Alireza Mardanshahi | Mazandaran University of Medical Sciences (original) (raw)
Papers by Alireza Mardanshahi
Current Drug Metabolism, 2022
Background: HER2 over-expression plays a crucial role in the cancer treatment protocol. This stud... more Background: HER2 over-expression plays a crucial role in the cancer treatment protocol. This study evaluates the effectiveness of organic anion and cation transport inhibitors and substrate on the tumor uptake of 99mTc-HYNIC-(Ser)3-LTVPWY radiotracer in SKOV-3 tumor-bearing nude mice. Methods: Before the injection of the radiolabeled peptide, SKOV-3 tumor-bearing nude mice were treated with furosemide, cimetidine, para-amino hippuric acid, and saline. The inhibition effects of the organic anion and cation transport inhibitors were compared with the control group. In both treatment and control groups, the tumor and renal accumulation of radiopeptide in mice bearing SKOV-3 tumors were assessed in biodistribution and SPECT imaging studies. Results: The biodistribution and imaging results suggested that all treated groups showed a higher tumor and higher normal tissue radioactivity compared to the control group. According to the tumor imaging study, the furosemidetreated group had slightly better tumor uptake and a higher tumor to muscle uptake ratio than other treatment groups. Conclusions: Administration of furosemide (an OAT inhibitor) increased radioactivity accumulation in the kidneys and blood and improved tumor radioactivity uptake. PAH (an anion transporter substrate) and cimetidine (an OCT inhibitor) have a minor effect on the accumulation of radioactivity in the kidneys and the acquired images.
Research Square (Research Square), Jul 17, 2023
The 5-hydroxytryptamine receptor (5-HTR) family involves seven classes of receptors. The 5-HT 7 R... more The 5-hydroxytryptamine receptor (5-HTR) family involves seven classes of receptors. The 5-HT 7 R is the newest member of this family and contributes to different physiological and pathological processes. As a pathology, Glioblastoma multiform (GBM) overexpresses 5-HT 7 R; hence, this study aims to develop radiolabeled aryl piperazine derivatives as 5-HT 7 R imaging agents. To that end, compounds 6 and 7 as 1-(3-nitropyridin-2-yl)piperazine derivatives were radiolabeled with fac-[ 99m Tc(CO) 3 (H 2 O) 3 ] + and (99m Tc(CO) 3-[6] and 99m Tc(CO)3-[7]) were obtained with high radiochemical purity (RCP>94%). 99m Tc(CO) 3-[6] and 99m Tc(CO)3-[7] possess high a nity toward 5-HT 7 R of the U-87 MG cell line. The calculated K i for them was 26.85±0.78 nM and 36.67±0.89 nM. The biodistribution study in normal mice indicates that the brain uptake of 99m Tc(CO) 3-[6] and 99m Tc(CO)3-[7] is the highest at 30 min postinjection (0.8±0.25 and 0.64±0.18 %ID/g, respectively). The data of the biodistribution study in the U87-MG xenograft model revealed that these radiotracers could accumulate in the tumor site, and the highest tumor uptake was observed at 60 min post-injection (3.38±0.65 and 3.27±0.5 %ID/g, respectively). The injection of pimozide can block the tumor's radiotracer uptake, indicating the binding of these radiotracers to the 5-HT 7 R. The imaging study in the xenograft model also con rms the biodistribution data. The acquired images clearly show the tumor site, and the tumor-to-muscle ratio for 99m Tc(CO) 3-[6] and 99m Tc(CO)3-[7] at 60 min was 3.33 and 3.88, respectively.
Current Drug Metabolism
Background: HER2 over-expression plays a crucial role in the cancer treatment protocol. This stud... more Background: HER2 over-expression plays a crucial role in the cancer treatment protocol. This study evaluates the effectiveness of organic anion and cation transport inhibitors and substrate on the tumor uptake of 99mTc-HYNIC-(Ser)3-LTVPWY radiotracer in SKOV-3 tumor-bearing nude mice. Methods: Before the injection of the radiolabeled peptide, SKOV-3 tumor-bearing nude mice were treated with furosemide, cimetidine, para-amino hippuric acid, and saline. The inhibition effects of the organic anion and cation transport inhibitors were compared with the control group. In both treatment and control groups, the tumor and renal accumulation of radiopeptide in mice bearing SKOV-3 tumors were assessed in biodistribution and SPECT imaging studies. Results: The biodistribution and imaging results suggested that all treated groups showed a higher tumor and higher normal tissue radioactivity compared to the control group. According to the tumor imaging study, the furosemidetreated group had sligh...
