Md. K A M R U L Hasan | McMaster University (original) (raw)

Papers by Md. K A M R U L Hasan

BMJ Open, 2023

Objectives: This study investigated the inequalities in access to maternal healthcare services in... more Objectives: This study investigated the inequalities in access to maternal healthcare services in Bangladesh.
Design and setting: This study used cross-sectional data from the nationally representative Bangladesh Demographic and Health Survey conducted in 2017–2018. The survey encompassed diverse regions and households across Bangladesh. The study used the Human Opportunity
Index (HOI) and Shapley’s decomposition technique are used to measure inequality in access to maternal healthcare opportunities.
Participants: This study included 20 127 women aged 15–49 years. Among them, 5012 women had live births in the preceding 3 years of the survey, forming the study sample. Primary and secondary outcome measures This study has no secondary outcome variable. The primary
the dependent variable is ‘adequate maternal healthcare,’ a dichotomous variable.
Results: Household wealth status contributed the highest to inequality in accessing adequate maternal healthcare services (41.4%), such as receiving at least four antenatal care (ANC) visits (39.7%), access to proper ANC (50.7% and 44.0%) and health facility birth (43.4%). Maternal educational status contributes to the second highest inequality among all factors in accessing adequate maternal healthcare (29.5%). Adequate maternal healthcare presented the lowest coverage rate and opportunity index among all (approximately 24% with HOI=17.2).
Conclusions: We found that adequate maternal healthcare had the lowest coverage and widest dissimilarity, while wealth index, education, and place
of residence are the major factors that contribute to inequalities in accessibility to maternal healthcare services in Bangladesh. These findings underscore a need for pro-poor interventions to narrow the economic inequalities between the poor and rich in terms of accessibility to maternal healthcare services. The results indicate the need for the Bangladeshi government and its health department to strengthen their commitment to improving female education. Investments should be made in initiatives that facilitate the proximity of maternal healthcare services to
women in rural areas.

Scientific Reports, 2024

Maternal health is a global public health concern. The paucity of antenatal care (ANC) during pre... more Maternal health is a global public health concern. The paucity of antenatal care (ANC) during pregnancy is directly associated with maternal mortality. This study assessed the individual and community-level determinants of quality ANC in six South-Asian countries. Data were obtained from a Demographic health survey of six South-Asian countries. This study included a sample of 180,567 (weighted) women aged 15–49 who had given birth in the preceding three years prior to the survey. The quality of ANC was determined by assessing whether a woman had received blood pressure monitoring, urine and blood sample screening, and iron supplements at any ANC visits. Frequency, percentage distribution, and inferential analysis (multilevel mixed-effects model) were conducted. The proportion of quality antenatal care utilization in South Asia was 66.9%. The multilevel analysis showed that women aged 35–49 years (AOR = 1.16; 95% CI = 1.09–1.24), higher education (AOR = 2.84; 95% CI = 2.69–2.99), middle wealth status (AOR = 1.55; 95% CI = 1.49–1.62), richest wealth status (AOR = 3.21; 95% CI = 3.04–3.39), unwanted pregnancy (AOR = 0.92; 95% CI = 0.89–0.95) and 2–4 birth order (AOR = 0.86; 95% CI = 0.83–0.89) were among the individual-level factors that were significantly associated with quality ANC utilization. In addition, rural residence (AOR = 0.77; 95% CI = 0.74–0.8), and big problem – distance to health facility (AOR = 0.63; 95% CI: 0.53–0.76) were the among community level factors there were also significantly associated with use of quality ANC. Meanwhile, women who lived in India (AOR: 22.57; 95% CI: 20.32–25.08) and Maldives (AOR: 33.33; 95% CI: 31.06–35.76) had higher odds of quality ANC than those lived in Afghanistan. Educational status, wealth status, pregnancy wantedness, sex of household head, birth order, place of residence, and distance to health facility were associated with quality ANC. Improving educational status, improving wealth status, reducing the distance to health facilities, and providing rural area-friendly interventions are important to increase the quality of ANC in South Asia.

