tevfik yoldemir | Marmara University (original) (raw)

Papers by tevfik yoldemir

Climacteric, 2020

The Internet of Things (IoT) is a system of interrelated computing devices with unique identifier... more The Internet of Things (IoT) is a system of interrelated computing devices with unique identifiers and the ability to transfer data over a network without human-to-human or human-to-computer intera...

Gynecological Endocrinology, 2021

Abstract Objective To investigate the anxiety levels among infertile women and their partners als... more Abstract Objective To investigate the anxiety levels among infertile women and their partners also factors that may affect the anxiety status Study design A total of 403 infertile couples who applied to Infertility Outpatient Clinics of a University-affiliated Teaching and Research Hospital were included in the study. The infertile group was divided into two groups as primary and secondary infertile. One hundred and thirty-two fertile couples who applied to Gynecology Outpatient Clinics composed the control group. Hamilton Anxiety Rating Scale (HAM-A) form was filled by the infertile couples to evaluate the anxiety status before they started their treatment. Results Three hundred and twenty infertile and 84 fertile couples completed the study. The mean total scores of HAM-A of women were similar between the groups. So were the scores of their husbands. In all groups, women had significantly higher mean total HAM-A scores than their husbands. There was no association between the mean HAM-A score of women and age, BMI, AFC, duration of marriage, duration of infertility, number of previous treatment cycles. Education status, working status and family structure of women did not correlate with the mean HAM-A score. Conclusion Unexplained primary and secondary infertile couples had similar anxiety scores before the commencement of fertility treatments. However, the scores were higher in women than their male partners. Since the burden of treatment and the likelihood of treatment failure might increase the level of anxiety the women could be offered proper cognitive coping and relaxation interventions.

Journal of Obstetrics and Gynaecology, 2020

This study aims to investigate the effects of progesterone on the possible changes in nuchal tran... more This study aims to investigate the effects of progesterone on the possible changes in nuchal translucency (NT) levels for patients diagnosed with threatened miscarriage. The study group was composed of 125 patients diagnosed with threatened miscarriage and taking 400 mg/day micronized orally progesterone at least for two weeks, the control group was composed of 160 healthy pregnant women not taking any progesterone. Crown rump length (CRL) NT thickness, Pregnancy-associated plasma protein-A (PAPP-A), free beta human chorionic gonadotropin (Beta-HCG) levels of patients were measured for assessment of aneuploidy risk. Both of the groups were divided into four subgroups to determine the relationship between thickness of NT and progesterone use for specific CRL measurements. CRL in the first, second, third and fourth group was 45-55 mm, 55-65 mm, 65-75 mm, 75-84 mm, respectively. The two groups were age and BMI matched. In all groups of CRL there were no significant difference in Mom levels of NT thickness, PAPP-A and free Beta-HCG between the study and control groups. There havent been any relation between NT thickness and progesterone use. IMPACT STATEMENT What is already known about this subject? Recently some studies have claimed that progesterone use might have caused atypical blood flow pattern on foetal circulation, which could possibly increase NT. If the NT thickness is affected by the use of progesterone, then the false positive rate of detecting Down Syndrome screening tests would increase. What the results of this study add? In this study we did not found any relation between NT thickness and progesterone use. What the implications are of these findings for clinical practice and/or further research? Using orally progesterone due to threatened miscarriage do not change NT thickness levels. Further studies have to be done with a large number of participants.

Yeditepe Medical Journal, 2015

Climacteric, 2016

ABSTRACT Reduced maternal fertility is the consequence of depletion of follicles with maternal ag... more ABSTRACT Reduced maternal fertility is the consequence of depletion of follicles with maternal aging. In a 35-year-old woman, approximately 9.1% of the residual follicle pool disappears annually without entering into the growing stage, whereas, in a 45-year-old woman, this number triples. After the age of 35 years, the frequency of aneuploidies in oocytes increases sharply. Roughly 50–70% of mature oocytes from a 40-year-old woman have chromosomal abnormalities. The clinical pregnancy and implantation rates are lower in midlife women. Various controlled ovarian stimulation interventions have been suggested for the management of women in advanced age, most of whom are likely to be poor-responder patients. Currently, systematic reviews and meta-analyses suggest that there is insufficient evidence to recommend most of the treatments proposed to improve pregnancy rates in these poor responders. Minimal stimulation or natural cycle in vitro fertilization may be offered, without compromising the already existing pregnancy results.

Jinekolojik ve obstetrik operasyonlarda eldiven delinmeleri sık olarak gözlenmekte ve bunların bü... more Jinekolojik ve obstetrik operasyonlarda eldiven delinmeleri sık olarak gözlenmekte ve bunların büyük bir çoğunluğu farkedilmeden oluşmaktadır. Operasyon eldivenlerinin delinmesi ile birlikte hepatit B, hepatit C ve HIV virüsü gibi patojenlerin infekte hastadan operasyon ekibine bulaşması veya operasyon alanının cerrahın elindeki bakteriler tarafından kontaminasyonu riski ortaya çıkmaktadır. Operasyon sırasındaki eldiven delinme sıklığını ve çift eldiven kullanımının iç eldivendeki delinmeleri engelleyici etkisini araştırmak amacıyla ; tek kat eldiven giyilerek yapılan 70 ve çift kat eldiven giyilerek yapılan 20 operasyondaki toplam 440 çift eldiven (880 tek eldiven) incelendi. Tek kat eldiven kullanılan operasyonların %60'ında eldiven perforasyonu saptanırken çift eldiven kullanımı ile içteki eldiven hasarının belirgin olarak azaldığı saptandı (%15). Eldiven delinme oranında azalma operasyon personelini hepatit B, hepatit C, HIV ve diğer kan yoluyla bulaşabilecek hastalıklardan ...