Nuclear Medicine Communications, 2019
Objective Arginine–glycine–aspartic acid (RGD) peptide with its specific binding affinity to inte... more Objective Arginine–glycine–aspartic acid (RGD) peptide with its specific binding affinity to integrin αvβ3, is widely investigated for the development of molecular imaging probes for diagnosis of αvβ3-positive tumors. The aim of this work was to evaluate the ability of 99mTc- HYNIC-D(RGD), a novel retro-inverso peptidomimetic derivative for U87MG tumor (αvβ3-positive) imaging. Methods HYNIC-D(RGD) labeled with 99mTc using tricine/EDDA as an exchange coligands. Single-photon emission computed tomography imaging and biodistribution study were performed in nude mice bearing U87MG xenograft tumor. Results The labeling yield was >95%. The radiopeptide showed high uptake value in the U87MG tumor relative to muscle after 2 hours (1.43 ± 0.05 vs. 0.22 ± 0.11 %ID/g). The tumor/muscle ratio was 6.5. Blocking experiment showed specific binding towards tumor. Single-photon emission computed tomography imaging study revealed that radiopeptide had prominent uptake in U87MG tumor. Conclusion Th...
Acute pyelonephritis (APN) is the main predisposing factor for renal cortical scar (RCS) performi... more Acute pyelonephritis (APN) is the main predisposing factor for renal cortical scar (RCS) performing. Hypertension is a complication of RCS and appears in 10-20 Percent of patient in their life. Diagnosis and treatment of APN are necessary for prevention of RCS. The aim of this review is assessment of 99mTc-DMSA (99mTc-dimercaptosuccinic acid) scan value in diagnosis of APN and RCS and comparison of its results with other diagnostic methods such as radiology and ultrasonography. Ultrasonography (US) showed almost 39 % of APN that diagnosed with 99mTC-DMSA scan. Computed Tomography Scan (CT scan) is a sensitive and effective method in diagnosis of APN and its complication. Spiral CT scan and Magnetic Resonance Imaging (MRI) are sensitive and relatively reliable tools in diagnosis of APN; however they are not practicable in the first evaluation and fallow up of infant and children with acute urinary tract infection. Power Doppler Ultrasonography (PDUS) demonstrated a sensitivity of 70 ...
Objective: The risk of cardiac death in diabetic patients is 3 times more than non-diabetics. But... more Objective: The risk of cardiac death in diabetic patients is 3 times more than non-diabetics. But it is not determined who need cardiac screening. About 41% of diabetic patients with silent ischemia are missed. the carotid intima-media thickness (CIMT) and ankel brachial index are two independent,simple and non invasive method in vascular complications diagnosis in diabetic patients.The aim of this study was to evaluate the assosiation of CIMT and ABI in prediction of silent myocardial ischemia in myocardial perfusion scintigraphy in Asymtomatic diabetic papulation. Materials and Methods: This was an analytic cross-sectional study. The convenient sampling was used. About 114 patients with diabetics and no history and symptom of coronary artery disease (CAD) were included. Myocardial perfusion scan (MPI), CIMT and ABI were done. All of statistical analysis was done by SPSS-20. Results: Totally114 diabetic patients without cronary artery disease symptoms were included .About 66.7% were female. The mean age of patients was 53.8± 8.6 years old. About 50% (57) of patients were normal. The mean of CIMT was 0.93 ± 0.21 and mean ABI was 0.97 ± 0.11. Regarding the anlysis of variance (ANOVA) there were significant differences of mean CIMT and ABI between normal and moderate to severe ischemia in MPI. Conclusion: Our findings showed that CIMT and ABI is significantly different between patients with and without ischemia. The CIMT and ABI are simple, non-invasive, and inexpensive tests that may be used to identify individuals who are at high risk of developing cardiovascular disease (diabetic patients).
Breast cancer is the second leading cause of cancer death among women. One in eight women will be... more Breast cancer is the second leading cause of cancer death among women. One in eight women will be diagnosed with breast cancer in their life period .There are several risk factors for progress of carcinogen cell. Zinc and lead have crucial role in oxidative stress and changes in their level can enhance progress of carcinogen cells. The purpose of this study is to discover the level of zinc and lead in plasma of breast cancer patients. One hundred numbers with breast carcinoma diagnosis was confirmed by pathological samples and the results were compared with standard values and amount of these elements was observed in the blood by atomic absorption. Zinc plasma level in patients was found to be 50.59 + 4.72 (μg/dl) with p value of p=0.003 which is lower than standard value (80 μg/dl). On the other hand, the plasma lead level was identified to be 6.24 + 1.173(μg/dl) in patients and zero in the standard value. According to the observation, breast cancer patients had a higher lead leve...