Middle East Current Psychiatry, 2024

The use of virtual reality (VR) in telepsychiatry signifies a paradigm shift in mental health car... more The use of virtual reality (VR) in telepsychiatry signifies a paradigm shift in mental health care. VR provides realistic, interactive environments for therapies like exposure therapy and cognitive behavioral therapy, resulting in reliable and reproducible scenarios that improve treatment effectiveness. This technology enhances accessibility for those with geographical or physical limitations, lowers stigma, and boosts patient engagement and adherence by making treatment activities more pleasurable and interesting. Furthermore, VR may emulate social interactions and circumstances that are difficult to replicate in typical treatment settings, providing useful practice for people with social anxiety or autism spectrum disorders (ASD). Despite its great potential, integrating VR into telepsychiatry offers problems such as high VR equipment costs, assuring clinical effectiveness and safety, and securing patient data. Future research should prioritize large-scale, randomized controlled trials to determine the efficacy of VR-based therapy, investigate long-term consequences, and offer cost-effective solutions. By tackling these issues and investing in novel research, VR has the potential to greatly improve telepsychiatry, making mental health care more effective, engaging, and easily available to people all over the world.

Annals of Medicine and Surgery, 2024

In the digital age, multitasking with several devices has become a daily occurrence, prompting co... more In the digital age, multitasking with several devices has become a daily occurrence, prompting concerns about the long-term consequences on brain hyperactivity and cognitive function. Digital multitasking, which involves managing many digital tasks at once, divides cognitive resources, resulting in higher cognitive load and brain hyperactivity. According to studies, this can impede cognitive skills like attention, memory, and decision-making while also contributing to emotions of tension and
anxiety. Chronic exposure to high cognitive load from multitasking has been connected to anxiety and depression symptoms, while chronic multitasking is associated with decreased working memory capacity and impaired executive function. Despite these findings, there is little research into the long-term effects of digital multitasking on brain health. Future studies should concentrate on long-term studies to examine changes in
brain function, cognitive performance, and mental health in regular multitaskers. Neuroimaging tools and interventions such as mindfulness training can provide more in-depth insights and effective solutions for mitigating the negative consequences. Understanding these effects is critical for encouraging healthier digital behaviors and creating supportive digital environments, which will ultimately lead to improved cognitive and mental health outcomes in a digitally connected world.

AJOG Global Reports, 2024

Phytochemistry Reviews, 2024

Pain is a common symptom which can result in disability and lower quality of life. The current re... more Pain is a common symptom which can result in disability and lower quality of life. The current review covers the use of medicinal plants as an alternative therapy for pain relief, as traditional painkillers like NSAIDs, opioids, and antidepressants can have serious side effects. Medicinal plants are effective, easily available, low-cost, and have fewer side effects. The review examines commonly used medicinal plants, their active components, their pharmacological activity, and their mechanism of action for different types of pain in humans and animal models. The review also discusses the use of herbal therapies for pain in various conditions, such as rheumatoid arthritis, neuropathies, osteoarthritis, dysmenorrhea, headache, migraine, wounds, low back pain, and chest pain, and weighs the advantages and disadvantages of using herbal therapies in light of recent research.

Diabetology, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

BMJ Open, 2023

Objectives This study investigated the inequalities in access to maternal healthcare services in ... more Objectives This study investigated the inequalities in access to maternal healthcare services in Bangladesh. Design and setting This study used cross-sectional data from the nationally representative Bangladesh Demographic and Health Survey conducted in 2017-2018.

Metabolism Open, 2023

This exploratory review article describes about the genetic factors behind Alzheimer's disease (A... more This exploratory review article describes about the genetic factors behind Alzheimer's disease (AD), their association with foods, and their relationships with cognitive impairment. It explores the dietary patterns and economic challenges in AD prevention. Methods: Scopus, PubMed and Google Scholar were searched for articles that examined the relationships between Diets, Alzheimer's Disease (AD), and Socioeconomic conditions in preventative Alzheimer's disease studies. Graphs and Network analysis data were taken from Scopus under the MeSH search method, including words, Alzheimer's, APoE4, Tau protein, APP, Amyloid precursor protein, Beta-Amyloid, Aβ, Mediterranean Diet, MD, DASH diet, MIND diet, SES, Socioeconomic, Developed country, Underdeveloped country, Preventions. The network analysis was done through VOS viewer. Results: Mediterranean diet (MD) accurately lowers AD (Alzheimer's Disease) risk to 53% and 35% for people who follow it moderately. MIND scores had a statistically significant reduction in AD rate compared to those in the lowest tertial (53% and 35% reduction, respectively). Subjects with the highest adherence to the MD and DASH had a 54% and 39% lower risk of developing AD, respectively, compared to those in the lowest tertial. Omega-6, PUFA, found in nuts and fish, can play most roles in the clearance of Aβ. Vitamin D inhibits induced fibrillar Aβ apoptosis. However, the high cost of these diet components rise doubt about the effectiveness of AD prevention through healthy diets. Conclusion: The finding of this study revealed an association between diet and the effects of the chemical components of foods on AD biomarkers. More research is required to see if nutrition is a risk or a protective factor for Alzheimer's disease to encourage research to be translated into therapeutic practice and to clarify nutritional advice.