Climacteric, 2012

To evaluate the frequency of the estrogen receptor (ER) gene PvuII and XbaI polymorphisms and the... more To evaluate the frequency of the estrogen receptor (ER) gene PvuII and XbaI polymorphisms and their associations with bone mineral density (BMD) in a group of postmenopausal Turkish women. A total of 125 healthy postmenopausal women and 125 premenopausal healthy young women as controls were included in the study. The PvuII and XbaI polymorphisms in the ER gene were studied by the polymerase chain reaction-restriction fragment length polymorphism method. The BMD of the lumbar vertebrae and femoral neck were measured by dual-energy X-ray absorptiometry. The frequencies of the ERα PVuII genotypes PP, Pp and pp were 20%, 54.4% and 25.6% in premenopausal and 24.8%, 44.8% and 30.4% in postmenopausal women, respectively. The frequencies of the ER XbaI genotypes XX, Xx, xx were 16.8%, 48.8% and 34.4% in premenopausal and 16.8%, 48% and 35.2% in postmenopausal women, respectively. There was no difference in the frequencies of ER gene polymorphisms between premenopausal and postmenopausal women. BMD measurements were not different between ER PvuII and XbaI genotypes in premenopausal and postmenopausal women. ER gene PvuII and XbaI polymorphisms have no major influence on bone mineral density in our group of postmenopausal women.

Climacteric, 2018

Endometriosis is classically defined as a chronic, recurrent and progressive disease. It is known... more Endometriosis is classically defined as a chronic, recurrent and progressive disease. It is known to be estrogen-dependent, but can still be observed during the peri-and postmenopausal periods. Medical management of endometriosis is palliative symptomatic relief. Surgery when properly and timely performed for the right person may treat endometriosis. However, there is always a risk of possible major or minor surgical complications, as well as loss of some functions due to nerve damage. Management of endometriosis in the woman approaching the end of her reproductive life may require special attention both due to the potential for recurrence and transformation into various endometriosis-associated malignancies.

Marmara Medical Journal, 2016

Endometriosis is defined as the presence of active endometrial tissue outside the uterine cavity ... more Endometriosis is defined as the presence of active endometrial tissue outside the uterine cavity affecting 15% of women at reproductive age. Ureteral endometriosis (UE) is a rare type of endometrial involvement affecting 0.1%-1% of women with endometriosis. UE is quite uncommon and underdiagnosed because of the patients' nonspecific symptoms of endometriosis. However, it is important to diagnose and manage UE treatment since it can lead to renal failure due to silent obstruction of the ureter. This case report describes a woman who presented with cyclic pelvic pain and left flank pain. Imaging studies and laparoscopic findings revealed bilateral endometrioma and deep infiltrating endometriosis (DIE) findings resulting in extrinsic infiltration of the ureter and hydronephrosis.

Marmara Medical Journal, 2015

Objective: Lower pregnancy rates have been reported in gonadotropin releasing hormone (GnRH) anta... more Objective: Lower pregnancy rates have been reported in gonadotropin releasing hormone (GnRH) antagonist cycles in comparison to those with agonist cycles. A non-significant difference of 3.3% in the pregnancy rate per cycle in favour of GnRH agonists was found. The possible difference between these two protocols could be a limiting factor. We aim to determine if the embryos developed in long down-regulated assisted reproductive technology (ART) cycles differ from the ones obtained in antagonist cycles among women matched for age and follicle-stimulating hormone (FSH) administered on cycle day 3. Patients and Methods: Retrospective cohort analysis was done on a population from a university affiliated hospital. 193 women undergoing standard in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment were included. The age and cycle day 3 FSH matched women undergoing either long or short protocols were compared. Group A consisted of women who had long down-regulation with GnRH analogues, group B consisted of women who had used GnRH antagonists. The clinical and ongoing pregnancy rates were compared. Day 3 embryo scores were compared between the groups. Results: Although mean number of aspirated and inseminated oocytes were similar for the groups and average embryo scores were comparable, clinical and ongoing pregnancy rates were higher in group A than in group B. The percentage of embryos with zero fragmentation and 8-10 blastomeres on day 3 was similar in antagonist and long agonist cycles. Conclusion: Long protocol ART cycles will result in comparable percentages of day 3 embryos with symmetric 8-10 blastomeres with zero fragmentation to those in antagonist cycles.

