Scott Raymond | Massachusetts General Hospital (original) (raw)

Papers by Scott Raymond

Research paper thumbnail of Spontaneous Intracranial Hypotension Caused by Thoracic Disc Disease

Headache: The Journal of Head and Face Pain, 2020

Research paper thumbnail of Does including neck CTA in work-up of suspected intracranial hemorrhage add value?

Emergency Radiology, 2018

PurposeNeck CT angiography (CTA) is frequently performed in conjunction with head CTA in patients... more PurposeNeck CT angiography (CTA) is frequently performed in conjunction with head CTA in patients presenting with clinical signs and symptoms concerning for acute intracranial hemorrhage, despite relatively low appropriateness (ACR Appropriateness Criteria 2–6). This decision is sometimes justified by suggesting that CTA neck findings are useful in planning subsequent catheter angiography.MethodsWe investigated the value of neck CTA in patients with suspected acute intracranial hemorrhage by reviewing 220 head and neck CTAs performed in our emergency room over a 24-month period for the indication of hemorrhage or headache. Images were reviewed by two neurointerventionalists to address the value of the neck CTA for planning catheter angiography.ResultsFindings helpful for performing catheter angiography were observed on neck CTA in 22% (Cohen kappa 0.65), and included anatomical arch variants such as a bovine arch, direct vertebral artery arch origin, and aberrant subclavian artery. However, findings that might substantially prolong angiography for more than 10 min if unknown occurred in 5% (Cohen kappa 0.69). Incidental findings prompting additional imaging or significant clinical action occurred in 20%. Subarachnoid hemorrhage on noncontrast head CT was strongly associated with a need for subsequent angiography.ConclusionsAlthough CTA neck can provide helpful information for planning catheter angiography, it rarely uncovers findings that would significantly prolong the procedure if unknown. Neck CTA is therefore only recommended in patients with a confirmed intracranial hemorrhage in a pattern consistent with aneurysm or arteriovenous shunt.

Research paper thumbnail of LVIS Blue as a low porosity stent and coil adjuvant

Journal of neurointerventional surgery, Jan 13, 2018

The LVIS Blue is an FDA-approved stent with 28% metallic coverage that is indicated for use in co... more The LVIS Blue is an FDA-approved stent with 28% metallic coverage that is indicated for use in conjunction with coil embolization for the treatment of intracranial aneurysms. Given a porosity similar to approved flow diverters and higher than currently available intracranial stents, we sought to evaluate the effectiveness of this device for the treatment of intracranial aneurysms. We performed an observational single-center study to evaluate initial occlusion and occlusion at 6-month follow-up for patients treated with the LVIS Blue in conjunction with coil embolization at our institution using the modified Raymond-Roy classification (mRRC), where mRRC 1 indicates complete embolization, mRRC 2 persistent opacification of the aneurysm neck, mRRC 3a filling of the aneurysm dome within coil interstices, and mRRC 3b filling of the aneurysm dome. Sixteen aneurysms were treated with the LVIS Blue device in conjunction with coil embolization with 6-month angiographic follow-up. Aneurysms w...

Research paper thumbnail of Imaging Brain Collaterals: Quantification, Scoring, and Potential Significance

Topics in magnetic resonance imaging : TMRI, 2017

Leptomeningeal collaterals provide the primary source of perfusion to ischemic brain tissue follo... more Leptomeningeal collaterals provide the primary source of perfusion to ischemic brain tissue following the onset of acute ischemic stroke and are becoming an important imaging biomarker for stroke therapy triage. Collateral circulation is predictive of infarct growth, end infarct volume, and response to endovascular therapy. The strength of the collateral circulation varies among patients and is partially dependent on genetic and modifiable risk factors. Collateral circulation may be assessed by standard angiographic techniques, including digital subtraction angiography, computed tomography and magnetic resonance (MR) angiography, as well as a growing array of advanced MR techniques including arterial spin labeling and dynamic MR angiography. Simple scoring systems are used to estimate the relative strength of the collateral circulation for a given patient, although there are some discrepancies in the predictive value of these systems. In this review, we discuss methods and technique...

