamin D was a significant independent predictor for TSH levels among euthyroid MNG patients. We recommend hypovitaminosis D evaluation and correction in patients with MNG.

Medical Oncology, 2015

The effect of neck radiation on parathyroid hormone (PTH) is studied on concern as late effect of... more The effect of neck radiation on parathyroid hormone (PTH) is studied on concern as late effect of radiotherapy for benign or malignant diseases. However, the early effect on PTH is still in debate and need further evaluations. We aimed, in our study, to assess early effect of neck radiation on PTH, and related calcium and phosphorus levels. Patients diagnosed with breast or head and neck cancer who planned to received radiotherapy to neck as a definite or a part of their treatment enrolled in this prospective single-arm study from June 2012 to June 2013. Laboratory assessment of PTH, serum calcium, phosphorus and albumin was obtained before starting radiotherapy, 3 weeks and 3 months after radiation. Fifty-two patients included 24 (46.2 %) males and 28(53.8 %) females. Median age of diagnosis was 55 years. Thirty-six patients had head and neck cancer, while 16 patients were diagnosed as breast cancer. The difference in PTH and calcium levels before and after radiotherapy was statistically significant (P = 0.014 and P = 0.001 for 3 weeks and P = 0.015 and P = 0.004 for 3 months, respectively); even after correction of calcium level according to albumin level, the same results were obtained, while there was no significant difference in their levels after 3 weeks in comparison with 3 months after radiotherapy. The variation of level of phosphorus was not significant. PTH and calcium can be affected early with neck radiation, so follow-up of calcium and PTH level is mandatory for cases that will receive neck radiotherapy.

Endocrine, Metabolic & Immune Disorders - Drug Targets

Background: Hypovitaminosis D and low testosterone levels are common in men with T2DM, and vitami... more Background: Hypovitaminosis D and low testosterone levels are common in men with T2DM, and vitamin D has been proposed to regulate pituitary-testicular function. Objective: We investigated the association between testosterone levels and the circulating vitamin D among type 2 diabetic males. Methodology: We recruited 95 type 2 diabetic males in this cross-sectional study, and investigated the circulating form of vitamin D which is 25-hydroxyvitamin D (25(OH) D). 25(OH) D level <30 ng/mL was used to define vitamin D insufficiency and 25(OH) D level <20 ng/ml defined deficiency. Testosterone deficiency was defined as a total testosterone level less than300 ng/dl. Result: Testosterone deficiency prevalence in type 2 diabetic males was 46.3%. Testosterone deficient diabetics had significantly lower 25(OH) D levels than patients with normal testosterone. We observed a higher prevalence of vitamin D deficiency in testosterone deficient diabetics compared with testosterone sufficient ...

Archivio Italiano di Urologia e Andrologia

Background and aims: it is unclear whether male hypogonadism is ascribable to the diabetic state ... more Background and aims: it is unclear whether male hypogonadism is ascribable to the diabetic state per se, or because of other factors, such as obesity or age. We aimed to investigate the prevalence and identify the predictors for testosterone deficiency among non-obese type 2 diabetic males. Methods: This cross-sectional study was conducted on 95 nonobese type 2 diabetic males with BMI below 30. We evaluated the total testosterone (TT) levels to determine prevalence and risk factors of testosterone deficiency. Serum TT ≤ 300 ng/dl defined testosterone deficiency. Results: The prevalence of testosterone deficiency was 29.1%. Testosterone deficient patients had statistically significantly higher visceral adiposity index (VAI), waist, and triglyceride in comparison with normal testosterone patients. TT level correlated with VAI, waist, BMI, LH, and age. VAI was the only significant predictor of TT levels even after adjustment for age and BMI in regression analysis. Furthermore, VAI was ...

