Marco Poloni | Mario Negri Institute for Pharmacological Research. Milan, IT (original) (raw)
Papers by Marco Poloni
QUALCOSA DA RICORDARE UNITA' D'ITALIA-150 ANNI Premessa L'occasione della presente pubblicazione ... more QUALCOSA DA RICORDARE UNITA' D'ITALIA-150 ANNI Premessa L'occasione della presente pubblicazione è data dalla ricorrenza dei 150 anni dell'Unità d'Italia. Il periodo prescelto è stato quello che va dal 1861 al 1915: dalla nascita dello Stato unitario fino all'intervento italiano nella prima guerra mondiale. Gli articoli intendono ricordare i contributi offerti alla costruzione dello Stato unitario da alcuni scienziati, politici, uomini di cultura e illustrare alcuni aspetti della società del tempo. I problemi affrontati dall'élite liberale furono molteplici e di natura non facile; alterni i risultati: moderno avanzamento in alcune parti d'Italia, stagnazione in altre. Di ciò i testi qui raccolti rendono testimonianza. Non si intende peraltro entrare nel merito delle analisi storiografiche complessive sull'argomento, se non per insistere con due precisazioni. La prima serve a ricordare che, oltre ad un Settecento riformatore, molto enfatizzato, c'è stato in Italia un Ottocento liberale, altrettanto riformatore ed altrettanto grande: nella seconda metà del secolo, ad esempio, esso ha mostrato i volti, proprio a livello ministeriale, di personaggi sulla cui onestà d'intenti non è dato eccepire: siano sufficienti i nomi di Cesare Matteucci, Giuseppe Zanardelli e Luigi Luzzatti. La seconda riguarda la cultura scientifica in Italia che, in quel medesimo periodo e fino al 1915, fu di alto livello, apprezzata su scala europea e internazionale, specialmente nei campi della matematica, dell'astronomia e della biologia. Alla prima generazione, che ebbe la funzione di traghettare gli ideali risorgimentali nelle pieghe del nuovo Stato, appartengono
Acta Neurologica Scandinavica, 2009
Objective: The purpose of this report is to describe care of a patient with chronic progressive e... more Objective: The purpose of this report is to describe care of a patient with chronic progressive external ophthalmoplegia and bilateral vestibular hypofunction. Clinical Features: A 66-year-old patient presented with limited eye movement and mild ptosis, which led to a diagnosis of chronic progressive external ophthalmoplegia. Rotary chair testing suggested vestibular involvement. Other symptoms included dizziness, problems with balance, and chronic stiffness in his cervical and thoracic regions. He had anxiety about loss of function and limited exercise habits because of fear of falling. Examination methods included balance assessment, kinetic aspects of walking, and videonystagmography. Intervention and Outcome: He had already begun regular practice of vestibular rehabilitation exercises before receiving 18 sessions of manual and instrument-assisted chiropractic manipulation, along with mobilization, stretching, and transverse massage, over 37 weeks. In addition to self-reported improvements, there was substantially decreased postural sway during balance assessment and there were small improvements in eye movement, ptosis, and walking. Conclusion: This patient showed improvements in balance, eye movements, and walking while undergoing multimodal chiropractic care and practicing eye and balance exercises.
Journal of neurology, neurosurgery, and psychiatry, Aug 23, 2018
To investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (... more To investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (ALS) in population-based case-control studies in three European countries using a validated and harmonised questionnaire. Patients with incident ALS and controls were recruited from five population-based registers in The Netherlands, Ireland and Italy. Demographic and data regarding educational level, smoking, alcohol habits and lifetime PA levels in both leisure and work time were gathered by questionnaire, and quantified using metabolic equivalent of task scores. Logistic regression models adjusting for PA-related factors were used to determine the association between PA and ALS risk, and forest plots were used to visualise heterogeneity between regions. 1557 patients and 2922 controls were included. We found a linear association between ALS and PA in leisure time (OR 1.07, P=0.01) and occupational activities (OR 1.06, P<0.001), and all activities combined (OR 1.06, P<0.001), wit...