Caspian Journal of Internal Medicine, 2021
Background: In this research, we aimed to survey the added value of single photon emission comput... more Background: In this research, we aimed to survey the added value of single photon emission computed tomography (SPECT) in comparison with planar whole body bone scan to visualize bone metastatic lesions in patients with breast cancer. Methods: A total of 80 patients with breast cancer (invasive ductal carcinoma) were examined with planar whole body bone scan and SPECT imaging using 99mTc-labelled methylene diphosphonate (99mTc-MDP). The patients with abnormal uptakes in SPECT imaging were also investigated with magnetic resonance imaging (MRI). Results: Among these 80 patients with normal whole body bone SPECT scan, 19 (23.25%) of them revealed abnormal 99mTc-MDP uptake in skeleton. Furthermore, these 19 patients were subjected to MRI and 3 (3.75%) of them were confirmed with metastatic bone lesion. Conclusion: The obtained data suggest that SPECT possess the added diagnostic over planar whole body bone scan.
Journal of Mazandaran University of Medical Sciences, 2016
Background and purpose: Estimation of the risks of radiation would be possible by identifying the... more Background and purpose: Estimation of the risks of radiation would be possible by identifying the dose received. Introducing the dose level from diagnostic procedures can be effective in reducing the patient dose, improving the quality of treatment, and increasing the safety of patients and staff. This study evaluated patient entrance surface dose (ESD), effective dose, and cumulative dose from most common radiography procedures. Materials and methods: A descriptive study was conducted in which patient dose level from most common radiography procedures in two referral hospitals (Imam Khomeini and Bu-Ali Sina, Sari, Iran) were evaluated in 2015. X-ray tube output was measured in 1m from the tube focal spot in several kVp. ESD (mGy) value in every procedure was calculated while considering its radiographic conditions (kV, mAs and FFD). The effective dose (ED) (mSv) per examination was also calculated from appropriate ED/ESD conversion factor and the cumulative dose (man-sivert) of ann...
Iranian Journal of Diabetes and Obesity, 2015
iabetes mellitus (DM) is an independent risk factor of cardiovascular disease (CAD) (1-3). CAD is... more iabetes mellitus (DM) is an independent risk factor of cardiovascular disease (CAD) (1-3). CAD is the leading cause of death in DM patients (4). Myocardial infarction (MI), Angina and sudden death rates in diabetic patients are higher than normal population (5). D 1. MD, Shahid Sadoughi University of Medical Sciences Yazd, Iran. 2. MD, Assistant Professor of Nuclear Medicine, Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 3. MD, Cardiologist, Afshar Hospital, Shahid Sadoughi University of Medical Sciences Yazd, Iran. 4. DDH, Assistant Professor of Maxilo Facial Radiology Dental Factuly Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5. Nuclear Medicine Specialist, Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. 6. MD, Assistant Professor Community Medicine. Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 7. MD, Department of Cardiology, Afshar ...
![Research paper thumbnail of Compartmental Analysis to Predict the Biodistribution of [166Ho]- DOTA-Bevacizumab for Targeted Radiotherapy Purpose](https://attachments.academia-assets.com/77160263/thumbnails/1.jpg)
](Purpose- The main aim of this study was to develop the pharmacokinetic model for the colorectal c... more Purpose- The main aim of this study was to develop the pharmacokinetic model for the colorectal cancer’s complex 166Ho-DOTA-Bevacizumab in normal and tumoral rats to analyze of behavior as a new composition for diagnosing and treatment. The use of compartmental analysis allows a mathematical separation of tissues and organs to determine the concentration of activity in each fraction of interest. Biodistribution studies are expensive and difficult to carry out in humans, but such data can be obtained easily in rodents and rat. Methods- We have developed a physiologically based pharmacokinetic model for scaling up activity concentration in each organ versus time. The mathematical model uses physiological parameters including organ volumes, blood flow rates, and vascular permeability. The compartments (organs) are connected anatomically. This allows the use of scale-up techniques to predict the new complex distribution in humans in each organ. Results- The concentration of the new comp...