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2021

AIMS We aimed to evaluate urinary CysC (cystanin c) as an early marker of diabetic nephropathy in... more AIMS We aimed to evaluate urinary CysC (cystanin c) as an early marker of diabetic nephropathy in patients with type 2 diabetes and investigate the correlation of urinary CysC with albuminuria and GFR. METHODOLOGY This case-controlled study was conducted on 66 type 2 diabetic patients who were classified according to albuminuria into 3 groups and consisting of 20 healthy subjects as the control group. We assessed urinary CysC, urinary albumin excretion rate (UACR). RESULTS Urinary CysC levels were significantly higher in normoalbuminuric diabetic compared with healthy control and there was a progressive linear increase in urinary CysC levels with increasing albuminuria in the diabetic patients. Despite insignificant deference in creatinine between participants groups, we observed significant differences between these groups as regard eGFR, urinary CysC, and UACR. Urinary CysC did not have significant correlations with any clinical or biochemical parameters. Moreover, urinary CysC had a statistically significant association with albuminuria and eGFR. CONCLUSION Urinary CysC levels correlated with UACR and GFR. It is linked to subclinical tubular injury and can be an earlier marker of kidney involvement, even before albuminuria and it is less influenced by non-renal factors. Therefore, Urinary CysC is useful biomarker for early diagnosis of diabetic nephropathy.

Journal of Endocrinology and Metabolism, 2021

Background: Recent studies reported lower androgen levels in coronavirus disease 2019 (COVID-19) ... more Background: Recent studies reported lower androgen levels in coronavirus disease 2019 (COVID-19) hospitalized patients which linked to a worse prognosis. However, these studies were conducted in patients with active disease and long-term consequences are still not yet known. Therefore, we aimed to evaluate the late impact of COVID-19 pneumonia on testosterone levels in late recovered, post-hospitalized males. Methods: We enrolled 55 COVID-19 pneumonia-recovered, posthospitalized male patients after an average of 60 days of discharge from the hospital and 40 age, body mass index (BMI), and waistmatched participants enrolled in this case-control study. The total testosterone cutoff point was set as 300 ng/dL and the cutoff point for luteinizing hormone (LH) was set as 9.4 IU/L. Results: Testosterone deficiency prevalence was 50.9%, and testosterone deficiency was mainly hypogonadotropic (60.7%). Late recovered COVID-19 pneumonia patients had significantly lower total testosterone and calculated free testosterone and higher testosterone to LH ratio and prevalence of testosterone deficiency in comparison with the control group. Testosterone-deficient COVID-19 pneumonia patients had significantly higher anthropometric parameters such as waist circumference and BMI, higher Charlson Comorbidity Index, and longer hospitalization time in comparison with testosterone-sufficient patients. Visceral obesity estimated with waist circumference was a significant predictor for total testosterone levels in COVID patients in regression analysis. Conclusion: Late recovered post-hospitalized COVID-19 pneumonia patients still have lower androgen levels and a higher prevalence of testosterone deficiency in comparison with matched control participants. Moreover, visceral obesity was the most significant predictor of low testosterone levels in recovered COVID-19 patients.

International Journal of Research in Medical Sciences, 2016

Diabetes mellitus (DM) affects an estimated 285 million people worldwide. This number is expected... more Diabetes mellitus (DM) affects an estimated 285 million people worldwide. This number is expected to reach 438 million by the year 2030. 1 On the other hand, Male hypogonadism (MHG) is a clinical syndrome that results from failure to produce physiological concentrations of testosterone. 2 MHG is significantly associated with various comorbidities reduced libido, erectile dysfunction, increased adiposity, low energy and fatigue. 3 Muscle weakness and low bone mass, Depression, anxiety loss of libido, and erectile dysfunction and decreased quality, abnormal lipid profile, CVS pathophysiologic change. 4-7 The association between low serum testosterone (LST) and diabetes (DM) has recently received substantial attention; studies have reported that male patients with ABSTRACT Background: Diabetes mellitus (DM) affects an estimated 285 million people worldwide. This number is expected to reach 438 million by the year 2030. The aim of this study was to determine the prevalence of male hypogonadism among Egyptian patients with type 2 diabetes and to identify the risk factors may be associated with low serum testosterone concentrations in men with type 2 diabetes. Methods: 140 male patients with type 2 diabetes were recruited in this cross-sectional study. This study WAS conducted from January 2012 to January 2016 in the endocrinology and metabolism unit, Mansoura University, Egypt. Results: We found 48 (34.2%) patients with hypogonadism (defined as TT ≤300 ng/dl) among 140 male patients with type 2 diabetes. 7 out of 48 (14.5%) patients with TT ≤300 ng/dl had high abnormal gondotrophins hormones levels while 41 patients out of 48 (85.5%) had normal gondotrophins hormones levels. We found BMI, WC, Hba1c, UACR, retinopathy ratio, nephropathy ratio, smoker ratio and patient on insulin therapy ratio were increased in the low TT group with statistically significance, but non statistically significant difference in age, diabetic duration, FSH, LH, Prolactin and lipid profile. In this study by using Pearson correlation, we found a statistically significant correlation between TT levels with BMI, WC, FSH, LH, Hba1c, and UACR (P value<0.05). Also by using stepwise multiple regression analysis, we found BMI, WC, LH, Hba1c, and UACR were statistically significant predictors of TT levels. In logistic regression analysis, we found Hba1c, UACR, and WC were statistically significant risk factors for MHG. Conclusions: Visceral obesity, higher Hba1c, and degree of albuminuria are independent risk factors for hypogonadism in Egyptian male patients with type 2 diabetes.