Rivista di patologia nervosa e mentale, 1974
Rivista di neurologia, 1974
Basic and applied histochemistry, 1988
Rat brain thiamine pyrophosphatase (TPPase) was separated by thin layer polyacrylamide gel isoele... more Rat brain thiamine pyrophosphatase (TPPase) was separated by thin layer polyacrylamide gel isoelectric focusing (IF) and stained with a modification of the lead conversion method of Allen and Hyncik (1963). 10 bands with TPPase activity were observed in the pH range 4.6-7.1. The overall IF pattern of TPPase was similar to that of uridine diphosphatase and inosine diphosphatase but was clearly different from that of adenosine diphosphatase, p-nitrophenyl phosphatase, alpha-naphthyl phosphatase and thiamine monophosphatase. A semiquantitative assessment of TPPase isoenzymes has been performed using laser densitometry.
Archives in Neurology & Neuroscience
Breathing pattern and respiratory mechanics in patients with amyotrophic lateral scle
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie
Electroencephalography and clinical neurophysiology, 1975
Rivista di patologia nervosa e mentale, 1974
The Italian Journal of Neurological Sciences, 1982
ABSTRACT
Journal of Hepatology, 1994
To evaluate the efficacy of recombinant interferon α-2b in the treatment of patients with acute p... more To evaluate the efficacy of recombinant interferon α-2b in the treatment of patients with acute post-transfusion hepatitis C, a randomized controlled trial was conducted in 33 acute post-transfusion hepatitis C patients; 16 patients received 3 million units of subcutaneously injected ...
European Respiratory Journal, 1997
Breathing pattern and respiratory mechanics in patients with amyotrophic lateral scle
Acta neurologica Belgica
ABSTRACT
Amyotrophic lateral sclerosis & frontotemporal degeneration, Feb 24, 2017
To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic even... more To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic events, age of trauma, and site of injury. A population-based case-control study was performed in five European countries (Italy, Ireland, France, United Kingdom, Serbia). Newly diagnosed ALS patients and matched controls were interviewed to collect relevant demographic factors and exposures. Key clinical features at diagnosis were collected in ALS patients. Trauma was any accidental event causing an injury. Injuries were dated and classified according to cause, severity, type, site, and complications. All exposures were censored five years before symptoms onset. Risks were computed as odds ratios (OR) with 95% confidence intervals (CI) using univariate and multivariate conditional logistic regression models. Five hundred and seventy-five ALS patients and 1150 controls were interviewed. Disabling traumatic events predominated in the cases (OR 1.54 (95% CI 1.24-1.92)) and maintained significa...
QUALCOSA DA RICORDARE UNITA' D'ITALIA-150 ANNI Premessa L'occasione della presente pubblicazione ... more QUALCOSA DA RICORDARE UNITA' D'ITALIA-150 ANNI Premessa L'occasione della presente pubblicazione è data dalla ricorrenza dei 150 anni dell'Unità d'Italia. Il periodo prescelto è stato quello che va dal 1861 al 1915: dalla nascita dello Stato unitario fino all'intervento italiano nella prima guerra mondiale. Gli articoli intendono ricordare i contributi offerti alla costruzione dello Stato unitario da alcuni scienziati, politici, uomini di cultura e illustrare alcuni aspetti della società del tempo. I problemi affrontati dall'élite liberale furono molteplici e di natura non facile; alterni i risultati: moderno avanzamento in alcune parti d'Italia, stagnazione in altre. Di ciò i testi qui raccolti rendono testimonianza. Non si intende peraltro entrare nel merito delle analisi storiografiche complessive sull'argomento, se non per insistere con due precisazioni. La prima serve a ricordare che, oltre ad un Settecento riformatore, molto enfatizzato, c'è stato in Italia un Ottocento liberale, altrettanto riformatore ed altrettanto grande: nella seconda metà del secolo, ad esempio, esso ha mostrato i volti, proprio a livello ministeriale, di personaggi sulla cui onestà d'intenti non è dato eccepire: siano sufficienti i nomi di Cesare Matteucci, Giuseppe Zanardelli e Luigi Luzzatti. La seconda riguarda la cultura scientifica in Italia che, in quel medesimo periodo e fino al 1915, fu di alto livello, apprezzata su scala europea e internazionale, specialmente nei campi della matematica, dell'astronomia e della biologia. Alla prima generazione, che ebbe la funzione di traghettare gli ideali risorgimentali nelle pieghe del nuovo Stato, appartengono
Acta Neurologica Scandinavica, 2009
Objective: The purpose of this report is to describe care of a patient with chronic progressive e... more Objective: The purpose of this report is to describe care of a patient with chronic progressive external ophthalmoplegia and bilateral vestibular hypofunction. Clinical Features: A 66-year-old patient presented with limited eye movement and mild ptosis, which led to a diagnosis of chronic progressive external ophthalmoplegia. Rotary chair testing suggested vestibular involvement. Other symptoms included dizziness, problems with balance, and chronic stiffness in his cervical and thoracic regions. He had anxiety about loss of function and limited exercise habits because of fear of falling. Examination methods included balance assessment, kinetic aspects of walking, and videonystagmography. Intervention and Outcome: He had already begun regular practice of vestibular rehabilitation exercises before receiving 18 sessions of manual and instrument-assisted chiropractic manipulation, along with mobilization, stretching, and transverse massage, over 37 weeks. In addition to self-reported improvements, there was substantially decreased postural sway during balance assessment and there were small improvements in eye movement, ptosis, and walking. Conclusion: This patient showed improvements in balance, eye movements, and walking while undergoing multimodal chiropractic care and practicing eye and balance exercises.