Research paper thumbnail of Multiphoton Imaging of Ultrasound Bioeffects in the Murine Brain

AIP Conference Proceedings, 2006

Research paper thumbnail of CT and MRI of Rare Extraintestinal Manifestations of Inflammatory Bowel Disease in Children and Adolescents

Journal of Pediatric Gastroenterology and Nutrition, 2016

Inflammatory bowel disease (IBD) is associated with a spectrum of extraintestinal manifestations ... more Inflammatory bowel disease (IBD) is associated with a spectrum of extraintestinal manifestations (EIMs) affecting many organ systems. EIMs can occur in over 40% of IBD patients and are associated with significant morbidity. They occur at any time point in the course of disease, often during an active phase of bowel inflammation, but sometimes preceding bowel disease. Prompt recognition of EIMs enables timely and more effective therapy. Physicians who image patients with IBD should be aware of the myriad extraintestinal conditions that may be detected on imaging studies, both within and outside of the abdomen, as they may predate the diagnosis of IBD. Cross sectional imaging of unusual conditions associated with IBD will be presented, including pathology in the hepatobiliary, pancreatic, genitourinary, musculoskeletal, mucocutaneous, vascular, neurologic and pulmonary systems.

Research paper thumbnail of Molecular imaging tools for studying Alzheimer's disease

Research paper thumbnail of IC-P-126

Research paper thumbnail of Focused ultrasound thermal surgery, imaging, and elastometry using the same phased array: feasibility study

IEEE Ultrasonics Symposium, 2004

I. MOTIVATION In recent years, MRI-guided focused ultrasound surgery has proven effective in a va... more I. MOTIVATION In recent years, MRI-guided focused ultrasound surgery has proven effective in a variety of clinical applications [1-2]. In these procedures, focused ultrasound is used as a thermal scalpel to ablate cancerous tissue. The process is monitored by MRI ...

Research paper thumbnail of Tomographic Fluorescence Lifetime Imaging

Biomedical Optics and 3-D Imaging, 2012

Research paper thumbnail of Patient Selection for Mechanical Thrombectomy

Clinical Neuroradiology, 2013

Research paper thumbnail of A direct approach to time domain fluorescence tomography based on asymptotic lifetime analysis

SPIE Proceedings, 2007

ABSTRACT A theoretical framework is presented that allows a lifetime based analysis of the entire... more ABSTRACT A theoretical framework is presented that allows a lifetime based analysis of the entire temporal diffuse fluorescence response curve from a turbid medium. Optimization studies using singular value decomposition analysis show that direct time domain fluorescence reconstructions are optimally performed using a few points near the peak and rise portions of the temporal response. It is also shown that the initial portion of the fluorescent response curve offers superior contrast-to-noise performance, while the late decay portions offer minimal cross-talk between multiple lifetime components.

Research paper thumbnail of MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits

Ultrasound in Medicine & Biology, 2005

Research paper thumbnail of Ultrasound Enhanced Delivery of Molecular Imaging and Therapeutic Agents in Alzheimer's Disease Mouse Models

Research paper thumbnail of Comparison of frequency-domain and time-domain fluorescence lifetime tomography

Research paper thumbnail of Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast

Research paper thumbnail of Time resolved fluorescence tomography of turbid media based on lifetime contrast

Research paper thumbnail of Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

Journal of the American Chemical Society, 2009

Research paper thumbnail of Lifetime-based tomographic multiplexing

Journal of Biomedical Optics, 2010

Near-infrared ͑NIR͒ fluorescence tomography of multiple fluorophores has previously been limited ... more Near-infrared ͑NIR͒ fluorescence tomography of multiple fluorophores has previously been limited by the bandwidth of the NIR spectral regime and the broad emission spectra of most NIR fluorophores. We describe in vivo tomography of three spectrally overlapping fluorophores using fluorescence lifetime-based separation. Timedomain images are acquired using a voltage-gated, intensified chargecoupled device ͑CCD͒ in free-space transmission geometry with 750 nm Ti:sapphire laser excitation. Lifetime components are fit from the asymptotic portion of fluorescence decay curve and reconstructed separately with a lifetime-adjusted forward model. We use this system to test the in vivo lifetime multiplexing suitability of commercially available fluorophores, and demonstrate lifetime multiplexing in solution mixtures and in nude mice. All of the fluorophores tested exhibit nearly monoexponential decays, with narrow in vivo lifetime distributions suitable for lifetime multiplexing. Quantitative separation of two fluorophores with lifetimes of 1.1 and 1.37 ns is demonstrated for relative concentrations of 1:5. Finally, we demonstrate tomographic imaging of two and three fluorophores in nude mice with fluorophores that localize to distinct organ systems. This technique should be widely applicable to imaging multiple NIR fluorophores in 3-D.

Research paper thumbnail of Modular design for in vivo optical imaging and ultrasound treatment in the murine brain

IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2007

Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric... more Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric constraints. We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope, and animals are imaged during ultrasound-induced blood-brain barrier disruption.