Population Medicine, 2022

For more than one and half years, the world has been combating outbreaks of the virus SARS-CoV-2 ... more For more than one and half years, the world has been combating outbreaks of the virus SARS-CoV-2 that caused COVID-19. Bangladesh reported its first COVID-19 case on 8 March 2020, with over 1.3 million confirmed cases and 21638 deaths as of 4 August 2021. Besides COVID-19 related health issues, this pandemic has caused great concern for other diseases, such as those that are mosquito-borne. Mosquito-borne diseases, e.g. malaria, dengue fever, zika, yellow fever, chikungunya, Japanese encephalitis, etc., affect nearly 700 million people worldwide every year. Especially in Bangladesh, mosquito-borne diseases cause high morbidity and mortality due to low socioeconomic status, propinquity to water reservoirs and forests, poor schooling, etc. Notably, Bangladesh is one of the four major malaria-endemic countries in SouthEast Asia. Dengue, spread by Aedes mosquitoes, infected 101354 people in 2019 in Bangladesh and afflicted 1405 people during the COVID-19 first wave in 2020. There is a sharp diminution in dengue cases; nevertheless, this decline may not always indicate a low infection rate. However, there is a high possibility of striking disparity in the reported data, which can be interconnected with COVID-19 related situations. Dengue shares some signs and symptoms with COVID-19, namely, lymphopenia, leukopenia, thrombocytopenia, elevated transaminases, malaise, headache, etc., leading to misdiagnosis. Similarly, some symptoms of malaria may be confused with the early symptoms of COVID-19, including fever, breathing difficulties, fatigue, acute onset of headache, etc., leading to an erroneous diagnosis with the possibility of co-infection being overlooked. Misdiagnosis causes hindrance and inappropriate treatment leading to escalation of mortality

Bulletin of National Research Center, 2022

Background: Black cumin (Nigella sativa) is a widely used ingredient of traditional medicine for ... more Background: Black cumin (Nigella sativa) is a widely used ingredient of traditional medicine for its broad-spectrum pharmacological actions, including analgesic, bronchial asthma, anti-inflammatory properties, and others. We sought to evaluate BC extracts' efficacy for the anti-inflammatory and analgesic properties using a comprehensive in vivo and in silico experimental setup. To investigate whether BC extract has anti-inflammatory and analgesic therapeutic potentials in vivo anti-inflammatory activity by carrageenan-induced rat paw edema, analgesic activity by acetic acidinduced writhing test and ingenuity analysis of the BC extracts in inflammation control. Results: The acetic acid-induced writhing test had shown a dose-dependent reduction of writhing number following BC administration. Rat paw edema test showed the dose-dependent reduction of paw edema volume following BC administration. Ingenuity Pathway Analysis (IPA) suggested BC extracts containing ferulic acid, p-coumaric acid, kaempferol, and quercetin can inhibit inflammation. Conclusions: This study suggests that bioactive compounds in BC extract act as an anti-inflammatory and analgesic agent by regulating several downstream and upstream inflammation pathways.

Bulletin of National Research Center, 2022

Background: Mucormycosis, a severe fungal infection, is an emerging public health concern during ... more Background: Mucormycosis, a severe fungal infection, is an emerging public health concern during the COVID-19 pandemic. This study aimed to investigate the perception of mucormycosis among Bangladeshi healthcare workers. Results: An exploratory cross-sectional study was carried out among the Bangladeshi healthcare workers from May 25, 2021, to June 5, 2021. The study found 422 responses from the healthcare workers of Bangladesh. Among the respondents, nearly half of them (45.26%) were doctors (n = 191). This study explored that the healthcare workers' mucormycosis perception scores were significantly associated with their age, gender, profession, monthly income, marital status, job type, and death of friends and family members due to COVID-19. Conclusions: This study emphasized the healthcare workers' mucormycosis perception along with other associated factors. The findings could help policymakers to mitigate mucormycosis and related infectious diseases emergencies in the post-COVID-19 situation.

