Anahita Nosrati | Mazandaran University of Medical Sciences (original) (raw)

Papers by Anahita Nosrati

Journal of Mazandaran University of Medical Sciences, Mar 15, 2014

Bladder cancer most commonly exists as an epithelial tumor in which around 90% of cases are trans... more Bladder cancer most commonly exists as an epithelial tumor in which around 90% of cases are transitional cell carcinoma (TCC) with a papillary appearance. The world health organization (WHO) classification defines new histological and molecular variants of urothelial carcinoma in 2004. One of them is plasmacytoid urothelial carcinoma (PUC). Less than 100 cases have been reported in the literature (with a reported incidence of up to 3%).There is limited data available on the clinicohistological features or prognosis of PUC. We reported a 58-yearold man with a complaint of right flank pain that referred to testis accompanied by gross hematuria and history of heavy smoking. Imaging showed polypoid mucosal thickening in posterolateral wall of bladder base. Patient was treated with TURBT and BCG. Finally, pathological study confirmed clinicodiagnosis of TCC (plasmacytoid type). PUC is a poor prognostic variant of TCC and early diagnosis is important. Review of other literatures showed early diagnosis of plasmacytoid urothelial carcinoma (PUC) cannot be made due to the absence of hematuria until the late stage of the disease. Cystoscopy and biopsy for earlier diagnosis of PUC because of delayed occurrence of hematuria are required. Patient follow-up after treatment for this variant of urothelial carcinoma is highly recommended. Further studies are needed for evaluation of relationship between smoking and PUC. J Mazand Univ Med Sci 2014; 23(Suppl 2): 218-21 (Persian).

Govaresh, May 25, 2014

Cancer stem cells are a subgroup of tumor cells that have the capability for self-renewal and dif... more Cancer stem cells are a subgroup of tumor cells that have the capability for self-renewal and differentiation and are characterized by multiple markers. Several studies have been conducted to identify these cells in colorectal cancer, including stem cell marker CD24. This study has evaluated the association of CD24 expression with clinicopathologic features and survival in an immunohistochemical )IHC) study that compared colorectal cancer tissues with adjacent normal tissues.

Middle East journal of digestive diseases, 2015

Esophageal squamous cell carcinoma is a rather common cancer in northern Iran. Incidence of adeno... more Esophageal squamous cell carcinoma is a rather common cancer in northern Iran. Incidence of adenocarcinoma of esophagus has an increasing trend in Iran. Co-existence of both cancers in one patient is very rare. We report a middle age woman from northern Iran with a typical presentation of esophageal cancer, who was found to have a dual esophageal cancer. The disease was found in the advanced stage with pulmonary metastasis at the presentation. Palliative chemo-radiotherapy induced partial clinical response.

Gastroenterology and hepatology from bed to bench, 2016

We aimed to study the expression of CD24 and CD133 in colorectal cancer and normal adjacent tissu... more We aimed to study the expression of CD24 and CD133 in colorectal cancer and normal adjacent tissues to assess a relationship between these markers and clinic-pathological characteristics and patient's survival. Cancer stem cells are a group of tumor cells that have regeneration and multi-order differentiation capabilities. Expression of CD24 and CD133 was studied in a paraffin block of colorectal cancer and normal tissues near tumors with the immuneohistochemical method in patients who were referred to Imam Khomeini Hospital in Sari. A total of 50 samples (25 males and 25 females) with a mean age of 67.57±13.9 years old with range 28-93 years, included 3 mucinous carcinoma and 47 adenocarcinoma. Expression of CD133 marker was negative in 29 cases and positive in 21 cases. Expression of CD24 in tissue near tumor cells was found in 30% of available samples. The relationship between expressing CD24 with treatment (surgery and chemotherapy) was significant and its relationship with ...