Gynecological Endocrinology, 2020

Abstract Objective To investigate whether polycystic ovary syndrome (PCOS) had further deteriorat... more Abstract Objective To investigate whether polycystic ovary syndrome (PCOS) had further deteriorating influence on endothelial function or cardiometabolic parameters in women with vitamin D deficiency during reproductive age. Study design The study group was composed of women with PCOS and vitamin D deficiency and insufficiency between the ages of 18 and 35 years. Age and body mass index (BMI)-matched women were chosen as controls. Serum 25(OH) Vit D levels below 20 ng/mL were considered as vitamin D deficiency. The cutoff level of vitamin D insufficiency was suggested at 30 ng/mL. Serum FSH, LH, estradiol, testosterone, DHEA-S, fasting glucose, total cholesterol, HDL, LDL, triglyceride levels were analyzed. Carotid artery intima-media thickness (CIMT) was measured, and the flow-mediated vasodilation (FMD) was calculated. Results CIMT and FMD values in both vitamin D deficiency and insufficiency subgroups showed no significant difference between PCOS and non-PCOS groups. There was a weak negative correlation between BMI, waist/hip ratio, CRP, and 25(OH) Vitamin D. Conclusion PCOS is a heterogeneous disease with different combinations of the diagnostic components. Vitamin D is an important variable for a healthy cardiovascular system. We did not find any difference in early atherosclerotic markers and cardiometabolic features between PCOS and non-PCOS group with Vitamin D deficiency.

Journal of Paediatrics and Child Health, 2018

To compare the post‐natal effects of delayed cord clamping (DCC) and early cord clamping (ECC) in... more To compare the post‐natal effects of delayed cord clamping (DCC) and early cord clamping (ECC) in term large‐for‐gestational age (LGA) infants.

Journal of Obstetrics and Gynaecology Research, 2017

The risk of cardiovascular disease is higher in women with polycystic ovary syndrome (PCOS) compa... more The risk of cardiovascular disease is higher in women with polycystic ovary syndrome (PCOS) compared to healthy individuals. Chronic inflammation, insulin resistance, hyperandrogenemia, hyperlipidemia and increased oxidative stress are known to have a role in the formation of atherosclerosis and cardiovascular disease. The aim of our study was to evaluate if cardiovascular risk varied according to different PCOS criteria, using carotid intima‐media thickness (CIMT), which is an important marker of major cardiovascular events in the later stages of life.

Journal of Minimally Invasive Gynecology, 2008

17%). In 199 patients (69.83%) we found some intrauterine pathology: 66 patientes (23.15%) with c... more 17%). In 199 patients (69.83%) we found some intrauterine pathology: 66 patientes (23.15%) with cornual obstruction, 60 patients (21.05%) with cervical stenosis, 31 patients (10.87%) with endometrial polyps, 16 patients (5.62%) with septated uterus, 14 patients (4.91%) with Ashermańs syndrome, 10 patients (3.50%) with uterine leiomyoma, and in 2 patients (0.73%) the procedure could not be completed. Of these 114 patients (40%) underwent a cycle of in vitro fertilization. 314 Open Communication Session 12dAdvances in MIG (7:30 AM d 7:35 AM)

International Journal of Gynecology & Obstetrics, 2009

International Journal of Gynecology & Obstetrics, 2010

To evaluate the prevalence of the different human papillomavirus (HPV) genotypes in women seen at... more To evaluate the prevalence of the different human papillomavirus (HPV) genotypes in women seen at 2 Marmara University Hospital gynecologic outpatient clinics in Istanbul, Turkey. Methods: From May 1 through August 31, 2008, specimens were obtained from 500 women for cytologic evaluation by the splitsample method. HPV types were identified by PCR and hybridization using a microarray that identifies 35 types. Results: The overall prevalence of HPV was 16.5%, multiple genotypes were found in 35.8% of the infected women, and 75% of the types were high risk; 79% of the infected women had negative cytologic results, 3.7% had ASCUS, 10% had LSIL, and 6% had HSIL; the highest infection rates were 36% for women aged 20 to 30 years and 35% for those aged 31 to 40 years; 65.2% of the infected women were university graduates; and 34% were single. Conclusion: HPV infection involved numerous types, most of them high risk, even in women with negative cytology results. Further studies with larger groups will provide more information on HPV distribution in Turkey, which may guide the development of local vaccination programs.

International Journal of Gynecology & Obstetrics, 2003

Gynecological Endocrinology, 2010

To determine if endometrial trauma during embryo transfer trials (ETTs) improves implantation and... more To determine if endometrial trauma during embryo transfer trials (ETTs) improves implantation and clinical pregnancy rates in intracytoplasmic sperm injection treatment cycles. One-hundred fifty women undergoing their first IVF treatment were included in a prospective randomised study in a University hospital clinic. ETTs were performed either on day 21 of the previous cycle, or on day 6 of the controlled ovarian hyperstimulatin (COH) cycle, or conducted at least two cycles before COH cycle. Clinical pregnancy and implantation rates were compared between the groups. There was no difference between the groups in terms of clinical pregnancy or implantation rates. Endometrial trauma by ETTs performed either during the preceding cycle or on day 6 of the COH cycle does not improve pregnancy rates.