P-glycoprotein (P-gp), is an important efflux pump involved in chemotherapy resistance in human c... more P-glycoprotein (P-gp), is an important efflux pump involved in chemotherapy resistance in human colon cancer. We investigated the efficacy of itraconazole as a P-gp inhibitor and its therapeutic synergistic relationship to paclitaxel through 99mTc-MIBI accumulation in HT-29 tumor-bearing nude mice. Histopathological screening along with in vitro experiments was done for further assessment. Itraconazole successfully inhibited P-gp mediated 99mTc-MIBI efflux, increasing its in vitro accumulation in itraconazole-receiving dishes. Notably, the co-administration of itraconazole with paclitaxel significantly enhanced the in vitro cytotoxicity effect of paclitaxel in itraconazole + paclitaxel wells containing HT-29 cells. Compared to the control, tumor volume in mice treated with itraconazole, paclitaxel and itraconazole +paclitaxel showed growth suppression approximately by 36.21, 60.02, and 73.3% respectively. And compared to paclitaxel group, the nude mice co-treated with paclitaxel and...
Introduction:In an ideal parallel-hole collimator, thickness of septal material should be suffici... more Introduction:In an ideal parallel-hole collimator, thickness of septal material should be sufficient to stop more than 95% of incident photons. However, some photons pass the septa without interaction or experience scattering before they reach the detector. In this study, we determined different contribution of collimator responses consist of geometrical response, septal penetration (SP) and scattering (SC) for low, medium and high energy collimators. Methods: A point source of activity with common energies in diagnostic nuclear medicine and three different collimators were simulated using SIMIND Monte Carlo code. Results: For Low Energy High Resolution (LEHR) collimator, SP was increased from 7% in 140 keV to 30% in 167keV and more than 75% in energies higher than 296keV. SC also was increased from 4% in 98keV to more than 15% in energies higher than 167keV and reached to its maximum (26%) in 296keV. For Medium Energy All Purpose (MEAP) collimator, SP was suddenly increased from 6%...
زمینه و هدف: بیماری های عروق کرونر موجب مرگ و میر، ناتوانی و تحمیل هزینه های زیادی می شود. ارزش ت... more زمینه و هدف: بیماری های عروق کرونر موجب مرگ و میر، ناتوانی و تحمیل هزینه های زیادی می شود. ارزش تشخیصی اسکن قلب برای تنگی عروق کرونر متفاوت گزارش شده است. هدف این مطالعه بررسی ارزش تشخیصی اسکن در مقایسه با آنژیوگرافی است. روش بررسی: این مطالعه از نوع مقطعی بوده و جامعه آماری بیماران مراجعه کننده به بخش پزشکی هسته ای بیمارستان قلب ساری بودند. 115 بیمار که نتیجه آنژیوگرافی آن ها معلوم بود انتخاب شدند. داده های مربوط به عوامل خطر بیماری عروق کرونر به وسیله پرسش نامه، جمع آوری گشت. نتایج با استفاده از آزمون t و کای اسکور با SPSS و استفاده از شاخص های حساسیت و ویژگی و ارزش پیشگویی مثبت و منفی مقایسه شدند. یافته ها: 62 نفر (9/53) زن و میانگین و انحراف معیار سن بیماران 67/9±85/56 سال بود که در گروه نرمال و گروه مبتلا به بیماری عروق کرونر اختلاف معنی دار داشته است (001/0>P). فراوانی سایر عوامل خطرزا به ترتیب فشارخون بالا (7/55)، سابقه خانوادگی بیماری قلبی (1/46) و دیابت (33) به دست آمد. بین فشارخون سیستولیک، کلسترول، HDL، LDL، تری گلیسیرید و شاخص توده بدنی با نتیجه آنژیوگرافی ارتباط آمار...
Colon cancer is one of the fatal cancers in the world that metastatic potential and resistance to... more Colon cancer is one of the fatal cancers in the world that metastatic potential and resistance to chemotherapy drugs are outstanding causes of cancer-induced mortality [1], [2], [3], [4]. We have investigated in vitro and in vivo anti-cancer effect of itraconazole and paclitaxel alone and their anti-cancer synergistic effect through MTT assay in YM-1 and HT-29 cell lines and in HT-29 tumor-bearing nude mice. Histopathological experiment was done for further assessment. Also, we evaluated the inhibitory effect of itraconazole on P-gp using specific in vivo biodistribution through 99mTc-MIBI uptake. 99mTc-MIBI, a myocardial perfusion imaging agent, is a useful radiotracer in diagnosis of some tumors and the liver and tumor accumulation of 99mTc-MIBI is changed by P-gp regulators [5], [6], [7], [8]. The data presented in this article are related to the research paper entitled “Itraconazole synergistically increases therapeutic effect of paclitaxel and 99mTc-MIBI accumulation, as a prob...