Research paper thumbnail of Spontaneous Intracranial Hypotension Caused by Thoracic Disc Disease

Headache: The Journal of Head and Face Pain, 2020

Research paper thumbnail of Does including neck CTA in work-up of suspected intracranial hemorrhage add value?

Emergency Radiology, 2018

PurposeNeck CT angiography (CTA) is frequently performed in conjunction with head CTA in patients... more PurposeNeck CT angiography (CTA) is frequently performed in conjunction with head CTA in patients presenting with clinical signs and symptoms concerning for acute intracranial hemorrhage, despite relatively low appropriateness (ACR Appropriateness Criteria 2–6). This decision is sometimes justified by suggesting that CTA neck findings are useful in planning subsequent catheter angiography.MethodsWe investigated the value of neck CTA in patients with suspected acute intracranial hemorrhage by reviewing 220 head and neck CTAs performed in our emergency room over a 24-month period for the indication of hemorrhage or headache. Images were reviewed by two neurointerventionalists to address the value of the neck CTA for planning catheter angiography.ResultsFindings helpful for performing catheter angiography were observed on neck CTA in 22% (Cohen kappa 0.65), and included anatomical arch variants such as a bovine arch, direct vertebral artery arch origin, and aberrant subclavian artery. However, findings that might substantially prolong angiography for more than 10 min if unknown occurred in 5% (Cohen kappa 0.69). Incidental findings prompting additional imaging or significant clinical action occurred in 20%. Subarachnoid hemorrhage on noncontrast head CT was strongly associated with a need for subsequent angiography.ConclusionsAlthough CTA neck can provide helpful information for planning catheter angiography, it rarely uncovers findings that would significantly prolong the procedure if unknown. Neck CTA is therefore only recommended in patients with a confirmed intracranial hemorrhage in a pattern consistent with aneurysm or arteriovenous shunt.

Research paper thumbnail of LVIS Blue as a low porosity stent and coil adjuvant

Journal of neurointerventional surgery, Jan 13, 2018

The LVIS Blue is an FDA-approved stent with 28% metallic coverage that is indicated for use in co... more The LVIS Blue is an FDA-approved stent with 28% metallic coverage that is indicated for use in conjunction with coil embolization for the treatment of intracranial aneurysms. Given a porosity similar to approved flow diverters and higher than currently available intracranial stents, we sought to evaluate the effectiveness of this device for the treatment of intracranial aneurysms. We performed an observational single-center study to evaluate initial occlusion and occlusion at 6-month follow-up for patients treated with the LVIS Blue in conjunction with coil embolization at our institution using the modified Raymond-Roy classification (mRRC), where mRRC 1 indicates complete embolization, mRRC 2 persistent opacification of the aneurysm neck, mRRC 3a filling of the aneurysm dome within coil interstices, and mRRC 3b filling of the aneurysm dome. Sixteen aneurysms were treated with the LVIS Blue device in conjunction with coil embolization with 6-month angiographic follow-up. Aneurysms w...

Research paper thumbnail of Imaging Brain Collaterals: Quantification, Scoring, and Potential Significance

Topics in magnetic resonance imaging : TMRI, 2017

Leptomeningeal collaterals provide the primary source of perfusion to ischemic brain tissue follo... more Leptomeningeal collaterals provide the primary source of perfusion to ischemic brain tissue following the onset of acute ischemic stroke and are becoming an important imaging biomarker for stroke therapy triage. Collateral circulation is predictive of infarct growth, end infarct volume, and response to endovascular therapy. The strength of the collateral circulation varies among patients and is partially dependent on genetic and modifiable risk factors. Collateral circulation may be assessed by standard angiographic techniques, including digital subtraction angiography, computed tomography and magnetic resonance (MR) angiography, as well as a growing array of advanced MR techniques including arterial spin labeling and dynamic MR angiography. Simple scoring systems are used to estimate the relative strength of the collateral circulation for a given patient, although there are some discrepancies in the predictive value of these systems. In this review, we discuss methods and technique...