Bulletin of the National Research Centre, 2022

Background: The COVID-19 pandemic jeopardized the traditional academic learning calendars due to ... more Background: The COVID-19 pandemic jeopardized the traditional academic learning calendars due to the closing of all educational institutions across the globe. To keep up with the flow of learning, most of the educational institutions shifted toward e-learning. However, the students' e-learning preference and e-learning readiness did not identify, particularly among the Bangladeshi female nursing students, where those can pose serious challenges. A cross-sectional study was carried out among the female nursing students between December 26, 2020, and January 11, 2021. A total of 237 students were recruited who have enrolled in e-learning at least the last 30 days of the participation. Multivariable linear regression models were fitted to find the association of students' preference, e-learning readiness domains, and other variables. Results: A cross-sectional study was conducted among the female nursing students to assess perceived e-learning readiness in the subdomains of readiness; availability, technology use, self-confidence, acceptance and training. The findings of the study revealed that the prevalence of preference for e-learning was 43.46%. The students did not prefer e-learning compared to 'prefer group' has significantly less availability of technology (β = − 3.01, 95% CI − 4.46, − 1.56), less use of technology (β = − 3.08, 95% CI − 5.11, − 1.06), less self-confidence (β = − 4.50, 95% CI − 7.02, − 1.98), less acceptance (β = − 5.96, 95% CI − 7.76, − 4.16) and less training need (β = − 1.86, 95% CI − 2.67, − 1.06). The age, degree, residence, parents' highest education, having a single room, and having any eye problems were significantly associated with the variation of availability of technology, use of technology, self-confidence, acceptance, and training need of e-learning.

Annals of medicine, 2021

Background: The COVID-19 pandemic has compelled all educational institutions from the conventiona... more Background: The COVID-19 pandemic has compelled all educational institutions from the conventional campus-based education system to e-learning worldwide. However, adapting to this new platform, e-learning readiness may cause perceived stress among students. This study aimed to examine the association between e-learning readiness and perceived e-learning stress and the relationship between sociodemographic and e-learning related factors. Results: A cross-sectional study was employed, where 1145 e-learning enrolled university students were surveyed. The result indicated that nearly 91% of students reported moderate (76.07%) to the higher level (14.85%) of perceived e-learning stress, whereas more than half of them (58.17%) were at the sub-optimum level of readiness. Furthermore, it was found that students with the sub-optimum level of readiness compared to optimum had a significantly higher chance of reporting moderate and high level of perceived e-learning stress. Besides, parents' highest education, residence, students' preference in (e-learning or learning format), and having any eye problems were associated with perceived e-learning stress. Conclusions: A sudden introduction of e-learning during the COVID-19 catastrophe has brought about challenges, including the students' readiness, that might exacerbate the perceived stress level in different ways. This study reported that most of the students were at sub-optimal levels of readiness and suffered from moderate to high levels of perceived e-learning stress. The findings should integrate into the education monitoring system to enhance students' coping strategies, incite readiness, straighten, and nourish existing policies.

Plos One, 2021

Background E-learning is a relatively trending system of education that has been placed over conv... more Background E-learning is a relatively trending system of education that has been placed over conventional campus-based learning worldwide, especially since the emergence of the COVID-19 pandemic. This study aimed to assess e-learning readiness among university students of a developing country like Bangladesh and identify the independent predictors of e-learning readiness.

Population Medicine, 2021

For the last one and half years, COVID-19 has caused an overwhelming loss of life as a respirator... more For the last one and half years, COVID-19 has caused an overwhelming loss of life as a respiratory infectious disease. Based on statistics of physical illness, children are the least affected group. However, that is not the case for mental health. In most cases, nurses and other front liner health workers depend on others like grandparents, relatives, or babysitters, to take care of their children. Due to the closing of schools as a non-pharmaceutical intervention to control COVID-19, youth spend more time on the internet, social media, online gaming, or any such influential addicting technologies. In addition, nurses now have to maintain prolonged quarantine after duty which increases the duration of separation from their family, which can further aggravate the mental health status of their children. These circumstances often are associated with depression, stress, loneliness, and other psychological distressed conditions. Action for change does not require a plethora of changes in the infrastructure, neither demands a large budget. All that is needed are some intervention programs to serve children and caregivers, implemented by the local government. These programs should focus on improving parental skills and responsiveness in understanding children, so as to better protect them from negative experiences. Mentoring the parents can pave the way for developing problem-solving skills in their children, boosting their self-esteem, and helping them to nurture them in the right way to set goals for a promising future. Parents need to monitor children for any signs of change in behavior and act on it patiently, keeping their naivety in mind. Special support from governments is required so that the healthcare professionals can take care of their children and continue their responsibilities during this global crisis.