Current Drug Metabolism, 2022
Background: HER2 over-expression plays a crucial role in the cancer treatment protocol. This stud... more Background: HER2 over-expression plays a crucial role in the cancer treatment protocol. This study evaluates the effectiveness of organic anion and cation transport inhibitors and substrate on the tumor uptake of 99mTc-HYNIC-(Ser)3-LTVPWY radiotracer in SKOV-3 tumor-bearing nude mice. Methods: Before the injection of the radiolabeled peptide, SKOV-3 tumor-bearing nude mice were treated with furosemide, cimetidine, para-amino hippuric acid, and saline. The inhibition effects of the organic anion and cation transport inhibitors were compared with the control group. In both treatment and control groups, the tumor and renal accumulation of radiopeptide in mice bearing SKOV-3 tumors were assessed in biodistribution and SPECT imaging studies. Results: The biodistribution and imaging results suggested that all treated groups showed a higher tumor and higher normal tissue radioactivity compared to the control group. According to the tumor imaging study, the furosemidetreated group had slightly better tumor uptake and a higher tumor to muscle uptake ratio than other treatment groups. Conclusions: Administration of furosemide (an OAT inhibitor) increased radioactivity accumulation in the kidneys and blood and improved tumor radioactivity uptake. PAH (an anion transporter substrate) and cimetidine (an OCT inhibitor) have a minor effect on the accumulation of radioactivity in the kidneys and the acquired images.
Research Square (Research Square), Jul 17, 2023
The 5-hydroxytryptamine receptor (5-HTR) family involves seven classes of receptors. The 5-HT 7 R... more The 5-hydroxytryptamine receptor (5-HTR) family involves seven classes of receptors. The 5-HT 7 R is the newest member of this family and contributes to different physiological and pathological processes. As a pathology, Glioblastoma multiform (GBM) overexpresses 5-HT 7 R; hence, this study aims to develop radiolabeled aryl piperazine derivatives as 5-HT 7 R imaging agents. To that end, compounds 6 and 7 as 1-(3-nitropyridin-2-yl)piperazine derivatives were radiolabeled with fac-[ 99m Tc(CO) 3 (H 2 O) 3 ] + and (99m Tc(CO) 3-[6] and 99m Tc(CO)3-[7]) were obtained with high radiochemical purity (RCP>94%). 99m Tc(CO) 3-[6] and 99m Tc(CO)3-[7] possess high a nity toward 5-HT 7 R of the U-87 MG cell line. The calculated K i for them was 26.85±0.78 nM and 36.67±0.89 nM. The biodistribution study in normal mice indicates that the brain uptake of 99m Tc(CO) 3-[6] and 99m Tc(CO)3-[7] is the highest at 30 min postinjection (0.8±0.25 and 0.64±0.18 %ID/g, respectively). The data of the biodistribution study in the U87-MG xenograft model revealed that these radiotracers could accumulate in the tumor site, and the highest tumor uptake was observed at 60 min post-injection (3.38±0.65 and 3.27±0.5 %ID/g, respectively). The injection of pimozide can block the tumor's radiotracer uptake, indicating the binding of these radiotracers to the 5-HT 7 R. The imaging study in the xenograft model also con rms the biodistribution data. The acquired images clearly show the tumor site, and the tumor-to-muscle ratio for 99m Tc(CO) 3-[6] and 99m Tc(CO)3-[7] at 60 min was 3.33 and 3.88, respectively.
Current Drug Metabolism
Background: HER2 over-expression plays a crucial role in the cancer treatment protocol. This stud... more Background: HER2 over-expression plays a crucial role in the cancer treatment protocol. This study evaluates the effectiveness of organic anion and cation transport inhibitors and substrate on the tumor uptake of 99mTc-HYNIC-(Ser)3-LTVPWY radiotracer in SKOV-3 tumor-bearing nude mice. Methods: Before the injection of the radiolabeled peptide, SKOV-3 tumor-bearing nude mice were treated with furosemide, cimetidine, para-amino hippuric acid, and saline. The inhibition effects of the organic anion and cation transport inhibitors were compared with the control group. In both treatment and control groups, the tumor and renal accumulation of radiopeptide in mice bearing SKOV-3 tumors were assessed in biodistribution and SPECT imaging studies. Results: The biodistribution and imaging results suggested that all treated groups showed a higher tumor and higher normal tissue radioactivity compared to the control group. According to the tumor imaging study, the furosemidetreated group had sligh...