Journal of Endocrinology and Metabolism

Background: Despite thyroid nodules mostly have benign nature, there are always malignancy risks.... more Background: Despite thyroid nodules mostly have benign nature, there are always malignancy risks. Therefore, understanding the mechanisms influencing this potential malignant transformation is highly important in thyroid cancer prevention strategies. We aimed in this case-control study to investigate the relationship of anthropometric parameters, and insulin resistance with thyroid nodules and the malignancy risk in nodular thyroid patients. Methods: This single-center case-control study included 81 patients with thyroid nodules who were divided into two groups according to post-thyroidectomy pathology: the malignant group included 36 differentiated thyroid carcinoma patients and the benign group included 45 patients. We compared the anthropometric and radiological parameters, homeostasis model assessment of insulin resistance (HOMA-IR), and insulin levels between both groups. Results: We observed significant differences as regard HOMA-IR, insulin levels and waist circumference between both groups. Benign thyroid nodules volume correlated with weight, waist, body mass index (BMI), fat percentage, age, HOMA-IR, and insulin levels. Malignant thyroid nodules volume did not correlate with any parameters apart from weight. We found that the final significant risk factor was HOMA-IR in stepwise logistic regression analysis. Conclusions: Malignant thyroid nodules are associated with higher insulin resistance, visceral obesity, and hyperinsulinemia. Furthermore, higher HOMA-IR is a significant risk factor for differentiated thyroid carcinoma.

Background: low 25-hydroxyvitamin have been identified in pathogenesis of colorectal cancer (CRC)... more Background: low 25-hydroxyvitamin have been identified in pathogenesis of colorectal cancer (CRC) with survival affection. Visceral fat tissue predisposes to chronic inflammation and release of growth factors that mediate colonic neoplasia.Aim of the work: to evaluate effect of vitamin D status and visceral obesity on cancer colon and to report the possible link between vitamin D and visceral obesity in those patients. Patients & Methods: Our patients were distributed in two groups; group 1 included cancer colon cases (no= 60) and 2nd group included control cases (no= 40). Clinical, anthropometric and pathological data were collected. Calculation of body mass index, visceral adiposity index (VAI) and detection of Vitamin D (25 OHD) serum level were performed to compare between groups. Results: There were significant differences in VAI and level of 25 OHD between both groups(P=0.011). We found significant higher prevalence of vitamin d deficiency in patient’ group [32 (53.3%) versus ...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016