BMC Research Notes, 2021

Objective: MPDB 2.0 is built to be the continuation of MPDB 1.0, to serve as a more comprehensive... more Objective: MPDB 2.0 is built to be the continuation of MPDB 1.0, to serve as a more comprehensive data repertoire for Bangladeshi medicinal plants, and to provide a user-friendly interface for researchers, health practitioners, drug developers, and students who wish to study the various medicinal & nutritive plants scattered around Bangladesh and the underlying phytochemicals contributing to their efficacy in Bangladeshi folk medicine. Results: MPDB 2.0 database (https:// www. medic inalp lantbd. com/) comprises a collection of more than five hundred Bangladeshi medicinal plants, alongside a record of their corresponding scientific, family, and local names together with their utilized parts, information regarding ailments, active compounds, and PubMed ID of related publications. While medicinal plants are not limited to the borders of any country, Bangladesh and its Southeast Asian neighbors do boast a huge collection of potent medicinal plants with considerable folk-medicinal history compared to most other countries in the world. Development of MPDB 2.0 has been highly focused upon human diseases, albeit many of the plants indexed here can serve in developing biofuel (e.g.: Jatropha curcas used in biofuel) or bioremediation technologies (e.g.: Amaranthus cruentus helps to reduce cadmium level in soil) or nutritive diets (Terminalia chebula can be used in nutritive diets) or cosmetics (Aloe vera used in cosmetics), etc.

Bioresearch Communication, 2021

To minimize the outspread of COVID-19, the government announced the closure of all educational in... more To minimize the outspread of COVID-19, the government announced the closure of all educational institutions on March 18, 2020, and it has continued since then. This extended break from educational institutes has affected the lives of students profoundly. Though face-to-face classes have been replaced by online classes, the effectiveness of the online learning system is impeded by poor technological infrastructure and stable internet access. Besides, important exams like board exams, university admission exams, and university semester exams have been suspended during this period resulting in session jam. Numerous students are also going through learning loss. Apart from academic loss, there have been reported augmented cases of child marriage, child labor, child abuse, malnutrition, and online abuse due to the extended shutdown. This protracted closure has also impacted students' mental health, physical activity, and behavioral changes. Hence, there have been increased incidences of depression, mental disorders, and suicides. Considering all these aspects, now both parents and students intend to recommence the in-person classes supporting the reopening of all institutes.

Journal of Molecular Graphics and Modelling, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Heliyon, 2021

Nature has always been an excellent source for many therapeutic compounds providing us with many ... more Nature has always been an excellent source for many therapeutic compounds providing us with many medicinal plants and microorganisms producing beneficial chemicals. Therefore, the demand for medicinal plants, cosmetics, and health products is always on the rise. One such plant from the Leguminosae family is licorice and the scientific name is Glycyrrhiza glabra Linn. It is an herb-type plant with medicinal value. In the following article, we shall elaborately look at the plants' phytochemical constituents and the pharmacological impact of those substances. Several compounds such as glycyrrhizin, glycyrrhizinic acid, isoliquiritin, and glycyrrhizic acid have been found in this plant, which can provide pharmacological benefit to us with its anti-cancer, anti-atherogenic, antidiabetic, anti-asthmatic, anti-inflammatory, anti-microbial, and antispasmodic activity. Alongside, these products have a different role in hepatoprotective, immunologic, memory-enhancing activity. They can stimulate hair growth, control obesity, and have anti-depressants, sedatives, and anticoagulant activity. This review examines recent studies on the phytochemical and pharmacological data and describes some side effects and toxicity of licorice and its bioactive components.