Nuclear Medicine Communications, 2019
Objective Arginine–glycine–aspartic acid (RGD) peptide with its specific binding affinity to inte... more Objective Arginine–glycine–aspartic acid (RGD) peptide with its specific binding affinity to integrin αvβ3, is widely investigated for the development of molecular imaging probes for diagnosis of αvβ3-positive tumors. The aim of this work was to evaluate the ability of 99mTc- HYNIC-D(RGD), a novel retro-inverso peptidomimetic derivative for U87MG tumor (αvβ3-positive) imaging. Methods HYNIC-D(RGD) labeled with 99mTc using tricine/EDDA as an exchange coligands. Single-photon emission computed tomography imaging and biodistribution study were performed in nude mice bearing U87MG xenograft tumor. Results The labeling yield was >95%. The radiopeptide showed high uptake value in the U87MG tumor relative to muscle after 2 hours (1.43 ± 0.05 vs. 0.22 ± 0.11 %ID/g). The tumor/muscle ratio was 6.5. Blocking experiment showed specific binding towards tumor. Single-photon emission computed tomography imaging study revealed that radiopeptide had prominent uptake in U87MG tumor. Conclusion Th...
Acute pyelonephritis (APN) is the main predisposing factor for renal cortical scar (RCS) performi... more Acute pyelonephritis (APN) is the main predisposing factor for renal cortical scar (RCS) performing. Hypertension is a complication of RCS and appears in 10-20 Percent of patient in their life. Diagnosis and treatment of APN are necessary for prevention of RCS. The aim of this review is assessment of 99mTc-DMSA (99mTc-dimercaptosuccinic acid) scan value in diagnosis of APN and RCS and comparison of its results with other diagnostic methods such as radiology and ultrasonography. Ultrasonography (US) showed almost 39 % of APN that diagnosed with 99mTC-DMSA scan. Computed Tomography Scan (CT scan) is a sensitive and effective method in diagnosis of APN and its complication. Spiral CT scan and Magnetic Resonance Imaging (MRI) are sensitive and relatively reliable tools in diagnosis of APN; however they are not practicable in the first evaluation and fallow up of infant and children with acute urinary tract infection. Power Doppler Ultrasonography (PDUS) demonstrated a sensitivity of 70 ...
Objective: The risk of cardiac death in diabetic patients is 3 times more than non-diabetics. But... more Objective: The risk of cardiac death in diabetic patients is 3 times more than non-diabetics. But it is not determined who need cardiac screening. About 41% of diabetic patients with silent ischemia are missed. the carotid intima-media thickness (CIMT) and ankel brachial index are two independent,simple and non invasive method in vascular complications diagnosis in diabetic patients.The aim of this study was to evaluate the assosiation of CIMT and ABI in prediction of silent myocardial ischemia in myocardial perfusion scintigraphy in Asymtomatic diabetic papulation. Materials and Methods: This was an analytic cross-sectional study. The convenient sampling was used. About 114 patients with diabetics and no history and symptom of coronary artery disease (CAD) were included. Myocardial perfusion scan (MPI), CIMT and ABI were done. All of statistical analysis was done by SPSS-20. Results: Totally114 diabetic patients without cronary artery disease symptoms were included .About 66.7% were female. The mean age of patients was 53.8± 8.6 years old. About 50% (57) of patients were normal. The mean of CIMT was 0.93 ± 0.21 and mean ABI was 0.97 ± 0.11. Regarding the anlysis of variance (ANOVA) there were significant differences of mean CIMT and ABI between normal and moderate to severe ischemia in MPI. Conclusion: Our findings showed that CIMT and ABI is significantly different between patients with and without ischemia. The CIMT and ABI are simple, non-invasive, and inexpensive tests that may be used to identify individuals who are at high risk of developing cardiovascular disease (diabetic patients).
Breast cancer is the second leading cause of cancer death among women. One in eight women will be... more Breast cancer is the second leading cause of cancer death among women. One in eight women will be diagnosed with breast cancer in their life period .There are several risk factors for progress of carcinogen cell. Zinc and lead have crucial role in oxidative stress and changes in their level can enhance progress of carcinogen cells. The purpose of this study is to discover the level of zinc and lead in plasma of breast cancer patients. One hundred numbers with breast carcinoma diagnosis was confirmed by pathological samples and the results were compared with standard values and amount of these elements was observed in the blood by atomic absorption. Zinc plasma level in patients was found to be 50.59 + 4.72 (μg/dl) with p value of p=0.003 which is lower than standard value (80 μg/dl). On the other hand, the plasma lead level was identified to be 6.24 + 1.173(μg/dl) in patients and zero in the standard value. According to the observation, breast cancer patients had a higher lead leve...