Background: The present research explores the correlation of visceral obesity index with Rotterda... more Background: The present research explores the correlation of visceral obesity index with Rotterdam criteria (hyperandrogenism and/or hyperandrogenemia, oligomenorrhea and Ultrasound polycystic ovarian morphology) among Egyptian polycystic ovary syndrome patients. Methods: We enrolled one hundred female patients with polycystic ovary syndrome with age ranged 18-44 years (mean age 26.83±6.092 years). Results: VAI very strongly correlated with waist circumference, TG and HDL-c, also moderately correlated with systolic B.P, BMI, HOMA-IR and insulin levels, also we found only insulin, menstrual cycles per year number and FGS were significant predictors of hyperandrogenemia in PCOS patients. Only Ultrasound polycystic ovarian morphology was a significant risk factor for oligomenorrhea in PCOS patients in logistic regression analysis. VAI, TT and Farman gallawy score can significantly predict number of the menstrual cycles per year number (p <0.05). In logistic regression analysis, only oligomenorrhea was a significant independent risk factor for PCOM (p <0.05). In addition, only VAI was a significant independent (p <0.05) risk factor for metabolic syndrome. Conclusions: VAI was an independent significant predictor for metabolic syndrome in patients with PCOS and a good marker of cardiometabolic risk in PCOS patients. In addition, VAI was significant predictors of annual menusteral cycle but not testosterone levels or polycystic ovarian morphology in PCOS. This study confirms the value of VAI in identification of patient with risk for metabolic syndrome and cardiometabolic risk in PCOS patients, but not found a role for VAI in diagnosis of PCOS.

Objectives: The aim of this study was to evaluate the prevalence and the risk factors of prolonge... more Objectives: The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Egyptian patients with type 2 diabetes. Patients and methods: We enrolled in this cross-sectional study from June 2011 to December 2015, a total of 220 patients (108 male & 112 female) with mean age 50.42± 7.453years diagnosed with type 2 DM. Results: In this study, we found (33.6%) 74 T2 DM patients with QTc>440 ms had statistically significant longer diabetes duration and, diastolic BP, Total cholesterol. LDL-C and UACR with 146 type 2 DM patients with ≤ 440QTc ms (P value ≤ 0.05). Also statistically significant higher incidence of insulin therapy, retinopathy and nephropathy has been founded in 74 T2 DM patients with QTc>440 Ms. By Pearson correlation, we found QTc interval significantly correlated with diabetes duration, Diastolic BP, TC , LDL-C and UACR., also by using multiple regression analysis we found LDL-c, diabetic duration and UACR were statistical...

Journal of Endocrinology and Metabolism

Background: We aimed to evaluate the effect of visceral obesity and vitamin D status on colon can... more Background: We aimed to evaluate the effect of visceral obesity and vitamin D status on colon cancer and to investigate the possible link between visceral obesity and vitamin D in those patients. Methods: This case-control study included 60 colon cancer patients and 40 subjects as control. Clinical, anthropometric, and pathological data were collected. Calculation of visceral adiposity index (VAI) and detection of vitamin D (25(OH)D) levels were performed and compared between groups. Results: There were significant differences in VAI and level of 25(OH)D between both groups. Moreover, we found a significantly higher prevalence of vitamin D deficiency in the patient' group (53.3%) versus the control group (32.5%). There was a significant different mean of VAI in vitamin D deficient patients versus non-deficient patients (P = 0.024). We found a significantly different means of VAI and vitamin D in the patients' group with different TNM stages, as higher stages are associated with a lower level of vitamin D and higher VAI. Conclusions: VAI and 25(OH)D were different in colon cancer patients compared with control. Likewise, they had different means with different TNM stages. Vitamin D may augment the inflammatory status in visceral obesity which is involved in tumorigenesis of colon cancer.

Diabetes & Metabolic Syndrome: Clinical Research & Reviews

Endocrine, Metabolic & Immune Disorders - Drug Targets

Background: Hyperprolactinemia can lead to weight gain, insulin resistance, abnormal glucose home... more Background: Hyperprolactinemia can lead to weight gain, insulin resistance, abnormal glucose homeostasis and dyslipidemia. Reversibility of these changes after normalization of prolactin with dopamine agonists is still controversial and needs more clarification. Objective: We aimed to: 1) evaluate and compare metabolic and anthropometric profile in female with newly diagnosed prolactin-secreting adenoma versus female idiopathic hyperprolactinemic patients; 2) compare the effects of one year cabergoline therapy on the metabolic profile and anthropometric parameters (by using visceral adiposity index as index for evaluation of adipose tissue dysfunction) in females with prolactinoma to female idiopathic hyperprolactinemic patients. Patients and Methods: We enrolled 40 female patients with newly diagnosed prolactinoma and 40 female patients with idiopathic hyperprolactinemia, who were matched according to: age; weight; BMI; waist; and prolactin levels. We enrolled the participants in t...