Journal of neurology, neurosurgery, and psychiatry, Aug 23, 2018
To investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (... more To investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (ALS) in population-based case-control studies in three European countries using a validated and harmonised questionnaire. Patients with incident ALS and controls were recruited from five population-based registers in The Netherlands, Ireland and Italy. Demographic and data regarding educational level, smoking, alcohol habits and lifetime PA levels in both leisure and work time were gathered by questionnaire, and quantified using metabolic equivalent of task scores. Logistic regression models adjusting for PA-related factors were used to determine the association between PA and ALS risk, and forest plots were used to visualise heterogeneity between regions. 1557 patients and 2922 controls were included. We found a linear association between ALS and PA in leisure time (OR 1.07, P=0.01) and occupational activities (OR 1.06, P<0.001), and all activities combined (OR 1.06, P<0.001), wit...
Rivista di patologia nervosa e mentale, 1974
Rivista di neurologia, 1974
Basic and applied histochemistry, 1988
Rat brain thiamine pyrophosphatase (TPPase) was separated by thin layer polyacrylamide gel isoele... more Rat brain thiamine pyrophosphatase (TPPase) was separated by thin layer polyacrylamide gel isoelectric focusing (IF) and stained with a modification of the lead conversion method of Allen and Hyncik (1963). 10 bands with TPPase activity were observed in the pH range 4.6-7.1. The overall IF pattern of TPPase was similar to that of uridine diphosphatase and inosine diphosphatase but was clearly different from that of adenosine diphosphatase, p-nitrophenyl phosphatase, alpha-naphthyl phosphatase and thiamine monophosphatase. A semiquantitative assessment of TPPase isoenzymes has been performed using laser densitometry.
Archives in Neurology & Neuroscience
Breathing pattern and respiratory mechanics in patients with amyotrophic lateral scle
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie
Electroencephalography and clinical neurophysiology, 1975
Rivista di patologia nervosa e mentale, 1974
The Italian Journal of Neurological Sciences, 1982
ABSTRACT
Journal of Hepatology, 1994
To evaluate the efficacy of recombinant interferon α-2b in the treatment of patients with acute p... more To evaluate the efficacy of recombinant interferon α-2b in the treatment of patients with acute post-transfusion hepatitis C, a randomized controlled trial was conducted in 33 acute post-transfusion hepatitis C patients; 16 patients received 3 million units of subcutaneously injected ...
European Respiratory Journal, 1997
Breathing pattern and respiratory mechanics in patients with amyotrophic lateral scle
Acta neurologica Belgica
ABSTRACT
Amyotrophic lateral sclerosis & frontotemporal degeneration, Feb 24, 2017
To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic even... more To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic events, age of trauma, and site of injury. A population-based case-control study was performed in five European countries (Italy, Ireland, France, United Kingdom, Serbia). Newly diagnosed ALS patients and matched controls were interviewed to collect relevant demographic factors and exposures. Key clinical features at diagnosis were collected in ALS patients. Trauma was any accidental event causing an injury. Injuries were dated and classified according to cause, severity, type, site, and complications. All exposures were censored five years before symptoms onset. Risks were computed as odds ratios (OR) with 95% confidence intervals (CI) using univariate and multivariate conditional logistic regression models. Five hundred and seventy-five ALS patients and 1150 controls were interviewed. Disabling traumatic events predominated in the cases (OR 1.54 (95% CI 1.24-1.92)) and maintained significa...