Caspian Journal of Internal Medicine, 2021
Background: In this research, we aimed to survey the added value of single photon emission comput... more Background: In this research, we aimed to survey the added value of single photon emission computed tomography (SPECT) in comparison with planar whole body bone scan to visualize bone metastatic lesions in patients with breast cancer. Methods: A total of 80 patients with breast cancer (invasive ductal carcinoma) were examined with planar whole body bone scan and SPECT imaging using 99mTc-labelled methylene diphosphonate (99mTc-MDP). The patients with abnormal uptakes in SPECT imaging were also investigated with magnetic resonance imaging (MRI). Results: Among these 80 patients with normal whole body bone SPECT scan, 19 (23.25%) of them revealed abnormal 99mTc-MDP uptake in skeleton. Furthermore, these 19 patients were subjected to MRI and 3 (3.75%) of them were confirmed with metastatic bone lesion. Conclusion: The obtained data suggest that SPECT possess the added diagnostic over planar whole body bone scan.
Journal of Mazandaran University of Medical Sciences, 2016
Background and purpose: Estimation of the risks of radiation would be possible by identifying the... more Background and purpose: Estimation of the risks of radiation would be possible by identifying the dose received. Introducing the dose level from diagnostic procedures can be effective in reducing the patient dose, improving the quality of treatment, and increasing the safety of patients and staff. This study evaluated patient entrance surface dose (ESD), effective dose, and cumulative dose from most common radiography procedures. Materials and methods: A descriptive study was conducted in which patient dose level from most common radiography procedures in two referral hospitals (Imam Khomeini and Bu-Ali Sina, Sari, Iran) were evaluated in 2015. X-ray tube output was measured in 1m from the tube focal spot in several kVp. ESD (mGy) value in every procedure was calculated while considering its radiographic conditions (kV, mAs and FFD). The effective dose (ED) (mSv) per examination was also calculated from appropriate ED/ESD conversion factor and the cumulative dose (man-sivert) of ann...
Iranian Journal of Diabetes and Obesity, 2015
iabetes mellitus (DM) is an independent risk factor of cardiovascular disease (CAD) (1-3). CAD is... more iabetes mellitus (DM) is an independent risk factor of cardiovascular disease (CAD) (1-3). CAD is the leading cause of death in DM patients (4). Myocardial infarction (MI), Angina and sudden death rates in diabetic patients are higher than normal population (5). D 1. MD, Shahid Sadoughi University of Medical Sciences Yazd, Iran. 2. MD, Assistant Professor of Nuclear Medicine, Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 3. MD, Cardiologist, Afshar Hospital, Shahid Sadoughi University of Medical Sciences Yazd, Iran. 4. DDH, Assistant Professor of Maxilo Facial Radiology Dental Factuly Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5. Nuclear Medicine Specialist, Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. 6. MD, Assistant Professor Community Medicine. Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 7. MD, Department of Cardiology, Afshar ...
Purpose- The main aim of this study was to develop the pharmacokinetic model for the colorectal c... more Purpose- The main aim of this study was to develop the pharmacokinetic model for the colorectal cancer’s complex 166Ho-DOTA-Bevacizumab in normal and tumoral rats to analyze of behavior as a new composition for diagnosing and treatment. The use of compartmental analysis allows a mathematical separation of tissues and organs to determine the concentration of activity in each fraction of interest. Biodistribution studies are expensive and difficult to carry out in humans, but such data can be obtained easily in rodents and rat. Methods- We have developed a physiologically based pharmacokinetic model for scaling up activity concentration in each organ versus time. The mathematical model uses physiological parameters including organ volumes, blood flow rates, and vascular permeability. The compartments (organs) are connected anatomically. This allows the use of scale-up techniques to predict the new complex distribution in humans in each organ. Results- The concentration of the new comp...