Endocrine, metabolic & immune disorders drug targets, 2017

The present research explored the relationship of vitamin D status with prolactin levels and aden... more The present research explored the relationship of vitamin D status with prolactin levels and adenoma size in female patients with newly diagnosed prolactinoma and determination of hypovitaminosis D prevalence among female patients with prolactinoma. We enrolled 67 female patients with newly diagnosed prolactinoma (41 with micro adenoma and 26 with macro adenoma) in this case-control study at the time of presentation. We selected 45 female subjects as a control group who were matched according to age, weight, height, body mass index and waist circumference. We investigated 25-hydroxyvitamin D, the major circulating form of vitamin D. Prolactinoma patients had significantly lower 25-hydroxyvitamin D levels in comparison with control subjects. Also, macroadenoma patients showed significantly lower 25-hydroxyvitamin D levels as compared to microadenomoa patients. By contrast, microadenoma patients had nonsignificant lower 25-hydroxyvitamin D levels in comparison with control subjects. F...

Endocrinología y Nutrición, 2016

Although the prevalence of MNG is widespread throughout the world, its pathogenesis is poorly und... more Although the prevalence of MNG is widespread throughout the world, its pathogenesis is poorly understood, and the complex interactions of both genetic predisposition and the individuals&amp;amp;amp;amp;amp;amp;#39; environment are likely. However, to the best of our knowledge, it remains unknown whether there is a relationship between vitamin D status and prevalence or pathogenesis of euthyroid MNG. Therefore, the goal of the present study was determination of vitamin D status in euthyroid MNG as well as exploration of the correlation between vitamin D status &amp;amp;amp;amp;amp;amp;amp; TSH levels. A total of 77 patients diagnosed with euthyroid MNG and 50 subjects without goiter were matched according to age, weight and BMI as control group in this case control study. We found that patients with euthyroid MNG had statistically significant lower mean of [25(OH)D] (24.21±8.68ng/mL) in comparison with its mean in control subjects (28.37±10.91ng/mL, P value=0.019). The 28 sufficient vitamin D MNG patients had statistically significant lower level of TSH than 49 insufficient vitamin D MNG patients. Vitamin D and TSH levels correlate with vitamin D levels in MNG patients in Pearson correlation. Also 25 OH vitamin D was a significant independent predictor for TSH levels among euthyroid MNG patients in regression analysis. Patients with euthyroid MNG have lower levels of vitamin D and TSH levels correlate with vitamin D levels in euthyroid MNG patients. In addition, 25 OH vitamin D was a significant independent predictor for TSH levels among euthyroid MNG patients. We recommend hypovitaminosis D evaluation and correction in patients with MNG.

Medical Oncology, 2015

The effect of neck radiation on parathyroid hormone (PTH) is studied on concern as late effect of... more The effect of neck radiation on parathyroid hormone (PTH) is studied on concern as late effect of radiotherapy for benign or malignant diseases. However, the early effect on PTH is still in debate and need further evaluations. We aimed, in our study, to assess early effect of neck radiation on PTH, and related calcium and phosphorus levels. Patients diagnosed with breast or head and neck cancer who planned to received radiotherapy to neck as a definite or a part of their treatment enrolled in this prospective single-arm study from June 2012 to June 2013. Laboratory assessment of PTH, serum calcium, phosphorus and albumin was obtained before starting radiotherapy, 3 weeks and 3 months after radiation. Fifty-two patients included 24 (46.2 %) males and 28(53.8 %) females. Median age of diagnosis was 55 years. Thirty-six patients had head and neck cancer, while 16 patients were diagnosed as breast cancer. The difference in PTH and calcium levels before and after radiotherapy was statistically significant (P = 0.014 and P = 0.001 for 3 weeks and P = 0.015 and P = 0.004 for 3 months, respectively); even after correction of calcium level according to albumin level, the same results were obtained, while there was no significant difference in their levels after 3 weeks in comparison with 3 months after radiotherapy. The variation of level of phosphorus was not significant. PTH and calcium can be affected early with neck radiation, so follow-up of calcium and PTH level is mandatory for cases that will receive neck radiotherapy.