Middle East Journal of Digestive Diseases, 2015

BACKGROUND Some recent studies reported human epidermal growth factor receptor (HER-2/neu) as a m... more BACKGROUND Some recent studies reported human epidermal growth factor receptor (HER-2/neu) as a marker that can be used in immunological studies of colorectal carcinoma for predicting the prognosis and the treatment. Therefore, we aimed to investigate the frequency of HER-2 expression in patients with colorectal cancer, and explore the relationship between clinicopathological prognostic factors and its expression based on immunohistochemical analysis. METHODS This study included 50 patients with a histologically proven diagnosis of colorectal carcinoma who received surgery at Imam Khomeini Hospital affiliated to Mazandaran University of Medical Sciences. First, HER-2/neu protein expressions were detected by immunohistochemistry and then the data extracted from recorded files. RESULTS The median age of the patients was 60.2±13.9 years (range: 25-93 years). There was no significant relationship between size of tumor, age, sex, lymph node metastases, distant metastasis, differentiation, and stage of the disease with positive expression of HER-2 in this study. CONCLUSION No significant relationship between expression of HER-2 and clinicopathological prognostic factors was found in our study. Further comprehensive and prospective trial with standard method to evaluate the role of HER-2 expression among patients with colorectal cancer is needed.

International journal of molecular and cellular medicine, 2014

Cancer stem cells (CSCs) are unique subpopulations that have the capacity to drive malignant prog... more Cancer stem cells (CSCs) are unique subpopulations that have the capacity to drive malignant progression with renewal abilities. Recently the role of some of CSCs in gastric adenocarcinoma has been studied. This study was performed in order to evaluate CD44 and CD133 expressions by immunohistochemistry in 95 primary gastric adenocarcinoma and their relation to clinical and pathological parameters of these tumors. There was a significant correlation between CD44 expression and cancer subtype (intestinal), tumor size (4-8 cm), depth of invasion, no lymphatic/vascular invasion and moderate differentiation. There was a significant correlation between CD133 expression and patient's age (> 65 years), cancer subtype (intestinal), tumor size (4-8 cm), depth of invasion and moderate differentiation. CSC markers like CD 44 and CD133 had high expression in primary gastric adenocarcinoma and had some relations to clinical and pathological parameters of tumors.

Asia Pacific Journal of Medical Toxicology, Sep 20, 2013

Archives of Clinical Infectious Diseases, 2016

Research in Molecular Medicine, Oct 15, 2014

Background: Breast cancer is the most common malignancy in females worldwide. Several etiological... more Background: Breast cancer is the most common malignancy in females worldwide. Several etiological factors including environmental factors have been recognized for breast cancer. Epstein Barr virus as a viral etiological factor has been proposed. So far, several studies have investigated the relationship between development of breast cancer and Epstein Barr virus, but few have been done in Iran. The aim of this study was to determine whether there was an association between EBV infection and female breast cancer in Iran. Materials and Methods: We analyzed paraffin embedded breast tissue specimens by polymerase chain reaction (PCR) including breast cancer specimens (as case group) and breast fibroadenoma specimens (as control group). PCR was performed to amplify specific sequences of EBV. Results: From 130 cases of breast samples, 67 cases of breast cancer tissues and 41 cases of breast fibroadenoma tissues had adequate quality and quantity of DNA to detect EBV. PCR for EBV was positive in 4 invasive ductal carcinoma specimens (7.3%) and only one of the fibroadenoma specimens (2.4%). No significant association was found between EBV infection and invasive ductal carcinoma (p> 0.05). Also, patient's age and histological grade of IDC were not correlated with EBV infection (p>0.05). Conclusion: We observed no etiologic association between EBV infection and invasive ductal carcinoma of female breast in our regions; however, further studies are required to elucidate this association.