Research paper thumbnail of Multiphoton Imaging of Ultrasound Bioeffects in the Murine Brain

AIP Conference Proceedings, 2006

Research paper thumbnail of CT and MRI of Rare Extraintestinal Manifestations of Inflammatory Bowel Disease in Children and Adolescents

Journal of Pediatric Gastroenterology and Nutrition, 2016

Inflammatory bowel disease (IBD) is associated with a spectrum of extraintestinal manifestations ... more Inflammatory bowel disease (IBD) is associated with a spectrum of extraintestinal manifestations (EIMs) affecting many organ systems. EIMs can occur in over 40% of IBD patients and are associated with significant morbidity. They occur at any time point in the course of disease, often during an active phase of bowel inflammation, but sometimes preceding bowel disease. Prompt recognition of EIMs enables timely and more effective therapy. Physicians who image patients with IBD should be aware of the myriad extraintestinal conditions that may be detected on imaging studies, both within and outside of the abdomen, as they may predate the diagnosis of IBD. Cross sectional imaging of unusual conditions associated with IBD will be presented, including pathology in the hepatobiliary, pancreatic, genitourinary, musculoskeletal, mucocutaneous, vascular, neurologic and pulmonary systems.

Research paper thumbnail of Molecular imaging tools for studying Alzheimer's disease

Research paper thumbnail of IC-P-126

Research paper thumbnail of Focused ultrasound thermal surgery, imaging, and elastometry using the same phased array: feasibility study

IEEE Ultrasonics Symposium, 2004

I. MOTIVATION In recent years, MRI-guided focused ultrasound surgery has proven effective in a va... more I. MOTIVATION In recent years, MRI-guided focused ultrasound surgery has proven effective in a variety of clinical applications [1-2]. In these procedures, focused ultrasound is used as a thermal scalpel to ablate cancerous tissue. The process is monitored by MRI ...

Research paper thumbnail of Tomographic Fluorescence Lifetime Imaging

Biomedical Optics and 3-D Imaging, 2012

Research paper thumbnail of Patient Selection for Mechanical Thrombectomy

Clinical Neuroradiology, 2013

Research paper thumbnail of A direct approach to time domain fluorescence tomography based on asymptotic lifetime analysis

SPIE Proceedings, 2007

ABSTRACT A theoretical framework is presented that allows a lifetime based analysis of the entire... more ABSTRACT A theoretical framework is presented that allows a lifetime based analysis of the entire temporal diffuse fluorescence response curve from a turbid medium. Optimization studies using singular value decomposition analysis show that direct time domain fluorescence reconstructions are optimally performed using a few points near the peak and rise portions of the temporal response. It is also shown that the initial portion of the fluorescent response curve offers superior contrast-to-noise performance, while the late decay portions offer minimal cross-talk between multiple lifetime components.

Research paper thumbnail of MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits

Ultrasound in Medicine & Biology, 2005

Research paper thumbnail of Ultrasound Enhanced Delivery of Molecular Imaging and Therapeutic Agents in Alzheimer's Disease Mouse Models

Research paper thumbnail of Comparison of frequency-domain and time-domain fluorescence lifetime tomography

Research paper thumbnail of Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast

Research paper thumbnail of Time resolved fluorescence tomography of turbid media based on lifetime contrast

Research paper thumbnail of Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

Journal of the American Chemical Society, 2009

Research paper thumbnail of Lifetime-based tomographic multiplexing

Journal of Biomedical Optics, 2010

Near-infrared ͑NIR͒ fluorescence tomography of multiple fluorophores has previously been limited ... more Near-infrared ͑NIR͒ fluorescence tomography of multiple fluorophores has previously been limited by the bandwidth of the NIR spectral regime and the broad emission spectra of most NIR fluorophores. We describe in vivo tomography of three spectrally overlapping fluorophores using fluorescence lifetime-based separation. Timedomain images are acquired using a voltage-gated, intensified chargecoupled device ͑CCD͒ in free-space transmission geometry with 750 nm Ti:sapphire laser excitation. Lifetime components are fit from the asymptotic portion of fluorescence decay curve and reconstructed separately with a lifetime-adjusted forward model. We use this system to test the in vivo lifetime multiplexing suitability of commercially available fluorophores, and demonstrate lifetime multiplexing in solution mixtures and in nude mice. All of the fluorophores tested exhibit nearly monoexponential decays, with narrow in vivo lifetime distributions suitable for lifetime multiplexing. Quantitative separation of two fluorophores with lifetimes of 1.1 and 1.37 ns is demonstrated for relative concentrations of 1:5. Finally, we demonstrate tomographic imaging of two and three fluorophores in nude mice with fluorophores that localize to distinct organ systems. This technique should be widely applicable to imaging multiple NIR fluorophores in 3-D.

Research paper thumbnail of Modular design for in vivo optical imaging and ultrasound treatment in the murine brain

IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2007

Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric... more Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric constraints. We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope, and animals are imaged during ultrasound-induced blood-brain barrier disruption.