P-glycoprotein (P-gp), is an important efflux pump involved in chemotherapy resistance in human c... more P-glycoprotein (P-gp), is an important efflux pump involved in chemotherapy resistance in human colon cancer. We investigated the efficacy of itraconazole as a P-gp inhibitor and its therapeutic synergistic relationship to paclitaxel through 99mTc-MIBI accumulation in HT-29 tumor-bearing nude mice. Histopathological screening along with in vitro experiments was done for further assessment. Itraconazole successfully inhibited P-gp mediated 99mTc-MIBI efflux, increasing its in vitro accumulation in itraconazole-receiving dishes. Notably, the co-administration of itraconazole with paclitaxel significantly enhanced the in vitro cytotoxicity effect of paclitaxel in itraconazole + paclitaxel wells containing HT-29 cells. Compared to the control, tumor volume in mice treated with itraconazole, paclitaxel and itraconazole +paclitaxel showed growth suppression approximately by 36.21, 60.02, and 73.3% respectively. And compared to paclitaxel group, the nude mice co-treated with paclitaxel and...
Introduction:In an ideal parallel-hole collimator, thickness of septal material should be suffici... more Introduction:In an ideal parallel-hole collimator, thickness of septal material should be sufficient to stop more than 95% of incident photons. However, some photons pass the septa without interaction or experience scattering before they reach the detector. In this study, we determined different contribution of collimator responses consist of geometrical response, septal penetration (SP) and scattering (SC) for low, medium and high energy collimators. Methods: A point source of activity with common energies in diagnostic nuclear medicine and three different collimators were simulated using SIMIND Monte Carlo code. Results: For Low Energy High Resolution (LEHR) collimator, SP was increased from 7% in 140 keV to 30% in 167keV and more than 75% in energies higher than 296keV. SC also was increased from 4% in 98keV to more than 15% in energies higher than 167keV and reached to its maximum (26%) in 296keV. For Medium Energy All Purpose (MEAP) collimator, SP was suddenly increased from 6%...
زمینه و هدف: بیماری های عروق کرونر موجب مرگ و میر، ناتوانی و تحمیل هزینه های زیادی می شود. ارزش ت... more زمینه و هدف: بیماری های عروق کرونر موجب مرگ و میر، ناتوانی و تحمیل هزینه های زیادی می شود. ارزش تشخیصی اسکن قلب برای تنگی عروق کرونر متفاوت گزارش شده است. هدف این مطالعه بررسی ارزش تشخیصی اسکن در مقایسه با آنژیوگرافی است. روش بررسی: این مطالعه از نوع مقطعی بوده و جامعه آماری بیماران مراجعه کننده به بخش پزشکی هسته ای بیمارستان قلب ساری بودند. 115 بیمار که نتیجه آنژیوگرافی آن ها معلوم بود انتخاب شدند. داده های مربوط به عوامل خطر بیماری عروق کرونر به وسیله پرسش نامه، جمع آوری گشت. نتایج با استفاده از آزمون t و کای اسکور با SPSS و استفاده از شاخص های حساسیت و ویژگی و ارزش پیشگویی مثبت و منفی مقایسه شدند. یافته ها: 62 نفر (9/53) زن و میانگین و انحراف معیار سن بیماران 67/9±85/56 سال بود که در گروه نرمال و گروه مبتلا به بیماری عروق کرونر اختلاف معنی دار داشته است (001/0>P). فراوانی سایر عوامل خطرزا به ترتیب فشارخون بالا (7/55)، سابقه خانوادگی بیماری قلبی (1/46) و دیابت (33) به دست آمد. بین فشارخون سیستولیک، کلسترول، HDL، LDL، تری گلیسیرید و شاخص توده بدنی با نتیجه آنژیوگرافی ارتباط آمار...
Colon cancer is one of the fatal cancers in the world that metastatic potential and resistance to... more Colon cancer is one of the fatal cancers in the world that metastatic potential and resistance to chemotherapy drugs are outstanding causes of cancer-induced mortality [1], [2], [3], [4]. We have investigated in vitro and in vivo anti-cancer effect of itraconazole and paclitaxel alone and their anti-cancer synergistic effect through MTT assay in YM-1 and HT-29 cell lines and in HT-29 tumor-bearing nude mice. Histopathological experiment was done for further assessment. Also, we evaluated the inhibitory effect of itraconazole on P-gp using specific in vivo biodistribution through 99mTc-MIBI uptake. 99mTc-MIBI, a myocardial perfusion imaging agent, is a useful radiotracer in diagnosis of some tumors and the liver and tumor accumulation of 99mTc-MIBI is changed by P-gp regulators [5], [6], [7], [8]. The data presented in this article are related to the research paper entitled “Itraconazole synergistically increases therapeutic effect of paclitaxel and 99mTc-MIBI accumulation, as a prob...