Journal of Food and Drug Analysis, 2016

Iranian journal of pharmaceutical research (IJPR)

Health promotion perspectives, 2013

In this study the effect of zinc chloride (ZnCl2) administration on the short-term and long-term ... more In this study the effect of zinc chloride (ZnCl2) administration on the short-term and long-term memory of rats were assessed. We enrolled six groups of adult female and control group of eight Wistar rats in each group. One group was control group with free access to food and water, and five groups drunk zinc chloride in different doses (20, 30, 50, 70 and 100 mg/kg/day) in drinking water for two weeks during lactation .One month after birth, a shuttle box used to short- term and long-term memory and the latency in entering the dark chamber as well. This experiment showed that maternal 70 mg/kg dietary zinc during lactation influenced the working memory of rats' offspring in all groups. Rats received 100 mg/kg/day zinc during lactation so they had significant impairment in working memory (short-term) of their offspring (P<0.05). There was no significant difference in reference (long-term) memory of all groups. Drug consumption below70 mg/kg/day zinc chloride during lactation ...

Iranian journal of pharmaceutical research : IJPR, 2013

liver injury induced by viruses, chemicals and drugs can be protected by different medicinal plan... more liver injury induced by viruses, chemicals and drugs can be protected by different medicinal plants. Feijoa sellowiana (Myrtaceae) is an evergreen bush native to southern areas of South America, as well as Iran where the fruits are very popular. Feijoa has shown a potent antimicrobial effect. Morever, the antioxidant activity of total Feijoa extract has also been reported. MDMA or ecstasy is a ring-substituted amphetamine derivative which has been abused as a widespread recreational drug by the young generation. Liver is a target organ for MDMA toxicity. In fact, this sense MDMA is metabolized by cytochromes P4502D, 2B and 3Aand reactive metabolites are readily oxidized to the corresponding o-qiuinones and reactive oxygen species (ROS). This study investigated whether methanilic Feijoa sellowiana fruits can produce biochemical changes using the Isolated Rat Liver Perfusion (IRLP) system. The, the liver was perfused with different concentrations of the extract (10, 20, 40, 50,100 mg/...

Advanced pharmaceutical bulletin, 2013

There are several reports about effects of Salvia spp. on CNS. The present experiment is undertak... more There are several reports about effects of Salvia spp. on CNS. The present experiment is undertaken to study effect of S. limbata, S. hypoleuca and S. macrosiphon on withdrawal syndrome in mice. Antinociceptive activities of aerial parts of Salvia spp. is investigated using hot plate method. In addition, the effect of its aerial parts on morphine dependence is investigated in mice. After induction of morphine dependency, different concentrations of plant extract are injected. To assess morphine withdrawal, naloxone (5 mg kg-1, i.p.) are injected into mice on the 5th day. Withdrawal syndrome is assessed by placing each mouse in a glass box 30 cm in height and recording the incidence of escape jumps for 60 minutes. A decrease in incidence of escape jumps is observed in morphine dependence mice. S. limbata and S. hypoleuca extracts produced a statistically significant inhibition of pain induced by hot plate latency at (500, 1000 and 1500 mg kg-1) i.p. A significant increase in pain thr...

Chronic Respiratory Disease, 2008

... Correspondence: Ayman O Soubani, MD, Associate Professor of Medicine, Division of Pulmonary, ... more ... Correspondence: Ayman O Soubani, MD, Associate Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep, Wayne State University School of Medicine, Harper University Hospital, 3990 John R-3 Hudson, Detroit, MI 48201, USA. ...

Aspergilloma infection consists of a mass of fungal hyphae, inflammatory cells, fibrin, mucus, an... more Aspergilloma infection consists of a mass of fungal hyphae, inflammatory cells, fibrin, mucus, and tissue debris and can colonize lung cavities due to underlying diseases such as tuberculosis, sarcoidosis, bronchiectasis, cavitary lung cancer, neoplasms, ankylosing spondylitis, bronchial cysts, and pulmonary infarction. Here we report coinfection of pulmonary hydatid cyst and aspergilloma in a 34-year-old female who had had history of minor thalassemia and suffered from chest pain, dyspnea, non-productive cough for at least five months, and hemoptysis for 20 days.