BMJ Open, 2023

Scientific Reports, 2024

Middle East Current Psychiatry, 2024

Annals of Medicine and Surgery, 2024

AJOG Global Reports, 2024

Phytochemistry Reviews, 2024

Diabetology, 2023

BMJ Open, 2023

Metabolism Open, 2023

Population Medicine, 2022

Bulletin of National Research Center, 2022

Bulletin of the National Research Centre, 2022

Annals of medicine, 2021

Plos One, 2021

Population Medicine, 2021

BMC Research Notes, 2021

Bioresearch Communication, 2021

Journal of Molecular Graphics and Modelling, 2021

Heliyon, 2021

PsyRxiv, 2021

‘Black fungus’ or ‘Mucormycosis’ is an emerging public health concern during the COVID-19 pandemi... more ‘Black fungus’ or ‘Mucormycosis’ is an emerging public health concern during the COVID-19 pandemic. The rise of black fungus cases here in Bangladesh among the COVID-19 infected persons has been raised reasonable alarming conditions among health care workers along with the general people. Therefore, this study aimed to investigate black fungus knowledge of Bangladeshi health care workers aiming the issue could be managed readily by the health care systems. A cross-sectional study was carried out among the Bangladeshi health care workers from May 25, 2021, to June 5, 2021. As COVID-19 restriction existed countrywide, data were collected via a semi-structured online questionnaire by following convenient and snowball sampling methods. The main outcome variable of this study was the black fungus knowledge score; was measured by a six items’ questionnaire. The other studied variables included socio-demographic, workplace, COVID-19, and health-related information of the respondents. The t-test and one-way ANOVA test were performed to investigate the association between the black fungus knowledge score and the studied variables. This study found 422 responses from the health care workers of Bangladesh. Among the respondents, nearly half of them (45.26%) were doctors (n= 191); where the nurses (n=161) were 38.15%, and other health care workers (n=70) were 16.59%. This study found that the black fungus knowledge mean scores of health care workers were significantly associated with seniority (p=0.001), gender (p-value = 0.012), profession (p <0.001), death of friends and family members due to COVID-19 (p=0.049), and, etc. Moreover, the gender, income, job type, and marital status of the respondents were also found to be significantly associated with the mean scores of several items of the black fungus knowledge questionnaire. Proper knowledge of health care workers regarding any emerging public health issues is considered as a sine qua non-indicator of implementing the health care system readily. This study emphasized the black fungus knowledge of the health care workers along with other associated factors. The study's findings could help the policymakers to mitigate the mucormycosis and other infectious diseases emergencies in the post-COVID-19 situation, where the wave of the pandemic was surging continuously.

Prediction of Deleterious Single Nucleotide Polymorphisms in Human p53 Gene, 2018

With a variety of accessible Single Nucleotide Polymorphisms (SNPs) data on human p53 gene, this ... more With a variety of accessible Single Nucleotide Polymorphisms (SNPs) data on human p53 gene, this investigation is intended to deal with detrimental SNPs in p53 gene by executing diverse valid computational tools, including Filter, SIFT, PredictSNP, Fathmm, UTRScan, ConSurf, Phyre, Tm-Adjust, I-Mutant, Task Seek after practical and basic appraisal, dissolvable openness, atomic progression, and analysing the energy minimization. Of 581 p53 SNPs, 420 SNPs are found to be missense or non-synonymous and 435 SNPs are in the 3 prime UTR and 112 SNPs are of every 5 prime UTR from which 16 non synonymous SNPs (nsSNPs) as non-tolerable while PredictSNP package predicted 14 (taking consideration SNP colored green by two or more than 2 analyses is neutral). By concentrating on six bioinformatics tools of various dimensions a combined output is generated where 14 nsSNPs are prone to exert a deleterious effect. By using diverse SNP analysing tools we have found 5 missense SNPs in the 3 crucial amino acids position in the DNA binding domain. The underlying discoveries are fortified by I-Mutant and Project HOPE. The ExPASy-PROSITE tools characterized whether the mutations located in the functional part of the protein or not. This study provides a decisive outcome concluding the accessible SNPs information by recognizing the five harming nsSNPs: rs28934573 (S241F), rs11540652 (R248Q), rs121913342 (R248W), rs121913343 (R273C) and rs28934576 (R273H). The findings of this investigation recognize the detrimental nsSNPs which enhance the danger of various kinds of oncogenesis in patients of different populations' in genome-wide studies (GWS).